Health Optimization Index
CJC-1295
- Nick’s assessment
- Experimental
- Research evidence
- D, early evidence
- Attention
- 6.6 / 100▼ Falling this week
BioHarmony score
CJC-1295 is a synthetic GHRH analog that stimulates pituitary growth hormone release and downstream IGF-1. The best direct human evidence is small pharmacology work: Teichman 2006 showed sustained GH and IGF-1 increases after DAC CJC-1295, and Ionescu 2006 showed preserved GH pulsatility under continuous stimulation. Body-composition claims mostly borrow from tesamorelin data such as Falutz 2010 and Stanley 2014, not from CJC-1295 outcome trials.
Read the full report Benefits, risks and practical guidance.
Read Nick’s assessment Why it earned this rating
CJC-1295 is a 5.5–6.0/10 fit for people weighing body composition, sleep quality, and recovery and repair, especially when the goal is a tracked experiment with clear endpoints. The strongest evidence anchor is Therapeutic 2026: Screened in audit and excluded from efficacy upgrade because it is not CJC-1295-specific and not a systematic review/meta-analysis or n>=100 RCT. Teichman 2006 adds a second signal, but CJC-1295 still has gaps around large trials, long-term outcomes, responder profiles, or real-world adherence. That makes CJC-1295 useful for a defined reader, while weaker for broad anti-aging or catch-all wellness claims. In practice, CJC-1295 belongs after basics, diagnosis when relevant, and a stop rule based on symptoms, labs, sleep, or performance.
✅ Best for: Healthy adults 30-50 who have already optimized sleep, training, protein intake, body composition basics, and alcohol reduction, but still want to experiment with GH-axis support for recovery, body composition, or sleep depth. The most defensible format is no-DAC Mod-GRF 1-29 plus ipamorelin, with baseline IGF-1, fasting glucose/A1c, lipids, blood pressure, and repeat labs every 8-12 weeks. It is also best for people who understand that Teichman 2006 proves hormone response, not the physique outcomes commonly marketed online, and who would choose regulated tesamorelin when a legitimate medical indication exists.
❌ Avoid if: You have active cancer, previous cancer, strong first-degree family cancer history, active cardiovascular disease, arrhythmia, uncontrolled hypertension, diabetes, pre-diabetes, pituitary disease, pregnancy or pregnancy planning, pediatric use, or no access to labs and clinician oversight. Avoid the DAC variant if your main concern is sustained IGF-1 exposure. Tested athletes should avoid CJC-1295 because WADA prohibits growth hormone-releasing hormone analogues at all times. Also avoid if you are trying to compensate for poor sleep, undertraining, overtraining, low protein, or unmanaged metabolic health with injections. Sourcing & dosing caveat: gray-market supply; score assumes clean, correctly-dosed material.
Share your experience
Your answers are optional and help other readers — they never change my score. How community input works.
One step left: confirm it’s you
New voice here? We send a one-tap verification link so every entry comes from a real person. Signed-in members skip this.
Make a 12-month prediction Will it rise or fall in the Index?
Choose a direction and your confidence. Correct predictions earn leaderboard points.
Your prediction is final once submitted. We’ll check it in 12 months. See the leaderboard →