Every intervention Outliyr has scored for endurance, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for endurance; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
59 of 122 evaluated interventions score 3.0+ out of 10 for endurance · 11 comparisons
Cheuvront 2014 makes the claim plausible but incomplete. The existing rationale points to this narrower claim: Strongest performance use case. this verified source supports dehydration-performance impairment, this verified source supports sodium loading…
The Norwegian 4x4 protocol aligns with broad umbrella reviews that show high-intensity interval training improves cardiorespiratory fitness more than inactivity and at least matches moderate-intensity continuous training (Poon 2024). Evidence from post-stroke…
Kodama 2009 supports the strongest part of the claim. The existing rationale points to this narrower claim: Zone 2 directly trains the aerobic base used by endurance athletes: fat oxidation, lactate clearance,…
Waldron 2018 reports 10 peer-reviewed articles; isolated oral taurine showed a small positive endurance-performance signal. Tzang 2024 points in the same direction, but route, dose, baseline status, and outcome tracking decide whether…
It is a sustained moderate-intensity aerobic stimulus with a heavier metabolic demand than unloaded walking. Adding torso load raises energy expenditure predictably with load and speed (Pandolf 1977), so each mile delivers…
SIT reliably improves cardiorespiratory fitness and endurance capacity in short order. Burgomaster 2005 roughly doubled cycle endurance time (26 to 51 minutes at about 80 percent VO2peak) after only six sessions over…
Zhou 2024 reports 27 publications, 597 participants; no significant broad improvement in endurance, lower-limb power, perceived exertion, or lactate area under the curve. The score stays conditional because Molecular Hydrogen still needs…
The existing rationale points to this narrower claim: Heat acclimation can expand plasma volume, improve sweat response, and reduce thermal strain, which supports endurance in hot environments. this verified source. That does…
Repeated post-exercise heat expands plasma volume, a known performance lever for endurance athletes, and Scoon 2007 measured a 32 percent increase in run time to exhaustion after roughly three weeks of post-training…
De Baaij 2015 anchors the most relevant signal. Magnesium fits endurance cardio when low intake, stress load, mineral loss, or a form-specific target makes deficiency correction plausible. The score stays bounded because…
Leal-Junior 2015 found phototherapy improved exercise performance and recovery outcomes across RCTs. The signal is most relevant when Red Light Therapy is used before or after training on working muscles. It is…
Liu 2024 reports 11 RCTs; 346 healthy participants; significant improvements reported across fatigue, cognition, and exercise-efficiency endpoints overall; endpoint details are limited. American points in the same direction, but route, dose, baseline…
The primary data for SLU-PP-332 in the endurance-cardio use case come from a mouse study that reported roughly a 20 % rise in treadmill running time and enhanced muscle oxidative capacity Billon…
Amini MR et al. 2024 is the best anchor here because it reports 23 randomized trials and 1664 participants and no significant blood-pressure improvement, with near-null pooled SBP and DBP effects. Iatan…
Cocoa and other flavanols acutely improve flow-mediated dilation and nitric-oxide availability, the same pathway dietary nitrate uses, and some trials show small improvements in exercise vascular responses. The evidence is thinner and…
Filip 2007 anchors the strongest signal. The existing rationale points to this narrower claim: Plausible ATP-cycle rationale and performance note, but no controlled endurance trial in trained athletes. That does not make…
Zhang 2025 supports endurance and aerobic-capacity gains, especially when BFR augments walking, cycling, or sport conditioning. The score stays bounded because Blood-Flow Restriction Training evidence for endurance cardio can depend on load…
Thavonlun 2026 reports 66 randomized participants; no significant ASMI improvement; both groups improved gait speed without between-group difference. Jackman 2017 points in the same direction, but route, dose, baseline status, and outcome…
