Peptide

Linaclotide (Linzess)

FDA-approved product existsImmune & gut
Not yet scored

BioHarmony verdict

Awaiting review

No BioHarmony report yet. It is queued for review; until then, rely on the status and sources below.

What is Linaclotide (Linzess)?

FDA-approved linaclotide is marketed as Linzess for irritable bowel syndrome with constipation and chronic idiopathic constipation, with age- and indication-specific dosing in the label.

Dosing as published

Approved labelLINZESS prescribing information for IBS-C, chronic idiopathic constipation, and pediatric functional constipation
PopulationAdults and pediatric patients covered by the approved LINZESS indications
DoseAdults: 290 mcg daily for IBS-C, or 145 mcg or 72 mcg daily for chronic idiopathic constipation. Pediatric dosing is 145 mcg daily for IBS-C age 7 and older and 72 mcg daily for functional constipation age 2 and older.
RouteOral capsule on an empty stomach at least 30 minutes before a meal
FrequencyOnce daily
DurationLong-term use within the approved indication
PreparationReady-to-use 72 mcg, 145 mcg, and 290 mcg capsules; no reconstitution. The label provides water, applesauce, and feeding-tube administration instructions for patients unable to swallow the capsule whole.
Source: Dosage and Administration sections 2.1-2.2; Dosage Forms and Strengths section 3

More reported protocols

Members

Members can compare additional reported doses, schedules, and preparation notes.

Trust & sourcing

US approvalFDA-approved product exists
CompoundingFDA-approved product exists; compounded copies are not FDA approved
Last checked2026-07-13
Next review2026-10-11

Primary sources

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  2. 7.5/10TB-500 (Thymosin Beta-4 Fragment)Strong recommendRecoveryNot FDA approvedTB-500 is a synthetic LKKTETQ fragment marketed for soft-tissue repair, but most human evidence is on full-length topical thymosin beta-4: Sosne 2023 reported corneal…
  3. 7.4/10GHK-Cu (Copper Peptide)Strong recommendRecoveryNot FDA approvedGHK-Cu is a human copper-binding tripeptide with the best evidence for topical skin repair and wound healing, including Mulder 1994 diabetic ulcer data showing 98.5%…
  4. 7.3/10Thymosin Alpha-1Strong recommendRecoveryNot FDA approvedFDA identifies immunogenicity and peptide-impurity concerns for compounded thymosin alpha-1 and says available safety information is inadequate.

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