Supplements & Ingredients

5 Best AKG Supplements in 2026: Benefits, Dosage, and Reviews

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By:Nick

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Expert reviewed by Nick Urban, Functional Health PractitionerFHP — Jun 2026

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4 Best AKG Supplements: Benefits, Dosage, & Review of Alpha-Ketoglutarate

Could alpha ketoglutarate (AKG) supplements be the closest thing to a fountain of youth?

The world of longevity medicine has focused primarily on powerful and natural NAD+ precursors and other body-protective ingredients.

For the most part, other classes of molecules have flown under the radar.

Yet the potential lifespan and healthspan-promoting properties of alpha-ketoglutarate are mind-blowing.

In this article, I will break down the latest science and benefits around alpha-ketoglutarate, and review all the best AKG supplements available.

What is Alpha Keto Glutarate

Alpha-ketoglutarate is a small molecule naturally abundant throughout the body. Although used for all kinds of bodily processes, AKG is famously used by mitochondria to generate energy.

Supplementation has become popular to replenish the levels that naturally decline with age. Preliminary findings show significant lifespan-enhancing benefits, but compared to many other ingredients, research is still emerging.

One of the most important criteria to consider when evaluating Alpha Ketoglutarate supplements is the form of that AKG.

Types of AKG

Best forms of alpha-ketoglutarate supplements

Alpha-ketoglutarate supplements come in all different forms. Most are just ordinary alpha-ketoglutarate.

Unfortunately, as much as 80% of normal oral AKG never reaches the bloodstream.

Yet scientists have discovered that alpha-ketoglutarate is the most effective, stable, and longest-lasting when bound to something else.

The two most common bioavailable forms are:

  • Arginine Alpha-Ketoglutarate (AAKG)
  • Calcium Alpha-Ketoglutarate (CaAKG)

AAKG is L-arginine (an amino acid involved in nitric oxide synthesis) bound to AKG. This form is good for the blood and hormone-enhancing properties of AKG. Overall, it’s far superior to traditional alpha-ketoglutarate but not as good as the next option.

CaAKG is calcium (an excitatory mineral) bound to AKG. As you’ll see in the science section, this is the form most commonly used in clinical research.

This is also the form studied in the limited human biological age literature. It lasts longer because it’s slowly absorbed in the gut and gradually enters the bloodstream. That makes CaAKG the most directly studied form for longevity, although human outcome evidence remains limited.

There are three other interesting forms to mention.

Creatine AKG (C-AKG) is creatine bound to alpha-ketoglutarate. Since AKG is a Krebs cycle intermediate, it easily enters cells and can deliver creatine into muscle cells. Entering the cell without needing a transporter like most creatine. Plus, we wouldn’t need an excitatory calcium counter-ion which theoretically makes it better for the nervous system.

Ornithine AKG (OKG) is the amino acid L-Ornithine bound to alpha-ketoglutarate. What’s interesting is that neither ingredient is very bioavailable on its own. Ornithine HCL can increase sleep quality in two ways.

By reducing the stress hormone cortisol and also levels of ammonia. Paradoxically, some people report finding OKG a bit stimulating.

Sodium AKG (Na-AKG) is another one popular in Polish studies. They claim it has a stronger effect than Ca-AKG, but I didn’t take the time to translate all the Polish research. Given the prevalence and necessity of sodium, this one seems like it warrants extra attention.

So far, the research on CaAKG and AAKG looks most promising.

The Best AKG Supplements & Products

Unlike many longevity supplements, there aren’t many quality alpha-ketoglutarate products available.

I weighted ingredient form, disclosed dose, serving simplicity, third-party testing, and price. Liposomal or phospholipid delivery can change pharmacokinetics, but none of these exact AKG products has shown superior human longevity outcomes.

These are the top AKG capsules and powders you can buy online.

AKG Supplements Compared

Codeage leads for one-capsule convenience and price, while DoNotAge and Renue disclose the AKG dose more clearly.

