Every intervention Outliyr has scored for weight loss, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for weight loss; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
58 of 107 evaluated interventions score 3.0+ out of 10 for weight loss · 25 comparisons
The evidence gives Tirzepatide a body-composition score of 9.0/10, based on a mean 15 % body-weight reduction in the pivotal SURMOUNT-1 trial Jastreboff 2022. Tirzepatide consistently lowers total mass, waist circumference, and…
Read the Tirzepatide report →For body composition, Essential Amino Acids scores 7.5/10 because Wittholz 2024 reports Systematic review found heterogeneity high enough that planned meta-analysis was not possible. Hughes 2024 points in the same direction, but…
Read the Essential Amino Acids report →Tesamorelin scores 7.5/10 for body composition, with the best signal coming from Badran et al. 2026. Phase 3 HIV lipodystrophy evidence supports the strongest body-composition signal: Falutz 2007 showed VAT reduction with…
Read the Tesamorelin report →Retatrutide's 7.5/10 body-composition score starts with Jastreboff 2023, then gets narrowed by the evidence gap. The existing rationale points to this narrower claim: Body-weight loss is historically large for a drug class,…
Read the Retatrutide report →For body composition, Full-Body EMS lands at 7.0/10 because context matters. Rodrigues-Santana 2023 found favorable body-composition effects across controlled WB-EMS trials, and Guretzki 2024 found a small favorable metabolic-syndrome score signal. The…
Read the Full-Body EMS report →Body composition scores 7.0 because loaded walking raises calorie cost and the loading stimulus supports lean mass. The most direct human signal comes from added external load: in a single-centre RCT of…
Read the Rucking (Weighted Walking) report →Body-composition scoring is 7.0/10 because Wilding 2021 reported 14.9% mean weight loss, but the lost weight is not automatically high-quality fat loss. Semaglutide lowers appetite so effectively that protein, resistance training, and…
Read the Semaglutide report →The body composition case for TRT (Testosterone Replacement Therapy) is 7.0/10 because Bhasin 1996 reports Classic androgen dose-response trial; supports anabolic mechanism but used supraphysiologic dosing in normal men, not standard TRT.…
Read the TRT (Testosterone Replacement Therapy) report →Body composition is where CagriSema is strongest. In the REDEFINE 1 Phase 3 trial, people without diabetes lost about 22.7% of body weight on-treatment and 20.4% on the broader estimand at 68…
Read the CagriSema (Cagrilintide + Semaglutide) report →Grass-Fed Whey Protein scores 6.5/10 for body composition because protein supplementation can improve satiety and lean-mass retention when total diet and training are aligned. The strongest support comes from Shimomura Y. et…
Read the Grass-Fed Whey Protein report →The body composition case for Time-Restricted Eating lands at 6.5/10 because the evidence points to a plausible use case without proving a universal response. Dai W et al. 2024 is the best…
Read the Time-Restricted Eating report →Body composition is orforglipron's strongest use case, with real Phase 3 weight loss as an oral pill. The 36 mg dose cut body weight about 11.2 percent at 72 weeks versus roughly…
Read the Orforglipron (Foundayo) report →Body composition is mazdutide's strongest case. The Phase 3 GLORY-1 trial showed about 14.84 percent weight loss at 48 weeks on the 6 mg dose versus roughly half a percent on placebo,…
Read the Mazdutide (IBI362) report →For body composition, Creatine Monohydrate scores 6.0/10 because Delpino 2022 reports WMD +0.68 kg lean overall (+1.46 kg males-only). Chilibeck 2017 points in the same direction, but route, dose, baseline status, and…
Read the Creatine Monohydrate report →The evidence shows that Norwegian 4x4 can modestly improve body-composition, with a meta-analysis of high-intensity interval training reporting an average 2 % reduction in body-fat percentage among overweight adults Poon 2024. Norwegian…
Read the Norwegian 4×4 report →Body composition scores 6.0/10 because the anthropometric meta-analyses are consistent but small in magnitude. Zarezadeh 2021 found body weight down 1.85 kg and waist circumference down 1.09 cm, with BMI moving only…
