Tesamorelin

What is Tesamorelin?

Tesamorelin is a prescription peptide that mimics growth hormone-releasing hormone and stimulates the pituitary GHRH receptor. Instead of injecting growth hormone directly, tesamorelin amplifies endogenous pulsatile GH release and raises downstream IGF-1. The practical result is a selective lipolytic signal that reduces visceral adipose tissue in the FDA-approved HIV lipodystrophy population while largely preserving subcutaneous fat.

From the BioHarmony report, reviewed 2026-09-19.

How it is thought to work

Binds pituitary GHRH receptors and amplifies endogenous pulsatile GH release, raising IGF-1 while preserving somatostatin-mediated negative feedback.

Safety watch-outs

• Severe edema or carpal tunnel symptoms
• Fasting glucose drift upward

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for Tesamorelin yet.

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