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Experimental · 5/10

P21 (P021)

Evidence E · thin evidence ▼ 14.7% momentum 🥇 First scout open
5/ 10

P21 (P021) is a CNTF-derived peptidomimetic that crosses the blood-brain barrier and, in mice, raises BDNF, lifts hippocampal neurogenesis, and lowers tau pathology in Alzheimer's models. The catch is total. There are zero human trials, the single independent in-vivo replication failed to reproduce the BDNF benefit, and almost all the positive work comes from the inventor, who co-founded the company commercializing it. Read the full breakdown →

The prediction game

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Ring Experimental Momentum 14.7% Updated Jul 20, 2026 How the Index ranks →

Verdict by Nick Urban, host of the High Performance Longevity podcast.

For education only, not medical advice. Supplements, peptides, and protocols can interact with medications and conditions. Talk to a qualified clinician before starting anything here.