Every intervention Outliyr has scored for heavy metal detox, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for heavy metal detox; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
16 of 90 evaluated interventions score 3.0+ out of 10 for heavy metal detox · 3 comparisons
Hamaya 2025 gives the most relevant evidence anchor. The existing rationale points to this narrower claim: this verified source measured toxic elements in blood, urine, and sweat and supports sweat as a…
Soh 2024 anchors the most relevant signal. Glycine fits heavy metal detox because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the endpoint. The score stays bounded…
The strongest human evidence is Nakano 2007, where 6 g/day of chlorella in pregnant women lowered breast-milk dioxin toxic-equivalents significantly (P=0.003) and raised milk IgA, consistent with the cell wall binding fat-soluble…
Semaglutide has no controlled evidence for clearing mercury, lead, cadmium, or other metals. Moiz 2024 supports fat loss, and fat loss can theoretically mobilize stored compounds, but mobilization is not detoxification. The…
No direct heavy-metal detoxification evidence was verified for EAA supplementation. This use case remains unsupported.
No direct evidence for heavy-metal clearance, chelation, or clinical detoxification. Use established detoxification protocols instead.
No direct heavy-metal detoxification evidence. Whole-body vibration is a mechanical training stimulus, not a chelation or elimination protocol.
No direct heavy-metal detox evidence exists. Metformin is not a chelator or detoxification protocol.
INSUFFICIENT_EVIDENCE for heavy-metal detoxification and no credible mechanism supports a detox claim.
Sweat does contain trace heavy metals, and sauna increases sweating, but the quantities excreted are small relative to renal clearance and there is no outcome evidence that sauna meaningfully lowers body burden…
Sweating can eliminate trace amounts of some compounds, but Zone 2 is not a heavy-metal detox protocol. Evidence-based detoxification requires exposure removal, testing, and medical treatment when indicated.
NAC binds some metals and supports glutathione-mediated clearance, but it is not a frontline chelator and dedicated human heavy-metal outcome trials are limited.
Often marketed for detox, but human chelation evidence is weak. The bigger issue is that uncertified spirulina can itself carry heavy metals, so the detox framing is the opposite of reassuring.
Fulvic acid has chelating properties, but shilajit itself can carry heavy metals when unpurified. Do not use it as a heavy-metal detox protocol.
Glutathione conjugates some toxins via Phase II enzymes and NAC is used in some metal-chelation contexts, but there is no GlyNAC clinical detox outcome.
Nothing matches those filters.
Monthly out-of-pocket cost at the most accessible legitimate channel, at the dose the score was given for. 2 of 16 are not priced yet; those cells are left blank rather than guessed.
| Intervention | Monthly cost | At dose | How you get it |
|---|---|---|---|
| Infrared Sauna | $36–$73 | 55-60 degrees C, 20-30 min | Over the counter |
| Glycine | $2–$3 | 3 g oral glycine | Over the counter |
| Chlorella | $10–$50 | 5-10 g/day | Over the counter |
| Semaglutide | $199–$349 | 0.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, 2.4 mg week 17 onward | Prescription |
| Essential Amino Acids | Not priced yet | ||
| Ca-AKG (Calcium Alpha-Ketoglutarate) | $15–$30 | 1 g/day generic Ca-AKG oral | Over the counter |
| Whole-Body Vibration | $50–$100 | 30 Hz, roughly 0.3g, 10-20 min standing | Over the counter |
| Metformin | $4–$30 | 500 mg with dinner for 1 week, then 500 mg twice daily for 1 week, then increase by 500 mg/week toward 1000 mg twice daily as tolerated | Prescription |
| Rapamycin | $15–$50 | 3 mg | Prescription |
| Traditional Sauna (Finnish Dry-Heat) | $50 | 15 to 20 minutes at 80 to 100 C | Over the counter |
| Zone 2 Cardio | Not priced yet | Over the counter | |
| NAC (N-Acetylcysteine) | $5–$15 | 600 to 1,200 mg/day | Over the counter |
| Spirulina | $10–$25 | 1 to 4.5 g/day | Over the counter |
| Shilajit | $25–$50 | 500 mg purified shilajit | Over the counter |
| GlyNAC (Glycine + N-Acetylcysteine) | $10–$30 | Glycine and NAC at ~100 mg/kg/day each | Over the counter |
| Glutathione (GSH) | $20–$45 | 1,000 mg/day | Over the counter |
Head-to-head reports and category rankings that name a winner on this use case.
NAC scores 8.0–8.5/10 and glutathione 6.0–6.5/10, and that gap is real. NAC is the cheaper upstream precursor with a six-decade clinical record, so start there. Glutathione earns its…
Spirulina scores 7.5–8.0/10 and chlorella 6.5–7.0/10, so spirulina is the better default for most people. It leads on blood pressure, blood sugar, inflammation and breathing. Chlorella leads on…
Traditional sauna scores 7.5–8.0/10 and infrared 7.0–7.5/10. Infrared actually scores higher on 20 of the 23 use cases both are rated on. Buy traditional anyway if hard outcomes…
Infrared Sauna, at 7.0–7.5 out of 10 for heavy metal detox. Hamaya 2025 gives the most relevant evidence anchor.
Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 5.5–6.0 out of 10 for heavy metal detox.
16 of the 90 interventions evaluated for heavy metal detox score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
