PT-141 (Bremelanotide)

What is PT-141 (Bremelanotide)?

PT-141, generic name bremelanotide, is a peptide that raises sexual desire from the brain rather than the bloodstream, and it's the only drug the FDA has approved for that purpose in premenopausal women. It activates melanocortin-4 receptors in the hypothalamus, which lifts dopamine signaling in the brain's reward and sexual-motivation circuits, per Pfaus 2022. That central mechanism is the whole point: it can help when the problem is wanting sex, not the physical ability to have it.

From the BioHarmony report, reviewed 2026-09-08.

Safety watch-outs

• Severe headache, chest pain, or a home blood-pressure reading at or above 180/110: stop and seek care.
• New or darkening moles, or pigment changes on the face, gums, or breasts: stop and see a dermatologist.
• Persistent low mood, blunted pleasure, or loss of motivation after dosing: stop
• the melanocortin-4 pathway is linked to anhedonia.
• Known cardiovascular disease or uncontrolled high blood pressure: do not use.

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for PT-141 (Bremelanotide) yet.

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