Thymosin Beta-4 (Full)

What is Thymosin Beta-4 (Full)?

Thymosin beta-4 (Tβ4) is the native 43-amino-acid actin-sequestering peptide first sequenced from calf thymus by Low, Hu, and Goldstein in 1981, and it pairs the cleanest Phase 1 intravenous safety record in this class with a mixed Phase 3 efficacy profile and a narrowing access path. Its primary biochemical job is sequestering monomeric G-actin to tune cytoskeletal polymerization, which downstream drives cell migration, angiogenesis through integrin-linked kinase activation, anti-apoptotic Akt signaling, and dampened innate inflammation.

From the BioHarmony report, reviewed 2026-09-08.

How it is thought to work

Sequesters monomeric G-actin to regulate cytoskeletal dynamics; promotes cell migration, angiogenesis, anti-apoptosis, and anti-inflammation; cleaved to the Ac-SDKP antifibrotic tetrapeptide

Safety watch-outs

• Active or recent cancer (within 5 years): do not use. Preclinical models and correlative human IHC data show Tβ4 promotes tumor migration…
• Pregnancy, breastfeeding, or pediatric use: avoid. No human reproductive safety data exists.
• Tested athlete subject to WADA: do not use. Banned at all times with a 30 to 45 day detection window.
• Material with no certificate of analysis, no third-party sequence confirmation, or with the label TB-500: this is the fragment, not native…
• New or worsening allergic reaction at the injection site: stop and consult a clinician.

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for Thymosin Beta-4 (Full) yet.

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