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Promising · 6.9/10

Metformin

Evidence A · strong evidence ▼ 13.0% momentum 🥇 First scout open
6.9/ 10

Metformin is a prescription biguanide with strongest evidence for type 2 diabetes and diabetes prevention: UKPDS 34 cut all-cause mortality 36% in overweight T2D, while DPP Knowler 2002 reduced diabetes progression 31% in high-risk prediabetes. Read the full breakdown →

The prediction game

Where does Metformin go in 12 months?

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The Crowd’s Call

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Your 12-month call on Metformin

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Weigh In

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Related reading

Ring Promising Momentum 13.0% Updated Jul 20, 2026 How the Index ranks →

Verdict by Nick Urban, host of the High Performance Longevity podcast.

For education only, not medical advice. Supplements, peptides, and protocols can interact with medications and conditions. Talk to a qualified clinician before starting anything here.