Health Optimization Index
CJC-1295 No DAC (Mod GRF 1-29)
- Nick’s assessment
- Promising
- Research evidence
- C, mixed evidence
- Attention
- 8.1 / 100▼ Falling this week
BioHarmony score
CJC-1295 No DAC (Mod GRF 1-29) is a short-acting GHRH peptide, almost always stacked with ipamorelin, that prompts a pulse of your own growth hormone. Human data exists only for the long-acting DAC version, per Teichman 2006; the no-DAC form has no dedicated human trial, and neither form has a human outcome study.
Read the full report Benefits, risks and practical guidance.
Read Nick’s assessment Why it earned this rating
It pairs a clean, physiological mechanism with an almost empty human outcomes file and a form that has never been tested in people. If you want a short-acting growth-hormone pulse to stack with ipamorelin, accept that the benefits are unproven, can source verified no-DAC material, and will monitor IGF-1 and glucose, it is a reasonable low-drama experiment. If you expect evidence-backed fat loss or recovery, the data is not there, and the better-supported path is tesamorelin plus ipamorelin, per Falutz 2007. The two biggest real-world frictions are the flushing reaction and unregulated sourcing.
✅ Best for: Experienced users who value a physiological, pulsatile growth-hormone pattern and will run it with ipamorelin. Older adults with lower baseline growth-hormone output, who tend to respond more. People chasing the most consistently reported effect, deeper sleep, who will judge it on their own response over a few weeks. Anyone who can verify they have the no-DAC form by certificate-of-analysis molecular weight and obtain pharmaceutical-grade material. Users who already have training, protein, and sleep dialed in and want a low-suppression add-on.
❌ Avoid if: You have active or hormone-sensitive cancer, since growth-hormone and IGF-1 signaling can promote proliferation. You are pregnant or breastfeeding, with no safety data. You have uncontrolled diabetes or insulin resistance, because growth hormone opposes insulin. You have significant cardiovascular disease, especially if considering the DAC form given its unresolved trial-death history. You compete in tested sport, since growth-hormone-releasing factors are banned at all times under WADA S2. You cannot verify source quality or form, because no-DAC is frequently mislabeled and research-chemical contamination may exceed the intrinsic pharmacological risk.
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