Circulation and nitric-oxide effects may support endurance physiology, but direct endurance-performance RCT evidence is limited. Pakhan 2024 reviewed PEMF and aerobic exercise for hypertension and found a positive direction, but called for…
Duff et al. 2024 supports the main pathway. Sun 2025 reported favorable heart-failure endpoints, but direct healthy-athlete performance trials are not strong enough for a higher score. The score stays bounded because…
Ramsay 2007 anchors the strongest signal. The existing rationale points to this narrower claim: Endurance-cardio evidence is indirect. In critical illness, this verified source found shorter ventilation and stay outcomes in distributive…
Tirzepatide produces reliable medium-term weight reduction, which can lower the metabolic cost of running and cycling, potentially enhancing VO2 max in overweight adults. However, the same trial noted that lean-mass loss may…
Semaglutide can improve relative fitness when body mass falls, while absolute performance can drop if training fuel and lean mass fall too. Wilding 2021 supports large weight loss, which can make hills,…
Cordyceps owns this use case, and the honest finding is modest. Chen 2010 gave healthy older adults Cs-4 for 12 weeks and saw a 10.5 percent rise in metabolic threshold and 8.5…
Soh 2024 anchors the most relevant signal. Glycine fits endurance cardio because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the endpoint. The score stays bounded because…
Endurance-cardio support is indirect. Tbeta4 cardiac and vascular preclinical studies such as Bock-Marquette 2004 and Smart 2007 do not translate into proven endurance performance in humans. That makes TB-500 (Thymosin Beta-4 Fragment)…
Kalafati 2010 found a meaningful rise in time to fatigue and fat oxidation in trained men, and Lu 2006 extended time to exhaustion while lowering oxidative-stress markers. Both are small double-blind trials,…
Whole-Body Vibration can raise muscle temperature and create a sensation of activation, but the data do not show meaningful improvements in aerobic capacity or VO2max. The primary outcomes in the cited trials…
MOTS-c earns an endurance-cardio signal from exercise-mimetic AMPK activation and mouse physical-capacity findings in Reynolds 2021, but no human VO2max, time-trial, or endurance RCT exists. That makes MOTS-c more defensible when endurance…
Exercise studies are suggestive but too small to rate as a core endurance tool. The strongest support comes from Yoo C. et al. 2021, but the practical rating stays bounded by study…
Bell 1998 showed caffeine + ephedrine improved time-to-exhaustion by 39% (17.5 vs 12.6 min) in 8 trained males at 5 mg/kg + 1 mg/kg. Bell 2000 lower-dose follow-up preserved approximately 60-66% improvement.…
Middle-aged athlete data support oxygen utilization and mitochondrial endpoints. Hadanny 2022 reports mitochondrial respiration and performance gains. Amoako 2021 finds mixed timing-dependent recovery effects in a sports meta-analysis. Broad endurance improvements remain…
Endurance evidence is limited. Testosterone-to-cortisol changes might help overreached athletes, but no robust VO2max, lactate-threshold, or endurance-performance RCT supports a higher score.
Exercise capacity improved in heart-failure patients in Lei 2017, which is a real clinical gain in a compromised population. In healthy athletes, however, controlled trials of CoQ10 for performance are mixed and…
Endurance-cardio evidence is moderate. Choudhary 2015 supports cardiorespiratory endurance in athletic adults, and Bonilla 2021 supports physical-performance benefits. This remains a training-support supplement, not an endurance drug.
Zempo-Miyaki 2017 saw VO2max rise from 42.1 to 44.9 mL/kg/min on a chlorella multicomponent supplement in young men, but the trial was small (n=34) and used a multi-ingredient product, so the endurance…
Liu 2022 found muscle-endurance and biomarker benefits in older adults, while walking-distance and ATP-production endpoints were not clearly significant vs placebo.
Modafinil endurance relevance is mostly vigilance preservation under sleep deprivation. Caldwell 2000 and Caldwell 2004 support operational performance during sleep loss, but not direct VO2 max or ordinary rested endurance gains. WADA…
Two very small crossover studies (N of 8 to 9) suggested faster rehydration and recovery with deep-ocean mineral water, but the samples are too small to lean on and never used Quinton.
