Every intervention Outliyr has scored for inflammation, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for inflammation; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
92 of 142 evaluated interventions score 3.0+ out of 10 for inflammation · 16 comparisons
LeBaron 2020 reports 60 participants over 24 weeks; reported improved lipids, glucose, HbA1c, inflammatory markers, and redox markers. Sim 2020 points in the same direction, but route, dose, baseline status, and outcome…
The evidence points to a plausible use case without proving a universal response. Farag N et al. 2025 is the best anchor here because it reports seven randomized trials and 438 patients…
Hamblin 2017 details NF-kB modulation, mitochondrial signaling, and local inflammatory effects. The practical strength is localized inflammation: joints, tendons, skin, oral tissue, or exercise-damaged muscle. Systemic inflammation claims are harder to prove…
Malcangi 2026 reports 15 human RCTs; consistent reductions in several inflammatory and oxidative-stress markers plus increases in antioxidant capacity; better trials still needed. Ma 2022 points in the same direction, but route,…
Oosterveld 2009 supports the strongest part of the claim. The existing rationale points to this narrower claim: Heat exposure can influence inflammatory signaling through stress-response proteins, vascular effects, and autonomic shifts. this…
Semaglutide reduces inflammatory load mainly through weight loss and metabolic repair, with Lincoff 2023 giving hard-outcome relevance in high-risk obesity. This is not a direct anti-inflammatory like an NSAID or a targeted…
Ahmadian 2017 reports Heart-failure RCT; 500 mg three times daily for 2 weeks affected atherogenic and inflammatory markers. The score stays conditional because Taurine still needs better outcome data for this exact…
Kumar 2023 anchors the most relevant signal. Glycine fits anti inflammatory because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the endpoint. The score stays bounded because…
Vasireddi 2025 anchors the most relevant signal. BPC-157 fits anti inflammatory when the target is tissue repair, vascular recruitment, or inflammation control, but the case still rests mostly on preclinical models. The…
The v0 anti-inflammatory score is retained because copper-tripeptide biology intersects with IL-6, TGF-beta, tissue remodeling, and skin irritation pathways. Hostynek 2011 supports transdermal delivery as an anti-inflammatory route, while Li 2016 found…
Lactoferrin consistently affects inflammatory signaling, but clinical translation varies. Berthon 2026 found lower virus-stimulated IL-6 at 600 mg/day and Pollio 2024 found lower ferritin and inflammatory markers in a small observational hyperferritinemia…
Wu 2025 anchors the most relevant signal. Thymosin Alpha-1 fits anti inflammatory when immune modulation is medically relevant and monitored rather than casually guessed. The score stays bounded because the best evidence…
SASP suppression is central to the mechanism; Hickson 2019 supports marker movement for D+Q but is preliminary and corrected-conclusion-sensitive. The score stays bounded because Senolytics evidence for anti inflammatory can depend on…
Sagai 2011 reports Personally verified mechanism review; Nrf2 activation, NF-kB modulation, lipid oxidation products, dose-toxicity tension. The score stays conditional because Ozone Therapy still needs better outcome data for this exact use…
NF-kB modulation and cytokine shifts provide the anti-inflammatory rationale. Rohde 2015 found lower postoperative interleukin-1beta, pain, inflammation, and narcotic use after TRAM flap reconstruction, but this remains a surgical-context signal rather than…
The cholinergic anti-inflammatory pathway has direct human support from implanted VNS work, including Koopman 2016 in rheumatoid arthritis; transcutaneous translation is promising but not settled. The score stays bounded because Vagus Nerve…
Harrison 2009 anchors the most relevant signal. Rapamycin fits anti inflammatory when mTORC1 modulation, autophagy, immune aging, or senescence biology is the actual target. The score stays bounded because human longevity endpoints…
Demidenko 2021 gives the most relevant evidence anchor. The existing rationale points to this narrower claim: IL-10 dependence is supported by this verified source in mice, where IL-10 loss removed lifespan and…
The existing rationale points to this narrower claim: Moderate aerobic training lowers chronic inflammatory burden in many populations through fat loss, improved insulin sensitivity, vascular function, and myokine signaling. Excessive. That does…
