Every intervention Outliyr has scored for autophagy, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for autophagy; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
30 of 98 evaluated interventions score 3.0+ out of 10 for autophagy · 2 comparisons
Harrison 2009 anchors the most relevant signal. Rapamycin fits autophagy when mTORC1 modulation, autophagy, immune aging, or senescence biology is the actual target. The score stays bounded because human longevity endpoints remain…
The existing rationale points to this narrower claim: this verified source shows autophagy dependence in animal cardioprotection; this verified source reviews spermidine's autophagy-centered anti-aging case. That does not make Spermidine a targeted…
Oosterveld 2009 is the cleanest verified anchor for this report. The existing rationale points to this narrower claim: Heat shock and stress-response biology connect sauna to proteostasis and cellular cleanup, but direct…
Semaglutide creates calorie reduction, and calorie restriction is the most plausible bridge to autophagy rather than a Semaglutide-specific human marker trial. No verified source in this report directly proves autophagy improvement from…
Jamialahmadi 2024 reports 7 trials; reported reductions in total cholesterol, triglycerides, and LDL, with no significant HDL change. Ye 2026 points in the same direction, but route, dose, baseline status, and outcome…
Human data show modest AMPK activation and downstream mTOR inhibition, as noted in the UKPDS trial (UK Prospective Diabetes Study Group 1998). Metformin's classic mechanism involves stimulating the cellular energy sensor AMPK,…
Red Light Therapy has plausible hormetic signaling, but this report has no direct human autophagy-marker trial. Karu 2010 supports mitochondrial photobiology, which can intersect with cellular cleanup pathways. The claim remains indirect.…
Kumar 2023 anchors the most relevant signal. Glycine fits autophagy because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the endpoint. The score stays bounded because many…
The evidence points to a plausible use case without proving a universal response. Leung GKW et al. 2025 is the best anchor here because it reports 33 randomized trials and 2821 individuals…
Indirect via cellular renewal after senescent-cell clearance; no direct human F+Q autophagy-marker trial was verified in the audit. The score stays bounded because Senolytics evidence for autophagy can depend on age, disease…
Filip 2007 is the cleanest verified anchor for this report. The existing rationale points to this narrower claim: this verified source connected AKG to ATP synthase, TOR signaling, and autophagy in C.…
Kodama 2009 gives the most relevant evidence anchor. The existing rationale points to this narrower claim: Sustained moderate exercise can activate autophagy pathways in muscle and metabolic tissue. Human practical evidence is…
High-Dose Melatonin has autophagy relevance through mitochondrial stress signaling and preclinical literature, but direct human autophagy endpoints are not established. The automitocrine PNAS paper supports a mitochondria-centered signaling model (Suofu et al.…
Urolithin A is best described as a selective mitophagy support compound, not a broad autophagy inducer. Andreux 2019 supports the human biomarker signature. That makes Urolithin A more defensible when autophagy is…
The existing rationale points to this narrower claim: Autophagy remains mostly inferred from mitochondrial stress signaling and redox adaptation. No direct human autophagy-marker study was verified in the audit, so. That does…
No direct autophagy evidence. Any effect would be indirect through sleep, stress reduction, or healthier behavior after better self-regulation. Do not frame neurofeedback as an autophagy intervention. The preserved v0.x score reflects…
Exercise-induced AMPK and mTOR signaling can support autophagy. Norwegian 4x4 likely contributes through intensity, but human autophagy outcomes are not the protocol's core evidence base.
EAAs acutely activate mTORC1, which suppresses autophagy. This is useful for muscle protein synthesis but opposite the goal of strict fasting or autophagy-focused protocols.
Exercise-like autophagy via AMPK and mTOR signaling is plausible as a secondary pathway, but direct human autophagy-marker evidence for WBV is absent.
Heat shock proteins and the heat-stress response overlap mechanistically with proteostasis and autophagy pathways, but human autophagy endpoints for sauna are absent. This stays a mechanism-only rating.
AMPK activation can induce autophagy in preclinical models, but no direct human autophagy-marker trial validates berberine as an autophagy protocol.
Weight loss and lower energy intake may secondarily affect autophagy, but tirzepatide is not a direct autophagy intervention.
Member-specific (resveratrol, urolithin A) mechanistic data exists, but the dietary class as a whole has limited human autophagy endpoints.
Autophagy remains a 3 because Pickart 2018 discusses proteasome and cell-cleaning pathways, but no direct human autophagy-marker trial exists.
Mitophagy improvement was reported among the aging hallmarks, but human autophagy endpoints for GlyNAC are minimal.
