Every intervention Outliyr has scored for endurance, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for endurance; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
58 of 109 evaluated interventions score 3.0+ out of 10 for endurance · 11 comparisons
On endurance-cardio, Electrolytes deserves 8.5/10 because Cheuvront 2014 makes the claim plausible but incomplete. The existing rationale points to this narrower claim: Strongest performance use case. this verified source supports dehydration-performance impairment,…
Read the Electrolytes report →The Norwegian 4x4 endurance-cardio use case scores 8.5/10, reflecting strong evidence that the 4-minute high-intensity intervals raise VO2max by about 7 % in healthy adults (Helgerud 2007). The Norwegian 4x4 protocol aligns…
Read the Norwegian 4×4 report →For endurance-cardio, Zone 2 Cardio lands at 8.5/10 because Kodama 2009 supports the strongest part of the claim. The existing rationale points to this narrower claim: Zone 2 directly trains the aerobic…
Read the Zone 2 Cardio report →Taurine is a 7.5/10 endurance and cardio fit because Waldron 2018 reports 10 peer-reviewed articles; isolated oral taurine showed a small positive endurance-performance signal. Tzang 2024 points in the same direction, but…
Read the Taurine report →Rucking earns 7.5 for endurance because it is a sustained moderate-intensity aerobic stimulus with a heavier metabolic demand than unloaded walking. Adding torso load raises energy expenditure predictably with load and speed…
Read the Rucking (Weighted Walking) report →Endurance-cardio earns 7.5/10 because SIT reliably improves cardiorespiratory fitness and endurance capacity in short order. Burgomaster 2005 roughly doubled cycle endurance time (26 to 51 minutes at about 80 percent VO2peak) after…
Read the Sprinting (Sprint Interval Training) report →Mechanistically, Molecular Hydrogen fits endurance and cardio at 7.0/10 because Zhou 2024 reports 27 publications, 597 participants; no significant broad improvement in endurance, lower-limb power, perceived exertion, or lactate area under the…
Read the Molecular Hydrogen report →Infrared Sauna's 7.0/10 endurance-cardio score starts with Kihara 2002, then gets narrowed by the evidence gap. The existing rationale points to this narrower claim: Heat acclimation can expand plasma volume, improve sweat…
Read the Infrared Sauna report →Endurance scores 6.8/10. Repeated post-exercise heat expands plasma volume, a known performance lever for endurance athletes, and Scoon 2007 measured a 32 percent increase in run time to exhaustion after roughly three…
Read the Traditional Sauna (Finnish Dry-Heat) report →Magnesium endurance cardio earns 6.6/10 because de Baaij 2015 anchors the most relevant signal. Magnesium fits endurance cardio when low intake, stress load, mineral loss, or a form-specific target makes deficiency correction…
Read the Magnesium report →Endurance-cardio scores 6.5/10 because Leal-Junior 2015 found phototherapy improved exercise performance and recovery outcomes across RCTs. The signal is most relevant when Red Light Therapy is used before or after training on…
Read the Red Light Therapy report →The practical endurance and cardio read on Astaxanthin is 6.5/10 because Liu 2024 reports 11 RCTs; 346 healthy participants; significant improvements reported across fatigue, cognition, and exercise-efficiency endpoints overall; endpoint details are…
Read the Astaxanthin report →The primary data for SLU-PP-332 in the endurance-cardio use case come from a mouse study that reported roughly a 20 % rise in treadmill running time and enhanced muscle oxidative capacity Billon…
Read the SLU-PP-332 report →The main limitation behind Ketogenic Diet's 6.0/10 endurance cardio score is that the evidence points to a plausible use case without proving a universal response. Amini MR et al. 2024 is the…
Read the Ketogenic Diet report →Endurance and cardio earns 5.8/10. Cocoa and other flavanols acutely improve flow-mediated dilation and nitric-oxide availability, the same pathway dietary nitrate uses, and some trials show small improvements in exercise vascular responses.…
Read the Polyphenols (Dietary) report →The practical endurance-cardio read on Ca-AKG (Calcium Alpha-Ketoglutarate) is 5.8/10 because Filip 2007 anchors the strongest signal. The existing rationale points to this narrower claim: Plausible ATP-cycle rationale and performance note, but…
