Proven · 7.6/10
Spermidine
Spermidine is a dietary polyamine that supports autophagy and mitophagy through EP300 inhibition and eIF5A hypusination. Its strongest human signal is the Kiechl 2018 Bruneck cohort, where higher dietary spermidine intake tracked with lower 20-year mortality. But the main cognition RCT, Schwarz 2022 SmartAge, missed its primary endpoint, and all published human efficacy trials used wheat germ extract rather than synthetic 3HCL. Read the full breakdown →
The prediction game
Where does Spermidine go in 12 months?
Lock a call and say how sure you are. Right and confident earns the most; a leaderboard spot is the prize. No money, no stakes.
The Crowd’s Call
Rising or fading over the next 12 months? Lock your call and find out if you saw it coming.
Be the first scout on record for Spermidine. Permanent credit on this page, plus points when your call resolves.
One call per intervention. It locks the moment you submit (no edits, no cancels) and resolves in 12 months. See the scout leaderboard →
Weigh In
Your input feeds the community signal shown beside my verdict. It informs the board and it never sets the score by itself. How community input works.
Same as above — one verification covers all your entries here.
For education only, not medical advice. Supplements, peptides, and protocols can interact with medications and conditions. Talk to a qualified clinician before starting anything here.