TRT can improve hemoglobin and training tolerance in deficient men, but it is not a clean endurance intervention and raises athlete compliance issues. WADA 2026 prohibits exogenous testosterone without a therapeutic-use exemption.
RAPA-EX-01 weakens exercise-adaptation claims, while a small 2025 older-men cardiovascular pilot is too early for strong scoring.
Improved recovery between efforts in intermittent sports.
The clearest exercise-related finding is the Hemila 2013 result that regular vitamin C halved cold incidence in marathon runners, skiers, and soldiers under heavy exertion, which protects training continuity. Direct performance enhancement…
Sessions create acute cardiovascular and ventilatory demand, but WB-EMS does not reliably improve VO2max. It should not replace Zone 2, intervals, or sport-specific conditioning for cardiorespiratory development.
Exercise capacity improved in the older-adult pilot, plausibly through better mitochondrial fuel oxidation, but there is no dedicated endurance trial in trained populations.
Liao 2021 found improved aerobic-capacity markers in amateur runners taking 300-1200 mg/day with training, but VO2max itself did not improve significantly.
Exogenous ketones do NOT reliably improve endurance performance. The definitive meta-analysis, Brooks 2022, pooled 8 studies and 80 participants and found no significant effect (Hedges g=0.14, 95% CI -0.20 to 0.47, p=0.42).…
Konopka 2019 found attenuated VO2max and mitochondrial-respiration adaptations during aerobic training in older adults. The score remains low for active endurance users.
A meta-analysis of 11 exercise studies in 254 adults by Kressler 2011 found a statistically significant but trivial 2 percent average endurance benefit, with high heterogeneity. Davis 2010 reported improved VO2max and…
Cardiovascular aging rationale exists via Kiechl 2018, but there are no exercise-performance RCTs.
Mitochondrial and high-altitude framing suggests possible endurance relevance, but no direct endurance-performance RCT justifies a higher score.
Animal data on physical work capacity (Morozov 1998) is consistent but human RCT data is absent. WADA ban makes this category academic for any tested athlete.
McDermott 2024 improved 6-minute walk in PAD, but broader endurance evidence remains limited and disease-specific.
The strongest 915-specific signal, and still mouse-only. Orally dosed 915 matched injected SLU-PP-332 on aerobic exercise capacity when exposure-adjusted, and induced muscle Ddit4 and mitochondrial genes that synergized with training (Billon et…
A few performance studies exist, including high-dose protocols, but practical-dose evidence is inconsistent. Davison 2021 frames the sport value more around illness, gut damage, and training continuity than direct endurance gains.
Endurance outcomes are inconsistent. Any VO2max or exercise-efficiency signal is small and not a primary reason to use omega-3.
Lower body mass can improve relative endurance in people with obesity, but caloric deficit, nausea, and lean-mass loss can impair training. No retatrutide exercise-performance trial supports direct endurance benefit.
Running capacity improved when paired with exercise in aged mice (Dimet-Wiley 2024); unproven in humans.
The strongest signal is anecdotal and preclinical. Longecity and Anthony Kunkel-style reports describe stamina and race recovery shifts, while single-lab animal work reports reduced skeletal muscle fatigue. There is no placebo-controlled human…
Nothing matches those filters.
Monthly out-of-pocket cost at the most accessible legitimate channel, at the dose the score was given for. 18 of 59 are not priced yet; those cells are left blank rather than guessed.
