Performance Research Small Molecule

SLU-PP-332

4.7/10

BioHarmony verdict

Neutral

SLU-PP-332 is a synthetic pan-ERR agonist developed in the Thomas Burris lab. Billon et al. 2023 showed increased mouse treadmill endurance after 8 days of injection, but no human trial, human pharmacokinetic study, or validated human dose exists.

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What is SLU-PP-332?

SLU-PP-332 is a synthetic exercise-mimetic research compound designed to activate the estrogen-related receptor family: ERR alpha, ERR beta, and ERR gamma. ERRs are orphan nuclear receptors that work with PGC-1 alpha to regulate mitochondrial biogenesis, fatty acid oxidation, oxidative muscle-fiber programs, and energy metabolism. In plain English, SLU-PP-332 tries to flip part of the same transcriptional switch endurance training flips.

From the BioHarmony report, reviewed 2026-09-08.

How it is thought to work

Activates estrogen-related receptor alpha, beta, and gamma, which partner with PGC-1 alpha to regulate mitochondrial biogenesis, fatty acid oxidation, oxidative muscle-fiber programs, and hepatic lipid handling.

Safety watch-outs

  • Severe agitation or insomnia
  • New muscle pain or weakness

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for SLU-PP-332 yet.

More reported protocols

Members

Members can compare additional reported doses, schedules, and preparation notes.

Educator coverage (4)

Attributed viewpoints, separate from primary research.

Trust & sourcing

US approvalInvestigational
CompoundingEligibility not established.
Last checked2026-07-13
Next review2027-01-09

Published studies describe SLU-PP-332 as a synthetic small-molecule pan-ERR agonist with exercise-mimetic effects in mouse models. Human safety and effectiveness have not been established.

Primary sources

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