Every intervention Outliyr has scored for metabolic health, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for metabolic health; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
83 of 137 evaluated interventions score 3.0+ out of 10 for metabolic health · 25 comparisons
Moiz 2024 found about 12.1 percentage points greater weight loss than placebo in non-diabetic obesity trials. The metabolic case is broad: weight, glucose, blood pressure, inflammation, liver fat, kidney risk, and cardiovascular…
Tirzepatide also lowered waist circumference, systolic blood pressure, and fasting glucose across multiple phase-3 studies, indicating broad metabolic benefit Liu 2024. Systematic reviews confirm that tirzepatide produces greater weight loss than placebo…
Metformin reduces the incidence of type 2 diabetes by about 31% in high-risk adults, according to the Diabetes Prevention Program trial Knowler 2002. The UK Prospective Diabetes Study showed lower mortality and…
Jastreboff 2023 is the cleanest verified anchor for this report. The existing rationale points to this narrower claim: Triple agonism targets appetite, glucose control, weight, waist circumference, and cardiometabolic markers. this verified…
Vabishchevich 2026 supports direction more than certainty. The existing rationale points to this narrower claim: Structured exercise reliably improves glycemic control. this verified source analyzed 47 RCTs in type 2 diabetes and…
Tzang 2024 reports 25 RCTs and 1024 participants; lower SBP, DBP, fasting blood glucose, and triglycerides; no significant adverse-effect excess. Guan 2020 points in the same direction, but route, dose, baseline status,…
Berberine's strongest overall domain is dysregulated metabolism. Liu 2025 found improvements in triglycerides, fasting glucose, waist circumference, LDL-C, total cholesterol, BMI, and 2-hour glucose in metabolic syndrome, while Shi 2025 emphasized broad…
The evidence points to a plausible use case without proving a universal response. Dai W et al. 2024 is the best anchor here because it reports 19 randomized trials, 568 participants and…
Asbaghi 2022 anchors the most relevant signal. Magnesium fits metabolic health when low intake, stress load, mineral loss, or a form-specific target makes deficiency correction plausible. The score stays bounded because effects…
LeBaron 2020 reports 60 participants over 24 weeks; reported improved lipids, glucose, HbA1c, inflammatory markers, and redox markers. Jamialahmadi 2024 points in the same direction, but route, dose, baseline status, and outcome…
Spirulina improves several risk factors at once. Huang 2018 pooled 12 trials and reported fasting glucose down 5.01 mg/dL, triglycerides down 39.2 mg/dL, and diastolic pressure down 7.17 mmHg. The lipid and…
Metabolic-health score mainly reflects iron metabolism and low-hemoglobin states, not weight loss. Christofi 2024 found oral bovine lactoferrin favored hemoglobin versus conventional iron preparations in low-Hb populations, while El-Hawy 2021 found lactoferrin…
Babraj 2009 improved insulin sensitivity by 23 percent in young men after two weeks of all-out sprints, with insulin area-under-curve down 37 percent. Metcalfe 2012 raised insulin sensitivity 28 percent in men…
Tesamorelin reduces VAT and triglyceride-related risk markers, but glucose effects are mixed. Stanley 2012 found VAT responders had better lipid and glucose patterns than nonresponders, while FDA labeling still warns about glucose…
The glycemic, lipid, blood-pressure, and endothelial benefits cluster into a coherent cardiometabolic improvement rather than one isolated marker. The Crowe-White 2022 flavan-3-ol dietary guideline, built on 157 RCTs and 15 cohorts, concluded…
The Norwegian 4x4 approach relies on four minutes of near-maximal effort repeated four times, which aligns with high-intensity interval training (HIIT) mechanisms that boost cardiorespiratory fitness. Meta-analyses such as Poon 2024 and…
Soh 2024 anchors the most relevant signal. Glycine fits metabolic health because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the endpoint. The score stays bounded because…
