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Promising · 6.2/10

Melanotan I (Afamelanotide)

Evidence B · good evidence ▲ 14.6% momentum 🥇 First scout open
6.2/ 10

Melanotan I is most defensible for photoprotection in EPP and planned UV exposure, with Langendonk 2015 reporting 69.4 vs 40.8 hours of pain-free sun exposure in the US trial. The wellness case is narrower than the prescription afamelanotide evidence. Read the full breakdown →

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Related reading

Ring Promising Momentum 14.6% Updated Jul 20, 2026 How the Index ranks →

Verdict by Nick Urban, host of the High Performance Longevity podcast.

For education only, not medical advice. Supplements, peptides, and protocols can interact with medications and conditions. Talk to a qualified clinician before starting anything here.