Read the Spirulina report →The strongest body composition argument for CJC-1295 is 6.0/10 because Falutz 2010 reports Tesamorelin class comparator RCT with safety extension; relevant for GHRH analog body-composition extrapolation but not direct CJC-1295 evidence. Stanley…
Read the CJC-1295 report →Modest weight loss confirmed: Shekelle 2003 JAMA pooled 0.9 kg/month above placebo across 20 trials; Boozer 2002 6-month RCT showed -5.3 vs -2.6 kg with herbal ephedra/caffeine 90/192 mg/day. Cho 2024 MD…
Read the Ephedrine report →The evidence base for SLU-PP-332 on the body-composition use case scores 6.0 / 10, because mouse studies reported reduced fat mass after treatment Billon 2024. The SLU-PP-332 compound showed exercise-mimetic activation of…
Read the SLU-PP-332 report →Body-composition earns 5.8/10 because Sun 2025 reported PBM-associated reductions in waistline and weight across obesity RCTs, but protocols and comparators varied. Red Light Therapy may help local fat or inflammation biology, yet…
Read the Red Light Therapy report →A 5.8/10 for body-composition fits Infrared Sauna because Hamaya 2025 supports direction more than certainty. The existing rationale points to this narrower claim: Session weight loss is mostly sweat and returns with…
Read the Infrared Sauna report →The 5.8/10 body composition score reflects evidence plus practical constraints. Elahi Vahed 2026 found modest reductions in body weight, BMI, and waist circumference across 23 trials, while older anthropometric reviews were mixed.…
Read the Berberine report →Rapamycin body composition earns 5.8/10 because Harrison 2009 anchors the most relevant signal. Rapamycin fits body composition when mTORC1 modulation, autophagy, immune aging, or senescence biology is the actual target. The score…
Read the Rapamycin report →Weight loss is real and competitive but not class-leading. The Phase 3 SYNCHRONIZE-1 obesity trial hit up to 16.6% mean weight loss versus 3.2% on placebo over 76 weeks, with 85% of…
Read the Survodutide (BI 456906) report →Blood-Flow Restriction Training is a 5.5/10 option for body composition, especially where the context resembles Barzyk et al. 2026. Body-composition benefit is mostly indirect through lean-mass gain, training adherence, and metabolic stress…
Read the Blood-Flow Restriction Training report →The strongest body composition argument for Taurine is 5.5/10 because Sasidharan 2026 reports 220 randomized; no significant overall fatigue benefit, with only hypothesis-generating post hoc subgroup signal. The score stays conditional because…
Read the Taurine report →Glycine body composition earns 5.5/10 because Soh 2024 anchors the most relevant signal. Glycine fits body composition because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the…
Read the Glycine report →Metformin modestly reduces body weight, achieving about a 2-3% loss in insulin-resistant adults, as shown in the Diabetes Prevention Program trial Knowler et al. 2002. The body-composition use case for Metformin receives…
Read the Metformin report →The body composition case for Ketogenic Diet lands at 5.5/10 because the evidence points to a plausible use case without proving a universal response. Leung GKW et al. 2025 is the best…
Read the Ketogenic Diet report →For readers prioritizing body composition, MOTS-c scores 5.5/10 today. Lee 2015 showed diet-induced obesity prevention in mice, and Lu 2019 showed ovariectomy-related adipose protection in mice. Human body-composition data from exogenous MOTS-c…
Read the MOTS-c report →Body composition is cagrilintide's strongest use case, and it is the only one resting on Phase 3 human data. In REDEFINE 1, cagrilintide monotherapy produced about 11.8 percent mean weight loss at…
Read the Cagrilintide (AM833) report →The body-composition case for Tongkat Ali is 5.2/10 because Leisegang 2022 gives the most relevant evidence anchor. The existing rationale points to this narrower claim: the cited study reported modest lean-mass gain,…
Read the Tongkat Ali report →Body composition is VK2735's flagship signal, and it is strong for the stage it is at. The peer-reviewed VENTURE Phase 2 injectable trial reported about 14.7 percent weight loss at the 15…
Read the VK2735 (Viking Therapeutics) report →Body composition is tesofensine's strongest use case and the whole reason it was repurposed for obesity. The 0.5 mg dose cut body weight about 9.2 percent and the 1.0 mg dose about…
