C60 (Buckminsterfullerene)

C60 (Buckminsterfullerene) shows modest antioxidant activity but the evidence does not support oral longevity claims for most users. The only reproducible human data come from a small cosmetic trial that found modest wrinkle reduction after topical application Kato et al. 2010, which does not translate to systemic benefits. Rodent studies that reported dramatic lifespan extension were limited to a single rat experiment and later corrected for figure errors Baati et al. 2012 and a subsequent corrigendum, while independent mouse work found no advantage over water controls and suggested possible harm when delivered in olive oil Shytikov et al. 2021. Accordingly, C60 (Buckminsterfullerene) may be of interest to highly controlled self-experiments focused on short-term recovery, but it carries uncertain efficacy and safety for broader longevity or performance use in general.

✅ Best for: High-stress endurance athletes, ultra-marathoners, and advanced self-experimenters who already have the basics handled, can afford therapeutic-grade C60 oil, can verify storage and quality controls, and accept that the human evidence base is functionally absent for oral longevity. The strongest fit is someone testing a short, measurable recovery block during unusually high training stress, with clear stop criteria and no fertility, pregnancy, medication, or cancer-treatment concerns.

❌ Avoid if: You are pregnant, planning pregnancy, breastfeeding, trying to conceive, pediatric, taking photosensitizing drugs, using anticancer therapy, using anticoagulants without clinician review, or unable to refrigerate and store C60 away from light. Avoid C60 if you want evidence-validated longevity interventions, are on a tight supplement budget, or would be using it before proven basics. The audit found no large human RCT, no meta-analysis, no Cochrane review, and no positive FDA efficacy signal for consumer health claims.