Biohackers and health optimization pros take supplements. A lot of them. Supplements for:
- Longevity
- Athletic performance
- Brain enhancement
- Mitigating disease
- Stress resilience
- Nutrient replenishment
- Sleeping deeper
- Injury & workout recovery
I’ve taken and tested over 187 of the best biohacking supplements, ingredients, and compounds.
Some I take daily. Mostly, however, I take them a few times, and the container sits untouched in a closet.
My personal stack has come from many iterations of testing the recommendations of the world’s foremost experts and formulators.
In this post, we’ll explore my top universal biohacking supplements that yield the most benefits to virtually everyone.
Nearly 65% of Americans are experimenting with biohacking methods in 2025, with about 75% using vitamins or supplements
Creatine enhances mental and physical performance with ~5 g/day aiding energy, brain health, sleep deprivation, and strength. Supported by both Outliyr and longevity experts like Dr. Peter Attia, who includes creatine among 5 essential supplements
Combining the precursor GAA + monohydrate increase brain creatine levels by 3.9X, muscle creatine by 8.5X, with less intracellular water bloat compared to creatine monohydrate alone
NMN supplements lead the charge over direct NAD+ due to better cellular absorption. The Qualia NAD+ supplement increased NAD+ levels by 67% in two 28-day double-blind, placebo-controlled clinical trials
Magnesium (particularly L-threonate) and L‑theanine gummies are surging amid Gen Z stress trends, with gummy formats growing ~57% YoY in 2025. Take 200mg magnesium L‑threonate before bed and 100mg L‑theanine in afternoon for calm focus
Biohackers at events like the LA longevity expo are using peptides (ie BPC‑157, TB-500, TA-1, MOTS‑c, GHK‑Cu) alongside NAD boosters and lifestyle tweaks to support tissue repair, mitochondrial health, and visible aging reversal. Note: most are experimental and not FDA‑approved
Berberine is gaining traction as a natural option for glycemic control and weight loss, with emerging research supporting its anti-obesity mechanisms (positioned as “nature’s Ozempic”). Dihydroberberine (DHB) has 5-10X greater absorption, rare GI side effects, faster onset of action, lasting about 40% longer with a lower dose
Best Biohacking & Personalized Nutrition Supplements
Proper regimens both fill any dietary gaps and boost health and performance even further.
Of course, the best biohacking supplement regimen is bio-individual, advanced, and personalized. Certain ingredients, however, work great for most people.
The Ultimate Biohacking Ingredients
The following are the best single ingredient supplements for biohacking. You don’t need to take all of them.
Biohacking, or better yet, bioharmonizing, is all about bioindividuality and what works best for you based on your needs and goals.
Magnesium
Magnesium is an essential mineral but it’s also one of the most common nutrient deficiencies.
It supports around 80% of your body’s critical processes from energy production, nervous system regulation, detoxification, and more (Nutrients).
From a book dedicated to this ingredient, I learned magnesium has dozens of health benefits.
The body uses magnesium for hundreds of processes, including:
- Energy generation
- Cellular and DNA repair
- Natural anti-anxiety, boosting mood, and improving mental health
- Increasing athletic performance
- Muscle relaxation and sleep enhancement
Sadly, again, almost all humans suffer from magnesium deficiency. Making it essential to add this mineral to your supplement stack.
Not just any magnesium will do. Form matters. There are many but I recommend:
- Pico-ionic liquid magnesium – highly bioavailable & absorbed into cells, concentrated, supports majority of metabolic functions
- Magnesium malate – highly absorbed, supports energy production, combats fatigue
- Magnesium chloride (spray) – transdermal absorption bypassing digestion for faster absoprtion; relieves muscle soreness & supports sleep
- Magnesium glycinate – highly absorbed, gentle on the digestive system, calming effect
- Magnesium L-threonate – crosses the blood-brain barrier, supports brain & cognitive health
Make sure your magnesium is pure, highly bioavailable, and will survive your digestive tract. Here’s my guide to the best magnesium supplements you can rely on.
Brown’s Gas & molecular hydrogen
Molecular hydrogen (H₂) is the smallest and lightest gas molecule in the universe. Its miniscule size allows it to penetrate and improve every organ and cell in the body.
As a selective antioxidant, H₂ lets beneficial free radicals like nitric oxide continue functioning while quelling problematic free radicals.
Benefits of supplementing H2 include:
- Offsetting damage of constant stress (Int J Mol Sci)
- Stabilizing blood sugar (J Syiah Kuala Dent Soc)
- Lowering inflammation (J Zhejiang Univ Sci B)
- Increasing mental clarity (Int J Mol Sci)
- Slowing neurodegeneration (Int J Mol Sci)
- Boosting NAD levels (Cell Metab)
- Anti-aging (J Zhejiang Univ Sci B)
Learn more about the myriad benefits and use cases of H₂ therapy in my ultimate guide.
H₂ was originally used in Japanese hospitals in the 1990s, Now, there are over 1,500 studies supporting its use for both healthy folks and 170 diseases.
The two primary hydrogen therapy forms are water generating machines and tablets. Tablets are more convenient, economical, and potent so I made a buyer’s guide on the best molecular hydrogen tablets.
There is an upgraded form of H₂ called Brown’s gas which has benefits over and above those of the usual H₂. After learning about it, inhaling Brown’s gas is now a part of my regular routine
Read my guide on Brown’s gas to learn why this technology is far superior, more therapeutic, and cheaper over the long term.
Essential amino acids
Amino acids are the raw buildings blocks of neurotransmitters and life. They are key to mental and physical performance.
For years, athletes swore by a subset of essential amino acids called branched-chain amino acids (BCAAs). BCAAs, however, contain just 3 of the 22 amino acids.
Emerging research continues to find that BCAAs don’t work as well as initially thought (Amino Acids Journal).
BCAAs have side effects that essential amino acids (EAAs) don’t (Nat Med., Nutrients, J Nutr.)
Of course, there are also important “non-essential” amino acids like glycine and taurine. Both of which are great for longevity and overall health.
EAAs stimulate growth and repair better than whey protein (Metabolism J). Amino acids also:
- Improve bone mineralization (JB&JS)
- Increase lean body mass (JB&JS)
- Boosts brainpower (tryptophan is later converted to serotonin) (NAP)
- Improves metabolic health (Biosci Biotechnol Biochem)
- Better sleep (Evid Based Complement Alternat Med)
- Accelerate weight loss (PLoS Biol.)
- Elevates energy
Even health optimizers are often deficient in one or more aminos. Whether you’re a Type-A office worker or athlete, check out this post for the science behind essential amino acids.
If I’m not consuming algae, on workout days I’d go for only the best essential amino acid supplements.
Shilajit
Shilajit is a natural, sticky, blackish-brown resin found primarily in the Himalayan mountains and other high-altitude regions. It forms over centuries from the slow decomposition of plants.
Called ‘black gold,’ shilajit contains over 40 minerals, with fulvic acid being its most notable compound. It is a staple in Ayurveda, the ancient Indian medical system.
Shilajit also contains:
- 84+ herbs, minerals, & trace minerals
- 20 amino acids
- Triterpenes
- Fulvic & humic acids
It can come in the following forms:
- Resin
- Powder
- Capsules
- Liquid extract
- Gummies
Russian medicine, Traditional Chinese Medicine (TCM), and Ayurveda have traditionally used shilajit for various diseases and health conditions.