Sustained moderate-intensity aerobic volume reliably improves glucose handling, lipids, and insulin sensitivity, and loaded walking delivers more of that stimulus per minute than walking alone. The supporting evidence is aerobic and resistance…
The evidence points to a plausible use case without proving a universal response. Eshaghhosseiny Z et al. 2024 is the best anchor here because it reports 10 clinical studies and 408 women…
Yoshino 2021 anchors the most relevant signal. NMN fits metabolic health when raising NAD+ is likely to matter for older, metabolically stressed, or performance-tracking users. The score stays bounded because NAD+ rises…
Ramsay 2007 supports the strongest part of the claim. The existing rationale points to this narrower claim: Mitochondrial ATP restoration supports the metabolic-health rationale, but direct insulin, glucose, or body-composition trials are…
ERR agonism by SLU-PP-332 shifts metabolism toward fatty-acid oxidation, improving energy expenditure and reducing hepatic fat in diet-induced obese and ob/ob mice. No human trials have measured glucose, lipid, weight, or liver…
Hamaya 2025 gives the most relevant evidence anchor. The existing rationale points to this narrower claim: Passive heating may improve some metabolic markers in specific populations, but this verified source found mostly…
Huang et al. 2025 gives the strongest anchor. Metabolic stress and muscle gain support metabolic health indirectly, with strongest relevance in deconditioned or older users who need low-load training. The score stays…
Sun 2025 found PBM improved waistline, weight, and BMI in obesity trials, though comparator heterogeneity limits confidence. This is an emerging use case rather than a core one. Red Light Therapy may…
Laurindo 2025 reports 8 randomized controlled studies; 312 randomized participants by included-study table; triglycerides and HDL-C improved; LDL-C and total cholesterol were not significant; certainty low to very low. Odeberg 2003 points…
Pooled diabetes data show modest but inconsistent glycemic improvements Fabregat-Fernandez 2024. Whole-Body Vibration has been examined in people with type 2 diabetes, where some trials report lower fasting glucose and better insulin…
The evidence points to a plausible use case without proving a universal response. Norouzzadeh et al. 2026 is the best anchor here because it reports 20 randomized trials, 1,208 participants and no…
Kumar 2023 reported a 64 percent fall in HOMA-IR plus reduced waist circumference, and the diabetes pilot Sekhar 2022 lowered insulin resistance and free fatty acids in 14 days. The metabolic story…
Baker et al. 2016 supports selective use. Senescent preadipocyte and adipose-inflammation mechanisms are plausible from preclinical D+Q work, but F+Q human metabolic endpoints are not proven. The score stays bounded because Senolytics…
The same Fallah 2018 meta-analysis reported a small fasting-glucose reduction of 4.23 mg/dL (P=0.041) alongside the lipid and blood-pressure shifts, suggesting a broad, gentle metabolic effect rather than a targeted one. The…
Lee 2015 showed MOTS-c improved insulin sensitivity and diet-induced obesity measures in mice, while Zhou 2024 found circulating MOTS-c differs by metabolic state in humans. No exogenous human trial exists. That makes…
Metabolic health improves broadly, not just on the scale. Across the Phase 3 program orforglipron significantly improved blood pressure, lipids, and waist circumference versus placebo, per Wharton 2025, and it lowered the…
Jones 2011 reports Corrected v0.x PMID; supports modest metabolic and sexual-function benefits in hypogonadal men with T2D or metabolic syndrome. The score stays conditional because TRT (Testosterone Replacement Therapy) still needs better…
Metabolic health gains are strong because CagriSema attacks weight and glucose together. In REDEFINE 2, people with type 2 diabetes saw large improvements and 74% reached an HbA1c at or below 6.5%,…
The supporting evidence overlaps with its glycemic and lipid data: Ashor 2017 reported modest HbA1c, fasting glucose, triglyceride, and total cholesterol improvements that scaled with baseline HbA1c, meaning the people who benefit…
