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Proven · 8/10

NAC (N-Acetylcysteine)

Evidence B · good evidence ▼ 9.5% momentum 🥇 First scout open
8/ 10

NAC (N-acetylcysteine) is the rate-limiting precursor to glutathione and the FDA-approved antidote for acetaminophen overdose, cutting hepatotoxicity to about 6 percent when given within 10 hours per Smilkstein 1988 (n=2,540). High-dose 600mg twice daily lowered COPD exacerbations 22 percent in the PANTHEON trial (Zheng 2014, n=1,006). It is cheap, oral, and well tolerated. Read the full breakdown →

The prediction game

Where does NAC (N-Acetylcysteine) go in 12 months?

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The Crowd’s Call

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Your 12-month call on NAC (N-Acetylcysteine)

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Be the first scout on record for NAC (N-Acetylcysteine). Permanent credit on this page, plus points when your call resolves.

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Ring Proven Momentum 9.5% Updated Jul 20, 2026 How the Index ranks →

Verdict by Nick Urban, host of the High Performance Longevity podcast.

For education only, not medical advice. Supplements, peptides, and protocols can interact with medications and conditions. Talk to a qualified clinician before starting anything here.