The NAD+-sirtuin axis touches autophagy signaling, but no human NMN autophagy-marker trial validates the claim.
AMPK activation and mTOR modulation are canonical autophagy triggers, so the mechanism is plausible, but J-147 has no direct autophagy endpoint measured.
Mitophagy regulation may be influenced by cardiolipin stabilization, but no human autophagy-flux data were verified for elamipretide.
BAM15 enhanced skeletal-muscle mitophagy and mitochondrial quality control in aged mice (Dantas et al. 2022). Mechanistic, preclinical.
Exercise activates autophagy, and ERR signaling overlaps with PGC-1 alpha energy programs. But SLU-PP-332 has no verified direct autophagy-marker study in humans or animals from the provided audit.
Nothing matches those filters.
Monthly out-of-pocket cost at the most accessible legitimate channel, at the dose the score was given for. 10 of 30 are not priced yet; those cells are left blank rather than guessed.
| Intervention | Monthly cost | At dose | How you get it |
|---|---|---|---|
| Rapamycin | $15–$50 | 3 mg | Prescription |
| Spermidine | $40–$90 | 1-3 mg/day oral WGE | Over the counter |
| Infrared Sauna | $36–$73 | 55-60 degrees C, 20-30 min | Over the counter |
| Semaglutide | $199–$349 | 0.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, 2.4 mg week 17 onward | Prescription |
| Molecular Hydrogen | Not priced yet | ||
| Metformin | $4–$30 | 500 mg with dinner for 1 week, then 500 mg twice daily for 1 week, then increase by 500 mg/week toward 1000 mg twice daily as tolerated | Prescription |
| Red Light Therapy | $17–$43 | 10-20 min at 6-12 inches, full chest/face/back rotation | Over the counter |
| Glycine | $2–$3 | 3 g oral glycine | Over the counter |
| Ketogenic Diet | $100 | Standard keto, 40-50 g total carbohydrate/day | Over the counter |
| Senolytics | Not priced yet | ||
| Ca-AKG (Calcium Alpha-Ketoglutarate) | $15–$30 | 1 g/day generic Ca-AKG oral | Over the counter |
| Zone 2 Cardio | Not priced yet | Over the counter | |
| High-Dose Melatonin | Not priced yet | ||
| Urolithin A | $50–$100 | 500 mg/day | Over the counter |
| Methylene Blue | $13–$40 | 0.5-5 mg oral | Over the counter |
| Neurofeedback | Not priced yet | ||
| Norwegian 4×4 | Not priced yet | Over the counter | |
| Essential Amino Acids | Not priced yet | ||
| Whole-Body Vibration | $50–$100 | 30 Hz, roughly 0.3g, 10-20 min standing | Over the counter |
| Traditional Sauna (Finnish Dry-Heat) | $50 | 15 to 20 minutes at 80 to 100 C | Over the counter |
| Berberine | $15–$25 | 500 mg berberine HCl three times daily with meals | Over the counter |
| Tirzepatide | $299–$449 | 2.5 to 5 to 7.5 to 10 to 12.5 to 15 mg | Prescription |
| Polyphenols (Dietary) | Not priced yet | ||
| GHK-Cu | $30–$100 | 0.5-3% topical serum or cream | Over the counter |
| GlyNAC (Glycine + N-Acetylcysteine) | $10–$30 | Glycine and NAC at ~100 mg/kg/day each | Over the counter |
| NMN (Nicotinamide Mononucleotide) | $40–$100 | 500 mg/day oral | Over the counter |
| J-147 | Not priced yet | ||
| SS-31 (Elamipretide) | $200–$500 | 5-10 mg/day subcutaneous | Grey market |
| BAM15 | Not priced yet | ||
| SLU-PP-332 | $30–$80 | 3-5 mg/day oral | Research use only |
Head-to-head reports and category rankings that name a winner on this use case.
Spermidine scores 7.5–8.0/10 and urolithin A 6.5–7.0/10, and they clean up different messes. Spermidine drives broad autophagy: autophagy 8.0/10, cardiovascular 7.8/10, longevity 7.5/10. Urolithin A drives selective mitophagy…
Metformin scores 6.5–7.0/10 and rapamycin 6.5–7.0/10, which settles nothing. Rapamycin owns the aging-biology rows: longevity 8.0/10, autophagy 8.5/10, senescence 7.8/10, plus replicated mouse lifespan data. Metformin owns everyday…
Rapamycin, at 8.5–9.0 out of 10 for autophagy. Harrison 2009 anchors the most relevant signal.
Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 5.5–6.0 out of 10 for autophagy.
30 of the 98 interventions evaluated for autophagy score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
