Humanin

What is Humanin?

Humanin is a tiny peptide your own mitochondria make, and that is the whole reason it is so interesting. It is a 24-amino-acid mitochondrial-derived peptide encoded inside your mitochondrial DNA, which means it is a native signal your body already produces, not a foreign drug invented in a lab. It scores Neutral at 5.5-6.0/10 because the biology is genuinely compelling while the human proof is missing. Researchers found that children of centenarians, who tend to live unusually long themselves, carry much higher circulating humanin, and that the peptide generally declines as people age, per Yen 2020. That is the kind of longevity-association story that gets attention.

From the BioHarmony report, reviewed 2026-09-08.

How it is thought to work

Cytoprotective and anti-apoptotic signaling via FPRL1, IGFBP-3 binding, and JAK/STAT3

Safety watch-outs

• Any active, recent, or suspected cancer: do not use, given the theoretical pro-survival and IGFBP-3 signaling concern.
• Worsening or progressive injection-site reaction with each dose: stop and reassess source quality.
• Any systemic reaction such as fever or spreading redness, which can signal a contaminated grey-market product: stop immediately.
• Pregnancy or breastfeeding: do not use, since there is no safety data.

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for Humanin yet.

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