Semax

What is Semax?

Semax is a synthetic neuropeptide derived from the ACTH 4-7 fragment with a Pro-Gly-Pro extension added for stability. It was developed in the Soviet and Russian peptide-pharmacology ecosystem and is best known outside Russia as an intranasal nootropic for focus, memory, and neuroprotection, though its registered medical use is regional rather than global.

From the BioHarmony report, reviewed 2026-09-08.

How it is thought to work

BDNF / TrkB and NGF signaling, cholinergic modulation, low-affinity melanocortin receptor activity, and enkephalin-degrading enzyme inhibition

Safety watch-outs

• Severe agitation or insomnia
• Nasal irritation or infection symptoms

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for Semax yet.

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