Read the Tesofensine report →Zone 2 Cardio's 5.0/10 body-composition score starts with Lang 2024, then gets narrowed by the evidence gap. The existing rationale points to this narrower claim: Zone 2 helps body composition mainly by…
Read the Zone 2 Cardio report →The evidence gives Whole-Body Vibration a modest 5.0/10 rating for influencing body-composition, with meta-analyses reporting only small, inconsistent changes in fat or lean mass Beom 2026. Whole-Body Vibration is better supported for…
Read the Whole-Body Vibration report →Body composition scores a modest 5.0/10. SIT raises fitness and metabolic markers strongly, but its direct fat-loss effect is smaller than its reputation. Vollaard 2017 argued that the cardiometabolic benefits of sprint…
Read the Sprinting (Sprint Interval Training) report →For body-composition, Ca-AKG (Calcium Alpha-Ketoglutarate) lands at 5.0/10 because Shahmirzadi 2020 supports the strongest part of the claim. The existing rationale points to this narrower claim: No direct body-composition evidence for Ca-AKG.…
Read the Ca-AKG (Calcium Alpha-Ketoglutarate) report →Melanotan II gets a borderline body-composition score because melanocortin signaling can suppress appetite, and animal MC4R work connects the pathway to feeding. The classic Nature paper showed melanocortinergic neurons influence feeding and…
Read the Melanotan II report →Improved fat oxidation during exercise is not the same as proven body-composition change. No dedicated body-composition RCT evidence of meaningful size.
Read the Astaxanthin report →Body composition scores 4.5/10. Kumar 2023 reported reduced waist circumference and fat mass in older adults, a real signal, but it is secondary to the metabolic effects and unproven as a primary…
Read the GlyNAC (Glycine + N-Acetylcysteine) report →Hydration and electrolyte support around training is plausible, but no trial shows Quinton changes fat mass or lean mass. The proxy magnesium-water lipid data is metabolic, not body-composition.
Read the Quinton Marine Plasma (Seawater Minerals) report →Fat loss is the strongest endpoint: obese mice lost roughly 5% of body weight with over 30% smaller fat cells, driven by fat burning rather than appetite suppression (Neelakantan 2018). No human…
Read the 5-Amino-1MQ report →Body composition is sermorelin's best-supported adult use, and it still scores only modestly because the human data is genuinely split. The strongest positive came from a 16-week study of a stabilized GHRH…
Read the Sermorelin (GHRH 1-29) report →Body composition scores moderate because the growth-hormone rise behind it is real and reproducible, but no adult human trial measures fat loss or lean mass for GHRP-2. Continuous dosing held growth hormone…
Read the GHRP-2 (Pralmorelin) report →Body composition is MK-677's best-documented effect, which is why it scores highest, but the win comes with an asterisk. The 2-year Nass 2008 trial added about 1.1 kg of fat-free mass versus…
Read the MK-677 (Ibutamoren) report →Body composition scores 4.0/10. Sauna does not meaningfully change fat mass; in-session weight loss is water that returns with rehydration. Any benefit is indirect through better recovery and training capacity, so this…
Read the Traditional Sauna (Finnish Dry-Heat) report →Body-composition evidence is effectively absent for oral or sublingual methylene blue. No verified body-fat, lean-mass, or weight-loss RCT was found in the audit, so v0's low score is preserved.
Read the Methylene Blue report →Weak. Acute appetite suppression (Stubbs 2018) is a plausible lever, but no trial shows exogenous ketones drive meaningful fat loss. They add calories and cost, and ketosis from a supplement does not…
Read the Exogenous Ketones report →Omi 2019 randomized 40 male athletes to EMIQ plus protein powder versus protein alone during resistance training and reported improved body composition. This is a small sports nutrition study and the effect…
Read the Quercetin report →Body composition is the headline use case but it rests on physiology, not human outcome data. GHRP-6 reliably raises growth hormone in people, per Bowers 1990, and the GHRH plus GHRP combination…
Read the GHRP-6 report →Body-composition evidence is formulation-specific and small; Gout 2010 supports Satiereal for snacking and satiety in mildly overweight women, not broad fat loss.