| Intervention | Monthly cost | At dose | How you get it |
|---|---|---|---|
| Electrolytes | Not priced yet | ||
| Norwegian 4×4 | Not priced yet | Over the counter | |
| Zone 2 Cardio | Not priced yet | Over the counter | |
| Taurine | $3–$10 | 1-3 g, 30-60 minutes before sleep | Over the counter |
| Rucking (Weighted Walking) | Not priced yet | ||
| Sprinting (Sprint Interval Training) | Not priced yet | ||
| Molecular Hydrogen | Not priced yet | ||
| Infrared Sauna | $36–$73 | 55-60 degrees C, 20-30 min | Over the counter |
| Traditional Sauna (Finnish Dry-Heat) | $50 | 15 to 20 minutes at 80 to 100 C | Over the counter |
| Magnesium | $10–$20 | 200-400 mg glycinate elemental | Over the counter |
| Red Light Therapy | $17–$43 | 10-20 min at 6-12 inches, full chest/face/back rotation | Over the counter |
| Astaxanthin | Not priced yet | ||
| SLU-PP-332 | $30–$80 | 3-5 mg/day oral | Research use only |
| Ketogenic Diet | $100 | Standard keto, 40-50 g total carbohydrate/day | Over the counter |
| Polyphenols (Dietary) | Not priced yet | ||
| Ca-AKG (Calcium Alpha-Ketoglutarate) | $15–$30 | 1 g/day generic Ca-AKG oral | Over the counter |
| Blood-Flow Restriction Training | Not priced yet | ||
| Essential Amino Acids | Not priced yet | ||
| PEMF (Pulsed Electromagnetic Field Therapy) | $3–$117 | 20-30 min mat session | Over the counter |
| Vagus Nerve Stimulation | $4–$8 | 10-20 min auricular tVNS at comfortable perceptible intensity | Over the counter |
| Methylene Blue | $13–$40 | 0.5-5 mg oral | Over the counter |
| Tirzepatide | $299–$449 | 2.5 to 5 to 7.5 to 10 to 12.5 to 15 mg | Prescription |
| Semaglutide | $199–$349 | 0.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, 2.4 mg week 17 onward | Prescription |
| Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga) | $15–$40 | 1.5 to 1.8 g/day standardized extract | Over the counter |
| Glycine | $2–$3 | 3 g oral glycine | Over the counter |
| TB-500 (Thymosin Beta-4 Fragment) | Not priced yet | ||
| Spirulina | $10–$25 | 1 to 4.5 g/day | Over the counter |
| Whole-Body Vibration | $50–$100 | 30 Hz, roughly 0.3g, 10-20 min standing | Over the counter |
| MOTS-c | $100–$200 | 5-10 mg SC | Research use only |
| Paraxanthine (Enfinity) | Not priced yet | ||
| Ephedrine | Not priced yet | ||
| Hyperbaric Oxygen Therapy | $3,000–$6,000 | 2.0 ATA for 90 minutes with air breaks | In clinic |
| Tongkat Ali | $20–$40 | 200 mg/day Physta standardized extract | Over the counter |
| Coenzyme Q10 (CoQ10 / Ubiquinol) | $15–$40 | 100-200 mg/day | Over the counter |
| Ashwagandha | $15–$30 | 300 mg KSM-66 with breakfast and 300 mg with dinner | Over the counter |
| Chlorella | $10–$50 | 5-10 g/day | Over the counter |
| Urolithin A | $50–$100 | 500 mg/day | Over the counter |
| Modafinil | $18–$35 | 200 mg oral tablet | Prescription |
| Quinton Marine Plasma (Seawater Minerals) | Not priced yet | ||
| TRT (Testosterone Replacement Therapy) | $50–$300 | Clinician-selected formulation at the lowest dose likely to restore physiologic testosterone | Prescription |
| Rapamycin | $15–$50 | 3 mg | Prescription |
| HRV Biofeedback | $5 | 20 min/session at individual RF (4.5 to 6.5 bpm) | Over the counter |
| Vitamin C (Ascorbic Acid) | Not priced yet | ||
| Full-Body EMS | Not priced yet | ||
| GlyNAC (Glycine + N-Acetylcysteine) | $10–$30 | Glycine and NAC at ~100 mg/kg/day each | Over the counter |
| NMN (Nicotinamide Mononucleotide) | $40–$100 | 500 mg/day oral | Over the counter |
| Exogenous Ketones | $38–$300 | Ester 10 to 25 g BHB | Over the counter |