Read the Ca-AKG (Calcium Alpha-Ketoglutarate) report →The strongest endurance cardio argument for Blood-Flow Restriction Training is worth 5.5/10, with Wang et al. 2023 as the anchor. Zhang 2025 supports endurance and aerobic-capacity gains, especially when BFR augments walking,…
Read the Blood-Flow Restriction Training report →Evidence for Essential Amino Acids in endurance and cardio lands at 5.5/10 because Thavonlun 2026 reports 66 randomized participants; no significant ASMI improvement; both groups improved gait speed without between-group difference. Jackman…
Read the Essential Amino Acids report →Vagus Nerve Stimulation earns 5.5/10 in endurance cardio because Duff et al. 2024 supports the main pathway. Sun 2025 reported favorable heart-failure endpoints, but direct healthy-athlete performance trials are not strong enough…
Read the Vagus Nerve Stimulation report →For readers prioritizing endurance cardio, PEMF (Pulsed Electromagnetic Field Therapy) scores 5.5/10 today. Circulation and nitric-oxide effects may support endurance physiology, but direct endurance-performance RCT evidence is limited. Pakhan 2024 reviewed PEMF…
Read the PEMF (Pulsed Electromagnetic Field Therapy) report →The practical endurance-cardio read on Methylene Blue is 5.5/10 because Ramsay 2007 anchors the strongest signal. The existing rationale points to this narrower claim: Endurance-cardio evidence is indirect. In critical illness, this…
Read the Methylene Blue report →The evidence gives Tirzepatide a 5.5/10 rating for the endurance-cardio use case, based on the weight-loss and heart-failure with preserved ejection fraction trial that reported improved aerobic function after significant fat loss…
Read the Tirzepatide report →Endurance-cardio scores 5.5/10 because Semaglutide can improve relative fitness when body mass falls, while absolute performance can drop if training fuel and lean mass fall too. Wilding 2021 supports large weight loss,…
Read the Semaglutide report →Cordyceps owns this use case, and the honest finding is modest. Chen 2010 gave healthy older adults Cs-4 for 12 weeks and saw a 10.5 percent rise in metabolic threshold and 8.5…
Read the Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga) report →Glycine endurance cardio earns 5.2/10 because Soh 2024 anchors the most relevant signal. Glycine fits endurance cardio because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the…
Read the Glycine report →For endurance cardio, TB-500 (Thymosin Beta-4 Fragment) lands at 5.2/10 because context matters. Endurance-cardio support is indirect. Tbeta4 cardiac and vascular preclinical studies such as Bock-Marquette 2004 and Smart 2007 do not…
Read the TB-500 (Thymosin Beta-4 Fragment) report →Whole-Body Vibration scores 5.0/10 for the endurance-cardio use case, reflecting modest evidence from randomized trials Peng 2024. Whole-Body Vibration can raise muscle temperature and create a sensation of activation, but the data…
Read the Whole-Body Vibration report →Endurance scores 5.0/10 for the same reason as energy. Kalafati 2010 found a meaningful rise in time to fatigue and fat oxidation in trained men, and Lu 2006 extended time to exhaustion…
Read the Spirulina report →The endurance cardio score is 5.0/10, and MOTS-c needs careful framing. MOTS-c earns an endurance-cardio signal from exercise-mimetic AMPK activation and mouse physical-capacity findings in Reynolds 2021, but no human VO2max, time-trial,…
Read the MOTS-c report →Paraxanthine scores 5.0/10 for endurance cardio because exercise studies are suggestive but too small to rate as a core endurance tool. The strongest support comes from Yoo C. et al. 2021, but…
Read the Paraxanthine (Enfinity) report →Ephedrine gets 5.0/10 for endurance cardio; the evidence supports a narrow read. Bell 1998 showed caffeine + ephedrine improved time-to-exhaustion by 39% (17.5 vs 12.6 min) in 8 trained males at 5…
Read the Ephedrine report →Middle-aged athlete data support oxygen utilization and mitochondrial endpoints. Hadanny 2022 reports mitochondrial respiration and performance gains. Amoako 2021 finds mixed timing-dependent recovery effects in a sports meta-analysis. Broad endurance improvements remain…
Read the Hyperbaric Oxygen Therapy report →Endurance evidence is limited. Testosterone-to-cortisol changes might help overreached athletes, but no robust VO2max, lactate-threshold, or endurance-performance RCT supports a higher score.
