Outliyr · Methodology · v1
How we measure biological age.
Outliyr Biological Age composes eight published scientific frameworks into one outcome metric. Every sub-age is transparent — inputs, weights, reference curves, and citations are listed in the open.
← Back to the calculatorCardiovascular
Formula version: 1.0.0
Inputs
vo2max— tier l3, weight 0.28resting_hr_avg— tier l3, weight 0.14hrv_avg— tier l3, weight 0.10stair_climb_q— tier l1, weight 0.12exercise_minutes_week— tier l1, weight 0.10smoker— tier l1, weight 0.10apob— tier l2, weight 0.08lpa— tier l2, weight 0.04bp_self_report— tier l1, weight 0.04
Citations
- Mandsager K et al. JAMA Netw Open 2018 — cardiorespiratory fitness and mortality
- Ridker PM. Circulation 2008 — apoB and cardiovascular risk
- ACC/AHA 2013 — pooled cohort risk equations
Metabolic
Formula version: 1.0.0
Inputs
fasting_glucose— tier l2, weight 0.22hba1c— tier l2, weight 0.22homa_ir— tier l2, weight 0.16fasting_insulin— tier l2, weight 0.10waist_cm— tier l1, weight 0.14fasting_tolerance_q— tier l1, weight 0.08post_meal_crash_q— tier l1, weight 0.08
Citations
- Matthews DR et al. Diabetologia 1985 — HOMA-IR
- IDF 2006 — Metabolic Syndrome consensus
Inflammatory
Formula version: 1.0.0
Inputs
hs_crp— tier l2, weight 0.32homocysteine— tier l2, weight 0.18fibrinogen— tier l2, weight 0.12ferritin— tier l2, weight 0.10joint_pain_q— tier l1, weight 0.10fatigue_q— tier l1, weight 0.08allergy_load_q— tier l1, weight 0.05alcohol_recovery_q— tier l1, weight 0.05
Citations
- Ridker PM. Circulation 2008 — hs-CRP and cardiovascular risk
- Refsum H et al. Clin Chem 2004 — homocysteine reference ranges
Immune
Formula version: 1.0.0
Inputs
illness_frequency_q— tier l1, weight 0.22recovery_time_q— tier l1, weight 0.18viral_reactivation_q— tier l1, weight 0.15autoimmune_q— tier l1, weight 0.12antibiotic_use_q— tier l1, weight 0.08vitamin_d— tier l2, weight 0.15neutrophil_lymphocyte_ratio— tier l2, weight 0.10
Citations
- Sayed N et al. Nat Aging 2021 — iAge inflammatory clock
- Shen-Orr SS et al. Cell Syst 2016 — IMM-AGE immune trajectory
Musculoskeletal
Formula version: 1.0.0
Inputs
chair_stand_30s— tier l1, weight 0.28pushups_one_set— tier l1, weight 0.18stair_pace_q— tier l1, weight 0.12groceries_in_one_trip_q— tier l1, weight 0.08grip_strength_kg— tier l1, weight 0.12recent_injury_q— tier l1, weight 0.07activity_load_avg— tier l3, weight 0.15
Citations
- Leong DP et al. Lancet 2015 — grip strength + mortality
- Bohannon RW. Percept Mot Skills 2006 — 30-sec chair stand reliability
Neuro-cognitive
Formula version: 1.0.0
Inputs
cognition_q— tier l1, weight 0.22brain_fog_q— tier l1, weight 0.18sleep_consistency_q— tier l1, weight 0.12word_recall_q— tier l1, weight 0.10homocysteine— tier l2, weight 0.12vitamin_d— tier l2, weight 0.08sleep_rem_avg— tier l3, weight 0.10sleep_deep_avg— tier l3, weight 0.08
Citations
- Buysse DJ et al. Psychiatry Res 1989 — PSQI
- Seshadri S et al. NEJM 2002 — homocysteine + cognitive decline
- Smith AD et al. Proc Natl Acad Sci USA 2010 — B-vitamins + brain atrophy
Hormonal / Stress
Formula version: 1.0.0
Inputs
pss10_total— tier l1, weight 0.22hpa_cluster_q— tier l1, weight 0.14energy_curve_q— tier l1, weight 0.08testosterone_total— tier l2, weight 0.12testosterone_free— tier l2, weight 0.08shbg— tier l2, weight 0.06dhea_s— tier l2, weight 0.06cortisol_am— tier l2, weight 0.06tsh— tier l2, weight 0.06hrv_stress_avg— tier l3, weight 0.12
Citations
- Cohen S et al. J Health Soc Behav 1983 — PSS-10
- Bhasin S et al. J Clin Endocrinol Metab 2010 — testosterone reference
Sleep / Circadian
Formula version: 1.0.0
Inputs
meq_total— tier l1, weight 0.18psqi_global— tier l1, weight 0.22sleep_duration_hours_q— tier l1, weight 0.12sleep_consistency_q— tier l1, weight 0.10nocturnal_waking_q— tier l1, weight 0.08sleep_total_avg— tier l3, weight 0.12sleep_efficiency_avg— tier l3, weight 0.10sleep_timing_std_hours— tier l3, weight 0.08
Citations
- Horne JA, Östberg O. Int J Chronobiology 1976 — MEQ
- Buysse DJ et al. Psychiatry Res 1989 — PSQI
