Tesofensine

What is Tesofensine?

Tesofensine is a lab-made small molecule that blocks the brain's reuptake of all three major monoamines, serotonin, noradrenaline, and dopamine, at once. That triple block raises the levels of those neurotransmitters, and the dominant result is that you stop feeling hungry. It is a triple monoamine reuptake inhibitor, and it is not a peptide.

From the BioHarmony report, reviewed 2026-09-08.

How it is thought to work

Blocks reuptake of all three central monoamines, suppressing appetite while raising sympathetic tone

Safety watch-outs

• Rising resting heart rate or blood pressure (the development-stalling cardiovascular signal): stop and consult a clinician.
• New or worsening anxiety, irritability, low mood, or insomnia (the monoamine and psychiatric signal): stop and reassess.
• Any cardiovascular disease, hypertension, arrhythmia, or elevated baseline resting heart rate: do not use.
• History of anxiety, mood disorder, or substance-use disorder: do not use without close supervision, given the stimulant-class mechanism.
• Grey-market or research-chemical material of unverified purity and dose: do not use.

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for Tesofensine yet.

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