Read the Saffron report →Body composition is 3.5/10. Green-tea catechin plus caffeine shows tiny fat-oxidation effects, but meaningful body-composition change from polyphenols alone is not established.
Read the Polyphenols (Dietary) report →Body-composition support is training-dependent. Wankhede 2015 supports resistance-training benefits, while cortisol reduction may help stressed users retain lean mass. It is not a fat-loss supplement and does little without training, protein, and…
Read the Ashwagandha report →Some cardiovascular reviews note small BMI or body-fat shifts, but there is no dedicated, adequately-powered body-composition RCT, and the protein content alone does not justify a higher score.
Read the Chlorella report →Robinson 2024 (Robinson 2024) did not show a reliable 12-week benefit for body weight or BMI at 200 mg/day. Chooi 2024 TANGO saw weight and liver-fat changes in a diet-centered trial, so…
Read the C15 (Pentadecanoic Acid) report →Testosterone and strength signals may indirectly support lean-mass goals when paired with training, but no body-composition RCT establishes fat-loss or muscle-gain effects.
Read the Shilajit report →Pencina 2023 found a short-term body-weight difference with MIB-626, but body composition and fat endpoints were not convincingly changed.
Read the NMN (Nicotinamide Mononucleotide) report →Nothing matches those filters.
Head-to-head reports and category rankings that name a winner on this use case.
Tirzepatide, at 6.1, then semaglutide at 6.0, then orforglipron at 5.8 if you want the pill. All three are approved, all three have real trial evidence, and all…
Ca-AKG, urolithin A and MOTS-c tie at 6.5, and only the first two are things you can legally buy. SS-31 follows at 6.0. The bottom three score low…
Tesamorelin, at 6.2, and only if you have a clinical reason. Every one of the nine scores 6.2 or lower, so the category tops out at worth trying…
Shilajit at 7.4, phosphatidylserine at 7.3, tongkat ali at 7.0. TRT ranks seventh at 5.7 and wins nine of the eleven use cases outright. That inversion is the…
Neither, if fat loss is the goal. Both score 2.0 on body composition, which is the row a vendor sells them on. AOD-9604 scores 4.6 overall and its…
No. Berberine scores 6.8 and semaglutide 6.0, and that gap misleads almost everyone who reads it. Berberine scores higher because it is cheap, oral and easy to stop,…
BPC-157 for structural repair, KPV for inflammation you cannot afford to stimulate. BPC-157 scores gut health 9.0 against KPV's 7.0 and wins nearly every other row, because it…
Bromantane, for anything you plan to repeat. It scores 7.1 against phenylpiracetam's 5.5 and wins every shared use case that is not a floor tie: energy 6.2 to…
No. Omega-3 scores 6.8 and C15:0 4.9, and the evidence gap is larger than the score gap. C15:0 has two small human trials. Omega-3 has outcome trials, prescription…
Tesamorelin, unless price is the only thing deciding. It is FDA-approved for visceral fat with Phase 3 trials behind it, while CJC-1295 is a gray-market research peptide whose…
These two get sold as the same thing, a scoop for gut and skin, and they share almost no mechanism. Colostrum is a gut and immune product: gut…
No, and the reason is mechanical. A drink raises blood ketones in an hour. It does not lower insulin, deplete glycogen or shift fuel use. The diet scores…
Tirzepatide, at 9.0 out of 10 for weight loss. The evidence gives Tirzepatide a body-composition score of 9.0/10, based on a mean 15 % body-weight reduction in the pivotal SURMOUNT-1 trial Jastreboff 2022.
Of the top-scoring options, Spirulina is the least expensive at about $10 a month, scoring 6.0 out of 10 for weight loss.
58 of the 107 interventions evaluated for weight loss score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
