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Promising · 6.5/10

MOTS-c

Evidence D · early evidence ▼ 9.6% momentum 🥇 First scout open
6.5/ 10

MOTS-c is a 16-amino-acid mitochondrial-derived peptide discovered in Lee 2015 that activates AMPK through the folate and purine pathway. Human evidence remains observational: Zhou 2024 pooled seven biomarker studies, but no published human RCT has tested exogenous MOTS-c for clinical outcomes. Read the full breakdown →

The prediction game

Where does MOTS-c go in 12 months?

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The Crowd’s Call

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Your 12-month call on MOTS-c

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Related reading

Ring Promising Momentum 9.6% Updated Jul 20, 2026 How the Index ranks →

Verdict by Nick Urban, host of the High Performance Longevity podcast.

For education only, not medical advice. Supplements, peptides, and protocols can interact with medications and conditions. Talk to a qualified clinician before starting anything here.