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Proven · 7.1/10

KPV (Lys-Pro-Val)

Evidence C · mixed evidence ▼ 14.6% momentum 🥇 First scout open
7.1/ 10

KPV is a three-amino-acid alpha-MSH fragment that reduced inflammation in mouse colitis models through PepT1 uptake and NF-kB pathway suppression, but it still has zero completed human RCTs. Dalmasso 2008 and Kannengiesser 2008 make the case compelling, while FDA and guideline gaps keep the score at 6.6. Read the full breakdown →

The prediction game

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The Crowd’s Call

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Your 12-month call on KPV (Lys-Pro-Val)

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Ring Proven Momentum 14.6% Updated Jul 20, 2026 How the Index ranks →

Verdict by Nick Urban, host of the High Performance Longevity podcast.

For education only, not medical advice. Supplements, peptides, and protocols can interact with medications and conditions. Talk to a qualified clinician before starting anything here.