Kars 2010 gives a small but direct human insulin-sensitivity signal. In obese adults, four weeks of TUDCA improved hepatic insulin sensitivity by 30 percent and skeletal-muscle insulin sensitivity by 28 percent Kars…
Exogenous ketones produce genuine acute metabolic effects. Myette-Cote 2018 found a ketone ester before an oral glucose load lowered glucose area-under-curve about 17 percent in 20 healthy adults. Stubbs 2018 showed a…
Ham 2024 randomized 75 adults to 350 mg magnesium per day from deep-seawater extract for 12 weeks and saw HOMA-IR fall (p=0.0102), fasting insulin fall (p=0.0238), and C-peptide fall (p=0.0220), while HbA1c…
Metabolic markers move broadly in the right direction. Across trials, triglycerides fell by roughly 27 to 37 percent, blood pressure dropped modestly, and serum uric acid declined substantially, per Ji 2023. The…
Weight reduction of this size reliably drags metabolic markers with it, and the sponsor reported improvements in waist circumference, blood pressure, lipids, glycemic markers and inflammatory markers alongside the primary endpoint (Eli…
Survodutide moves several metabolic levers at once. A 16-week head-to-head against semaglutide in type 2 diabetes showed comparable blood-sugar lowering plus more weight loss, per Bluher 2024. A post-hoc analysis found blood…
Metabolic health is one of the better-supported sulforaphane indications. Axelsson 2017 reported broccoli sprout extract improved fasting glucose and HbA1c in 97 type 2 diabetes patients, with effects concentrated in the obese…
Filip 2007 anchors the strongest signal. The existing rationale points to this narrower claim: No direct human metabolic-health RCT. AKG's central metabolism role is relevant but does not yet translate into glucose,…
Honda 2017 saw triglycerides and non-esterified fatty acids fall alongside ALT in fatty-liver patients, which is metabolically relevant. The GlyNAC trials from the Sekhar group reported improvements in insulin resistance and mitochondrial…
Cheuvront 2014 supports the strongest part of the claim. The existing rationale points to this narrower claim: Magnesium is a cofactor in hundreds of enzymatic reactions and hydration status supports metabolic regulation.…
Pittas 2019 anchors the most relevant signal. Vitamin D3 + K2 fits metabolic health when deficiency, bone risk, immune seasonality, or fat-soluble nutrient gaps are present. The score stays bounded because benefits…
The cardiovascular and mortality cohort data implies a broad metabolic benefit, since the men who saunaed most also had lower blood pressure and inflammation, and heat stress activates several pathways that overlap…
The signal is conditional. Guretzki 2024 found a small favorable metabolic-syndrome score effect, but individual lipids, insulin markers, and inflammatory biomarkers are not reliably moved. The likely pathway is muscle mass and…
Martens 2018 gives the most relevant evidence anchor. The existing rationale points to this narrower claim: NAD+ increase supports metabolic pathways, but this verified source found no insulin-sensitivity improvement in obese men…
Metabolic health scores moderately because amylin signaling improves several markers at once without forcing insulin secretion. Slowed gastric emptying and suppressed post-meal glucagon flatten glucose excursions, and the large weight loss in…
The metabolic story is mixed. A 2018 meta-analysis in Current Pharmaceutical Design found curcumin lowered fasting glucose, HOMA-IR, HbA1c, and triglycerides in metabolic syndrome, but showed no significant effect on LDL or…
Metabolic health looks promising on early data but rests on the same short window. In the VENTURE Phase 2 injectable trial, about 78 percent of prediabetic participants returned to normal glucose levels…
Modest fat loss preserves lean mass: Astrup 1992 Metabolism showed 4.5 kg additional fat loss with 2.8 kg less FFM loss vs placebo over 8 weeks in 14 obese women on E+C…
Vangipurapu 2019 found nine amino acids associated with decreased insulin secretion and elevated glucose over 7.4 years in Finnish men. Observational design prevents causality, but it justifies caution with chronic high-dose use.
