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Health Optimization Index

SLU-PP-915

Nick’s assessment
Experimental
Research evidence
E, thin evidence
Attention
8.1 / 100▲ Rising this week
4.7/ 10

BioHarmony score

SLU-PP-915 is an orally active pan-ERR agonist, a later analog of the injection-only SLU-PP-332. Its one real advance is the oral route. Its own demonstrated effect is narrow, oral exercise-capacity parity with injected 332 plus a five-day brown-fat gene signal, and it has never been tested in a human.

Read the full report Benefits, risks and practical guidance.

Read Nick’s assessment Why it earned this rating

SLU-PP-915 is a real chemical advance on an interesting compound and one of the worse things a person could buy right now, and both come from the same fact. The oral route is a legitimate improvement over 332, and the 915-specific evidence behind it is two mouse studies. The mechanism is coherent, the oral bioavailability is a published result rather than a marketing line, and the exercise-capacity parity with injected 332 is real in mice (Billon et al. 2026). That is where the good news stops. There is no human data, no dose, no safety package, and the fat-loss story vendors attach to 915 actually belongs to SLU-PP-332. The more-selective claim is unverified. Score it as a compound to watch through its first real toxicology and human work, not one to source from a research-chemical vendor and dose by guesswork.

✅ Best for: Researchers and coaches tracking the ERR-agonist exercise-mimetic class who want a reference point for where oral 915 sits against injected 332. People who want the honest state of the 915-specific evidence rather than the vendor version that blends it with 332's fat-loss data. Anyone comparing the SLU-PP series who needs the distinction between the two compounds drawn clearly. Writers and analysts covering the exercise-mimetic space who want the primary literature separated from the marketing.

❌ Avoid if: You are looking for a fat-loss compound to take, since 915's own data shows exercise capacity and one brown-fat gene, not weight loss, and no human has ever been dosed. You would be buying research-chemical powder, which carries no purity guarantee, no dose verification and no recourse. You have any cardiac concern, since the mechanism touches cardiac fuel metabolism and has never been tested in a human heart. You are inclined to weight-scale a mouse dose to your own body, which is guesswork with no pharmacokinetic basis for 915 in people.

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Updated Sep 14, 2026 How the Index ranks →

Educational information, not medical advice. Ask a qualified clinician about risks and interactions. Independent ratings: no affiliate links, sponsored placements or paid rankings.