Codeage Liposomal Calcium AKGCaAKG capsuleNot disclosed60 servingsOne-capsule value$29.99URBAN 10%
DoNotAge CaAKGCaAKG capsule400 mg per capsuleVaries by doseDose transparency$49URBAN 10%
NOVOS CoreCaAKG powder blend1,100 mg30 servingsAll-in-one formula$109urban5 $5
Renue LIPO CaAKGLiposomal CaAKG300 mg per capsule90 capsulesLiposomal format$48.95
Renue ShieldCaAKG blend100 mg per serving60 servingsMulti-ingredient blend$69.95

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Use the comparison to match the format to your goal. A disclosed dose matters if you are trying to follow a specific protocol, while capsule count and serving size matter more for consistency.

Codeage appears first for one-capsule convenience and price. Its missing dose disclosure is a real limitation, so DoNotAge or Renue may be the better fit if label transparency is your priority.

Codeage Liposomal Calcium AKG: Best One-Capsule Value

BEST ONE-CAPSULE
Codeage Liposomal Calcium AKG supplement bottle front view

Is Liposomal Calcium AKG worth it?

I have not personally taken Codeage Liposomal Calcium AKG. I evaluated it from the current label, serving format, official price, affiliate discount, and human evidence on calcium alpha-ketoglutarate. No published human outcome trial tests this exact formula, and the liposomal label does not establish better results.

Form
Calcium alpha-ketoglutarate capsule
Serving size
1 capsule
Servings
60
Supply
2 months
Dietary fit
Vegan, non-GMO, dairy-free, gluten-free, and soy-free

Best For

  • You want calcium AKG as the primary ingredient without a proprietary blend
  • You prefer one capsule per day
  • You need a vegan formula free of dairy, gluten, and soy

Skip If

  • You need a disclosed milligram dose before buying
  • You want a published human outcome trial on this exact formula
  • You expect the liposomal label to guarantee better results

Pros

  • Calcium AKG is the primary ingredient
  • One capsule per serving with 60 servings
  • Two-month supply at one capsule per day
  • Made in a cGMP-certified US facility

Cons

  • Nick has not personally taken this product
  • The current rendered page does not disclose the calcium AKG dose
  • No published human outcome trial exists on this exact formula

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Price$29.99 $26.99
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Codeage gives you a one-capsule CaAKG formula with 60 servings. I have not taken this product, so its first-place position reflects the formula, price, partner discount, and current evidence rather than personal results.

The one-capsule serving and two-month supply are convenient. The tradeoff is dose transparency: the current rendered product page does not state the amount of CaAKG, and no published human outcome trial tests this exact formula.

DoNotAge CaAKG: Best Overall AKG Supplement

BEST OVERALL
DoNotAge CaAKG supplement container on white background
Form
Calcium alpha-ketoglutarate
AKG per capsule
400 mg
Suggested serving
1 to 2 capsules
Formula
No fillers or binders
Dietary
Vegan
Testing
Third-party tested

Best For

  • You want a straightforward CaAKG supplement from a longevity-focused brand
  • You prefer a filler-free vegan formula
  • You value third-party testing

Skip If

  • You want a liposomal AKG formula
  • You prefer an all-in-one longevity blend
  • You want the highest AKG amount per serving

Pros

  • Nick rated it the best overall AKG option for a reputable, affordable single-ingredient formula
  • Provides 400 mg of CaAKG per capsule with no fillers or binders
  • Vegan formula with third-party testing

Cons

  • Nick noted that several capsules may be needed to reach the larger doses used in many longevity protocols
  • Uses standard capsules instead of liposomal delivery

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Price$49 $44.10
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Do Not Age (appropriately abbreviated DNA) is one of the fastest-growing research-backed longevity supplement vendors. Founded by Alan Graves, DNA’s mission is to fight aging. This is one of the best shops for European bioharmonizers as they are based out of the UK.

Do Not Age’s Ca-AKG is exactly what you’d expect—pure AKG with nothing else added. Every product comes with their Do Not Age Quality Guarantee meaning that it’s guaranteed to arrive at your doorstep with full potency. Most supplements sit, decay, and degrade long before they reach you. DNA products do not, which has made them popular with researchers and scientists.

