Peptide

Plecanatide (Trulance)

FDA-approved product existsImmune & gut
Not yet scored

BioHarmony verdict

Awaiting review

No BioHarmony report yet. It is queued for review; until then, rely on the status and sources below.

What is Plecanatide (Trulance)?

FDA-approved plecanatide is marketed as Trulance for chronic idiopathic constipation and irritable bowel syndrome with constipation in adults.

Dosing as published

Approved labelTRULANCE prescribing information for chronic idiopathic constipation and IBS-C
PopulationAdults covered by the approved TRULANCE indications
Dose3 mg
RouteOral tablet with or without food
FrequencyOnce daily
DurationLong-term use within the approved indication
PreparationReady-to-use 3 mg tablet; no reconstitution. The label permits crushing in applesauce or water and gives nasogastric or gastric feeding-tube instructions.
Source: Dosage and Administration sections 2.1-2.2; Dosage Forms and Strengths section 3

More reported protocols

Members

Members can compare additional reported doses, schedules, and preparation notes.

Trust & sourcing

US approvalFDA-approved product exists
CompoundingFDA-approved product exists; compounded copies are not FDA approved
Last checked2026-07-13
Next review2026-10-11

Primary sources

  1. 7.5/10BPC-157Strong recommendRecoveryNot FDA approvedBPC-157 is a 15-amino-acid gastric peptide fragment with consistent preclinical repair data, including a 2025 sports-medicine systematic review of 36 studies with 35…
  2. 7.5/10TB-500 (Thymosin Beta-4 Fragment)Strong recommendRecoveryNot FDA approvedTB-500 is a synthetic LKKTETQ fragment marketed for soft-tissue repair, but most human evidence is on full-length topical thymosin beta-4: Sosne 2023 reported corneal…
  3. 7.4/10GHK-Cu (Copper Peptide)Strong recommendRecoveryNot FDA approvedGHK-Cu is a human copper-binding tripeptide with the best evidence for topical skin repair and wound healing, including Mulder 1994 diabetic ulcer data showing 98.5%…
  4. 7.3/10Thymosin Alpha-1Strong recommendRecoveryNot FDA approvedFDA identifies immunogenicity and peptide-impurity concerns for compounded thymosin alpha-1 and says available safety information is inadequate.

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