Tissue Repair Research

TB-500 (Thymosin Beta-4 Fragment)

7.5/10

BioHarmony verdict

Strong recommend

TB-500 is a synthetic LKKTETQ fragment marketed for soft-tissue repair, but most human evidence is on full-length topical thymosin beta-4: Sosne 2023 reported corneal healing in 6 of 10 RGN-259 subjects versus 1 of 8 placebo.

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What is TB-500 (Thymosin Beta-4 Fragment)?

TB-500 is the peptide-market name for a synthetic fragment commonly described as Ac-LKKTETQ, derived from the broader biology of thymosin beta-4. Most published human and animal literature is not on TB-500 itself. It is on full-length Tbeta4, a 43-amino-acid protein involved in actin dynamics, cell migration, angiogenesis, inflammation resolution, and tissue repair.

From the BioHarmony report, reviewed 2026-09-08.

How it is thought to work

G-actin monomer binding, cell migration support, angiogenesis signaling, inflammation modulation, matrix remodeling.

Safety watch-outs

  • Injection-site infection
  • Rapidly worsening swelling or pain

Full risk profile in the BioHarmony report.

Dosing as published

No approved-label or study protocol is recorded for TB-500 (Thymosin Beta-4 Fragment) yet.

More reported protocols

Members

Members can compare additional reported doses, schedules, and preparation notes.

Educator coverage (8)

Attributed viewpoints, separate from primary research.

Trust & sourcing

US approvalNot FDA approved
CompoundingWithdrawn from Category 2 nomination; eligibility is not established
Last checked2026-07-13
Next review2026-10-11

FDA identifies immunogenicity and peptide-impurity concerns for compounded TB-500 and says it has not identified human exposure data for the fragment.

Primary sources

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