The most defensible metabolic angle is in statin users and people with cardiovascular risk, where CoQ10's cardiac benefits and antioxidant action overlap. As a primary metabolic intervention it is weak; as part…
Zhang 2025 pooled 25 RCTs and found improvements in several glycolipid and blood-pressure markers, but no significant changes for several insulin, lipid, BMI, or waist endpoints.
Metabolic health is mostly mechanistic; the strongest human data is the cardiovascular and mortality cohort rather than glycemic endpoints. Treat as unproven for blood sugar specifically.
The Arabi 2023 umbrella review of cardiometabolic meta-analyses found quercetin lowers SBP and insulin but does not affect DBP, lipids, inflammation, anthropometrics, FBG, or HOMA-IR consistently. Tamtaji 2019 in metabolic syndrome populations…
One small human RCT lowered LDL-C and blood pressure but raised insulin resistance; the net metabolic picture is mixed and underpowered.
Metabolic-health evidence is inconsistent and population-dependent. Timmers 2011 showed calorie-restriction-like metabolic effects in obese humans, but Poulsen 2013 did not replicate meaningful benefit in obese men at high dose. Yoshino 2012 was…
Preserved v0.x score. Metabolic claims are mostly mechanism and anecdote. Diabetic-foot-ulcer work such as Lima E Silva Filho 2024 is wound-care evidence in diabetic patients, not proof of glucose-control or insulin-sensitivity benefit.…
BAM15 improved insulin sensitivity across tissues in hyperinsulinemic-euglycemic clamp studies in diet-induced obese mice, the most rigorous mechanistic metabolic readout available in animals (Alexopoulos et al. 2020), with an independent lab confirming…
Metabolic health improves mostly downstream of the weight loss rather than as a direct effect. In a respiration-chamber study the drug raised satiety, lifted nighttime energy expenditure about 4.6 percent, and increased…
Mixed evidence: PEARL biomarkers were mostly neutral, while chronic exposure and labeling keep glucose and lipid risk high.
Diabetic wound-care evidence is strong, and reviews suggest HBOT can affect glucose handling acutely. McIntosh 2021 documents intra-session glucose changes in patients with diabetes. This does not make hyperbaric oxygen therapy a…
Gai 2025 reviews anti-aging and metabolic endpoints, but the human metabolic evidence is not strong enough to make this a primary use case.
Indirect metabolic support through oxidative-stress reduction and homocysteine lowering, but no large metabolic-outcome RCT base. Not a glucose or weight intervention.
Metabolic benefit is mostly secondary to stress reduction. Salve 2019 supports modest movement in stress-linked cardiometabolic measures, but there is no dedicated high-confidence metabolic RCT base. Additive glucose lowering with diabetes medications…
Metabolic claims are indirect through testosterone support in older men. No strong human glucose, insulin, or body-composition trial supports Tongkat Ali as a metabolic-health tool.
The metabolic picture is weak where it matters. A 2018 crossover trial found oral butyrate improved insulin sensitivity only in lean subjects, with no effect in the metabolic syndrome group most likely…
Indirect via stress reduction, cortisol lowering, improved sleep.
Mineral content and fulvic-acid transport could support metabolic enzyme function, but human metabolic outcomes are not well-tested. Use this as indirect support, not a glucose or lipid intervention.
A preliminary Taiwan pilot suggested HbA1c movement in prediabetes, but the result is not enough for a strong metabolic-health claim. Weight, glucose, and insulin endpoints need larger peer-reviewed trials.
Downstream mitochondrial signal only. Hodzic Kuerec 2024 found no clear anthropometric or broad metabolic outcome effect in humans.
Composition reviews note antidiabetic activity in animal models, but no human metabolic trial exists; the effect is preclinical only.
Hanssen 2015 Nature Medicine showed 10 days of cold acclimation (14-15 degC, 2-6h/day) raised peripheral insulin sensitivity by approximately 43 percent in n=8 type 2 diabetes patients via skeletal-muscle GLUT4 translocation. Van…
Glucose tolerance normalized in obese mice, but mostly with related NNMT inhibitors such as JBSNF-000088 (Kannt 2018), not 5-Amino-1MQ itself.