These are some of shilajit’s benefits:
- Boosts male fertility & testosterone
- Anti-inflammatory & antioxidant
- Supports cognitive health
- Enhances bone health
- Reduces fatigue
- Enhances physical performance
- Adaptogenic
- Supports immune function
Moreover, shilajit enhances the bioavailability of whatever you consume, amplifying their effects. Food, drinks, nootropics, supplements, you’ll feel stronger benefits even at lower doses.
There’s more to discover about this ‘nectar of the gods’ in my shilajit guide.
Just make sure you get real shilajit. There are cheap, fake ones, and they contain heavy metals and other contaminants. Others strongly dilute the active ingredients, making it much less effective.
After years of testing, I’ve compiled the best shilajit supplements & brands you can buy from.
Electrolytes
Electrolytes are minerals that are essential for many critical bodily functions. You need over 70 minerals for optimal health.
The main types are:
- Sodium
- Potassium
- Chloride
- Calcium
- Magnesium
- Phosphate
- Bicarbonate
Supplementing with electrolytes:
- Prevents dehydration
- Improves endurance
- Reduces muscle cramps during intense activity
- Promotes healthy nerve & muscle function
- Supports bone health, blood pressure, and metabolic processes
Sadly, 1/3 of Americans are deficient in at least 10 minerals, dramatically impairing bodily processes and functions. Causing low energy levels, brain fog, headaches, and muscle cramps.
You can address the deficiency with a nourishing diet and by taking supplements.
Avoid commercial products or sports drinks as they usually contain harmful additives. Or they use the wrong ingredients at ineffective dosages and with low bioavailability.
The top-quality electrolyte supplements include the 5 essential electrolytes critical for hydration and bodily functions:
- Sodium: Maintains fluid balance and nerve impulses
- Chloride:Supports fluid secretion and acid-base balance
- Potassium: Crucial for muscle function and nerve signaling
- Calcium: Important for muscle contraction and bone health
- Magnesium: Supports muscle relaxation and energy production
Including these electrolytes ensures comprehensive replenishment, especially after sweating or intense exercise.
Creatine
Creatine is a naturally occurring compound primarily stored in muscle cells. It is among the most well-studied sports nutrition supplements ever.
Evidence suggests that it’s one of the most impactful, safe, and cheap over-the-counter physical performance enhancers available (Examine nutrition database). From increasing lean body mass, power output, to boosting anaerobic running capacity (sprinting).
Key benefits of creatine include:
- Improved muscle strength & mass
- Enhanced high-intensity exercise performance
- Enhanced cognitive & neurological function
- Improved metabolic & cardiovascular health
- Support for aging population
Discussions on creatine had a resurgence after influencers started talking about its benefits on the brain. Read my guide on creatine as a nootropic to learn more.
Creatine is widely regarded as safe and effective, with a recommended daily intake of about 3 grams to support general health and fitness throughout life.
Collagen
Collagen is the most abundant protein in the human body. It serves as a crucial structural component in connective tissues such as skin, bones, tendons, ligaments, cartilage, and muscles.
It provides strength, structure, and elasticity to these tissues, making it popular for improving skin, hair, and nail health.
But collagen does more than make you look younger.
Collagen supports:
- Joint & bone health
- Gut & digestion
- Fascia health
- Muscle recovery & growth
- Wound healing
- Brain health
- Cardiovascular health
- Sleep quality
Collagen is the best source of anti-aging amino acids like glycine, proline, and hydroxyproline.
After your mid-20s, collagen naturally declines with age. Making supplementation important, what with the modern diet having fewer of the top dietary sources like bone broth and pork rinds.
There are 28 distinct collagen types but only 5 are worth supplementing: Type I, II, III, V, X.
Read my article on other ways to increase collagen naturally to fully take advantage of poweful nutrient.
Methylene blue
Methylene blue is a synthetic compound with a long history of use as both a dye and a medication.
First synthesized in 1876, it’s known for its vivid blue color and its wide-ranging applications in medicine, science, and industry.
It’s no wonder it’s called a ‘magic bullet.’ It even made it to the World Health Organization’s List of Essential Medicines.
Here’s a comprehensive guide on methylene blue for all you need to know about this powerful compound.
This table lists some of its mechanisms and benefits.
| Mechanism ⚙️ | Benefit ✅ |
|---|---|
| Improves cellular energy production | Increased energy, reduced fatigue, and improved cellular health |
| Neutralizes free radicals & reduces oxidative stress | Protects brain health, slows down neurodegenerative diseases like Alzheimer’s and Parkinson’s |
| Increases brain-derived neurotrophic factor (BDNF) & enhances brain metabolism | Improves memory, attention, and executive function |
| Influences neurotransmitter levels & inhibits monoamine oxidase | Alleviates anxiety & depression, lifts mood |
| Supports mitochondrial function | Slows cellular aging, promotes healthier skin, and accelerates wound healing |
| Enhances immune function | Eradicates pathogens without harming human cells |
There’s not a lot of reliable sources in the market so follow this list of the best methylene blue supplements.
NAD+
Nicotinamide adenine dinucleotide (NAD) is a vital coenzyme found in all living cells. It is indispensable for life, impacting energy, repair, aging, and overall health.
Its decline is linked to aging and disease.
“…without the presence of NAD+, we would probably die in 30 seconds.”— NMN.com
Benefits of increasing your levels of NAD include:
- Improved mental clarity
- Greater energy
- Enhanced mood
- Repair of damaged cells
- Improved sleep
- Restored mitochondria function (Cells J)
- Protection of metabolism
- Improved muscle function and exercise capacity
- Slowing down of aging
NAD is the closest known fountain of youth.
According to Dr. Greg Kelly, N.D. and expert in anti-aging and regenerative medicine,
“NAD+ impacts key hallmarks of aging: mitochondrial dysfunction, genomic instability, gut dysbiosis, and cellular senescence.”
Unfortunately, as you age, NAD+ levels decline. Fortunately, you can naturally boost NAD+ with these strategies I outline in my guide to boosting NAD naturally.
Once you’ve got the basics down, supplement with NAD+ to optimize your levels increases its effectiveness.
Astaxanthin
Astaxanthin is a powerful fat-soluble carotenoid pigment found naturally in certain algae and seafood such as salmon, krill, and shrimp. It’s responsible for their red-orange color.
There’s a long list of evidence-based astaxanthin benefits, some of which are:
- Improves heart health by lowering blood pressure, cholesterol, & triglycerides
- Slows brain aging & protecting cognitive health
- Promotes vision & eye health
- Activates longevity genes
- Protects cartilage, joints, & muscles from oxidative stress
- Protects skin from UV light damage
It’s nature’s most powerful antioxidant, outperforming vitamin C, E, and beta-carotene in neutralizing free radicals and reducing oxidative stress.
Unfortunately, not all astaxanthin brands area equal. Here’s my list of the most reliable and best astaxanthin supplements.
Chlorella & spirulina micro-algae
Algae is one of the simplest and most effective foods and supplements money can buy. But of the many types of algae, only spirulina and chlorella have an impressive track record of benefitting humans.
