Skip to content
← The Index board

Experimental · 4.9/10

PE-22-28

Evidence E · thin evidence ▼ 11.5% momentum 🥇 First scout open
4.9/ 10

PE-22-28 is a synthetic spadin analogue that blocks the TREK-1 potassium channel, a target with a clean and well-characterized link to fast-acting antidepressant effects in rodents, per Mazella 2010 and Djillani 2017. The mechanism is promising and the rodent antidepressant data is real, but there are zero human trials, the dosing is biphasic in a way that can flip the effect, and it is grey-market only. Read the full breakdown →

The prediction game

Where does PE-22-28 go in 12 months?

Lock a call and say how sure you are. Right and confident earns the most; a leaderboard spot is the prize. No money, no stakes.

The Crowd’s Call

Rising or fading over the next 12 months? Lock your call and find out if you saw it coming.

Your 12-month call on PE-22-28

New voice here? We send a one-tap verification link so every entry comes from a real person. Signed-in members skip this.

Be the first scout on record for PE-22-28. Permanent credit on this page, plus points when your call resolves.

One call per intervention. It locks the moment you submit (no edits, no cancels) and resolves in 12 months. See the scout leaderboard →

Weigh In

Your input feeds the community signal shown beside my verdict. It informs the board and it never sets the score by itself. How community input works.

Tried it in real life?

Which ring does it deserve?

Same as above — one verification covers all your entries here.

Related reading

Ring Experimental Momentum 11.5% Updated Jul 20, 2026 How the Index ranks →

Verdict by Nick Urban, host of the High Performance Longevity podcast.

For education only, not medical advice. Supplements, peptides, and protocols can interact with medications and conditions. Talk to a qualified clinician before starting anything here.