Laukkanen 2018 found sauna frequency inversely associated with C-reactive protein in 2,084 men, with mean CRP falling from 2.41 at 1 session per week to 1.65 at 4 to 7 sessions. Repeated…
Multiple polyphenol classes lower circulating inflammatory markers including CRP in controlled trials, and the mechanism (modulation of NF-kB signaling and oxidative load) is well characterized. The Crowe-White 2022 guideline review reflects this…
Anti-inflammatory support is stronger than many other secondary claims. Sosne 2007 reviews corneal anti-inflammatory mechanisms, and Wang 2024 shows pro-resolving pathway activation in keratitis models. Systemic human inflammation outcomes are still unproven.…
Sung 2025 reports cell and 3D skin model study, not a clinical trial. Dalmasso 2008 points in the same direction, but route, dose, baseline status, and outcome tracking decide whether KPV (Lys-Pro-Val)…
Curcumin lowers C-reactive protein consistently across trials. A 2023 umbrella meta-analysis pooling over 5,800 participants (Naghsh and colleagues) reported a CRP effect size around 0.74, most pronounced under 10 weeks and at…
Tirzepatide's anti-inflammatory effect appears secondary to weight loss and metabolic improvement rather than a direct cytokine-blocking action. Trials such as the SURMOUNT-1 extension reported decreases in hs-CRP that correlated with the magnitude…
High-Dose Melatonin has a moderate anti-inflammatory score because sepsis and COVID trials used higher doses and reported clinical or inflammatory improvements. A phase I sepsis dose-escalation study tested 20 to 100 mg…
The inflammation evidence is real but smaller than the cardiometabolic case. Shahraki Jazinaki 2025 pooled 7 trials in 283 subjects and found C-reactive protein falling 0.55 mg/L, a significant result. Mohiti 2021,…
Earthing's anti-inflammatory claim rests on this single trial and a narrative review that links grounding to reduced cytokine activity (Oschman 2015). Both sources are low-tier: the trial lacks a sham control and…
Kaviani et al. 2022 is the best anchor here because it reports umbrella meta-analysis and CRP, IL-6, and TNF-alpha reductions support modest anti-inflammatory effect. Liu et al. 2025 adds context, but the…
In advanced cancer patients, Takahashi 2018 reported significant reductions in IL-1 beta, IL-6, and TNF-alpha within two weeks of fucoidan supplementation, and the asthma RCT by Yeh 2022 showed lower IL-8 alongside…
Hyperbaric Oxygen Therapy is proposed to modulate inflammation in wounds, fibromyalgia, and neuro-recovery, but human endpoint certainty varies across conditions. Systematic reviews show modest benefits for Crohn's disease and hard-to-heal wounds, yet…
Metformin activates AMPK, a cellular energy sensor that can dampen NF-kappaB signaling, a pathway that drives cytokine production. In metabolically unhealthy individuals, improved insulin sensitivity from Metformin often coincides with lower circulating…
The evidence points to a plausible use case without proving a universal response. World Anti-Doping Agency 2026 is the best anchor here because it reports dietary timing itself is not yet a…
Vagal anti-inflammatory pathway; reduced TNF-alpha in one small RCT. Mechanism plausible, direct human RCTs limited. The score stays bounded because HRV Biofeedback evidence for anti inflammatory can depend on breathing cadence, adherence,…
While chronic exercise lowers systemic inflammation over months, the near-maximal intervals used in Norwegian 4x4 act as an acute stress that can transiently raise inflammatory markers. Benefits appear strongest when sessions are…
Hagiyama 2024 reports 12 RCTs; 622 patients; low-certainty improvement in patient-reported outcomes and very-low-certainty strength signal after lower-limb surgeries. Wittholz 2024 points in the same direction, but route, dose, baseline status, and…
Pandit 2016 anchors the most relevant signal. Shilajit fits anti inflammatory when purified resin is matched to hormones, sperm parameters, strength fatigue, bone markers, or energy tracking. The score stays bounded because…
Whole-Body Vibration produces an acute inflammatory response that resembles moderate exercise, which may be useful for short-term immune activation. Over repeated sessions, some trials report modest reductions in circulating cytokines such as…
Fatima et al. 2024 is the best anchor here because it reports five randomized trials, 254 participants and reduced HAM-A anxiety scores and improved several sleep parameters, with high heterogeneity. Arumugam et…
Kumar 2023 reported IL-6 down 78 percent and TNF-alpha down 54 percent at 16 weeks, with the anti-inflammatory cytokine IL-10 nearly doubling, a consistent and sizable shift across multiple markers. The mechanism…