To get the therapeutic dose, you’ll need a much larger serving. This is a notable downside but for the price and everything you else you can get, it’s still a top-grade supplement.

I am a fan of Do Not Age’s CaAKG because the company is reputable and the product is affordable.

NOVOS Core: Best All-In-One AKG Formula

BEST ALL-IN-ONE FORMULA
NOVOS Core longevity powder sachets and prepared drink

Is NOVOS Core worth it?

Twelve to 13 evidence-based ingredients from a Harvard and MIT team target multiple aging pathways in a longevity powder with published clinical-trial data. Capsule fans lose out (powder only), and it overlaps if you already dose the ingredients solo.

Form
Powder sachet
Servings
30
Ingredients
12
CaAKG per serving
1,100 mg
Aging hallmarks addressed
12
Flavors
Orange, Tropical Passion, Unflavored

Best For

  • You want the most scientifically validated longevity supplement
  • You prefer powder format for flexible dosing
  • You value clinical trial backing for anti-aging claims

Skip If

  • You dislike powder supplements or prefer capsules
  • You are on a tight budget (premium pricing)
  • You already take many of the 12 individual ingredients

Pros

  • Developed by Harvard and MIT longevity researchers
  • 12-13 evidence-based ingredients targeting multiple aging pathways
  • Backed by published clinical trial data
  • Powder format allows flexible dosing

Cons

  • Powder format doesn't suit everyone (no capsule option)
  • Premium pricing
  • Overlapping ingredients if you already supplement individually
  • Relatively newer company in the longevity space

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Price$109 $104
Use code URBAN5 for $5 off
Get Exclusive Deal, Save $5
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Created by Chris Mirabile, NOVOS is a company of longevity scientists and doctors formulating products to slow the aging process. Their science team has backgrounds from Harvard, MIT, and other top institutions.

NOVOS Core, their flagship product, is one of few that targets all 10 known root causes of aging. This supplement also claims to improve appearance, brain function, and energy levels. How can they possibly target all known hallmarks of aging?

NOVOS Core uses 12 ingredients, collectively backed by over 190 studies. NOVOS didn’t take any shortcuts, using clinical dosages of each. Every serving includes a full 1,100mg dose of calcium alpha-ketoglutarate.

Usually, a formula like this would require you to take a whole handful of capsules. NOVOS took a different approach and formulated this all-in-one product into a drink. Every serving comes in its own sachet, containing unsanitized powder.

I have three main criticisms against NOVOS. First, I couldn’t find a CoA or any evidence of third-party lab testing (a major issue). Without that, we don’t know purity or safety.

Second, they included an unnecessary filler, Silicon Dioxide, in the formula. Third is the price. NOVOS Core is among the most expensive longevity formulas.

If you want the most comprehensive, clinically-dosed all-in-one longevity formula that includes Ca-AKG, and don’t mind the lack of third-party testing, NOVOS Core is worth considering.

Renue by Science LIPO CaAKG: Best Liposomal AKG Supplement

BEST LIPOSOMAL
Renue by Science LIPO CaAKG supplement bottle
Form
Liposomal capsule
CaAKG per capsule
300 mg
Calcium per capsule
60 mg
AKG per capsule
240 mg
Capsule count
90
Serving size
1 capsule
Testing
Third-party tested

Best For

  • You want a liposomal CaAKG capsule
  • You prefer a one-capsule serving
  • You value published third-party testing

Skip If

  • You want the largest labeled CaAKG dose
  • You only buy products with an Outliyr discount
  • You prefer a non-liposomal formula

Pros

  • Nick highlighted the balance of potency and value in this liposomal CaAKG option
  • Provides a one-capsule serving with 300 mg of CaAKG
  • Third-party testing certificates are published by the manufacturer

Cons

  • No Outliyr discount is available
  • The label dose is lower than standard high-dose CaAKG products

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Price$48.95
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Founded by Bryan Nettles, Renue By Science (formerly Alive by Science) offers longevity supplements with the goal of helping your healthspan and quality of life. So that you can do the things you love, for longer.

