Health Optimization Index
Ca-AKG (Calcium Alpha-Ketoglutarate)
- Nick’s assessment
- Promising
- Research evidence
- D, early evidence
- Attention
- 8.1 / 100▼ Falling this week
BioHarmony score
Ca-AKG is a calcium salt of alpha-ketoglutarate, a Krebs-cycle metabolite tied to epigenetic enzymes, inflammation signaling, and bone turnover. Mouse lifespan and frailty data from Shahmirzadi 2020 are strong, but human longevity evidence still rests on weak methylation-age data and a pending controlled trial.
Read the full report Benefits, risks and practical guidance.
Read Nick’s assessment Why it earned this rating
Ca-AKG (Calcium Alpha-Ketoglutarate) is a 6.5–7.0/10 fit for people treating aging biology as a tracked experiment, especially bone turnover, frailty, inflammation, or methylation-age curiosity, because the best signal is still preclinical longevity plus narrow human bone and methylation-age evidence. Shahmirzadi 2020 gives the strongest anchor, while Filip 2007 adds useful context without closing the case. The honest gap is simple: human lifespan, functional aging, and everyday performance data are not there yet. That puts Ca-AKG (Calcium Alpha-Ketoglutarate) in the tracked-experiment category, not the automatic-staple category. In practice, Ca-AKG (Calcium Alpha-Ketoglutarate) makes the most sense when you monitor bone markers, inflammatory markers, sleep, training response, or methylation panels and avoid treating Ca-AKG (Calcium Alpha-Ketoglutarate) like a proven anti-aging pill.
✅ Best for: Adults over 50 with elevated epigenetic age, especially if they are already measuring GrimAge, DunedinPACE, TruAge, or similar clocks and can repeat the same test after 4-7 months. Postmenopausal women with osteopenia who understand that Filip 2007 supports bone-turnover markers, not fracture prevention. Longevity stack builders who accept that Shahmirzadi 2020 is mouse data and Demidenko 2021 is uncontrolled. People with elevated inflammatory markers who want a low-cost experiment around the IL-10 and inflammaging pathway. Generic Ca-AKG users who can keep total supplemental calcium sane and do not need a felt daily effect.
❌ Avoid if: You have primary hyperparathyroidism, active coronary artery calcification, advanced atherosclerosis where supplemental calcium is discouraged, severe CKD with eGFR under 30, active IDH-mutant malignancy, pregnancy, or lactation. Avoid high-dose Ca-AKG if you already take calcium, eat a high-calcium fortified diet, or use Rejuvant plus high-retinol foods or cod liver oil. Skip it if you expect stimulant-like energy, visible anti-aging changes, or FDA-reviewed disease claims. Ca-AKG is a mechanism-trust supplement with promising animal data, thin human longevity data, and no major guideline endorsement for healthy-aging use.
Share your experience
Your answers are optional and help other readers — they never change my score. How community input works.
One step left: confirm it’s you
New voice here? We send a one-tap verification link so every entry comes from a real person. Signed-in members skip this.
Make a 12-month prediction Will it rise or fall in the Index?
Choose a direction and your confidence. Correct predictions earn leaderboard points.
Your prediction is final once submitted. We’ll check it in 12 months. See the leaderboard →