The mechanism is sound: ergothioneine dampens reactive oxygen species and has reduced inflammatory markers in cell and animal models, and the cardiovascular protection seen in Smith 2020 is partly attributed to anti-inflammatory…
The evidence points to a plausible use case without proving a universal response. McKenzie AL et al. 2024 is the best anchor here because it reports 122 five-year completers and diabetes remission…
Denk 2025 and the 2024 systematic review support anti-inflammatory and immune-metabolic signals, though disease-level inflammation outcomes are unproven. That makes Urolithin A more defensible when anti inflammatory is a real bottleneck and…
Rothenberg 2025 supports direction more than certainty. The existing rationale points to this narrower claim: Anti-inflammatory claims are plausible through nitric-oxide pathway modulation, but direct consumer trials are limited. this verified source…
It lowers some oxidative-stress and inflammatory markers in trials, consistent with its reducing-agent chemistry, and the blood pressure and glycemic improvements in Juraschek 2012 and Ashor 2017 plausibly run partly through reduced…
Schwarz 2022 supports the strongest part of the claim. The existing rationale points to this narrower claim: this verified source measured biomarkers in older adults, but anti-inflammatory benefit remains secondary rather than…
Menon 2025 anchors the most relevant signal. Lion's Mane fits anti inflammatory when the goal is gentle mushroom-based support for cognition, mood, nerve biology, or gut-immune signaling over weeks. The score stays…
Several trials report modest reductions in inflammatory markers like CRP and IL-6 with CoQ10, consistent with its membrane-antioxidant action, and this plausibly contributes to its cardiovascular effects. But few trials isolate inflammation…
Anti-inflammatory effect is biologically real but clinical translation is mixed. Selected cytokine and gastritis marker shifts are documented in small trials, and NRF2 activation suppresses NF-kB signaling preclinically. The negatives are notable:…
Meta-analysis of human trials by Ou 2020 found no overall effect on CRP, IL-6, or TNF-alpha, with subgroup signals only. Disease-specific signals exist, including reductions in oxidative stress and inflammatory markers in…
Glutathione status modulates redox-sensitive inflammatory signaling, and the liposomal pilot reported a 35 percent drop in the oxidative marker 8-isoprostane. But no glutathione trial has shown consistent reductions in core inflammatory markers…
Butyrate's anti-inflammatory action is well grounded in mechanism, since it inhibits HDACs and promotes regulatory T cells in the gut. In the active ulcerative colitis trial (n=36), oral sodium butyrate lowered ESR…
Fourman et al. 2020 supports a plausible benefit. Stanley 2011 reported inflammatory-marker changes that tracked with visceral-fat reduction, and Fourman 2020 showed downregulation of hepatic inflammatory gene sets in HIV-associated NAFLD. The…
Anti-inflammatory effects are plausible as a polyphenol-class pattern, but resveratrol-specific clinical superiority is not established. Tomé-Carneiro 2012 reported favorable inflammatory and fibrinolytic markers in CVD-risk patients, while Akbari 2020 found mixed lipid…
Jastreboff 2023 anchors the strongest signal. The existing rationale points to this narrower claim: Inflammation may improve secondarily through fat loss, liver-fat reduction, and metabolic improvement. Direct inflammatory-disease trials are not available;…
Anti-inflammatory action is well-supported preclinically and biologically, but human direct-inflammation endpoints are thin. Tβ4 dampens NF-κB-driven cytokine output, and its cleavage product Ac-SDKP is independently anti-inflammatory and antifibrotic across heart, kidney, and…
Anti-inflammatory effects are mechanistically supported and appear in cardiometabolic and retinal models, but clinical inflammatory endpoints are weaker than mood and sleep outcomes.
Vahedi-Mazdabadi 2023 supports inflammatory-biomarker reductions in randomized trials involving berberine or barberry. Translation to clinical inflammatory disease outcomes remains narrower than the mechanism suggests.
Anti-inflammatory action is the core mechanism, well supported preclinically but thin on direct human inflammation endpoints. Activating the innate repair receptor dampens innate immune-cell activation and reprograms a tissue-damaging environment into a…
Zhai 2017 showed anti-inflammatory and anti-MRSA effects in mice, including reduced pro-inflammatory cytokine signaling. This supports a preclinical inflammation signal but not a human anti-inflammatory indication.