| Metformin | $4–$30 | 500 mg with dinner for 1 week, then 500 mg twice daily for 1 week, then increase by 500 mg/week toward 1000 mg twice daily as tolerated | Prescription |
| Quercetin | $20–$50 | 200 mg/day | Over the counter |
| Spermidine | $40–$90 | 1-3 mg/day oral WGE | Over the counter |
| Shilajit | $25–$50 | 500 mg purified shilajit | Over the counter |
| Bromantane (Ladasten) | $12–$30 | 30 mg | Grey market |
| NR (Nicotinamide Riboside) | $40–$50 | 250-300 mg/day oral | Over the counter |
| SLU-PP-915 | Not priced yet | ||
| Colostrum | $60–$80 | 20 g/day powder, split AM/PM if tolerated | Over the counter |
| Omega-3 | $20–$40 | 1-2 g/day combined EPA+DHA | Over the counter |
| Retatrutide | $130–$960 | 2 mg, then 4 mg, then 8 mg or 12 mg weekly depending on protocol and tolerability | Research use only |
| 5-Amino-1MQ | $95–$190 | 50 to 100 mg oral, once daily | Grey market |
| C60 (Buckminsterfullerene) | Not priced yet |
Head-to-head reports and category rankings that name a winner on this use case.
This page ranks by the live body-composition subrating, not the overall BioHarmony score, since body composition is the goal this category is built around. Tirzepatide leads both measures.…
This page ranks by the live endurance-cardio subrating, not by BioHarmony overall, and the order flips. SLU-PP-332 leads at 6.5–7.0/10 despite carrying the lowest overall score on the…
Neither, if fat loss is the goal. Both score 2.0–2.5/10 on body composition, which is the row a vendor sells them on. AOD-9604 scores 3.0–3.5/10 overall and its…
Bromantane, for anything you plan to repeat. It scores 7.0–7.5/10 against phenylpiracetam's 5.5–6.0/10 and wins every shared use case that is not a floor tie: energy 6.2/10 to…
CoQ10 scores 7.0–7.5/10 and methylene blue 6.0–6.5/10, yet methylene blue wins eleven of the seventeen shared use cases. The overall gap is risk, not effect. Methylene blue inhibits…
No, and the reason is mechanical. A drink raises blood ketones in an hour. It does not lower insulin, deplete glycogen or shift fuel use. The diet scores…
Lion's Mane scores 7.0–7.5/10 and the reishi, cordyceps and chaga blend category scores 5.0–5.5/10. If cognition is the goal, buy the one species: lion's mane takes cognition-focus 7.0/10…
Spermidine scores 7.5–8.0/10 and urolithin A 6.5–7.0/10, and they clean up different messes. Spermidine drives broad autophagy: autophagy 8.0/10, cardiovascular 7.8/10, longevity 7.5/10. Urolithin A drives selective mitophagy…
Taurine scores 8.0–8.5/10 and glycine 7.5–8.0/10, close enough that the overall numbers pick nothing. Taurine wins cardiovascular and metabolic endpoints outright. Glycine wins antioxidant, skin and connective tissue.…
CoQ10 scores 7.0–7.5/10 and urolithin A scores 6.5–7.0/10, so CoQ10 wins on the numbers and costs two to six times less. It takes cardiovascular, energy, antioxidant and both…
Norwegian 4x4 scores 8.0–8.5/10 and Zone 2 cardio 8.0–8.5/10, so the 0.2 gap decides nothing. Your weekly hours decide it. Pick 4x4 when you have under two hours…
Electrolytes, at 8.5–9.0 out of 10 for endurance. Cheuvront 2014 makes the claim plausible but incomplete.
Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 5.0–5.5 out of 10 for endurance.
C60 (Buckminsterfullerene) scores 3.0–3.5 out of 10 for endurance but only 3.0–3.5 overall, landing in the caution tier once safety, side effects, cost and effort are counted.
59 of the 122 interventions evaluated for endurance score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
