Mitochondrial Small Molecule

BAM15

InvestigationalWeight & metabolicLongevity & cellular
5.0/10

BioHarmony verdict

Neutral

BAM15 is an experimental mitochondrial uncoupler that reversed diet-induced obesity and insulin resistance in mice without raising body temperature, the effect that made 2,4-dinitrophenol lethal. It has never been tested in a single human, and is sold only as an unregulated research chemical.

Read full report

What is BAM15?

BAM15 is an experimental compound that makes cells burn more fuel by letting protons leak across the inner mitochondrial membrane. In mice it reversed obesity and insulin resistance without the overheating that killed people who took its predecessor.

From the BioHarmony report, reviewed 2026-09-09.

How it is thought to work

Mitochondrial uncoupling without plasma-membrane depolarization

Safety watch-outs

  • Fever, profuse sweating or a racing heart: stop immediately and seek care, since that is the DNP toxicity pattern.
  • Confusion, muscle rigidity or dark urine: stop and seek emergency care, since that pattern points to a rhabdomyolysis or hyperthermia…
  • Any product without a verified certificate of analysis: do not take it, because no approved supply of BAM15 exists anywhere.

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for BAM15 yet.

More reported protocols

Members

Members can compare additional reported doses, schedules, and preparation notes.

Educator coverage (3)

Attributed viewpoints, separate from primary research.

Trust & sourcing

US approvalInvestigational
CompoundingEligibility not established.
Last checked2026-07-13
Next review2027-01-09

BAM15 is a small-molecule mitochondrial uncoupler studied in cells and animal models. Published evidence does not establish human safety, effectiveness, or dosing.

Primary sources

  1. 6.5/10MOTS-cWorth tryingWeight & metabolicNot FDA approvedMOTS-c is a 16-amino-acid mitochondrial-derived peptide discovered in Lee 2015 that activates AMPK through the folate and purine pathway.
  2. 6.2/10IpamorelinWorth tryingRecoveryNot FDA approvedIpamorelin is a selective growth-hormone secretagogue with strong receptor selectivity but almost no human efficacy data: its only completed human efficacy trial…
  3. 6.1/10TirzepatideWorth tryingWeight & metabolicFDA-approved product existsTirzepatide is a once-weekly subcutaneous dual GIP plus GLP-1 receptor agonist with unusually large weight-loss and glycemic effects.
  4. 6.0/10Semaglutide (GLP-1 Agonist)Worth tryingWeight & metabolicFDA-approved product existsSemaglutide is a prescription GLP-1 receptor agonist that produced 14.9% mean weight loss in STEP-1 and cut 3-point MACE by 20% in SELECT, but the 6.0-6.5/10 score holds…

Free guide

The Ultimate Peptides Guide

Spot stronger candidates, weak evidence, and seller red flags before you buy.

Free. Includes evidence and regulatory updates. Unsubscribe anytime.