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Promising · 6.5/10

Ca-AKG (Calcium Alpha-Ketoglutarate)

Evidence D · early evidence ▲ 14.6% momentum 🥇 First scout open
6.5/ 10

Ca-AKG is a calcium salt of alpha-ketoglutarate, a Krebs-cycle metabolite tied to epigenetic enzymes, inflammation signaling, and bone turnover. Mouse lifespan and frailty data from Shahmirzadi 2020 are strong, but human longevity evidence still rests on weak methylation-age data and a pending controlled trial. Read the full breakdown →

The prediction game

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Ring Promising Momentum 14.6% Updated Jul 20, 2026 How the Index ranks →

Verdict by Nick Urban, host of the High Performance Longevity podcast.

For education only, not medical advice. Supplements, peptides, and protocols can interact with medications and conditions. Talk to a qualified clinician before starting anything here.