Health Optimization Index
MK-777 (Acetamoren)
- Nick’s assessment
- Experimental
- Research evidence
- E, thin evidence
- Attention
- 10.1 / 100▲ Rising this week
BioHarmony score
MK-777, sold as acetamoren, is marketed as a next-generation oral MK-677 analog, yet it has never been tested in one published trial. Every efficacy claim is borrowed from MK-677 (ibutamoren), the studied parent compound. If you want that effect, the parent holds the evidence; the relabel does not.
Read the full report Benefits, risks and practical guidance.
Read Nick’s assessment Why it earned this rating
MK-777 is MK-677's reputation wearing a new name. If you want the growth hormone secretagogue effect, the parent has the real evidence and this analog has none, which is why it scores 4.5–5.0/10 and lands below the studied MK-677 at 4.9/10. The honest finding is that no science establishes MK-777 works, is safer, or is next-generation relative to MK-677. That positioning is marketing language riding on a better-known, actually-studied molecule.
✅ Best for: Researchers and analysts mapping the gray-market secretagogue space who need a documented example of a relabel with no data of its own. Writers covering peptide and research-chemical marketing who want the honest evidence state rather than the vendor version. Anyone weighing MK-777 against its parent who needs the comparison spelled out. Not people looking for a compound to take today.
❌ Avoid if: You want a growth hormone secretagogue you can take now, in which case the studied parent MK-677 has the human record MK-777 lacks. You are prone to elevated fasting glucose or insulin resistance, since the parent-class effect raises glucose. You compete in tested sport, because the class is WADA-banned. You cannot verify a vendor's purity, which for an unlisted molecule is a real sourcing risk.
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