Read the Tongkat Ali report →Endurance earns 4.5/10. Exercise capacity improved in heart-failure patients in Lei 2017, which is a real clinical gain in a compromised population. In healthy athletes, however, controlled trials of CoQ10 for performance…
Read the Coenzyme Q10 (CoQ10 / Ubiquinol) report →Endurance-cardio evidence is moderate. Choudhary 2015 supports cardiorespiratory endurance in athletic adults, and Bonilla 2021 supports physical-performance benefits. This remains a training-support supplement, not an endurance drug.
Read the Ashwagandha report →Zempo-Miyaki 2017 saw VO2max rise from 42.1 to 44.9 mL/kg/min on a chlorella multicomponent supplement in young men, but the trial was small (n=34) and used a multi-ingredient product, so the endurance…
Read the Chlorella report →Liu 2022 found muscle-endurance and biomarker benefits in older adults, while walking-distance and ATP-production endpoints were not clearly significant vs placebo.
Read the Urolithin A report →Modafinil endurance relevance is mostly vigilance preservation under sleep deprivation. Caldwell 2000 and Caldwell 2004 support operational performance during sleep loss, but not direct VO2 max or ordinary rested endurance gains. Score…
Read the Modafinil report →Two very small crossover studies (N of 8 to 9) suggested faster rehydration and recovery with deep-ocean mineral water, but the samples are too small to lean on and never used Quinton.
Read the Quinton Marine Plasma (Seawater Minerals) report →TRT can improve hemoglobin and training tolerance in deficient men, but it is not a clean endurance intervention and raises athlete compliance issues. WADA 2026 prohibits exogenous testosterone without a therapeutic-use exemption.
Read the TRT (Testosterone Replacement Therapy) report →C60 endurance scoring remains 4.5 because the strongest signal is anecdotal and preclinical. Longecity and Anthony Kunkel-style reports describe stamina and race recovery shifts, while single-lab animal work reports reduced skeletal muscle…
Read the C60 (Buckminsterfullerene) report →RAPA-EX-01 weakens exercise-adaptation claims, while a small 2025 older-men cardiovascular pilot is too early for strong scoring.
Read the Rapamycin report →Improved recovery between efforts in intermittent sports.
Read the HRV Biofeedback report →Endurance scores 4.0/10. The clearest exercise-related finding is the Hemila 2013 result that regular vitamin C halved cold incidence in marathon runners, skiers, and soldiers under heavy exertion, which protects training continuity.…
Read the Vitamin C (Ascorbic Acid) report →Sessions create acute cardiovascular and ventilatory demand, but WB-EMS does not reliably improve VO2max. It should not replace Zone 2, intervals, or sport-specific conditioning for cardiorespiratory development.
Read the Full-Body EMS report →Exercise capacity improved in the older-adult pilot, plausibly through better mitochondrial fuel oxidation, but there is no dedicated endurance trial in trained populations. Scores 4.0/10.
Read the GlyNAC (Glycine + N-Acetylcysteine) report →Liao 2021 found improved aerobic-capacity markers in amateur runners taking 300-1200 mg/day with training, but VO2max itself did not improve significantly.
Read the NMN (Nicotinamide Mononucleotide) report →Exogenous ketones do NOT reliably improve endurance performance. The definitive meta-analysis, Brooks 2022, pooled 8 studies and 80 participants and found no significant effect (Hedges g=0.14, 95% CI -0.20 to 0.47, p=0.42).…
Read the Exogenous Ketones report →Konopka 2019 found attenuated VO2max and mitochondrial-respiration adaptations during aerobic training in older adults. The score remains low for active endurance users.