Renue By Science uses liposomal encapsulation technology, combined with third-party lab testing for potency and safety which can be found in the accompanying certificate of analysis (CoA).

Renue By Science’s CaAKG is a strong. Each serving contains 300mg of CaAKG, likely delivering the equivalent dosing of over 1,000mg but without the issues of consuming large supplement doses.

Between the potency and price, this can be a good pick-up.

Renue Shield: Best Multi-Ingredient AKG Blend

BEST MULTI-INGREDIENT BLEND
Renue by Science Shield liposomal supplement bottle
Form
Liposomal capsule blend
Serving size
2 capsules
Servings
60
Vitamin C per serving
500 mg
CaAKG per serving
100 mg
PEA per serving
100 mg
Hyaluronic acid per serving
50 mg

Best For

  • You want a multi-ingredient longevity blend
  • You prefer a liposomal capsule formula
  • You want CaAKG alongside vitamin C, PEA, and hyaluronic acid

Skip If

  • You want the original NAD Defender formula
  • You specifically want berberine in the blend
  • You prefer a single-ingredient CaAKG product

Pros

  • The current formula combines four complementary compounds in one liposomal blend
  • Provides 60 servings with published third-party testing
  • Nick highlighted the earlier NAD Defender formula as an appealing all-in-one option for active users

Cons

  • The current Shield formula differs substantially from the NAD Defender formula Nick originally reviewed
  • The current formula no longer contains berberine
  • Requires two capsules per serving

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Price$69.95
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NAD Defender is designed to spare the body’s molecule of anti-aging—NAD+. It does so by reducing systemic inflammation, something beneficial to virtually all modern humans.

Aside from the lower dose, the calcium alpha-ketoglutarate inside this product is no different than their pure AKG. What sets it apart, however, is the stack of other longevity ingredients.

NAD Defender contains Berberine, HLA, and of course, Ca-AKG. I like this formula for hard-charging athletes and anyone that’s physically active. HLA improves connective tissue, while CaAKG acts as an ergogenic workout aid, and the berberine keeps blood sugar steady. Also making it a solid choice for those in their later years.

NAD Defender is an affordable longevity supplement stack that includes CaAKG.

AKG Supplement Health & Longevity Benefits

Health and Lonegvity Benefits

The ketoglutarate family is well-researched, with my current search yielding thousands of papers.

Initially, alpha-ketoglutarate was investigated and used in the treatment of various disease states.

Modern recent studies have focused on its use to improve the function of cells via a measurement called biological age.

Recent research suggests that AKG benefits at least two hallmarks of aging:

Alpha ketoglutarate reduces inflammation caused by senescent cells. Indirectly improving NAD+ levels.

It seems to improve the expression of genes (called epigenetics) and helps cells express themselves in an optimal youthful state.

Finally, AKG stimulates the body’s protective mechanisms and pathways.

Now, let’s explore the most common uses and benefits of supplementing alpha ketoglutarate.

Muscle growth & athletic recovery

Decades ago, bodybuilders were among the first to take AKG supplements. They use it for several reasons. For one, muscle tissue contains a high concentration of mitochondria.

Improving mitochondrial function results in better workouts, in turn increases muscle building. Additionally, alpha-ketoglutarate benefits muscle tissue in two other ways.

First, it inhibits muscle protein breakdown. Second, it stimulates protein synthesis. AKG can even stimulate the production of the nutrient-delivery molecule called Nitric Oxide (NO).

AKG shows promise to boost performance, muscle growth, and speed up recovery.

Energy & endurance

The process of creating new mitochondria, called mitochondrial biogenesis, directly improves sports performance. The more mitochondria you have (and the better they function), the higher your energy levels.

This is why AKG is a natural ingredient in many top mitochondria supplements.