Chlorella is a powerful green algae that contains chlorophyll more than any other source.
Chlorella helps:
- Remove toxins, heavy metals, and pesticides
- Kill harmful bacteria
- Promote gut health
- Support blood building
- Improve sleep health
- Boost cellular repair
- Speed up recovery time from workouts and injury
A daily handful of chlorella tablets can even substitute for greens.
After a long night of drinking, a small handful of tablets helps the body break down toxins from the alcohol, hydrates with trace minerals, bolsters the immune system, and even sobers me up.
Spirulina, on the other hand, is a blue-green algae. It is a performance powerhouse. It has the highest concentration of collagen and protein in the world.
20-30 little tablets can:
- Fuel workouts
- Stave off appetite & hunger
- Increase energy
- Flood the body with a rich source of bioavailable essential amino acids & essential fatty acids
Unlike fish, spirulina doesn’t oxidize and go rancid before it reaches you.
You can buy them separately as pressed tablets or powder, or get them compounded.
For greater control over dosage, I get the tablets separately. But 50/50 blends are common and convenient.
Make sure you buy organic, cold-pressed, non-GMO as algae is a bioremedient that accumulates heavy metals and contaminants.
I’ve reviewed the best spirulina and chlorella supplements so you know the right ones to buy as well.
Vitamin D3 + K2
Vitamin D is actually a pro-hormone, a substance that the body converts to a hormone.
Vitamin D is involved in over 1,000 biological processes. Sadly, it is one of the 3 most common vitamin deficiencies.
When your Vitamin D levels are low, you will likely experience:
- Depression
- Allergies
- Fatigue
- Faster aging
- Weakened immune system
- Skin health complications
- Blunted exercise recovery (Nutrients Journal)
- Decreased testosterone (Nutrients Journal)
It’s essential to supplement with D3 (the more potent form of Vitamin D compared to D2) to increase your D levels. But it’s important to take D3 with K2.
Otherwise, you risk having too much calcium in the blood (hypercalcemia), a toxic condition. And end up with stiffened and damaged blood vessels, impairing blood flow.
Vitamin D3 and K2 work as a complementary pair. They ensure calcium is absorbed efficiently and directed to your bones and teeth. Protecting the cardiovascular system from harmful calcium buildup.
Berberine
Berberine is a natural plant compound that:
- Controls blood sugar
- Reduces inflammation
- Improves cholesterol levels & trigylcerides
- Supports heart health
I use it for preemptive damage control during rare moments I indulge in high-carb foods.
I’ve tested over a dozen of the best glucose disposal agents (GDAs). And I quantified my experiment with the NutriSense continuous glucose monitor.
Berberine won by a landslide in keeping my blood sugar at a healthy level.
In 2021, I discovered the upgraded version called dihydroberberine (DHB). DHB is more bioavailable, longer lasting, and more effective than normal berberine.
You’ll often find DHB listed as GlucoVantage, the branded, patented form, in supplement labels. Here are the top berberine supplements I’ve found.
Omega-3
Omega-3 oils are oils high in omega-3 fatty acids, a group of polyunsaturated fatty acids that include:
- Eicosapentaenoic acid (EPA) – found in marine oils and has powerful anti-inflammatory effects
- Docosahexaenoic acid (DHA) – also abundant in marine oils and is crucial for brain development & function, making up about 8% of brain weight
- Alpha-linolenic acid (ALA) – found in plant oils like flaxseed, hemp, walnut; needs to convert to EPA then to DHA in the body; significantly less bioavailable as conversion process is very inefficient
These fatty acids are essential for health because the body cannot make them. You need to get them through your diet or supplementation.
Omega-3 oils are found in various foods and supplements:
- Marine sources – Fatty fish such as salmon, mackerel, sardines, and herring are rich in EPA and DHA
- Plant sources – Flaxseed, hemp, and walnut oils are rich in ALA
- Supplements – Fish oil, krill oil, and algae oil supplements provide concentrated EPA and DHA
Omega-3 fatty acids offer a wide range of health benefits. Below is a table summarizing the benefits from each type.
| Omega-3 Type 🔗 | Source 🧬 | Key Functions & Benefits 💪 |
|---|---|---|
| ALA 🌿 | Flaxseed, walnuts, hemp | Heart, immune, and nervous system support, even without conversion to EPA & DHA (Biomed Res Int, rxlist) |
| EPA ❤️ | Fatty fish, fish oil, krill oil | Anti-inflammatory, heart rhythm regulation |
| DHA 🧠 | Fatty fish, fish oil, krill oil | Brain development, cognitive function, eye health |
When choosing an omega-3 oil supplement, choose one that’s highly bioavailable and more stable in the presence of heat & air. Exposure to high heat and air will degrade omega-3s, turning them into inflammatory free radicals.
I’ve sorted the common omega-3 oil supplements in order of most bioavailable to the least for easy reference.
| Omega-3 oil 💧 | Form ⚛️ | Good to know 📝 |
|---|---|---|
| Krill oil 🦐 | Phospholipid – most available form | • Cleaner, more environmentally sustainable • Doesn’t contain synthetic oils • Antarctic krill for highest quality & lowest ecosystem impact • Cold-pressed oil preserves benefits • Hard capsules better than soft gels for maximum freshness & protection against oxidation |
| Salmon oil & roe 🍣 | Phospholipid | • 40-70% of DHA in salmon roe is in phospholipid form • Contains less heavy metals like mercury |
| TG Fish oil 🐟 | Triglyceride | Better absorbed & utilized than ethyl ester but not as high as with phospholipids |
| EE Fish oil ⚗️ | Ethyl ester | Best to avoid this form |
| Flaxseed, hemp, walnut oil 🌰 | ALA | Low bioavailability due to inefficient conversion: • ALA → EPA (limited conversion, ~5-10%) • EPA → DHA (further limited conversion, ~0.5-5%) • ALA conversion to DHA is indirect and very inefficient. |
You can do a deeper study on this with my ultimate guide to omega-3 supplements.
Ashwagandha
Ashwagandha is an adaptogenic herb that is a favorite of naturopathic doctors around the world. Adaptogens like Ashwagandha bring bodily systems back into their optimal state (homeostasis).
Today, that generally means normalizing cortisol and the stress hormone response.
Some of the popular benefits of Ashwagandha include:
- Promoting longevity
- Improving mitochondrial health
- Improving glucose metabolism
- Slowing biological aging
- Increasing vitality
- Reducing acute and chronic stress
- Improving overall well-being
- Increasing energy levels
I take it daily in my morning “mud water” drink that consists of a number of adaptogens and longevity-boosting compounds.
I use whole root powder, but make sure to purchase a product that’s standardized to 5% withanolides (the primary active ingredient) or more.
Exogenous ketones
Exogenous ketones are supplements that elevate blood ketone levels. They induce nutritional ketosis even when eating carbs without the biological stress of long-term carb restriction.
They come primarily in the following forms:
- Ketone salts
- Ketone esters
- Keton salt/ester blends
- Medium chain triglycerides (MCTs)
Ketone salts & esters directly raise blood ketone levels while MCTs are rapidly metabolized by the liver to produce ketones.
