Tissue Repair Research

KPV (Lysine-Proline-Valine)

Not FDA approvedRecovery & tissue repairSkin & hairImmune & gut
7.1/10

BioHarmony verdict

Strong recommend

KPV is a three-amino-acid alpha-MSH fragment that reduced inflammation in mouse colitis models through PepT1 uptake and NF-kB pathway suppression, but it still has zero completed human RCTs. Dalmasso 2008 and Kannengiesser 2008 make the case compelling, while FDA and guideline gaps keep the score at 7.0-7.5/10.

Read full report

What is KPV (Lysine-Proline-Valine)?

KPV is a three-amino-acid peptide, Lys-Pro-Val, corresponding to amino acids 11-13 of alpha-melanocyte-stimulating hormone. In practical biohacker language, KPV is an experimental anti-inflammatory peptide used mostly for gut inflammation, IBD-adjacent symptoms, allergic rhinitis experiments, and topical skin inflammation. The strongest mechanistic finding is that Dalmasso 2008 showed KPV can enter intestinal and immune cells through PepT1 and reduce inflammatory signaling in mouse colitis models.

From the BioHarmony report, reviewed 2026-09-08.

How it is thought to work

PepT1-mediated cellular uptake with downstream NF-kB and MAPK inflammatory-pathway suppression in cell and mouse models.

Safety watch-outs

  • Injection-site infection
  • Worsening immune symptoms

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for KPV (Lysine-Proline-Valine) yet.

More reported protocols

Members

Members can compare additional reported doses, schedules, and preparation notes.

Trust & sourcing

US approvalNot FDA approved
CompoundingWithdrawn from Category 2 nomination; eligibility is not established
Last checked2026-07-13
Next review2026-10-11

FDA says it has not identified human exposure data for KPV and lacks enough information to determine whether administration would cause harm.

Primary sources

  1. 7.5/10BPC-157Strong recommendRecoveryNot FDA approvedBPC-157 is a 15-amino-acid gastric peptide fragment with consistent preclinical repair data, including a 2025 sports-medicine systematic review of 36 studies with 35…
  2. 7.5/10TB-500 (Thymosin Beta-4 Fragment)Strong recommendRecoveryNot FDA approvedTB-500 is a synthetic LKKTETQ fragment marketed for soft-tissue repair, but most human evidence is on full-length topical thymosin beta-4: Sosne 2023 reported corneal…
  3. 7.4/10GHK-Cu (Copper Peptide)Strong recommendRecoveryNot FDA approvedGHK-Cu is a human copper-binding tripeptide with the best evidence for topical skin repair and wound healing, including Mulder 1994 diabetic ulcer data showing 98.5%…
  4. 7.3/10Thymosin Alpha-1Strong recommendRecoveryNot FDA approvedFDA identifies immunogenicity and peptide-impurity concerns for compounded thymosin alpha-1 and says available safety information is inadequate.

Free guide

The Ultimate Peptides Guide

Spot stronger candidates, weak evidence, and seller red flags before you buy.

Free. Includes evidence and regulatory updates. Unsubscribe anytime.