Every intervention Outliyr has scored for weight loss, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for weight loss; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
63 of 119 evaluated interventions score 3.0+ out of 10 for weight loss · 26 comparisons
Tirzepatide consistently lowers total mass, waist circumference, and body-fat percentage across diverse adult cohorts. A 52-week Chinese trial reported greater weight loss with 10 mg and 15 mg doses versus placebo Zhao…
Wittholz 2024 reports Systematic review found heterogeneity high enough that planned meta-analysis was not possible. Hughes 2024 points in the same direction, but route, dose, baseline status, and outcome tracking decide whether…
Phase 3 HIV lipodystrophy evidence supports the strongest body-composition signal: Falutz 2007 showed VAT reduction with subcutaneous fat largely preserved, and Stanley 2012 linked responder VAT loss to improved metabolic markers. The…
The existing rationale points to this narrower claim: Body-weight loss is historically large for a drug class, with up to 24.2% in this verified source. Body-composition quality depends on resistance. That does…
Eloralintide produced the largest weight reduction of any single-agent amylin drug reported so far, 20.1% at 48 weeks on 9 mg against 0.4% on placebo, with 82.3% of that arm losing at…
Rodrigues-Santana 2023 found favorable body-composition effects across controlled WB-EMS trials, and Guretzki 2024 found a small favorable metabolic-syndrome score signal. The effect is training-like, not a direct fat-loss shortcut. That makes Full-Body…
Loaded walking raises calorie cost and the loading stimulus supports lean mass. The most direct human signal comes from added external load: in a single-centre RCT of 59 adults with obesity, a…
Wilding 2021 reported 14.9% mean weight loss, but the lost weight is not automatically high-quality fat loss. Semaglutide lowers appetite so effectively that protein, resistance training, and total calories need deliberate management.…
Bhasin 1996 reports Classic androgen dose-response trial; supports anabolic mechanism but used supraphysiologic dosing in normal men, not standard TRT. The score stays conditional because TRT (Testosterone Replacement Therapy) still needs better…
Body composition is where CagriSema is strongest. In the REDEFINE 1 Phase 3 trial, people without diabetes lost about 22.7% of body weight on-treatment and 20.4% on the broader estimand at 68…
Protein supplementation can improve satiety and lean-mass retention when total diet and training are aligned. The strongest support comes from Shimomura Y. et al. 2006, but the practical rating stays bounded by…
The evidence points to a plausible use case without proving a universal response. Dai W et al. 2024 is the best anchor here because it reports 19 randomized trials, 568 participants and…
Body composition is orforglipron's strongest use case, with real Phase 3 weight loss as an oral pill. The 36 mg dose cut body weight about 11.2 percent at 72 weeks versus roughly…
Body composition is mazdutide's strongest case. The Phase 3 GLORY-1 trial showed about 14.84 percent weight loss at 48 weeks on the 6 mg dose versus roughly half a percent on placebo,…
Delpino 2022 reports WMD +0.68 kg lean overall (+1.46 kg males-only). Chilibeck 2017 points in the same direction, but route, dose, baseline status, and outcome tracking decide whether Creatine Monohydrate matters for…
The evidence shows that Norwegian 4x4 can modestly improve body-composition, with a meta-analysis of high-intensity interval training reporting an average 2 % reduction in body-fat percentage among overweight adults Poon 2024. A…
The anthropometric meta-analyses are consistent but small in magnitude. Zarezadeh 2021 found body weight down 1.85 kg and waist circumference down 1.09 cm, with BMI moving only in trials lasting 12 weeks…
Falutz 2010 reports Tesamorelin class comparator RCT with safety extension; relevant for GHRH analog body-composition extrapolation but not direct CJC-1295 evidence. Stanley 2014 points in the same direction, but route, dose, baseline…
Modest weight loss confirmed: Shekelle 2003 JAMA pooled 0.9 kg/month above placebo across 20 trials; Boozer 2002 6-month RCT showed -5.3 vs -2.6 kg with herbal ephedra/caffeine 90/192 mg/day. Cho 2024 MD…
Mouse studies reported reduced fat mass after treatment Billon 2024. The SLU-PP-332 compound showed exercise-mimetic activation of oxidative pathways and increased energy expenditure in sedentary and obese rodents, which translated into modest…
Sun 2025 reported PBM-associated reductions in waistline and weight across obesity RCTs, but protocols and comparators varied. Red Light Therapy may help local fat or inflammation biology, yet most body-composition change still…
Hamaya 2025 supports direction more than certainty. The existing rationale points to this narrower claim: Session weight loss is mostly sweat and returns with rehydration. Passive heating may modestly affect cardiometabolic markers,…
Elahi Vahed 2026 found modest reductions in body weight, BMI, and waist circumference across 23 trials, while older anthropometric reviews were mixed. This is not an Ozempic-like effect and is concentrated in…
Harrison 2009 anchors the most relevant signal. Rapamycin fits body composition when mTORC1 modulation, autophagy, immune aging, or senescence biology is the actual target. The score stays bounded because human longevity endpoints…
