Ozone Therapy

Ozone Therapy is a 5.0–5.5/10 fit for people weighing acute pain, chronic pain, and wound healing, especially when the goal is a tracked experiment with clear endpoints. The strongest evidence anchor is Lima 2024: Verified audit Track 1 source; six clinical trials with positive diabetic-foot-ulcer signals and considerable risk-of-bias caveats. Liu 2025 adds a second signal, but Ozone Therapy still has gaps around large trials, long-term outcomes, responder profiles, or real-world adherence. That makes Ozone Therapy useful for a defined reader, while weaker for broad anti-aging or catch-all wellness claims. In practice, Ozone Therapy belongs after basics, diagnosis when relevant, and a stop rule based on symptoms, labs, sleep, or performance.

✅ Best for: Adults with chronic discogenic low back pain refractory to conservative care who are considering a fluoroscopy-guided intradiscal procedure with a qualified specialist; dental patients using ozone as an adjunct to scaling and root planing, oral-ulcer management, implant-site healing, or endodontic pain control under dentist supervision; wound-care patients using topical ozone or ozonated oil as adjunct to standard care, not as a replacement; experienced self-experimenters using conservative rectal insufflation with clear endpoints, G6PD awareness, and stop rules; chronic-illness users who understand that Yang 2024 is a pilot PASC signal, not proof for chronic Lyme, MCAS, or EBOO.

❌ Avoid if: You have G6PD deficiency, pregnancy, uncontrolled hyperthyroidism, bleeding diathesis, therapeutic anticoagulation, recent thrombocytopenia, or an unscreened PFO before MAH, EBOO, or any blood route. Avoid direct IV gas and EBOO for general wellness. Avoid any practitioner who cannot explain route, concentration, total dose, sterile technique, emergency plan, contraindications, and PFO screening. Avoid ozone as a sole cancer, chronic Lyme, MCAS, detox, anti-aging, or performance protocol. Competitive athletes should avoid MAH and EBOO unless cleared by anti-doping counsel because WADA prohibits intravascular blood manipulation methods.