No direct metabolic-health evidence. A TESTS 2025 subgroup signal by diabetes was exploratory and does not establish glucose, insulin, or weight benefits.
Mitochondrial function underlies metabolic health, but direct human metabolic endpoint data are limited and no diabetes or insulin-sensitivity RCT drives this report.
Metabolic health is humanin's second-strongest mechanistic story, but it sits at a moderate score because the cleanest data came from rodents and a more potent analogue. Continuous central humanin infusion improved whole-body…
Insulin-sensitivity and glucose improvement belong to the 332 dataset (Billon et al. 2024), not to a dedicated 915 trial. Mechanistically shared, but 915-specific metabolic evidence is thin.
Robinson 2024 (Robinson 2024, n=30, 12 weeks, 200 mg/day) raised circulating C15:0 but did not show a reliable full-cohort improvement in fasting glucose, insulin, HOMA-IR, body weight, BMI, or hs-CRP. The updated…
Nothing matches those filters.
Monthly out-of-pocket cost at the most accessible legitimate channel, at the dose the score was given for. 26 of 83 are not priced yet; those cells are left blank rather than guessed.
| Intervention | Monthly cost | At dose | How you get it |
|---|---|---|---|
| Semaglutide | $199–$349 | 0.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, 2.4 mg week 17 onward | Prescription |
| Tirzepatide | $299–$449 | 2.5 to 5 to 7.5 to 10 to 12.5 to 15 mg | Prescription |
| Metformin | $4–$30 | 500 mg with dinner for 1 week, then 500 mg twice daily for 1 week, then increase by 500 mg/week toward 1000 mg twice daily as tolerated | Prescription |
| Retatrutide | $130–$960 | 2 mg, then 4 mg, then 8 mg or 12 mg weekly depending on protocol and tolerability | Research use only |
| Zone 2 Cardio | Not priced yet | Over the counter | |
| Taurine | $3–$10 | 1-3 g, 30-60 minutes before sleep | Over the counter |
| Berberine | $15–$25 | 500 mg berberine HCl three times daily with meals | Over the counter |
| Time-Restricted Eating | Not priced yet | ||
| Magnesium | $10–$20 | 200-400 mg glycinate elemental | Over the counter |
| Molecular Hydrogen | Not priced yet | ||
| Spirulina | $10–$25 | 1 to 4.5 g/day | Over the counter |
| Lactoferrin | $25–$50 | 250-300 mg apolactoferrin | Over the counter |
| Sprinting (Sprint Interval Training) | Not priced yet | ||
| Tesamorelin | $250–$500 | 2 mg subcutaneous daily in the evening | Prescription |
| Polyphenols (Dietary) | Not priced yet | ||
| Norwegian 4×4 | Not priced yet | Over the counter | |
| Glycine | $2–$3 | 3 g oral glycine | Over the counter |
| Rucking (Weighted Walking) | Not priced yet | ||
| Ketogenic Diet | $100 | Standard keto, 40-50 g total carbohydrate/day | Over the counter |
| NMN (Nicotinamide Mononucleotide) | $40–$100 | 500 mg/day oral | Over the counter |
| Methylene Blue | $13–$40 | 0.5-5 mg oral | Over the counter |
| SLU-PP-332 | $30–$80 | 3-5 mg/day oral | Research use only |
| Infrared Sauna | $36–$73 | 55-60 degrees C, 20-30 min | Over the counter |
| Blood-Flow Restriction Training | Not priced yet | ||
| Red Light Therapy | $17–$43 | 10-20 min at 6-12 inches, full chest/face/back rotation | Over the counter |
| Astaxanthin | Not priced yet | ||
| Whole-Body Vibration | $50–$100 | 30 Hz, roughly 0.3g, 10-20 min standing | Over the counter |
| Omega-3 | $20–$40 | 1-2 g/day combined EPA+DHA | Over the counter |