Weight loss is real and competitive but not class-leading. The Phase 3 SYNCHRONIZE-1 obesity trial hit up to 16.6% mean weight loss versus 3.2% on placebo over 76 weeks, with 85% of…
Body-composition benefit is mostly indirect through lean-mass gain, training adherence, and metabolic stress rather than direct fat-loss evidence. The score stays bounded because Blood-Flow Restriction Training evidence for body composition can depend…
Sasidharan 2026 reports 220 randomized; no significant overall fatigue benefit, with only hypothesis-generating post hoc subgroup signal. The score stays conditional because Taurine still needs better outcome data for this exact use…
Soh 2024 anchors the most relevant signal. Glycine fits body composition because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the endpoint. The score stays bounded because…
Metformin modestly reduces body weight, achieving about a 2-3% loss in insulin-resistant adults, as shown in the Diabetes Prevention Program trial Knowler et al. 2002. In the UKPDS overweight cohort, Metformin users…
The evidence points to a plausible use case without proving a universal response. Leung GKW et al. 2025 is the best anchor here because it reports 33 randomized trials and 2821 individuals…
Lee 2015 showed diet-induced obesity prevention in mice, and Lu 2019 showed ovariectomy-related adipose protection in mice. Human body-composition data from exogenous MOTS-c remains absent. That makes MOTS-c more defensible when body…
Body composition is cagrilintide's strongest use case, and it is the only one resting on Phase 3 human data. In REDEFINE 1, cagrilintide monotherapy produced about 11.8 percent mean weight loss at…
Leisegang 2022 gives the most relevant evidence anchor. The existing rationale points to this narrower claim: the cited study reported modest lean-mass gain, and androgen support can help older or low-testosterone men…
Body composition is VK2735's flagship signal, and it is strong for the stage it is at. The peer-reviewed VENTURE Phase 2 injectable trial reported about 14.7 percent weight loss at the 15…
Body composition is tesofensine's strongest use case and the whole reason it was repurposed for obesity. The 0.5 mg dose cut body weight about 9.2 percent and the 1.0 mg dose about…
The existing rationale points to this narrower claim: Zone 2 helps body composition mainly by raising weekly energy expenditure and improving metabolic flexibility. Direct fat loss is modest without nutrition. That does…
Whole-Body Vibration is better supported for preserving lean mass in older adults than for delivering outright fat loss. Trials in postmenopausal women show possible benefits for bone health, but the impact on…
Shahmirzadi 2020 supports the strongest part of the claim. The existing rationale points to this narrower claim: No direct body-composition evidence for Ca-AKG. Any effect would likely be indirect through frailty, training…
SIT raises fitness and metabolic markers strongly, but its direct fat-loss effect is smaller than its reputation. Vollaard 2017 argued that the cardiometabolic benefits of sprint training, not body-fat reduction, are the…
Ostarine reliably shifts body composition toward lean mass with a smaller fat change as a secondary result. The healthy-elderly trial paired its +1.4 kg lean gain with a roughly 0.6 kg fat…
Melanotan II gets a borderline body-composition score because melanocortin signaling can suppress appetite, and animal MC4R work connects the pathway to feeding. The classic Nature paper showed melanocortinergic neurons influence feeding and…
Improved fat oxidation during exercise is not the same as proven body-composition change. No dedicated body-composition RCT evidence of meaningful size.
Kumar 2023 reported reduced waist circumference and fat mass in older adults, a real signal, but it is secondary to the metabolic effects and unproven as a primary weight-loss tool.
Hydration and electrolyte support around training is plausible, but no trial shows Quinton changes fat mass or lean mass. The proxy magnesium-water lipid data is metabolic, not body-composition.
The strongest use case, and still animal-only. BAM15 reversed established diet-induced obesity and cut fat mass in mice without touching lean mass or food intake, replicated across independent labs (Alexopoulos et al.…
Fat loss is the strongest endpoint: obese mice lost roughly 5% of body weight with over 30% smaller fat cells, driven by fat burning rather than appetite suppression (Neelakantan 2018). No human…
Body composition is sermorelin's best-supported adult use, and it still scores only modestly because the human data is genuinely split. The strongest positive came from a 16-week study of a stabilized GHRH…
Body composition scores moderate because the growth-hormone rise behind it is real and reproducible, but no adult human trial measures fat loss or lean mass for GHRP-2. Continuous dosing held growth hormone…
Body composition is MK-677's best-documented effect, which is why it scores highest, but the win comes with an asterisk. The 2-year Nass 2008 trial added about 1.1 kg of fat-free mass versus…
Sauna does not meaningfully change fat mass; in-session weight loss is water that returns with rehydration. Any benefit is indirect through better recovery and training capacity, so this stays low.