Choi 2007 showed Pinus densiflora pollen extract at 100 to 200 mg/kg inhibited formalin pain and carrageenan edema in mice comparably to indomethacin, and Lee 2009 found it suppressed NO, TNF-alpha, IL-1,…
TRT may modestly improve inflammatory markers in hypogonadal men with metabolic syndrome, but it is not a primary anti-inflammatory therapy. Lifestyle, adiposity reduction, periodontal care, sleep, and omega-3 status usually matter more.
Consistent preclinical anti-inflammatory signal across reishi, cordyceps, and chaga polysaccharides and triterpenes, plus an O. sinensis dialysis meta-analysis showing lower CRP, but human outcome certainty is low.
ERR activation modulated inflammatory gene expression in preclinical kidney models. Wang et al. 2023 supports a mouse anti-inflammatory signal, but there is no human CRP, cytokine, symptom, or inflammatory-disease endpoint.
Strong preclinical anti-inflammatory mechanism but limited direct human outcome data; rated cautiously below neutral pending controlled human inflammatory-marker trials.
Some inflammatory-marker shifts appear in exercise studies, but BFR-specific anti-inflammatory evidence is limited and secondary.
Glutathione repletion lowers oxidative and inflammatory load mechanistically, but dedicated anti-inflammatory clinical endpoints are inconsistent across trials.
Lactoferrin, PRPs, and gut-barrier effects support an anti-inflammatory rationale, but human outcomes are indirect. Hajihashemi 2024 describes mixed gastrointestinal disease findings rather than broad anti-inflammatory clinical proof.
Thymulin suppresses inflammatory signaling across several animal and cell models. It selectively reduced LPS-induced IL-1beta and blocked NF-kappaB nuclear movement in an alveolar model, per Haddad 2009, and it modulated NF-kappaB and…
Reductions in cardiovascular and liver markers are consistent with lower inflammatory load, but few chlorella trials measure inflammation directly as the primary endpoint, keeping this an inferred rather than demonstrated benefit.
Chronic training lowers systemic inflammation over months, but the all-out efforts of SIT are an acute oxidative and inflammatory stressor; net benefit depends on adequate recovery between sessions.
Reduces mitochondrial ROS-driven inflammatory signaling in the mechanism literature, but human inflammatory biomarker evidence is limited and not a primary clinical endpoint strength.
BHB inhibits the NLRP3 inflammasome in preclinical models, a real and interesting mechanism, but human anti-inflammatory outcome data for exogenous ketones is sparse. Mechanism outpaces clinical proof.
The anti-inflammatory effect is mechanistically well-described, especially for joints, where pentosan lowers inflammatory mediators and helps normalize joint fluid, per Ghosh 1999. That maps onto the clinical improvements seen in the small…
Cortisol reduction is adjacent to inflammation control, but no direct CRP, IL-6, or clinical inflammatory-disease RCT supports a higher score.
Anti-inflammatory activity is VIP's best-characterized and most defensible claim, and it is the use most people are chasing. The cleanest human demonstration is a 4-week open-label inhaled-VIP study in 20 sarcoidosis patients…
Muscle contraction releases myokines that can support lower inflammatory tone, but WB-EMS trials do not consistently improve inflammatory biomarkers. The score reflects indirect exercise physiology rather than direct anti-inflammatory evidence.
Indirect. Regular moderate aerobic exercise lowers chronic inflammatory markers, but excessive loaded volume can raise them; the net depends on dose and recovery.
Any benefit is indirect via joint and tissue support rather than systemic inflammatory-marker suppression. HA is not a reliable way to move CRP or IL-6, and trials do not support a strong…
NAD+ biology intersects with inflammatory pathways, but human NMN anti-inflammatory outcomes are not established. Keep this in the indirect-mechanism bucket.
Elhassan 2019, Norheim 2024, and Ahmadi 2025 support inflammatory-marker interest, but clinical outcome translation remains early.
J-147 suppressed neuroinflammatory markers in aging and sepsis models (Qiu et al. 2023). Animal-only.
Nasal irrigation reduces local inflammatory symptoms, but there is no systemic anti-inflammatory marker trial of the oral product.
NF-kB suppression and IKK inhibition are well-characterized in cell and rodent inflammation models. Salehi 2019 summarizes broad preclinical anti-inflammatory data. No human RCT has measured inflammatory markers as a primary endpoint for…
UC-II has an immune-tolerance mechanism relevant to synovial inflammation, and Lugo 2013 supports joint-function benefit in healthy adults. Systemic inflammation endpoints remain weak.