Why take exogenous ketones? Because ketones:
- Help you achieve nutritional ketosis independent of carb and protein intake (Nutr Metab)
- Reduce blood sugar levels (Nutr Metab, Exp Physiol)
- Improve energy production in mitochondria (Nutr Metab)
- Decrease oxidative stress and inflammation (Nutr Metab, Exp Neurol)
- Improve cognitive function and motor performance (Exp Physiol, Front Nutr, Front Aging Neurosci)
- Decrease appetite (Obesity J)
Be wary of fake “ketones.” Not all products slapped with the word ‘ketone’ across it or lists it in its ingredients work as real ketones.
Raspberry ketones are an example. These are just marketing gimmicks.
Do your research to know which are legitimate exogenous ketones. Start with my guide to exogenous ketones.
Turmeric
Turmeric is a rhizome in the ginger family, and it’s a staple in both Chinese and Ayurvedic medicines.
Curcumin, the primary active ingredient in turmeric, blocks the production of inflammatory cells and proteins.
But turmeric is far more than curcumin (about 5 percent of the plant).
Turmeric contains turmerosaccharides. These are water-soluble bioactive polysaccharides extracted from about 95 percent of the turmeric plant.
Though less known, turmerosaccharides greatly:
- Improve joint health (Inflammopharmacology Journal)
- Reduce overuse problems (Inflammopharmacology Journal)
- Protect cartilage (Inflammopharmacology Journal)
- Increase collagen (Inflammopharmacology Journal)
- Reduce both chronic and acute inflammation (Antiinflamm Antiallergy Agents Med Chem)
Turmeric contains many compounds with antioxidant, antibacterial, antifungal, antiviral, and detoxifying properties.
The Top Biohacking Supplements of 2025
Now that we’ve discussed the best ingredients and compounds to have on your supplement stack, let’s dive into the top product choices for each.
Although these are powerful supplements for your health, it’s crucial that you get them from the right sources.
Best magnesium: RnA ReSet ReMag
Certificate of Analysis published on website
Pure magnesium source
No additives & preservatives
Can drink in one sitting or consume throughout the day
95.5% 5-star reviews
Subscribing saves you 5%
Few users have reported a laxative effect
Taste needs getting used to
Natural crystallization can occur due to high magnesium concentration; doesn’t affect product quality
ReMag Liquid Magnesium is formulated by the pioneer in magnesium therapy, Dr. Carolyn Dean.
Her unique 18-step process transforms magnesium chloride into a highly concentrated 60,000ppm solution of stabilized picometer magnesium ions.
This 99.99%-pure formula is designed for optimal absorption, going directly to your cells while avoiding digestive discomfort.
It also significantly reduces the laxative effect common with most magnesium supplements.
Best Brown’s Gas & molecular hydrogen: AquaCure AC50
There are 2 ways to take molecular hydrogen therapy: tablets and generators. Each has its place in your biohacking routine.
Extremely durable
Safest & highest-quality hydrogen machine
Generates up to 50 liters of Brown’s gas per hour
Capable of 24/7 operation without overheating
Built to worldwide industrial & safety standards like CSA/UL & Australian safety standards
Multi-step in-house testing on every machine produced
No negative side effects shown in all published studies
Requires minimal maintenance
100% no-questions-asked 1-year money- back satisfaction guarantee
Lifetime manufacturer’s warranty
Comes with access to extensive online AquaCure resources
Daunting initial set up
Cannot use tap water; must use only distilled water
Expensive upfront
Not defined as a medical device by the FDA
The AquaCure AC50 is a device that safely generates Brown’s Gas. It’s the result of inventor George Wiseman’s 40+ years of research and thousands of customer feedback.
Its durability, safety and multiple uses makes it economical in the long run. You can use it for inhalation, generating H₂ water, topical gas and water, electrically expanded water (ExW), new water, and deuterium-depleted water (DDW).
The AC50 has been part of my daily health optimization routine ever since I first started using it. You can read my experience in my detailed AquaCure AC50 review.
You can also check out the top hydrogen machines guide if you want to look into other options.
If the AquaCure Brown’s Gas system is out of your budget, H2 tablets are also great for beginners. DrinkHRW makes the strongest tablets on the market.
Certified to International Hydrogen Standards Association (IHSA) standards
3rd-party lab tested
No reported side effects in all published literature
Minimal synthetic additives and are GRAS
Convenient
Some say the tablets take longer to dissolve
Batch compliance certificate needs updating; expired Jan 31, 2024
Drink HRW Rejuvenation generates 12.4 ppm of H₂ concentration, more than any other brand. These are the same tablets usually used in research.
Rejuvenation is also potent because their formula keeps more of the H₂ in the water instead of quickly evaporating.
I take it whenever I’m sleep deprived, sore from a brutal workout, or will be in a biologically stressful environment (like plane travel).
Just dissolve 1 tablet in 12-17oz of water in an open cup. Wait 1-2 minutes for it to dissolve and drink immediately. The company recommends using 2 tablets a day.
Best essential amino acids: Amino Co Perform
Vegan, keto-friendly, & halal
Non-GMO
No gluten & soy
Multiple flavor options
Doctor endorsed
100% science-backed
60-day money-back guarantee
Subscribing saves you 15%
Contains artificial sweeteners
Not suitable for individuals avoiding or sensitive to caffeine
The Amino Company focuses on researching and developing targeted amino acid supplements. It’s no wonder their amino acids are super effective.
Perform, their EAA supplement for athletic performance, has been proven in controlled clinical trials to 4X muscle performance, reduce fatigue, and improve recovery.
Perform’s ideal proportion of amino acids supports optimal neurotransmitter balance during exercise. It crosses the blood-brain barrier, enhancing memory, focus, and concentration.
Just mix 1 scoop in 8oz. of water or your coffee or smoothie. It might make your coffee taste odd because Perform’s flavors are fruity.
Start drinking it 30 minutes before you exercise, and continue to drink it during the activity.
Best shilajit: Pure Himalayan Shilajit
Sourced from pristine mountains
Free from pollutants, no fillers, binders, & artificial additives
3rd-party lab tested
Safe for even pets
Made using traditional methods of purification & minimal processing
60-day money-back guarantee
People with sensitivity may have a mild allergy reaction
Certificate of Analysis on website is not current (May 2021)
Pure Himalayan Shilajit is pure and authentic shilajit harvested from pristine, high-altitude regions of the Himalayas. Their team has extensive experience working with this adaptogen and no other vendor offers as much variety.
They deliver the best quality shilajit in various forms: Solid, soft resin, standard resin, liquid, and tablets.
So since its 2015 inception, Pure Himalayan has become the premier source of shilajit.
Best Electrolytes: Paleovalley Essential Electrolytes
Highest-quality whole food ingredients
Uses unrefined & unpolluted sea salt sourced from an ancient seabed
No refined sugar, dairy, soy, gluten
No fillers, synthetic ingredients & artificial additives
Flavored naturally without additives – monk fruit, organic turmeric root, organic flavors from real fruit
60-day 100% money-back guarantee
Some people may experience allergic reactions or sensitivities to certain ingredients
Excessive intake can disrupt the body’s electrolyte balance
Some question “natural flavors” because it tastes too sweet
Paleovalley is known for creating nature-derived, high-quality health products & delicious snacks. Nature knows how to maximize hydration so it’s crucial that you avoid synthetic electrolyte ingredients.
