Best Interventions for Addiction Recovery, Ranked by Evidence

Every intervention Outliyr has scored for addiction recovery, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for addiction recovery; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.

7 of 28 evaluated interventions score 3.0+ out of 10 for addiction recovery · 1 comparison

Ranked for Addiction Recovery

Category

  1. NAC (N-Acetylcysteine)

    6.5 /10 for addiction recovery 8.0/10 overall Strong recommend Amino Acid

    Addiction support scores 6.5/10 on a real but fragile glutamatergic signal. NAC modulates glutamate through the cystine-glutamate antiporter, which is plausibly anti-craving. Gray 2012 found cannabis-dependent adolescents on NAC had 2.4 times…

    Read the NAC (N-Acetylcysteine) report →

  2. Tirzepatide

    4.5 /10 for addiction recovery 6.1/10 overall Worth trying Metabolic & Incretin Peptide

    GLP 1 class interest in alcohol and reward pathways is real. Tirzepatide specific substance use RCT evidence is insufficient. Appetite and reward changes may reduce alcohol craving in anecdotes or observational signals.…

    Read the Tirzepatide report →

  3. Rapamycin

    4.0 /10 for addiction recovery 6.8/10 overall Worth trying Pharmaceutical & Drug

    INSUFFICIENT_EVIDENCE for substance-use disorder treatment or harm reduction.

    Read the Rapamycin report →

  4. Full-Spectrum Hemp (CBD)

    4.0 /10 for addiction recovery 6.5/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Early human signals for cannabis and tobacco craving reduction exist but are small and preliminary; not established.

    Read the Full-Spectrum Hemp (CBD) report →

  5. Kava (Piper methysticum)

    3.5 /10 for addiction recovery 6.0/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Sometimes used as a non-addictive alternative to alcohol or benzodiazepines for relaxation, and it lacks a withdrawal syndrome, but it has no validated role in addiction treatment and must never be combined…

    Read the Kava (Piper methysticum) report →

  6. Bromantane (Ladasten)

    3.0 /10 for addiction recovery 7.1/10 overall Strong recommend Other Pharmaceutical

    Often discussed in the context of the dopamine-biosynthesis mechanism for post-substance fatigue and apathy, but no published human addiction-recovery RCT for Bromantane exists. Treat as speculative.

    Read the Bromantane (Ladasten) report →

  7. DSIP (Delta Sleep-Inducing Peptide)

    3.0 /10 for addiction recovery 6.1/10 overall Worth trying Neuropeptide

    This is the most interesting human signal: two uncontrolled 1980s Swiss series reported rapid relief of alcohol and opioid withdrawal symptoms, per Dick 1983 and Dick 1984. The response rates are open-label…

    Read the DSIP (Delta Sleep-Inducing Peptide) report →

Comparisons that judge addiction recovery

Head-to-head reports and category rankings that name a winner on this use case.

Questions about addiction recovery

What scores highest for addiction recovery?

NAC (N-Acetylcysteine), at 6.5 out of 10 for addiction recovery. Addiction support scores 6.5/10 on a real but fragile glutamatergic signal.

What is the cheapest thing that works for addiction recovery?

Of the top-scoring options, NAC (N-Acetylcysteine) is the least expensive at about $5 a month, scoring 6.5 out of 10 for addiction recovery.

How many interventions has Outliyr scored for addiction recovery?

7 of the 28 interventions evaluated for addiction recovery score 3.0 out of 10 or better, which is the cut-off for appearing on this page.