Skin And Cosmetic Research

GHK-Cu (Copper Peptide)

7.4/10

BioHarmony verdict

Strong recommend

GHK-Cu is a human copper-binding tripeptide with the best evidence for topical skin repair and wound healing, including Mulder 1994 diabetic ulcer data showing 98.5% median closure versus 60.8% vehicle. Systemic injection remains unproven in human trials.

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What is GHK-Cu (Copper Peptide)?

GHK-Cu is the copper-bound form of the human tripeptide glycyl-L-histidyl-L-lysine. Think of GHK as a small carrier peptide and Cu2+ as the copper ion it holds. Together, GHK-Cu acts less like a stimulant and more like a repair signal: it helps deliver copper into contexts where collagen, elastin, glycosaminoglycans, antioxidant enzymes, keratinocytes, fibroblasts, and wound-bed remodeling are already active.

From the BioHarmony report, reviewed 2026-09-08.

Safety watch-outs

  • Injection-site infection
  • Copper excess symptoms: nausea, metallic taste, abdominal pain

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for GHK-Cu (Copper Peptide) yet.

More reported protocols

Members

Members can compare additional reported doses, schedules, and preparation notes.

Educator coverage (5)

Attributed viewpoints, separate from primary research.

Trust & sourcing

US approvalNot FDA approved
CompoundingInjectable nomination withdrawn from Category 2; eligibility is not established
Last checked2026-07-13
Next review2026-10-11

FDA identifies immunogenicity and peptide-impurity concerns for injectable compounded GHK-Cu and notes that human safety data are limited.

Primary sources

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