Performance Research Small Molecule
SLU-PP-332
BioHarmony verdict
Neutral
SLU-PP-332 is a synthetic pan-ERR agonist developed in the Thomas Burris lab. Billon et al. 2023 showed increased mouse treadmill endurance after 8 days of injection, but no human trial, human pharmacokinetic study, or validated human dose exists.
Read full reportWhat is SLU-PP-332?
SLU-PP-332 is a synthetic exercise-mimetic research compound designed to activate the estrogen-related receptor family: ERR alpha, ERR beta, and ERR gamma. ERRs are orphan nuclear receptors that work with PGC-1 alpha to regulate mitochondrial biogenesis, fatty acid oxidation, oxidative muscle-fiber programs, and energy metabolism. In plain English, SLU-PP-332 tries to flip part of the same transcriptional switch endurance training flips.
From the BioHarmony report, reviewed 2026-09-08.
How it is thought to work
Activates estrogen-related receptor alpha, beta, and gamma, which partner with PGC-1 alpha to regulate mitochondrial biogenesis, fatty acid oxidation, oxidative muscle-fiber programs, and hepatic lipid handling.
Safety watch-outs
- Severe agitation or insomnia
- New muscle pain or weakness
Full risk profile in the BioHarmony report.
Dosing as published
No approved-label or study protocol is recorded for SLU-PP-332 yet.
More reported protocols
MembersMembers can compare additional reported doses, schedules, and preparation notes.
Educator coverage (4)
Attributed viewpoints, separate from primary research.
- Why Longevity Protocols Fail: Peptides, Stacks & the Science of PrecisionAlex Kikel · 2026-07-03
- My Top Peptide Stack for Mental Clarity & Muscle RepairAlex Kikel · 2025-07-08
- New Study On SLU-PP-332 Just ReleasedHunter Williams · 2026-03-29
- SLU-PP-332 Dosage Per Day: How Much and When to Take ItJay Campbell · 2026-07-12
Trust & sourcing
Published studies describe SLU-PP-332 as a synthetic small-molecule pan-ERR agonist with exercise-mimetic effects in mouse models. Human safety and effectiveness have not been established.
Primary sources
- A Synthetic ERR Agonist Alleviates Metabolic SyndromePubMed / Journal of Pharmacology and Experimental Therapeutics · 2024-01-01
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