Read the Metformin report →A meta-analysis of 11 exercise studies in 254 adults by Kressler 2011 found a statistically significant but trivial 2 percent average endurance benefit, with high heterogeneity. Davis 2010 reported improved VO2max and…
Read the Quercetin report →Cardiovascular aging rationale exists via Kiechl 2018, but there are no exercise-performance RCTs.
Read the Spermidine report →Mitochondrial and high-altitude framing suggests possible endurance relevance, but no direct endurance-performance RCT justifies a higher score.
Read the Shilajit report →Animal data on physical work capacity (Morozov 1998) is consistent but human RCT data is absent. WADA ban makes this category academic for any tested athlete.
Read the Bromantane (Ladasten) report →McDermott 2024 improved 6-minute walk in PAD, but broader endurance evidence remains limited and disease-specific.
Read the NR (Nicotinamide Riboside) report →A few performance studies exist, including high-dose protocols, but practical-dose evidence is inconsistent. Davison 2021 frames the sport value more around illness, gut damage, and training continuity than direct endurance gains.
Read the Colostrum report →Endurance outcomes are inconsistent. Any VO2max or exercise-efficiency signal is small and not a primary reason to use omega-3.
Read the Omega-3 report →Lower body mass can improve relative endurance in people with obesity, but caloric deficit, nausea, and lean-mass loss can impair training. No retatrutide exercise-performance trial supports direct endurance benefit.
Read the Retatrutide report →Running capacity improved when paired with exercise in aged mice (Dimet-Wiley 2024); unproven in humans.
Read the 5-Amino-1MQ report →Nothing matches those filters.
Head-to-head reports and category rankings that name a winner on this use case.
Tirzepatide, at 6.1, then semaglutide at 6.0, then orforglipron at 5.8 if you want the pill. All three are approved, all three have real trial evidence, and all…
Ca-AKG, urolithin A and MOTS-c tie at 6.5, and only the first two are things you can legally buy. SS-31 follows at 6.0. The bottom three score low…
Neither, if fat loss is the goal. Both score 2.0 on body composition, which is the row a vendor sells them on. AOD-9604 scores 4.6 overall and its…
Bromantane, for anything you plan to repeat. It scores 7.1 against phenylpiracetam's 5.5 and wins every shared use case that is not a floor tie: energy 6.2 to…
CoQ10 scores 7.1 and methylene blue 6.1, yet methylene blue wins eleven of the seventeen shared use cases. The overall gap is risk, not effect. Methylene blue inhibits…
No, and the reason is mechanical. A drink raises blood ketones in an hour. It does not lower insulin, deplete glycogen or shift fuel use. The diet scores…
Lion's Mane scores 7.2 and the reishi, cordyceps and chaga blend category scores 5.8. If cognition is the goal, buy the one species: lion's mane takes cognition-focus 7.0…
Spermidine scores 7.6 and urolithin A 6.5, and they clean up different messes. Spermidine drives broad autophagy: autophagy 8.0, cardiovascular 7.8, longevity 7.5. Urolithin A drives selective mitophagy…
Taurine scores 8.1 and glycine 7.9, close enough that the overall numbers pick nothing. Taurine wins cardiovascular and metabolic endpoints outright. Glycine wins antioxidant, skin and connective tissue.…
CoQ10 scores 7.1 and urolithin A scores 6.5, so CoQ10 wins on the numbers and costs two to six times less. It takes cardiovascular, energy, antioxidant and both…
Norwegian 4x4 scores 8.5 and Zone 2 cardio 8.3, so the 0.2 gap decides nothing. Your weekly hours decide it. Pick 4x4 when you have under two hours…
Electrolytes, at 8.5 out of 10 for endurance. On endurance-cardio, Electrolytes deserves 8.5/10 because Cheuvront 2014 makes the claim plausible but incomplete.
Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 5.2 out of 10 for endurance.
58 of the 109 interventions evaluated for endurance score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
