Metabolic Research
5-Amino-1MQ
BioHarmony verdict
Neutral
5-Amino-1MQ is a synthetic NNMT-inhibitor research compound that cut fat mass in obese mice and raised NAD+ in cultured fat cells (Neelakantan 2018), but it has zero human trials. Oral 50 to 150 mg is the only route with pharmacokinetic support; injectable microgram doses are likely too low to work.
Read full reportWhat is 5-Amino-1MQ?
5-Amino-1MQ is a synthetic small molecule that blocks an enzyme called NNMT (nicotinamide N-methyltransferase), which in animal studies frees up raw material for NAD+ and helps mice lose fat (Neelakantan 2018) and rebuild aging muscle (Neelakantan 2019). It is marketed for fat loss, muscle and strength, energy, and longevity, and sold as a research compound rather than an approved drug or supplement. It has never been tested in a single human trial. Oral dosing of 50 to 150 mg is the only route with pharmacokinetic support, while the popular injectable microgram protocols are almost certainly too low to do anything.
From the BioHarmony report, reviewed 2026-09-08.
How it is thought to work
Blocks the NNMT enzyme, sparing nicotinamide for NAD+ and preserving methyl groups
Safety watch-outs
- Heart palpitations, severe anxiety, or blood pressure spikes
- Persistent insomnia despite morning-only dosing
- Any product that acts like a diuretic or causes unexpected symptoms (possible counterfeit)
- Pregnancy, breastfeeding, or active or prior cancer: stop and consult a medical professional
Full risk profile in the BioHarmony report.
Dosing as published
No approved-label or study protocol is recorded for 5-Amino-1MQ yet.
More reported protocols
MembersMembers can compare additional reported doses, schedules, and preparation notes.
Educator coverage (2)
Attributed viewpoints, separate from primary research.
- 5 Amino 1MQ - Build Muscle And Burn Fat At The Same TimeHunter Williams · 2026-03-29
- 5-Amino 1MQ: Benefits, Dosage & Side EffectsJay Campbell · 2026-04-29
Trust & sourcing
The reviewed evidence for 5-amino-1MQ is preclinical. A published study describes NNMT inhibition and metabolic effects in cells and mouse models; it does not establish safety or effectiveness in humans.
Primary sources
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in micePubMed / Biochemical Pharmacology · 2018-01-01
Related peptides for recovery & tissue repair
Free guide
The Ultimate Peptides Guide
Spot stronger candidates, weak evidence, and seller red flags before you buy.