TNF-alpha and IL-6 reductions in mouse LPS-depression model (Tallerova 2011) and IL-6, IL-17, IL-4 reductions in C57BL/6 anxious-depression model (Tallerova 2011 EKF). No human inflammation RCT.
Post-ischemic immune and inflammatory gene-expression effects appear in Medvedeva et al. 2014, but Semax is not a primary anti-inflammatory intervention for systemic conditions.
Inflammation-gene modulation exists in mouse spleen models, including Kolomin 2014, but Selank is not a proven anti-inflammatory therapy.
Antioxidant and oxidative-stress findings imply possible downstream anti-inflammatory effects, but direct inflammatory-marker evidence is thin. No verified human Epitalon trial measured CRP, IL-6, TNF-alpha, pain inflammation, or disease-specific inflammatory outcomes.
hsCRP fell across trials, consistent with weight loss; not an anti-inflammatory drug in its own right.
BAM15 lowered inflammatory lipid species in obese mice and reduced renal neutrophil infiltration in sepsis (Tsuji et al. 2023). Animal only.
Robinson 2024 (Robinson 2024) did not show a reliable full-cohort hs-CRP benefit over 12 weeks. Phang / Chooi TANGO did not establish systemic inflammatory-marker reduction as the main C15-specific outcome. Claims around…
Nothing matches those filters.
Monthly out-of-pocket cost at the most accessible legitimate channel, at the dose the score was given for. 31 of 92 are not priced yet; those cells are left blank rather than guessed.
| Intervention | Monthly cost | At dose | How you get it |
|---|---|---|---|
| Molecular Hydrogen | Not priced yet | ||
| Celebrex (Celecoxib) | Not priced yet | ||
| Red Light Therapy | $17–$43 | 10-20 min at 6-12 inches, full chest/face/back rotation | Over the counter |
| Astaxanthin | Not priced yet | ||
| Infrared Sauna | $36–$73 | 55-60 degrees C, 20-30 min | Over the counter |
| Semaglutide | $199–$349 | 0.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, 2.4 mg week 17 onward | Prescription |
| Taurine | $3–$10 | 1-3 g, 30-60 minutes before sleep | Over the counter |
| Glycine | $2–$3 | 3 g oral glycine | Over the counter |
| BPC-157 | $40–$80 | 250 to 500 mcg SC 1 to 2x/day near injury site | Grey market |
| GHK-Cu | $30–$100 | 0.5-3% topical serum or cream | Over the counter |
| Lactoferrin | $25–$50 | 250-300 mg apolactoferrin | Over the counter |
| Thymosin Alpha-1 | $100–$400 | 1.6 mg subcutaneous | Prescription |
| Senolytics | Not priced yet | ||
| Ozone Therapy | $520–$2,600 | 20-30 mcg/mL ozone, roughly 1,000-1,500 mcg total per session | In clinic |
| PEMF (Pulsed Electromagnetic Field Therapy) | $3–$117 | 20-30 min mat session | Over the counter |
| Vagus Nerve Stimulation | $4–$8 | 10-20 min auricular tVNS at comfortable perceptible intensity | Over the counter |
| Rapamycin | $15–$50 | 3 mg | Prescription |
| Ca-AKG (Calcium Alpha-Ketoglutarate) | $15–$30 | 1 g/day generic Ca-AKG oral | Over the counter |
| Zone 2 Cardio | Not priced yet | Over the counter | |
| Traditional Sauna (Finnish Dry-Heat) | $50 | 15 to 20 minutes at 80 to 100 C | Over the counter |
| Polyphenols (Dietary) | Not priced yet | ||
| TB-500 (Thymosin Beta-4 Fragment) | Not priced yet | ||
| KPV (Lys-Pro-Val) | $40–$100 | 250-500 mcg/day oral | Grey market |
| Curcumin | $15–$40 | 500 mg curcuminoids | Over the counter |
| Tirzepatide | $299–$449 | 2.5 to 5 to 7.5 to 10 to 12.5 to 15 mg | Prescription |
| High-Dose Melatonin | Not priced yet | ||
| Spirulina | $10–$25 | 1 to 4.5 g/day | Over the counter |
| Earthing | Not priced yet | Over the counter | |
| Omega-3 | $20–$40 | 1-2 g/day combined EPA+DHA | Over the counter |
| Fucoidan (Brown Seaweed Polysaccharide) | Not priced yet | ||
| Hyperbaric Oxygen Therapy | $3,000–$6,000 | 2.0 ATA for 90 minutes with air breaks | In clinic |
