Experimental
MK-677 (Ibutamoren)
The prediction game
Call it: rising or fading?
Where does MK-677 (Ibutamoren) stand 12 months from now? Lock your call with a confidence level. When the window closes, the Brier rule scores your calibration: right and confident earns the most, wrong and confident costs the most. Points and a leaderboard spot are the whole prize. No stakes, no money.
One call per intervention. It locks the moment you submit: no edits, no cancels. It resolves when the 12-month window closes.
The Crowd’s Call
Rising or fading over the next 12 months? Lock your call and find out if you saw it coming.
Community Signal
No weigh-ins yet. Be the first and set the early signal.
Evidence
Evidence grade: C (mixed evidence)
Graded from the strength of the published research, independent of any verdict on this page.
Evidence Anchor
BioHarmony 4.9/10
MK-677 sits at a Neutral 4.8 because it is the best-evidenced growth-hormone secretagogue you can name and still not a clear win, which is an unusual place to land. The practical read: if you want oral convenience, deeper sleep, and lean-mass support, and you genuinely accept a certain glucose cost plus a cardiac caveat, it is a reasonable monitored experiment on verified product. If you are chasing proven strength, function, or longevity, the data actively argues against it, and a cleaner path exists. The score is justified because a strong evidence base full of negative results is exactly that, strong and discouraging at the same time. Merck developed MK-677 for years and never brought it to market. Despite evidence of target engagement, it was ineffective at slowing the progression of Alzheimer disease, the cleanest sign that raising IGF-1 is not the same as helping. Sevigny 2008✅ Best for: Experienced users who value an oral, once-daily option over injections and will not miss the needle. People whose main goals are deeper sleep and lean-mass support rather than maximal strength, since the strength evidence is absent. Older adults with lower baseline growth hormone, who tend to respond more on the hormone markers. Anyone with clean fasting glucose and no cardiac history who will actually track glucose, HbA1c, and IGF-1 on a schedule. Users who can source third-party-tested material and verify identity, given documented mislabeling. ❌ Avoid if: You have diabetes, pre-diabetes, or metabolic syndrome, because MK-677 reliably worsens glucose control. You have heart failure or significant cardiac disease, given the congestive-heart-failure signal that halted a trial and the fluid-retaining mechanism. You have active or prior cancer, since IGF-1 is mitogenic and chronically raising it is a theoretical tumor-promotion risk. You compete in tested sport, since it is banned at all times under WADA category S2. You cannot verify source quality, because grey-market products are frequently mislabeled and sometimes contain other unapproved drugs entirely.
Read the full BioHarmony report
My score and my verdict: one signal of three, never the whole answer.
Momentum
Signals begin with Edition 2
Direction needs two weekly snapshots to compare, so the arrows stay off until the next edition. Attention tracking is already running.
In the news this week: Jay Campbell.
Momentum = how fast attention is rising across search, Reddit, PubMed, podcasts, and curated industry newsletters this week; it can flag an item as Overhyped/Fading, but it never overrides the evidence behind Proven. How momentum works.
- Ring
- Experimental
- Trend
- Begins with Edition 2
- Momentum
- 0.0%
- BioHarmony Score
- 4.9/10
- Last Updated
- Jul 2, 2026
Sources
- BioHarmony score
- Search trend delta
- Reddit velocity
- PubMed publication count
- Podcast mention frequency
- Curated newsletter mentions
The score anchors the ring; the other five drive momentum, which can nudge the ring by one step at most. How placement works.
Weigh In
Your input feeds the community signal shown beside my verdict. It informs the board and it never sets the score by itself. How community input works.
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