Essential Electrolytes contains 60+ trace minerals from unprocessed ancient sea salt, organic coconut water, seawater, and seaweed extract.
The whole food ingredients give you a potent, full spectrum of electrolytes, minerals, and trace minerals.
It contains some natural sugar, but when I measure my fasting blood sugar with a CGM, 1-2 servings of Paleovalley Essential Electrolytes doesn’t cause any spike.
Best creatine: LVLUP Health Crevolution
High-quality & pure ingredients
3rd-party lab tested
Allergen free
No artificial colors or flavors
Subscribing saves you 10%
Ingredients easily absorb moisture; always close lid tightly to avoid clumping
Some have had problems with customer service
Crevolution is the biohacker’s favorite creatine.
It’s a combination of:
- Creatine monohydrate
- Creatine hydrochloride (HCl)
- Magnesium chelate
- Guanidinoacetic acid (GAA)
- Tri-methyl glycine (TMG)
- Highly branched cyclic dextrin (HBCD)
This unique formulation assures better absorption and increased creatine uptake and utilization.
It also reduces any potential side effects, like increased homocysteine, due to TMG ensuring proper conversion of GAA to creatine.
Best collagen: Organifi Collagen
Collagen sourced only from real food
Glyphosate residue free
No added sugar
No gluten, dairy, soy, nuts, & legumes
Unflavored – can be mixed with other drinks, even in yogurt
60-day guarantee
30-35% discount for purchases of 3-6 bottles
Subscribing saves you 10%
92.4% 5-star reviews
Certificate of Analysis not publicly available
Contains a Proposition 65 warning label, indicating it may contain substances known to cause cancer or reproductive harm according to California regulations
Could trigger allergic reactions in individuals with fish and egg allergies
Organifi Collagen is combined from 4 whole-food sources to provide the 5 collagen types worth supplementing: Type I, II, III, V, and X.
Their collagen is sourced from:
- Chicken bone broth
- Pasture-raised cows
- Wild-caught fish
- Eggshell membrane collagen
Its fully hydrolyzed form ensures easy absorption in hot or cold drinks, while supporting beauty (skin, hair, nails), joint integrity, gut health, bones, metabolism, and immunity
Best methylene blue: LVLUP Health Mito Blue
Practitioner formulated
Ingredients work synergistically
Contains ultra-pure ingredients
Uses only clean, functional fillers
3rd-party lab tested
Certificates of Analysis available on website
Slower onset of effects (2-2.2 hours) compared with other forms like troches
Not suitable for those taking SSRIs, SNRIs, or MAO inhibitors unless supervised
Potential risk for serotonin syndrome if used with psychedelics
LVLUP Health innovates and produces some of the highest quality supplement formulations. Their take on methylene blue is a high-purity formula with a low dose of 10mg, the sweet spot for many people.
Even with the low dose, Mito Blue utilizes highly synergistic ingredients:
- USP 99% methylene blue
- Actyl L-carnitine
- Ubiquinol
- PQQ
It’s designed to powerfully support and protect mitochondrial function, helping optimize your overall wellness.
Unlike some multi-ingredient formulas, everything in this should be well tolerated by most people.
Best NAD+ booster: Qualia NAD+
Boosts NAD+ levels by 67%
Ethically-sourced, highest-quality ingredients
Fully disclosed ingredients & dosages
Natural & minimal excipients
Non-GMO & gluten-free
3rd-party lab tested
Massive 58% off on first purchase, then $10/shipment discount thereafter when you subscribe
100-day money-back guarantee
Can cause flushing (due to niacin) when taking substantially above the daily value
Benefits may take a while to manifest
Qualia NAD+ is clinically proven to boost NAD+ levels by 67%. This was shown in a double-blind, placebo-controlled clinical trial.
It combines 3 NAD+ precursors:
- NIAGEN® (nicotinamide riboside chloride)
- Niacin (nicotinic acid)
- Nicotinamide (niacinamide)
These 3 precursors follow different cellular pathways to form NAD+, providing a comprehensive approach to boosting NAD+ levels.
The formula also includes complementary ingredients like 8 B vitamins, magnesium, trans-resveratrol, and Coffeeberry® to support NAD+ production and cellular energy.
Best astaxanthin: AX3 Bio-Pure Astaxanthin
3X more bioavailable
Environmentally-friendly production method
Endorsed by physicians & researchers
The only brand proven effective in clinical research
Potentially increases lifespan equivalent to 9 years
No known side effects
Free of shellfish & major allergens
Subscription only but can cancel any time
Astaxanthin may interact with blood pressure drugs, hormone treatments, or 5-alpha-reductase inhibitors
Some rare reports on allergic reactions
AX3 BioPure Astaxanthin stands out for its ultra-pure, high-potency formula designed for optimal cellular absorption.
Unlike standard supplements, it delivers 12 mg of astaxanthin per serving paired with their patented technology for enhanced bioavailability.
The company specializes in astaxanthin only. So it’s no surprise that AX3 Bio-Pure Astaxanthin is the best one on the market.
AX3 follows a subscription-only model to help you make it part of your daily routine. Its benefits are best experienced when taken consistently over time.
Best Chlorella & Spirulina: VITALITYbits
Safe, pure, & nutrient-dense
Convenient; just swallow & go
Safe for children & pets
No toxins or heavy metals
ISO 9000 certification, GMP certification, FDA-approved, 3rd-party lab tested
USDA-certified organic
Zero sugar & naturally gluten free
Subscribing saves you 20%
Green stools after taking can be expected
Might make the skin more sensitive to sunlight
Green, earthy flavor needs getting used to
Common mild side effects include digestive discomfort, headaches, possible allergies
When choosing your algae supplement, you can buy spirulina and chlorella separately or opt for a 50/50 blend for savings and convenience.
The following are the best I’ve found, all from the same company:
- RECOVERYbits – chlorella
- ENERGYbits – spirulina
- VITALITYbits- 50/50 blend of spirulina & chlorella
The company, ENERGYbits, is the cleanest and purest supplier of these algae.
They grow their chlorella and spirulina organically in freshwater tanks using triple-filtered mountain spring water to prevent contamination.
Their sustainable farming techniques preserve all the algaes’ nutrients and enzymes.
All their algae supplements do not contain any binders, fillers, or additives. Just algae—spirulina, chlorella, or both.
They’ve made it easy and convenient to take 40+ nutrients in the form of tiny tablets or ‘bits.’ They call it “bits of whole food.”
Best D3 + K2: RnA ReSet D3K2 ReSet
Notable clean formulation
No preservatives, additives, or fillers
Non-GMO
No animal by-products
Certificate of analysis available on website
Responsive & caring customer service
Plant-derived ingredients may be allergenic to some
Suspicious lack of negative reviews
Backed by the same philosophy of nutrient synergy found in the ReMag and ReMyte formulas by Dr. Carolyn Dean, D3K2 ReSet comes in a bioavailable form, with clean formulation, and synergistic nutrient support.
It features:
- Liposomal delivery – enhanced absorption & faster delivery compared to capsules or tablets
- Vitamin D3 – Sourced naturally to optimize immune, bone, & mood support
- Vitamin K2 (MK-7, all-trans) – The most bioactive form of K2, essential for directing calcium to bones instead of arteries.
