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Health Optimization Index

CJC-1295

Nick’s assessment
Experimental
Research evidence
D, early evidence
Attention
6.6 / 100▼ Falling this week
5.5/ 10

BioHarmony score

CJC-1295 is a synthetic GHRH analog that stimulates pituitary growth hormone release and downstream IGF-1. The best direct human evidence is small pharmacology work: Teichman 2006 showed sustained GH and IGF-1 increases after DAC CJC-1295, and Ionescu 2006 showed preserved GH pulsatility under continuous stimulation. Body-composition claims mostly borrow from tesamorelin data such as Falutz 2010 and Stanley 2014, not from CJC-1295 outcome trials.

Read the full report Benefits, risks and practical guidance.

Read Nick’s assessment Why it earned this rating

CJC-1295 is a 5.5–6.0/10 fit for people weighing body composition, sleep quality, and recovery and repair, especially when the goal is a tracked experiment with clear endpoints. The strongest evidence anchor is Therapeutic 2026: Screened in audit and excluded from efficacy upgrade because it is not CJC-1295-specific and not a systematic review/meta-analysis or n>=100 RCT. Teichman 2006 adds a second signal, but CJC-1295 still has gaps around large trials, long-term outcomes, responder profiles, or real-world adherence. That makes CJC-1295 useful for a defined reader, while weaker for broad anti-aging or catch-all wellness claims. In practice, CJC-1295 belongs after basics, diagnosis when relevant, and a stop rule based on symptoms, labs, sleep, or performance.

✅ Best for: Healthy adults 30-50 who have already optimized sleep, training, protein intake, body composition basics, and alcohol reduction, but still want to experiment with GH-axis support for recovery, body composition, or sleep depth. The most defensible format is no-DAC Mod-GRF 1-29 plus ipamorelin, with baseline IGF-1, fasting glucose/A1c, lipids, blood pressure, and repeat labs every 8-12 weeks. It is also best for people who understand that Teichman 2006 proves hormone response, not the physique outcomes commonly marketed online, and who would choose regulated tesamorelin when a legitimate medical indication exists.

❌ Avoid if: You have active cancer, previous cancer, strong first-degree family cancer history, active cardiovascular disease, arrhythmia, uncontrolled hypertension, diabetes, pre-diabetes, pituitary disease, pregnancy or pregnancy planning, pediatric use, or no access to labs and clinician oversight. Avoid the DAC variant if your main concern is sustained IGF-1 exposure. Tested athletes should avoid CJC-1295 because WADA prohibits growth hormone-releasing hormone analogues at all times. Also avoid if you are trying to compensate for poor sleep, undertraining, overtraining, low protein, or unmanaged metabolic health with injections. Sourcing & dosing caveat: gray-market supply; score assumes clean, correctly-dosed material.

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Updated Sep 14, 2026 How the Index ranks →

Educational information, not medical advice. Ask a qualified clinician about risks and interactions. Independent ratings: no affiliate links, sponsored placements or paid rankings.