| GlyNAC (Glycine + N-Acetylcysteine) | $10–$30 | Glycine and NAC at ~100 mg/kg/day each | Over the counter |
| Senolytics | Not priced yet | ||
| Chlorella | $10–$50 | 5-10 g/day | Over the counter |
| MOTS-c | $100–$200 | 5-10 mg SC | Research use only |
| Orforglipron (Foundayo) | $149–$299 | Start low, step up to 36 mg | Prescription |
| TRT (Testosterone Replacement Therapy) | $50–$300 | Clinician-selected formulation at the lowest dose likely to restore physiologic testosterone | Prescription |
| CagriSema (Cagrilintide + Semaglutide) | $80–$160 | 0.25 mg, then 0.5 mg, then 1.0 mg, then 1.7 mg, then 2.4 mg of each | Research use only |
| Vitamin C (Ascorbic Acid) | Not priced yet | ||
| TUDCA (Tauroursodeoxycholic Acid) | $12–$91 | 500-1,750 mg | Over the counter |
| Exogenous Ketones | $38–$300 | Ester 10 to 25 g BHB | Over the counter |
| Quinton Marine Plasma (Seawater Minerals) | Not priced yet | ||
| Mazdutide (IBI362) | $400–$420 | Step up over several weeks to 6 mg | Grey market |
| Eloralintide (LY3841136) | $432–$540 | 9 mg once weekly | Research use only |
| Survodutide (BI 456906) | $300–$500 | 2.4, 4.8, or 6.0 mg | Research use only |
| Sulforaphane | $25–$60 | Broccoli sprout extract delivering about 150 micromoles sulforaphane per day | Over the counter |
| Ca-AKG (Calcium Alpha-Ketoglutarate) | $15–$30 | 1 g/day generic Ca-AKG oral | Over the counter |
| Glutathione (GSH) | $20–$45 | 1,000 mg/day | Over the counter |
| Electrolytes | Not priced yet | ||
| Vitamin D3 + K2 | Not priced yet | ||
| Traditional Sauna (Finnish Dry-Heat) | $50 | 15 to 20 minutes at 80 to 100 C | Over the counter |
| Full-Body EMS | Not priced yet | ||
| NR (Nicotinamide Riboside) | $40–$50 | 250-300 mg/day oral | Over the counter |
| Cagrilintide (AM833) | $70–$170 | 0.25 mg, then 0.5 mg, 1.0 mg, 1.7 mg, then 2.4 mg | Research use only |
| Curcumin | $15–$40 | 500 mg curcuminoids | Over the counter |
| VK2735 (Viking Therapeutics) | $100–$400 | 2.5 to 5 mg | Research use only |
| Ephedrine | Not priced yet | ||
| Essential Amino Acids | Not priced yet | ||
| Coenzyme Q10 (CoQ10 / Ubiquinol) | $15–$40 | 100-200 mg/day | Over the counter |
| Saffron | Not priced yet | ||
| Ergothioneine | Not priced yet | ||
| Quercetin | $20–$50 | 200 mg/day | Over the counter |
| Fucoidan (Brown Seaweed Polysaccharide) | Not priced yet | ||
| Resveratrol | Not priced yet | ||
| Ozone Therapy | $520–$2,600 | 20-30 mcg/mL ozone, roughly 1,000-1,500 mcg total per session | In clinic |
| BAM15 | Not priced yet | ||
| Tesofensine | Not priced yet | ||
| Rapamycin | $15–$50 | 3 mg | Prescription |
| Hyperbaric Oxygen Therapy | $3,000–$6,000 | 2.0 ATA for 90 minutes with air breaks | In clinic |
| Spermidine | $40–$90 | 1-3 mg/day oral WGE | Over the counter |
| NAC (N-Acetylcysteine) | $5–$15 | 600 to 1,200 mg/day | Over the counter |
| Ashwagandha | $15–$30 | 300 mg KSM-66 with breakfast and 300 mg with dinner | Over the counter |
| Tongkat Ali | $20–$40 | 200 mg/day Physta standardized extract | Over the counter |
| Sodium Butyrate | Not priced yet | ||
| HRV Biofeedback | $5 | 20 min/session at individual RF (4.5 to 6.5 bpm) | Over the counter |
| Shilajit | $25–$50 | 500 mg purified shilajit | Over the counter |
| Lion’s Mane | $20–$40 | 3 g/day fruiting body extract | Over the counter |
