Health Optimization Index
MK-777 (Acetamoren)
- Nick’s assessment
- Experimental
- Research evidence
- E, thin evidence
- Attention
- 8.1 / 100▲ Rising this week
BioHarmony score
MK-777, sold as acetamoren, is marketed as a next-generation oral MK-677 analog, yet it has never been tested in one published trial. Every efficacy claim is borrowed from MK-677 (ibutamoren), the studied parent compound. If you want that effect, the parent holds the evidence; the relabel does not.
Read the full report Benefits, risks and practical guidance.
Read Nick’s assessment Why it earned this rating
MK-777 is MK-677's reputation wearing a new name. If you want the growth hormone secretagogue effect, the parent has the real evidence and this analog has none, which is why it scores 4.5 and lands below the studied MK-677 at 4.9. The honest finding is that no science establishes MK-777 works, is safer, or is next-generation relative to MK-677. That positioning is marketing language riding on a better-known, actually-studied molecule.
✅ Best for: Researchers and analysts mapping the gray-market secretagogue space who need a documented example of a relabel with no data of its own. Writers covering peptide and research-chemical marketing who want the honest evidence state rather than the vendor version. Anyone weighing MK-777 against its parent who needs the comparison spelled out. Not people looking for a compound to take today.
❌ Avoid if: You want a growth hormone secretagogue you can take now, in which case the studied parent MK-677 has the human record MK-777 lacks. You are prone to elevated fasting glucose or insulin resistance, since the parent-class effect raises glucose. You compete in tested sport, because the class is WADA-banned. You cannot verify a vendor's purity, which for an unlisted molecule is a real sourcing risk.
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