Body-composition evidence is effectively absent for oral or sublingual methylene blue. No verified body-fat, lean-mass, or weight-loss RCT was found in the audit, so v0's low score is preserved.
Weak. Acute appetite suppression (Stubbs 2018) is a plausible lever, but no trial shows exogenous ketones drive meaningful fat loss. They add calories and cost, and ketosis from a supplement does not…
Omi 2019 randomized 40 male athletes to EMIQ plus protein powder versus protein alone during resistance training and reported improved body composition. This is a small sports nutrition study and the effect…
Body composition is the headline use case but it rests on physiology, not human outcome data. GHRP-6 reliably raises growth hormone in people, per Bowers 1990, and the GHRH plus GHRP combination…
Green-tea catechin plus caffeine shows tiny fat-oxidation effects, but meaningful body-composition change from polyphenols alone is not established.
Body-composition evidence is formulation-specific and small; Gout 2010 supports Satiereal for snacking and satiety in mildly overweight women, not broad fat loss.
Body-composition support is training-dependent. Wankhede 2015 supports resistance-training benefits, while cortisol reduction may help stressed users retain lean mass. It is not a fat-loss supplement and does little without training, protein, and…
Some cardiovascular reviews note small BMI or body-fat shifts, but there is no dedicated, adequately-powered body-composition RCT, and the protein content alone does not justify a higher score.
Testosterone and strength signals may indirectly support lean-mass goals when paired with training, but no body-composition RCT establishes fat-loss or muscle-gain effects.
Pencina 2023 found a short-term body-weight difference with MIB-626, but body composition and fat endpoints were not convincingly changed.
Extrapolated, not demonstrated for 915. Chronic fat-mass and body-weight reduction is an SLU-PP-332 finding (Billon et al. 2024); for 915 there is only a five-day brown-fat gene signal (Johansen et al. 2025),…
Borrowed from the parent, which raised fat-free mass but did not reliably cut fat mass. Zero MK-777-specific measurements exist.
Robinson 2024 (Robinson 2024) did not show a reliable 12-week benefit for body weight or BMI at 200 mg/day. Chooi 2024 TANGO saw weight and liver-fat changes in a diet-centered trial, so…
Nothing matches those filters.
Monthly out-of-pocket cost at the most accessible legitimate channel, at the dose the score was given for. 19 of 63 are not priced yet; those cells are left blank rather than guessed.
| Intervention | Monthly cost | At dose | How you get it |
|---|---|---|---|
| Tirzepatide | $299–$449 | 2.5 to 5 to 7.5 to 10 to 12.5 to 15 mg | Prescription |
| Essential Amino Acids | Not priced yet | ||
| Tesamorelin | $250–$500 | 2 mg subcutaneous daily in the evening | Prescription |
| Retatrutide | $130–$960 | 2 mg, then 4 mg, then 8 mg or 12 mg weekly depending on protocol and tolerability | Research use only |
| Eloralintide (LY3841136) | $432–$540 | 9 mg once weekly | Research use only |
| Full-Body EMS | Not priced yet | ||
| Rucking (Weighted Walking) | Not priced yet | ||
| Semaglutide | $199–$349 | 0.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, 2.4 mg week 17 onward | Prescription |
| TRT (Testosterone Replacement Therapy) | $50–$300 | Clinician-selected formulation at the lowest dose likely to restore physiologic testosterone | Prescription |
| CagriSema (Cagrilintide + Semaglutide) | $80–$160 | 0.25 mg, then 0.5 mg, then 1.0 mg, then 1.7 mg, then 2.4 mg of each | Research use only |
| Grass-Fed Whey Protein | $40–$80 | 20-40 g protein | Over the counter |
| Time-Restricted Eating | Not priced yet | ||
| Orforglipron (Foundayo) | $149–$299 | Start low, step up to 36 mg | Prescription |
| Mazdutide (IBI362) | $400–$420 | Step up over several weeks to 6 mg | Grey market |