| Urolithin A | $50–$100 | 500 mg/day | Over the counter |
| Pine Pollen | $20–$45 | 5 to 10 g powder per day | Over the counter |
| Cold Plunge | Not priced yet | Over the counter | |
| 5-Amino-1MQ | $95–$190 | 50 to 100 mg oral, once daily | Grey market |
| Thymosin Alpha-1 | $100–$400 | 1.6 mg subcutaneous | Prescription |
| SS-31 (Elamipretide) | $200–$500 | 5-10 mg/day subcutaneous | Grey market |
| Humanin | $100–$300 | 1 mg subcutaneous, twice weekly | Research use only |
| SLU-PP-915 | Not priced yet | ||
| C15 (Pentadecanoic Acid) | $40–$50 | 200 mg/day | Over the counter |
Head-to-head reports and category rankings that name a winner on this use case.
This page ranks by the live body-composition subrating, not the overall BioHarmony score, since body composition is the goal this category is built around. Tirzepatide leads both measures.…
This page ranks by the live endurance-cardio subrating, not by BioHarmony overall, and the order flips. SLU-PP-332 leads at 6.5–7.0/10 despite carrying the lowest overall score on the…
This page ranks by the live Body Composition subrating, fat loss and body composition, not the overall BioHarmony score. Tesamorelin leads at 7.5–8.0/10, and it also carries the…
This page ranks by hormonal fit, not overall BioHarmony score. TRT leads at 9.0–9.5/10. Phosphatidylserine sits fifth at 5.5–6.0/10 despite the second highest overall score here, 7.0–7.5/10. That…
Neither, if fat loss is the goal. Both score 2.0–2.5/10 on body composition, which is the row a vendor sells them on. AOD-9604 scores 3.0–3.5/10 overall and its…
No. Berberine scores 6.5–7.0/10 and semaglutide 6.0–6.5/10, and that gap misleads almost everyone who reads it. Berberine scores higher because it is cheap, oral and easy to stop,…
No. Omega-3 scores 6.5–7.0/10 and C15:0 3.0/10, and the evidence behind the two is not close. C15:0 has two small human trials. Omega-3 has outcome trials, prescription forms…
Tesamorelin, unless price is the only thing deciding. It is FDA-approved for visceral fat with Phase 3 trials behind it, while CJC-1295 is a gray-market research peptide whose…
CoQ10 scores 7.0–7.5/10 and methylene blue 6.0–6.5/10, yet methylene blue wins eleven of the seventeen shared use cases. The overall gap is risk, not effect. Methylene blue inhibits…
On weight loss they tie, and neither is a drug you can legitimately buy. Both score 7.5/10 for body composition, and both are investigational Lilly molecules with phase…
No, and the reason is mechanical. A drink raises blood ketones in an hour. It does not lower insulin, deplete glycogen or shift fuel use. The diet scores…
Start on sermorelin. Ipamorelin scores higher overall, yet sermorelin wins thirteen of the sixteen shared use cases and it is the one an anti-aging clinic actually prescribes. Ipamorelin…
Semaglutide, at 9.0–9.5 out of 10 for metabolic health. Moiz 2024 found about 12.1 percentage points greater weight loss than placebo in non-diabetic obesity trials.
Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 6.5–7.0 out of 10 for metabolic health.
C15 (Pentadecanoic Acid) scores 3.0–3.5 out of 10 for metabolic health but only 3.0–3.5 overall, landing in the caution tier once safety, side effects, cost and effort are counted.
83 of the 137 interventions evaluated for metabolic health score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