D3K2 ReSet obtains its D3 from lichen and K2 from natto, both vegan sources. This makes it ideal for vegans or those avoidable animal products.
Best berberine: BiOptimizers Berberine Breakthrough
Science-backed ingredients
Contains the more bioavailable & potent form, dihydroberberine (DHB)
Proprietary blend of synergistic & clinically-dosed blood sugar control ingredients
Clinically tested
100% natural & drug free
No synthetic additives
365-day money back guarantee
Experienced & friendly customer service
Some may still experience mild digestive discomfort if sensitive to DHB
Can interact with certain medications like diabetes medications, blood thinners, statins, immunosuppresants, etc.
Mentions of unresolved negative reviews
Berberine Breakthrough uses dihydroberberine (DHB) in its formulation, making it more bioavailable, efficient, and potent.
DHB bypasses the inefficient conversion step that berberine requires in the gut, making it gentler on the digestive system. You get less or no bloating, gas, or stomach pain as you would with berberine.
Berberine Breakthrough also includes 3 other patented, clinically-studied ingredients:
- Bitter melon extract
- Cinnulin PF (cinnamon bark 20:1)
- Innoslim (Panax ginseng & astragalus)
These 3 also support healthy blood sugar and glucose metabolism.
Best omega-3 oil: Paleovalley Wild Caught Fish Roe
Gently freeze-dried to preserve full range of nutrients & prevents oxidation
Wild caught in pristine waters means significantly lower mercury level
3rd-party lab tested
No fillers & flow agents
No fishy ‘burps’
60-day 100% money-back guarantee
6-capsule serving might be too much for some
Some experience a mild aftertaste if not taken with food
Still not suitable for those with fish allergies
Paleovalley is known for its no-compromise approach to high-quality, nutrient-dense, minimally-processed whole food ingredients.
Its Wild Caught Fish Roe supplement is no exception. It’s made with 100% wild caught fish roe of salmon, cod, and pollock in pristine waters.
With wild-caught fish eggs, you get the full-spectrum omega-3 and nutrient profile, higher bioavailability, and more natural, less processed form. Unlike typical fish oil supplements.
With each serving, you get:
- EPA
- DHAs
- ALA
- DPA
- Choline
- Selenium
- Phosphorus
- Vitamins E, C, D, B2
- Protein
Clean, whole food ingredients and minimal processing make Paleovalley Wild Caught Fish Roe a superior choice for supporting brain, eye, cardiovascular, and overall health.
Best ashwagandha: Bulk Supplements Ashwagandha Root Extract
No added sugar, dairy, yeast, soy, gluten
3rd-party tested
Certificate of analysis available upon request
NSF certified & FDA-registered cGMP manufacturing facility
600mg ashwagandha (withania somnifera) per capsule
Only $0.10 per serving
Also available in powder form
Limited customer reviews
Higher risk of liver damage connected with prolonged use or higher doses of ashwagandha
Reported batch quality issues before
Sensitive individuals may experience gastrointestinal issues and/or drowsiness
Bulk Supplements is a trusted supplier of over 500 pure, safe, and high-quality supplement ingredients to consumers and manufacturers. It prides itself in maintaining all health code and government regulations.
It’s high-quality Ashwagandha root extract capsules are safe & effective. One bottle contains 240 capsules and will last almost 8 months.
Best Exogenous Ketones: KetoneAid Ke4
Science-backed
No caffeine, sugar, and ketone salts
Vegan
World Anti-Doping Agency (WADA) compliant
Discounted for packs of 12 & 35
Tastes bitter, similar to a shot of apple cider vinegar; sucralose version tastes better
Not designed for weight loss
Relatively expensive
KetoneAid Ke4 is a drink whose primary ingredient, ketone monoester, is the molecule used in 90% of exogenous clinical trials.
It’s taken by many elite athletes to help fuel their performance and endurance, especially during competitions.
Ke4 is very convenient for travel. You can use the 5ml cap to measure out the amount you need.
If you’re just starting with exogenous ketones, take 5ml, 1-2x/day. The average intake is 10ml (2 capfuls). Some users say the sweet spot is at 3 capfuls.
Best Turmeric + Curcurmin: Paleovalley Turmeric Complex
Uses only high-quality, certified organic whole foods
100% pure
No fillers, binders, flow agents
Non-GMO, no gluten, grain, soy, dairy
Easy to swallow capsules
No flavor or aftertaste
Free shipping & handling for orders of 3 bottles or more
60-day 100% money-back guarantee, no questions asked
May interact with certain medications
Turmeric can slow blood clotting, increasing the risk of bruising & bleeding, especially if taken with blood thinners
Paleovalley Turmeric Complex is a blend of organic:
- Turmeric
- Ginger
- Rosemary
- Cloves
- Black pepper
- Coconut oil powder
It uses the whole turmeric, not just curcumin. Whole turmeric contains around 300 beneficial compounds and is more powerful than isolated curcumin.
Turmeric, ginger, rosemary, and cloves are some of the most powerful spices for regulating inflammation and reducing oxidative stress.
The coconut oil powder and black pepper maximizes absorption of the supplement’s superfoods.
Best multivitamin for men & for women: Performance Lab NutriGenesis Multi
Effects begin 30 minutes after ingestion
Highly bioavailable formula
No soy, egg, fish, shellfish, dairy, peanut, tree nuts, wheat, or other allergens
No gluten, caffeine, synthetic additives, artificial colors & preservatives
Non-GMO and non-irradiated
Clean Label Project validated
In-house & 3rd-party lab tested
No bright yellow pee you get with inferior quality, poorly dosed synthetic multivitamins
4 capsules/day might be too much or inconvenient for some
Formulation avoids iron overdose risk in men, but may have to source separately if you are a male needing iron supplementation
NutriGenesis Multi for Men and for Women are premium, science-backed multivitamins designed specifically to meet each gender’s unique nutritional needs.
Developed by PerformanceLab, what sets this multivitamin apart is its use of NutriGenesis®. This technology complexes vitamins and minerals with natural cofactors like probiotics, fiber, and enzymes.
NutriGenesis Multi for Men provides a comprehensive blend of 24 essential vitamins and minerals. These are in doses crucial for male vitality, energy, immune support, cognitive function, and hormonal health such as testosterone production.
NutriGenesis Multi for Women also contains a precise blend of 24 essential vitamins and minerals. The dosages, though, are optimized for women’s unique health needs like iron replenishment and hormone balance.
Nutrients are not synthesized or isolated. Rather, they are grown in an ultra-clean lab setting.
The result? Enhanced bioavailability and absorption, mimicking how nutrients occur in whole foods. Delivering more potent nutrients at smaller doses compared to traditional multis.
Because there are more nutrients, PerformanceLab recommends taking 4 capsules/day (2 in the AM and 2 in the PM) to get the optimal levels.
Best nootropic formula: Nootopia Dopa Drops
Promotes dopaminergic activity
Helps maintain energy levels, cognitive stamina, & high performance
No jitters or crashes typical of stimulants
365-day money-back guarantee
Subscribing saves you $39
Expensive
Some might experience side effects due to the combination of multiple stimulants
Undisclosed dosages of ingredients in dopamine support & energy support blends
Dopa Drops by Nootopia is designed to naturally boost your brain’s dopamine production. It enhances motivation, focus, and emotional processing.
