Bioregulator Research

Pinealon

Not FDA approvedBrain, mood & sleepLongevity & cellular
6.4/10

BioHarmony verdict

Worth trying

Pinealon (Glu-Asp-Arg, or EDR) is a synthetic Khavinson tripeptide marketed for neuroprotection and cognition. Independent biophysics confirms it can contact DNA, per Silanteva 2019, but the only human data is a single uncontrolled cohort of 32, per Meshchaninov 2015, with no registered trial anywhere.

Read full report

What is Pinealon?

Pinealon is a synthetic tripeptide, Glu-Asp-Arg, usually shortened to EDR, and it is one of Vladimir Khavinson's short-peptide bioregulators developed in Russia. It gets marketed for neuroprotection, cognition, and brain aging. The short version of my read: the cell biology is genuinely interesting, but the human evidence simply is not there. There are no registered human trials anywhere, no FDA record, and no published effect size for human cognition. The strongest human data is a single open-label cohort of 32 people from the lab that created it, per Meshchaninov 2015, with no placebo and no blinding.

From the BioHarmony report, reviewed 2026-09-08.

Safety watch-outs

  • Any unexplained fatigue, easy bruising, or signs of low blood counts: stop and get a complete blood count, given the reported…
  • Any new neurological symptom while dosing an unproven grey-market peptide: stop and consult a clinician.
  • Injection-site reaction, fever, or signs of contamination from an injectable preparation: stop immediately, since sterility is unverified.
  • Any active or suspected cancer: do not use
  • a compound claimed to alter gene expression in cells has no safety data in that setting.

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for Pinealon yet.

More reported protocols

Members

Members can compare additional reported doses, schedules, and preparation notes.

Educator coverage (2)

Attributed viewpoints, separate from primary research.

Trust & sourcing

US approvalNot FDA approved
CompoundingNo FDA-approved U.S. product is identified in the reviewed source set
Last checked2026-07-13
Next review2027-01-09

Pinealon, also called the EDR tripeptide, has mechanistic, cell, animal, and limited Russian clinical literature. A 2020 review discusses possible gene-expression mechanisms, but the evidence does not establish an FDA-approved treatment.

Primary sources

  1. 7.1/10SemaxStrong recommendRecoveryNot FDA approvedSemax is a Russian-developed ACTH 4-7 + PGP heptapeptide with the strongest human signal in post-stroke recovery, including a 110-patient Gusev et al.
  2. 6.9/10SelankWorth tryingBrain & sleepNot FDA approvedSelank is a synthetic tuftsin-derived heptapeptide studied as a non-sedating anxiolytic.
  3. 6.7/10Epitalon (Epithalon)Worth tryingBrain & sleepNot FDA approvedEpitalon is a synthetic AEDG tetrapeptide with in vitro telomerase and telomere data, animal lifespan signals, and Russian pineal-peptide melatonin studies.
  4. 6.3/10CerebrolysinWorth tryingRecoveryNot FDA approvedCerebrolysin is a porcine brain-derived peptide mixture given by IV or IM infusion.

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