At the same time, optimized mitochondria translate into greater endurance capacity by delaying the onset of fatigue. Acute use seems better suited for longer efforts rather than power or strength athletes. Continual usage shows benefits to different forms of exercise.

Although one poorly designed trial didn’t show much benefit in well-trained individuals.

Healthspan & longevity

Calcium alpha-ketoglutarate and arginine AKG have regained popularity due to their unparalleled anti-aging & healthspan-improving potential.

Most of the animal research on AKG looks quite promising. In 2014, AKG improved the lifespan of a kind of worm called C. Elegans by 47.3%! Follow-up research in 2018 and 2019 found similarly impressive results in flys.

More recently in 2020, one of the world’s leading anti-aging research institutes fed mice alpha-ketoglutarate. The Buck Institute’s study found treatment with CaAKG resulted in a 9.6% to 12.8% median lifespan increase.

Healthspan is the measure of lifestyle that accounts for the quality of those years. After all, lifespan extension is only valuable if you’re able to enjoy those years.

In that mouse study, CaAKG reduced frailty and compressed late-life morbidity. That makes AKG a serious geroscience candidate, but it remains animal evidence. It does not prove that any AKG supplement extends human lifespan or healthspan.

Biological age evidence

All longevity enthusiasts seek supplements that can reverse biological age. Although we cannot yet directly “turn back the clock”, certain interventions can certainly slow the rate as we age. So, for example, with every calendar year we age only 0.5 biological years.

Biological age reversal often correlates closely with healthspan.

Indeed, several papers support Calcium alpha-ketoglutarate’s ability to slow biological aging.

The most cited human result is a 2021 retrospective analysis of 42 people taking Rejuvant, a formula containing CaAKG plus vitamins. DNA methylation age fell by an average of about eight years after roughly seven months. The study had no randomized placebo group, and the multi-ingredient formula prevents attributing the change to CaAKG alone.

A 2023 protocol for the ABLE trial describes a double-blind, placebo-controlled study of 120 middle-aged adults taking 1 gram of sustained-release CaAKG for six months. That publication is a protocol, not a result.

A separate randomized CaAKG trial registered in 2025 tests 2 grams daily for 12 weeks against placebo. No results are posted, so the controlled human evidence still has not caught up with the animal data and marketing.

I have used and reviewed the TruDiagnostic epigenetic age test, so I know how noisy and context-dependent a clock result can be. I am interested in testing CaAKG, but I would not call a clock change proven age reversal without controlled outcome data.

Bone density & skin health

Calcium alpha-ketoglutarate seems to impact other areas that decline with age. Skin appearance and bone density are actually powerful biomarkers of longevity.

Damaged skin has higher levels of senescent cells, which causes all kinds of downstream aging issues (and senescent cell burden is a hallmark of aging). Ca-AKG seems to keep skin youthful and healthy. It also stimulates the synthesis of collagen and protein to support optimal detoxification and normal cellular function.

So far in mice, this supplement also appears to improve bone mass, reduce bone loss, and accelerate bone regeneration.

Fertility improved

Can α-ketoglutarate help those struggling with fertility?

As humans continue to postpone childbearing into later years, fertility issues have skyrocketed. One 2021 study investigated the role of alpha-ketoglutarate and age-related fertility.

They noticed significant fertility improvements from long-term supplementation, and the researchers used mice to tease out the mechanisms.

While certainly promising, I’d like to see clinical research in humans.

Detox & immunity

Detoxification is the natural process the body uses to rid itself of byproducts of metabolism, cellular waste, and other toxins. AKG can help rebalance the immune system and keep the body running optimally.

On the detoxification front, alpha-ketoglutarate helps the body remove excess ammonia and nitrogen from the blood. These result from the metabolism of dietary protein and can quickly accumulate. Ammonia in large quantities is toxic. By improving ammonia clearance, AKG supports optimal detoxification.

Alpha-ketoglutarate also positively modulates the immune system. It helps specialized immune cells called macrophages mount more appropriate immune responses. AKG provides hungry immune cells with an amino acid called glutamine and the neurotransmitter glutamate. Increasing the number and activity of immune cells like neutrophils, phagocytosis, lymphocytes, and macrophages.