It supplies your brain with the nutrients needed to sustain dopamine release over time. Not like pharmaceutical drugs that artificially stimulate dopamine and risk subsequent crashes.
Mark Effinger, AKA Mr. Noots, the best brain chemist and master of nootropics, formulated Dopa Drops. Its unique & synergistic blend makes it more potent and effective than most other nootropics.
Some key ingredients include:
- Mucuna pruriens – a tropical legume that increases dopamine levels
- DL-Phenylalanine (DLPA) – supports dopamine levels
- Acetyl L-Tyrosine – a precursor to neurotransmitters that supports focus & stress response
- TeaCrine – boosts energy, focus, motivation, & performance
- Dynamine – a fast-acting alkaloid that boosts the brain & energy
Together with Dopa Drops’ other ingredients, they create a synergistic effect. An effect that amplifies motivation and pleasure when paired with positive dopamine-triggering events.
Even more notable, Dopa Drops helps you “ascend” past emotional blocks and procrastination, providing a sustained pathway to productivity and creative problem-solving.
You’ll feel the effects in around 45 minutes and peaks at 90 minutes.
For a powerful motivation boost + energy, Dopa Drops is the way to go.
Best prebiotics, probiotics & postbiotics: Qualia Probiotic+
Rebalances entire gut ecosystem
Non‑GMO, vegan, gluten-free
Science-backed & fully-disclosed ingredients
Natural & minimal excipients
Produced in FDA‑registered, GMP‑compliant facilities
Follows ISO/USP standards for ingredient quality
3rd-party lab tested
Subscribing saves you 50%
100-day money-back guarantee
Expensive if you don’t subscribe
Some report powder doesn’t easily dissolve & gets chunky
May experience temporary digestive issues like bloating, diarrhea, mild stomach discomfort when starting
Qualia Probiotic+ is a comprehensive blend of 28 prebiotics, probiotics, postbiotic, fermented foods, and other synergistic ingredients.
Developed by Qualia Life Sciences, each ingredient is carefully selected to provide synergistically optimal support for your microbiome. It’s an all-in-one gut health solution in one convenient scoop.
1 scoop contains:
- 3 shelf-stable spore form probiotics – survives travel thru digestive tract
- 4 prebiotic fibers
- 5 digestive enzymes
- 12 fermented berries & herbs
- 1.5 billion postbiotics
- 3 billion live probiotic organisms
It’s a a clinically-informed, ethically-sourced formula that combines shelf‑stable spore probiotics, pre‑ and post‑biotics, digestive enzymes, fermented foods, magnesium, and fiber.
You’ll experience:
- Better nutrient absorption
- Less bloating & gas
- Healthier bowel regularity
- Strengthened gut-brain axis
- Improved gut lining integrity
- Stronger immune function
Qualia Probiotic+ delivers a truly holistic, all‑in‑one solution for gut health, immune resilience, nutrient absorption, and even mood support
Best for weight loss: Healthgevity IGNITE+
Reduces adiposity & visceral fat
Raises metabolic rate & calorie burning
Improves glucose tolerance & glucose control
Science-backed ingredients
Formulated with top medical researchers & clinicians
Manufactured according to cGMP standards
Every batch analyzed for identity, potency, contaminants, heavy metals, pesticides, & microbes
No savings offered for subscribing
May cause bloating or gas when first taking it
Ignite+ by Healthgevity is an advanced metabolic optimization formula designed to:
- Enhance metabolism
- Improve insulin signaling
- Support healthy body composition
It reduces glucose uptake and prevents insulin resistance. How? By combining several powerful glucose disposal agents that synergistically support various body processes that control blood sugar.
The following are its notable ingredients and their roles:
- InnoSlim®- reduces glucose absorption by 42%, increases glucose uptake in muscle & fat cells by 68%, aids appetite control, & improves insulin resistance
- MitoBurn® (L-BAIBA): Mimics exercise effects by promoting fatty acid reduction, ketone production, browning of white fat, & AMPK activation
- GlucoVantage® (Dihydroberberine) – lowers blood glucose levels significantly & improves insulin sensitivity & body composition
- Factor21® (Bitter Melon Extract) – activates AMPK & regulates Fibroblast Growth Factor 21 (FGF21) that enhances insulin secretion & inhibits fat cell growth.
- DNF-10 Satiety Peptide Complex- reduces hunger signals by lowering neuropeptide Y & ghrelin expression
- CalorieBurn GP® (Grains of Paradise seed extract) – stimulates thermogenic brown adipose tissue, increasing calorie burning up to fivefold & promoting visceral fat loss
- Actiponin® (Gynostemma pentaphyllum extract) – activates AMPK, significantly reducing body fat, weight, & waist circumference
All these make Ignite+ a comprehensive & potent solution for biochacking weight loss.
Though this list is comprehensive, it’s not perfect. Because no 2 people are exactly alike. Some of these will work great for you, some you’ll find you don’t need at all.
It can also feel overwhelming to know there are so many biohacking supplements to choose from. So, that’s what we’ll tackle next.
How to Choose Biohacking Supplements
Choosing the best biohacking supplements requires careful thought and research. It goes beyond slick marketing strategies and aesthetic packaging.
I go right into the meat of the supplements with criteria like ingredient quality, sourcing, manufacturing process and testing. After all, I’m putting them in my body so I’d better know exactly what they are and what they do.
I evaluate the following criteria carefully, and so should you when choosing your supplements:
- Quality & purity of ingredients – Are they organic, free of toxins like heavy metals and harmful microbes? Do their products contain fillers, additives, preservatives?
- Sourcing – Where are the ingredients from? Is it from a reputable source? Is the source uncontaminated? How do they source them? Through ethical practices that minimize contamination?
- Manufacturing process – What is their manufacturing process, facility, and distribution? What certifications do they hold or standards do they adhere to? Ideally, they’d be NSF-certified or follow cGMP standards. Is their process sustainable or environmentally friendly?
- 3rd-party lab testing – Do their ingredients and/or product batches undergo rigrorous & verified 3rd party lab testing? Are their Certificates of Analysis (CoA) published on their website or made available upon request? Are the CoAs current?
- Formulation – Are they transparent about their ingredients and amount of each or do they have a proprietary formula? I like to go with those with transparency
- Form – Is the form of their supplements bioavailable, potent, and/or effective?
- Customer reviews – How many reviews are there? Are the reviews mostly positive or negative? Is there a recurring theme or issue in the reviews? How does their customer service fare?
- Availability – It doesn’t make much sense if they’re the best supplement of their kind but their product is always unavailable. How do they handle shipping? Do they deliver to your area?
As you become more versed in biohacking supplements and their criteria, choosing the right supplements will become intuitive or second nature to you.
Safety & Dosage
The FDA regulates supplements differently from pharmaceuticals. It does not approve dietary supplements for safety or effectiveness before they are marketed.
It is the responsibility of the manufacturers and distributors to ensure their products are safe and properly labeled before sale.
It is our responsibility as consumers to do our due diligence in evaluating the safety and appropriateness of a supplement for our biology.
