Skin And Cosmetic Research

AHK-Cu (Copper Tripeptide)

InvestigationalSkin & hair
6.5/10

BioHarmony verdict

Worth trying

AHK-Cu is a topical copper tripeptide, Alanine-Histidine-Lysine plus copper, marketed for hair growth. Its entire AHK-Cu-specific evidence base is one unreplicated in-vitro study from 2007, per Pyo, with no human trial. It is harmless as a cosmetic but barely studied.

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What is AHK-Cu (Copper Tripeptide)?

AHK-Cu is a synthetic copper-binding tripeptide, the amino acids Alanine, Histidine, and Lysine carrying a copper ion, sold mostly as a topical cosmetic for hair growth. Think of it as the lesser-known cousin of GHK-Cu: the two molecules differ by a single amino acid, yet their evidence bases are not even close. The proposed logic is targeted copper delivery to skin and follicle tissue, where copper helps cross-link collagen and elastin and where the peptide is said to raise VEGF and wake up the dermal-papilla cells that drive follicle growth, per Pyo 2007. That story is coherent.

From the BioHarmony report, reviewed 2026-09-08.

How it is thought to work

Targeted copper delivery to skin and follicle tissue, with proposed VEGF and dermal-papilla stimulation

Safety watch-outs

  • Persistent or spreading scalp rash, swelling, or contact dermatitis: stop applying and let the skin recover.
  • Anyone considering injectable or mesotherapy use: it is off-label, non-approved, and unstudied for AHK-Cu
  • do not inject.

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for AHK-Cu (Copper Tripeptide) yet.

More reported protocols

Members

Members can compare additional reported doses, schedules, and preparation notes.

Trust & sourcing

US approvalInvestigational
CompoundingEligibility not established.
Last checked2026-07-13
Next review2027-01-09

AHK-Cu has ex vivo human hair-follicle and cultured dermal-papilla-cell research. That laboratory evidence does not establish clinical effectiveness, injectable use, or an FDA-approved hair-loss treatment.

Primary sources

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