Other immune benefits of AKG likely stem from its beneficial changes to the gut microbiome.

Stem cell rejuvenation

Another AKG benefits worth discussing is its impact on stem cells.

Stem cells are a form of generalized cells naturally present throughout the body that can take the form of any tissue. These “jack of all trades” cells are incredibly valuable and important to maintain health. They decline with age, and so does the body’s ability to repair and regenerate.

One 2020 study showed that AKG supplementation can protect a form of stem cells called mesenchymal stromal/stem cells (MSCs) from damage.

Although this study investigated bone stem cells specifically, I’d love to see it replicated for other tissue types.

Biomarker improvements

AKG improves various other biomarkers too.

First, it appears to improve phosphate metabolism. This in turn helps correct obesity.

Several mouse studies have found that it improves the parameters of arterial health.

Finally, a bunch of Polish University studies has uncovered some impressive anti-aging effects.

Optimally Using AKG Supplements

Using alpha ketoglutarate supplements is safe and straightforward.

There are a few things to note before getting started.

Dose & form

First, you’ll quickly notice that dosage varies based on several factors.

The primary being:

  • Delivery technology
  • Goal
  • Form

Normal capsules and powders will require much larger doses to get the same effects as low-dose liposomal encapsulated products.

Also, your ideal use depends on your goals.

For muscle growth, endurance, recovery, and sports performance, athletes prefer either arginine alpha-ketoglutarate (AAKG) or creatine alpha-ketoglutarate (CAG). These two are most favorable to muscle tissue and hormones. Most take 1 to 12 grams taken either pre-exercise or post-exercise.

For longevity, anti-aging, and biohacking, the exact protocol is less clear. Most of the research has used CaAKG, so I prefer that form when evaluating longevity claims.

The ideal dose of a normal powder would be 500mg – 1,200mg. The liposomal dose will depend on the preparation, so you’ll want to follow the label’s recommendations.

Safety

Overall, AKG is well tolerated and considered safe in typical dosages. I recommend following the dosage instructions on the product’s label.

So far there are no documented side effects attributed to alpha-ketoglutarate alone.

Upgrade Your Ca-AKG

There are several things you can combine/stack together with AKG to get far better, biosynergistic effects.

After all, the trial that showed an 8-year biological age reversal contained other ingredients that amplified the benefits of AKG.

Vitamin B6

The cheapest and simplest addition to a Ca-AKG stack would be vitamin B6 or a vitamin B complex. Since we’re commonly deficient in B vitamins, it’s a good idea on its own. B vitamins improve the energy generation process and also work to increase the absorption of AKG.

Whey protein stack

As explained in my guide to grass-fed whey protein powder, this one is a godsend for health optimizers. It’s ultra-pure, nicely combats anabolic resistance, and ameliorates one of the primary risks of aging — frailty. High-quality whey, specifically grass-fed, contains all kinds of beneficial peptides, growth factors, and regenerative molecules. This is key for the elderly and athletes alike.

NAD+ precursor

You’ve probably heard of NMN or NR, thanks to the work of Dr. David Sinclair. Both of these boost levels of the body’s master energy reservoir called NAD+.

NAD+ is like gasoline in the body and powers vital longevity pathways and proteins like SIRTUINS. Levels drop swiftly after the age of 40-50, and people often report massive quality-of-life enhancements from supplementing these or living an NAD+ optimized lifestyle.

Spermidine

The most exciting longevity supplement I began using in 2022, spermidine is the only known agent that improves six of the nine hallmarks of aging. It’s notable for its hair, skin, and nail regenerative effects. As well as slight cognitive benefits.

Most relevantly, spermidine promotes the cellular cleanup process of autophagy and protects the human genome (and epigenome). To learn more about this longevity superstar, read my research-backed guide and review of the best spermidine supplements.

Adding Alpha Ketoglutarate To The Optimized Longevity Stack?