| Metformin | $4–$30 | 500 mg with dinner for 1 week, then 500 mg twice daily for 1 week, then increase by 500 mg/week toward 1000 mg twice daily as tolerated | Prescription |
| Time-Restricted Eating | Not priced yet | ||
| HRV Biofeedback | $5 | 20 min/session at individual RF (4.5 to 6.5 bpm) | Over the counter |
| Norwegian 4×4 | Not priced yet | Over the counter | |
| Essential Amino Acids | Not priced yet | ||
| Shilajit | $25–$50 | 500 mg purified shilajit | Over the counter |
| Whole-Body Vibration | $50–$100 | 30 Hz, roughly 0.3g, 10-20 min standing | Over the counter |
| Ashwagandha | $15–$30 | 300 mg KSM-66 with breakfast and 300 mg with dinner | Over the counter |
| GlyNAC (Glycine + N-Acetylcysteine) | $10–$30 | Glycine and NAC at ~100 mg/kg/day each | Over the counter |
| Ergothioneine | Not priced yet | ||
| Ketogenic Diet | $100 | Standard keto, 40-50 g total carbohydrate/day | Over the counter |
| Urolithin A | $50–$100 | 500 mg/day | Over the counter |
| Methylene Blue | $13–$40 | 0.5-5 mg oral | Over the counter |
| Vitamin C (Ascorbic Acid) | Not priced yet | ||
| Spermidine | $40–$90 | 1-3 mg/day oral WGE | Over the counter |
| Lion’s Mane | $20–$40 | 3 g/day fruiting body extract | Over the counter |
| Coenzyme Q10 (CoQ10 / Ubiquinol) | $15–$40 | 100-200 mg/day | Over the counter |
| Sulforaphane | $25–$60 | Broccoli sprout extract delivering about 150 micromoles sulforaphane per day | Over the counter |
| Quercetin | $20–$50 | 200 mg/day | Over the counter |
| Glutathione (GSH) | $20–$45 | 1,000 mg/day | Over the counter |
| Sodium Butyrate | Not priced yet | ||
| Tesamorelin | $250–$500 | 2 mg subcutaneous daily in the evening | Prescription |
| Resveratrol | Not priced yet | ||
| Retatrutide | $130–$960 | 2 mg, then 4 mg, then 8 mg or 12 mg weekly depending on protocol and tolerability | Research use only |
| Thymosin Beta-4 (Tβ4) | Not priced yet | ||
| Saffron | Not priced yet | ||
| Berberine | $15–$25 | 500 mg berberine HCl three times daily with meals | Over the counter |
| ARA-290 (Cibinetide) | Not priced yet | ||
| MOTS-c | $100–$200 | 5-10 mg SC | Research use only |
| Pine Pollen | $20–$45 | 5 to 10 g powder per day | Over the counter |
| TRT (Testosterone Replacement Therapy) | $50–$300 | Clinician-selected formulation at the lowest dose likely to restore physiologic testosterone | Prescription |
| Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga) | $15–$40 | 1.5 to 1.8 g/day standardized extract | Over the counter |
| SLU-PP-332 | $30–$80 | 3-5 mg/day oral | Research use only |
| Full-Spectrum Hemp (CBD) | Not priced yet | ||
| Blood-Flow Restriction Training | Not priced yet | ||
| NAC (N-Acetylcysteine) | $5–$15 | 600 to 1,200 mg/day | Over the counter |
| Colostrum | $60–$80 | 20 g/day powder, split AM/PM if tolerated | Over the counter |
| Thymulin (Zinc-Thymulin) | $22–$65 | Low microgram range, with zinc status confirmed first | Research use only |
| Chlorella | $10–$50 | 5-10 g/day | Over the counter |
| Sprinting (Sprint Interval Training) | Not priced yet | ||
| SS-31 (Elamipretide) | $200–$500 | 5-10 mg/day subcutaneous | Grey market |
| Exogenous Ketones | $38–$300 | Ester 10 to 25 g BHB | Over the counter |
| Pentosan Polysulfate (Elmiron) | Not priced yet | ||
| Tongkat Ali | $20–$40 | 200 mg/day Physta standardized extract | Over the counter |
| VIP (Vasoactive Intestinal Peptide) | Not priced yet | ||
| Full-Body EMS | Not priced yet | ||
| Rucking (Weighted Walking) | Not priced yet | ||
| Hyaluronic Acid | Not priced yet | ||
| NMN (Nicotinamide Mononucleotide) | $40–$100 | 500 mg/day oral | Over the counter |
| NR (Nicotinamide Riboside) | $40–$50 | 250-300 mg/day oral | Over the counter |
