Hormone Signaling

Gonadorelin (GnRH)

FDA-approved product existsGH axis & hormones
6.3/10

BioHarmony verdict

Worth trying

Gonadorelin is synthetic GnRH, a decapeptide that tells the pituitary to release LH and FSH. It was formerly FDA-approved (Factrel, Lutrepulse) and is now used off-label as a TRT add-on to preserve fertility, though that use is extrapolated from hCG data, per Hsieh 2013, not from a dedicated trial.

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What is Gonadorelin (GnRH)?

Gonadorelin is synthetic GnRH, the natural hormone your hypothalamus pulses to run your entire reproductive system. It is a small 10-amino-acid peptide, and when it binds the GnRH receptor on your pituitary, it tells that gland to release luteinizing hormone and follicle-stimulating hormone. Those two gonadotropins then drive your testes or ovaries. So gonadorelin is not some fringe research chemical. It is a copy of the master switch at the top of the hormonal chain, and the pharmacology is textbook-clear, per Millar 2004. That clarity is real, and the safety profile is clean and reversible.

From the BioHarmony report, reviewed 2026-09-08.

How it is thought to work

Binds the GnRH receptor on pituitary gonadotropes, driving LH and FSH release

Safety watch-outs

  • Falling or flat LH and FSH despite frequent dosing (possible axis suppression from too-continuous exposure): cut frequency and consult a…
  • Worsening testicular shrinkage on the adjunct: reassess dosing pattern and source quality.
  • Signs of a hypersensitivity reaction after injection (rash, swelling, breathing trouble): stop and seek care.
  • Uncertain source identity, sterility, or dose from compounded or grey-market product: do not use until verified.

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for Gonadorelin (GnRH) yet.

More reported protocols

Members

Members can compare additional reported doses, schedules, and preparation notes.

Educator coverage (1)

Attributed viewpoints, separate from primary research.

Trust & sourcing

US approvalFDA-approved product exists
CompoundingHistorical approvals do not make currently promoted compounded products FDA approved
Last checked2026-07-13
Next review2026-10-11

FDA records show historical approvals for gonadorelin products including Factrel for diagnostic use and Lutrepulse for hypothalamic amenorrhea. Those records do not support the registry's promoted TRT-fertility or post-cycle protocols.

Primary sources

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  2. 6.4/10Kisspeptin-10Worth tryingGH & hormonesNot FDA approvedKisspeptin-10 is an investigational reproductive neuropeptide that activates the HPG axis through the KISS1R receptor.
  3. 6.2/10IpamorelinWorth tryingRecoveryNot FDA approvedIpamorelin is a selective growth-hormone secretagogue with strong receptor selectivity but almost no human efficacy data: its only completed human efficacy trial…
  4. 6.0/10TesamorelinWorth tryingWeight & metabolicFDA-approved product existsTesamorelin is a stabilized GHRH analog that reduced visceral adipose tissue in the landmark Falutz 2007 HIV lipodystrophy Phase 3 trial and has newer support for…

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