When considering the safety and dosage of biohacking supplements, several key factors should be kept in mind to minimize risks and maximize benefits:
- Consult your healthcare professional – Always talk to a doctor, nutritionist, or healthcare provider before starting any biohacking supplement. Especially important if you have existing medical conditions or take prescription medications
- Understand potential side effects – Supplements are generally safe but some may experience side effects such as digestive issues, mood changes, or sleep disturbances. Monitor your body’s response carefully and adjust or discontinue use if adverse effects occur
- Research the quality & purity of supplements – Choose supplements from reputable brands that adhere to rigorous testing and manufacturing standards. Such supplements reduce the risk of unexpected adverse effects
- Take the proper dosage & be consistent – Supplements are most effective when taken regularly and at proper dosages. Over- or under-dosing can reduce efficacy or increase risk. Establishing a routine helps maintain consistency
- Use diagnostic testing to guide supplementation – Regular blood testing, especially whole blood diagnostics rather than just serum tests, can provide accurate insights into your micronutrient status
- Be cautious with combining multiple compounds – Studies on the long-term safety of combining various biohacking supplements is still building up
This data helps tailor supplement choices and dosages to your individual needs and avoid unnecessary or excessive intake.
Research thoroughly, ask your doctor and proceed with caution when stacking supplements. Interactions between them may pose unknown risks
With all these said, remember that you are a unique individual. Your body’s response to a certain supplement just might be worlds apart from that of your biohacking buddy.
My best advice is to consult your doctor, research thoroughly to make well-informed choices, and monitor the effects of supplements on you. Even better that you undergo diagnostic testing to determine deficiencies or genetic conditions for a more personalized supplement stack.
And remember, it’s always better to start low and slow and gradually build up, if needed, according to how your body responds.
Biohacking Supplement Questions & Answers
I gathered the most common questions I’ve encountered regarding biohacking supplements and answer them for you below. Let me know in the comments if you have questions not covered here.
Which supplements are foundational for almost everyone?
Core supplements include magnesium, collagen, electrolytes, omega‑3s, vitamin D3+K2, EAAs, creatine, and NAD+ precursors (like NMN & NR). They support essential functions—sleep, joint health, hydration, cardiovascular health, and muscle/brain energy. Many other substances like shilajit and micro-algae (spirulina & chlorella) provide a diverse array of micronutrients.
What are biohacking supplements and why do they matter?
Biohacking supplements are targeted nutrients and compounds (like NAD⁺ precursors, adaptogens, and amino acids) designed to optimize performance, longevity, recovery, and resilience by enhancing underlying biological systems. They’re popular because they help close dietary gaps and support advanced health goals. With virtually zero effort required.
Are biohacking supplements safe?
Many supplements are safe when taken appropriately and the source ingredients are pure and high quality. Do your research on the supplement company. And consult your doctor before taking them, especially if you take prescription medications, due to possible interactions.
How do biohacking supplements for weight loss work?
Biohacking supplements for weight loss support metabolism, fat burning, and overall health. They work best when combined with personalized, data-driven dietary changes tailored to your metabolism. Read my biohacking weight loss guide for strategies to lose fat fast.
How do nootropics fit into biohacking?
Nootropics are supplements that enhance cognitive functions such as memory, focus, and mental stamina. They include caffeine, botanical extracts like Bacopa monnieri, and nutrients like lutein and zeaxanthin. Learn more about these brain enhancers in my nootropics beginners’ guide.
How do biohacking supplements for men differ from those for women?
Biohacking supplements for men and women differ primarily due to biological and hormonal variations that affect metabolism, nutrient needs, and responses to supplementation.
Women’s biohacking often focuses on supporting hormonal balance. Supplements are tailored to menstrual cycles and life stages like menopause. Men typically require higher protein intake for muscle building and lower (or no) iron intake to avoid toxicity. Learn the right way to biohack if you’re a woman.
Are supplements a substitute for a healthy diet?
No, supplements are meant to complement a balanced diet, not replace it.
How do you ensure supplement effectiveness?
Regular intake and establishing a routine help. Using combination products simplifies supplementation. Also, monitoring nutrient levels through advanced blood diagnostics is recommended for personalized optimization.
Finding Your Optimal Biohacking Supplements
I hope you found this list helpful.
The best supplement regimen starts by addressing directly deficiencies. Filling any deficiencies makes adaptogens, longevity molecules, and fancy supplements work better.
If I could only choose five, as I often do when I travel, I’d pick:
- Algae (spirulina and chlorella)
- Magnesium
- EAAs
- Shilajit
- Custom nootropic
Of course, you’re not limited to five, and what works best for you will take some testing.
While these are some of my favorite overall biohacking supplements, I take others to:
- Re-vitalize the body
- Dramatically boost energy
- Sharpen the mind
- Increase motivation
- Slow the aging process
- Protect the brain
- Rapidly build muscle and shed body fat
- Drop into the flow state
It’s also worth reiterating that supplements shouldn’t replace healthy lifestyle practices. Make sure you’re still eating nutritious food, exercising, getting enough sleep, managing stress, etc.
Check out my peak performance supplement stack here, or visit the internet’s best biohacker’s shop for exclusive discounts and reviews on the latest products.
Am I missing any? What supplements do you take? Let me know in the comments.
Hi Nick,
Thanks for your articles. This blog is one of the most professional and relevant that can be found. I live in France and the blog about biohacking are rare…
I have a question please, what is your opinion on the composition of this holistic supplement? Thanks
https://www.unae.fr/boutique/multivitamines/elite-multivitamines-holistique/
Hi Benjamin,
Glad they are helpful! I just tried to translate that website and it isn’t the easiest to get all the info in English. Overall, I like the formulation. It is quite expensive though, each serving is 2 sachets and 30 sachets are $129 Euros. Making each full serving ~8.6 Euros. Do you use this?
Hi, thanks for your answer.
No i use a version more “basic” and less expensive.
I was just wondering if the value for money was worth it.
I use this one : https://www.unae.fr/boutique/multivitamines/essentiel-multivitamines/
It’s hard to find good suppliers with a good formulation and bioavailable forms.
I compared with LifeExtension multi supplements which seems often overdosed imo. What do you think ?
Hard to weigh in because I am sure the page translator is getting some words wrong and I certainly don’t want to steer you in the wrong direction! It does look decent though.
I agree. It’s extremely difficult to find a quality, bioavailable, non-toxic multi. Companies often put overages in the products because certain ingredients aren’t bioavailable and/or are mostly excreted. Beta-carotene is one such example.
I personally get most of my vitamins, minerals, and nutrients from a combo of micro-algae (spirulina & chlorella) and desiccated grass-fed organ capsules (when I don’t eat it). My blood work looks better than ever with no multi (I actually had too much of certain things previously when on a multi).
Very interesting. I have also personally tested spirulina in recent years, but rather as a one-month cure at the change of seasons than as a continuous intake.
Right after reading your articles on the subject, I decided to try grass-fed organ capsules because I have a lot of trouble with the taste and texture of organ meats.
I apparently found a good and ethical supplier in Sweden that a lot of biohackers seem to recommend in Europe.
I’m going to stop my multi and test it to see the difference in feeling and analysis.
Thanks Nick for your advice.
Hey Benjamin, I know that it has been quite a while since you wrote, but I’m curious how your experiment went! That is, if you tested the grass-fed organ meat capsules.
A very good blog on Biohacking Supplements. Thank you for sharing.
Glad you like it!