Skin And Cosmetic Research
AHK-Cu (Copper Tripeptide)
BioHarmony verdict
Worth trying
AHK-Cu is a topical copper tripeptide, Alanine-Histidine-Lysine plus copper, marketed for hair growth. Its entire AHK-Cu-specific evidence base is one unreplicated in-vitro study from 2007, per Pyo, with no human trial. It is harmless as a cosmetic but barely studied.
Read full reportWhat is AHK-Cu (Copper Tripeptide)?
AHK-Cu is a synthetic copper-binding tripeptide, the amino acids Alanine, Histidine, and Lysine carrying a copper ion, sold mostly as a topical cosmetic for hair growth. Think of it as the lesser-known cousin of GHK-Cu: the two molecules differ by a single amino acid, yet their evidence bases are not even close. The proposed logic is targeted copper delivery to skin and follicle tissue, where copper helps cross-link collagen and elastin and where the peptide is said to raise VEGF and wake up the dermal-papilla cells that drive follicle growth, per Pyo 2007. That story is coherent.
From the BioHarmony report, reviewed 2026-09-08.
How it is thought to work
Targeted copper delivery to skin and follicle tissue, with proposed VEGF and dermal-papilla stimulation
Safety watch-outs
- Persistent or spreading scalp rash, swelling, or contact dermatitis: stop applying and let the skin recover.
- Anyone considering injectable or mesotherapy use: it is off-label, non-approved, and unstudied for AHK-Cu
- do not inject.
Full risk profile in the BioHarmony report.
Dosing as published
No approved-label or study protocol is recorded for AHK-Cu (Copper Tripeptide) yet.
More reported protocols
MembersMembers can compare additional reported doses, schedules, and preparation notes.
Trust & sourcing
AHK-Cu has ex vivo human hair-follicle and cultured dermal-papilla-cell research. That laboratory evidence does not establish clinical effectiveness, injectable use, or an FDA-approved hair-loss treatment.
Primary sources
- The effect of tripeptide-copper complex on human hair growth in vitroPubMed / Archives of Pharmacal Research · 2007-07-01
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