| J-147 | Not priced yet | ||
| Quinton Marine Plasma (Seawater Minerals) | Not priced yet | ||
| Apigenin | $15–$35 | 25-50 mg pure apigenin 30-60 min before bed | Over the counter |
| Collagen Peptides | $8–$40 | 2.5-10 g hydrolyzed collagen peptides | Over the counter |
| Bromantane (Ladasten) | $12–$30 | 30 mg | Grey market |
| Semax | $12–$60 | 300-600 mcg/day of 0.1% spray | Grey market |
| Selank | $30–$60 | 0.15% intranasal spray, roughly 1-3 sprays per nostril per day depending on actuation size | Grey market |
| Epitalon | $95–$1,100 | 5-10 mg/day subcutaneous | Grey market |
| Orforglipron (Foundayo) | $149–$299 | Start low, step up to 36 mg | Prescription |
| BAM15 | Not priced yet | ||
| C15 (Pentadecanoic Acid) | $40–$50 | 200 mg/day | Over the counter |
Head-to-head reports and category rankings that name a winner on this use case.
This page ranks by the live body-composition subrating, not the overall BioHarmony score, since body composition is the goal this category is built around. Tirzepatide leads both measures.…
This page ranks by the live endurance-cardio subrating, not by BioHarmony overall, and the order flips. SLU-PP-332 leads at 6.5–7.0/10 despite carrying the lowest overall score on the…
GHK-Cu wins this on evidence. It has human wound and skin data behind it. AHK-Cu has one unreplicated dish study and no human trial at all. Use GHK-Cu…
Neither, if fat loss is the goal. Both score 2.0–2.5/10 on body composition, which is the row a vendor sells them on. AOD-9604 scores 3.0–3.5/10 overall and its…
BPC-157 for structural repair, KPV for inflammation you cannot afford to stimulate. BPC-157 scores gut health 9.0–9.5/10 against KPV's 7.0–7.5/10 and wins nearly every other row, because it…
No. Omega-3 scores 6.5–7.0/10 and C15:0 3.0/10, and the evidence behind the two is not close. C15:0 has two small human trials. Omega-3 has outcome trials, prescription forms…
Different jobs, same shelf. Quercetin scores 6.5–7.0/10 and curcumin 5.5–6.0/10, and that gap is the liver-safety signal rather than a difference in effect. Curcumin wins joints, inflammatory markers,…
Spermidine scores 7.5–8.0/10 and urolithin A 6.5–7.0/10, and they clean up different messes. Spermidine drives broad autophagy: autophagy 8.0/10, cardiovascular 7.8/10, longevity 7.5/10. Urolithin A drives selective mitophagy…
Sulforaphane scores 6.5–7.0/10 and glutathione 6.0–6.5/10, and both have a delivery problem. Sulforaphane needs active myrosinase or you absorb half as much. Plain oral glutathione barely raises blood…
Thymulin scores 6.5–7.0/10, thymalin 5.5–6.0/10, and they are not interchangeable. Thymulin is a defined zinc-dependent peptide with receptor-level science, stronger inflammation data and a much cheaper course. Thymalin…
HBOT scores 5.5–6.0/10 and ozone 5.0–5.5/10, but ozone wins several use cases outright. Pick HBOT for wounds, cognition and neuro recovery, at $3,000 to $6,000 a month. Pick…
Lactoferrin scores 7.0–7.5/10 against colostrum's 6.5–7.0/10, and lactoferrin is one protein inside colostrum. Buy lactoferrin when iron handling, acne or H. pylori is the target, at $25 to…
Molecular Hydrogen, at 8.0–8.5 out of 10 for inflammation. LeBaron 2020 reports 60 participants over 24 weeks; reported improved lipids, glucose, HbA1c, inflammatory markers, and redox markers.
Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 7.0–7.5 out of 10 for inflammation.
C15 (Pentadecanoic Acid) scores 3.0–3.5 out of 10 for inflammation but only 3.0–3.5 overall, landing in the caution tier once safety, side effects, cost and effort are counted.
92 of the 142 interventions evaluated for inflammation score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
