Experimental
SLU-PP-332
The prediction game
Call it: rising or fading?
Where does SLU-PP-332 stand 12 months from now? Lock your call with a confidence level. When the window closes, the Brier rule scores your calibration: right and confident earns the most, wrong and confident costs the most. Points and a leaderboard spot are the whole prize. No stakes, no money.
One call per intervention. It locks the moment you submit: no edits, no cancels. It resolves when the 12-month window closes.
The Crowd’s Call
Rising or fading over the next 12 months? Lock your call and find out if you saw it coming.
Community Signal
No weigh-ins yet. Be the first and set the early signal.
Evidence
Evidence grade: D (early evidence)
Graded from the strength of the published research, independent of any verdict on this page.
Evidence Anchor
BioHarmony 4.7/10
SLU-PP-332 may provide modest increases in mitochondrial oxidative capacity and treadmill endurance for highly controlled self-experiments, yet the evidence is limited to rodent models and human safety data are absent. The synthetic pan-ERR agonist boosted mouse exercise performance after eight days of daily injection, an effect that depended on ERR alpha activation and was linked to enhanced fatty-acid oxidation [Billon 2023](https://pubmed.ncbi.nlm.nih.gov/36988910/). Follow-up mouse studies reported improvements in obesity-related metabolic markers, including lower fasting glucose and reduced hepatic fat, when SLU-PP-332 was administered over several weeks [Billon 2024](https://pubmed.ncbi.nlm.nih.gov/37739806/). Cardiovascular mouse models also showed better ejection fraction and reduced fibrosis after treatment [Xu 2024](https://pmc.ncbi.nlm.nih.gov/articles/PMC10842599/). Because no human pharmacokinetic or dose-finding trials exist, any benefit in people remains speculative and must be weighed against unknown adverse-event risk. ✅ Best for: Advanced biohackers with medical supervision who are explicitly studying exercise-mimetic pharmacology, understand the corrected evidence base, and accept that SLU-PP-332 is preclinical only. The strongest fit is a researcher or unusually risk-tolerant self-experimenter who has already optimized training, nutrition, sleep, creatine, cardiometabolic labs, and body composition fundamentals. It may also be worth following academically if you care about ERR pharmacology, mitochondrial medicine, obesity-drug development, heart-failure metabolism, or doping-control evolution. ❌ Avoid if: You want human clinical evidence before exposure; you take medications; you have cardiovascular disease, active or historical cancer, liver or kidney disease, psychiatric instability, or fertility goals; you are pregnant, breastfeeding, under 25, or competing in tested sport. Avoid SLU-PP-332 if you cannot independently verify product identity and purity, or if you are using it as a substitute for exercise. The audit found no FDA approval, no Cochrane review, no human trial, and no medical-society endorsement. Sourcing & dosing caveat: gray-market supply; score assumes clean, correctly-dosed material.
Read the full BioHarmony report
My score and my verdict: one signal of three, never the whole answer.
Momentum
Signals begin with Edition 2
Direction needs two weekly snapshots to compare, so the arrows stay off until the next edition. Attention tracking is already running.
In the news this week: Jay Campbell.
Momentum = how fast attention is rising across search, Reddit, PubMed, podcasts, and curated industry newsletters this week; it can flag an item as Overhyped/Fading, but it never overrides the evidence behind Proven. How momentum works.
- Ring
- Experimental
- Trend
- Begins with Edition 2
- Momentum
- 5.8%
- BioHarmony Score
- 4.7/10
- Last Updated
- Jul 2, 2026
Sources
- BioHarmony score
- Search trend delta
- Reddit velocity
- PubMed publication count
- Podcast mention frequency
- Curated newsletter mentions
The score anchors the ring; the other five drive momentum, which can nudge the ring by one step at most. How placement works.
Weigh In
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