Alpha-ketoglutarate is one of those molecules that hasn’t gotten the attention it deserves. That seems to be changing, as major anti-aging institutes are now beginning to explore its potential.

Although it’s no panacea, it does meet the criteria of an ideal longevity product.

  1. There’s longevity research backing its effects in both cells, animals, and humans
  2. It improves multiple mechanisms of aging
  3. It appears quite safe as it’s naturally occurring within the body, its decline coincides closely with the normal aging process, and it has a multi-decade history of use

Supplementing alpha-ketoglutarate makes sense for athletes or those looking to fully optimize their mitochondria and energy reserves, or more advanced longevity biohackers.

Overall AKG would not be the only longevity ingredient I’d use. But it’s a good addition to a balanced longevity supplement stack.

For these reasons, I will give alpha-ketoglutarate a…

Bioharmony Score: 4.1/5

My favorite AKG vendors are Renue by Science for highly bioavailable and pure alpha-ketoglutarate, and then NOVOS Core for an all-in-one formulation.

What do you think? Do you use AKG? Let me know why or why not in the comments below!

Scientific References (15)
  1. healthspan (pubmed.ncbi.nlm.nih.gov)
  2. berberine (pubmed.ncbi.nlm.nih.gov)
  3. Inflammation (pubmed.ncbi.nlm.nih.gov)
  4. poorly designed trial (doi.org)
  5. C. Elegans by 47.3%! Follow-up (ncbi.nlm.nih.gov)
  6. impressive results (pubmed.ncbi.nlm.nih.gov)
  7. treatment with CaAKG resulted in a 9.6% to 12.8% median lifespan increase (cell.com)
  8. 2021 retrospective analysis of 42 people taking Rejuvant (pubmed.ncbi.nlm.nih.gov)
  9. 2023 protocol for the ABLE trial (pubmed.ncbi.nlm.nih.gov)
  10. 2021 study (pubmed.ncbi.nlm.nih.gov)
  11. more appropriate immune responses (pubmed.ncbi.nlm.nih.gov)
  12. neutrophils, phagocytosis, lymphocytes, and macrophages (ncbi.nlm.nih.gov)
  13. beneficial changes to the gut microbiome (ncbi.nlm.nih.gov)
  14. 2020 study (pubmed.ncbi.nlm.nih.gov)
  15. parameters of arterial health (pubmed.ncbi.nlm.nih.gov)

Post Tags: Longevity, Product Roundup, Supplements

5 reader comments

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  1. Howdy, Nick,
    Really an inspiring article on the benefits of taking AKG. I am 84, have been training with weights for 63 years. I’m talking lifting heavy, muscle-building workouts, leaving the gym bone-tired. A couple years ago I started reading about NMN and it’s supposed benefits (lots of healthy mice out there). At the same time I found a biological age test using the results of blood lab markers. I tested out to 20 years younger than my chrono age at the time, 82. This is with no NMN or NR, only resistance training (hard training, no “muscle-toning” workouts).
    My recent bio-age test, using minimal dose nmn, at 62 vs 84 chrono age.
    I have ordered CaAKG Lipo from Renue by Science. Will see how that goes.
    Thank you for the informative wordsmithing.

    0 Reply
    1. Peptides Longevity

      Hey Max,

      Wow! That’s quite impressive. Any secrets you can share that you’ve used to slow your biological aging? Which BioAge test did you take? I’m also curious how your AKG experiment went.

      0 Reply
  2. Really liked this article! I have been taking Nad+ for over a year now and have more energy, but need more! At age 68 I want to try AKG! I have wrote down a lot of what I just read. And would like to know where I can find age testing?

    0 Reply
    1. Peptides Longevity

      Hey Sharry. I totally get it, who doesn’t want more energy!? I’m hoping the price of AKG comes down some more. It’s still pretty pricey. Sure. Check out this article on BioAge testing. There are a few cool free options that have recently come out that I plan on updating that article with!

      Best,
      Nick

      0 Reply