| Creatine Monohydrate | Not priced yet | ||
| Norwegian 4×4 | Not priced yet | Over the counter | |
| Spirulina | $10–$25 | 1 to 4.5 g/day | Over the counter |
| CJC-1295 | $80–$200 | 1-2 mg subcutaneous | Grey market |
| Ephedrine | Not priced yet | ||
| SLU-PP-332 | $30–$80 | 3-5 mg/day oral | Research use only |
| Red Light Therapy | $17–$43 | 10-20 min at 6-12 inches, full chest/face/back rotation | Over the counter |
| Infrared Sauna | $36–$73 | 55-60 degrees C, 20-30 min | Over the counter |
| Berberine | $15–$25 | 500 mg berberine HCl three times daily with meals | Over the counter |
| Rapamycin | $15–$50 | 3 mg | Prescription |
| Survodutide (BI 456906) | $300–$500 | 2.4, 4.8, or 6.0 mg | Research use only |
| Blood-Flow Restriction Training | Not priced yet | ||
| Taurine | $3–$10 | 1-3 g, 30-60 minutes before sleep | Over the counter |
| Glycine | $2–$3 | 3 g oral glycine | Over the counter |
| Metformin | $4–$30 | 500 mg with dinner for 1 week, then 500 mg twice daily for 1 week, then increase by 500 mg/week toward 1000 mg twice daily as tolerated | Prescription |
| Ketogenic Diet | $100 | Standard keto, 40-50 g total carbohydrate/day | Over the counter |
| MOTS-c | $100–$200 | 5-10 mg SC | Research use only |
| Cagrilintide (AM833) | $70–$170 | 0.25 mg, then 0.5 mg, 1.0 mg, 1.7 mg, then 2.4 mg | Research use only |
| Tongkat Ali | $20–$40 | 200 mg/day Physta standardized extract | Over the counter |
| VK2735 (Viking Therapeutics) | $100–$400 | 2.5 to 5 mg | Research use only |
| Tesofensine | Not priced yet | ||
| Zone 2 Cardio | Not priced yet | Over the counter | |
| Whole-Body Vibration | $50–$100 | 30 Hz, roughly 0.3g, 10-20 min standing | Over the counter |
| Ca-AKG (Calcium Alpha-Ketoglutarate) | $15–$30 | 1 g/day generic Ca-AKG oral | Over the counter |
| Sprinting (Sprint Interval Training) | Not priced yet | ||
| Ostarine (MK-2866 / enobosarm) | Not priced yet | ||
| Melanotan II | $25–$55 | Variable | Research use only |
| Astaxanthin | Not priced yet | ||
| GlyNAC (Glycine + N-Acetylcysteine) | $10–$30 | Glycine and NAC at ~100 mg/kg/day each | Over the counter |
| Quinton Marine Plasma (Seawater Minerals) | Not priced yet | ||
| BAM15 | Not priced yet | ||
| 5-Amino-1MQ | $95–$190 | 50 to 100 mg oral, once daily | Grey market |
| Sermorelin (GHRH 1-29) | $129–$250 | 100 mcg | Prescription |
| GHRP-2 (Pralmorelin) | $20–$40 | 100 mcg | Grey market |
| MK-677 (Ibutamoren) | $30–$60 | 10 to 12.5 mg | Grey market |
| Traditional Sauna (Finnish Dry-Heat) | $50 | 15 to 20 minutes at 80 to 100 C | Over the counter |
| Methylene Blue | $13–$40 | 0.5-5 mg oral | Over the counter |
| Exogenous Ketones | $38–$300 | Ester 10 to 25 g BHB | Over the counter |
| Quercetin | $20–$50 | 200 mg/day | Over the counter |
| GHRP-6 | $20–$40 | 100 mcg | Grey market |
| Polyphenols (Dietary) | Not priced yet | ||
| Saffron | Not priced yet | ||
| Ashwagandha | $15–$30 | 300 mg KSM-66 with breakfast and 300 mg with dinner | Over the counter |
| Chlorella | $10–$50 | 5-10 g/day | Over the counter |
| Shilajit | $25–$50 | 500 mg purified shilajit | Over the counter |
| NMN (Nicotinamide Mononucleotide) | $40–$100 | 500 mg/day oral | Over the counter |
| SLU-PP-915 | Not priced yet | ||
| MK-777 (Acetamoren) | Not priced yet | ||
| C15 (Pentadecanoic Acid) | $40–$50 | 200 mg/day | Over the counter |
Head-to-head reports and category rankings that name a winner on this use case.
This page ranks by the live body-composition subrating, not the overall BioHarmony score, since body composition is the goal this category is built around. Tirzepatide leads both measures.…
This page ranks by the live endurance-cardio subrating, not by BioHarmony overall, and the order flips. SLU-PP-332 leads at 6.5–7.0/10 despite carrying the lowest overall score on the…
This page ranks by the live Body Composition subrating, fat loss and body composition, not the overall BioHarmony score. Tesamorelin leads at 7.5–8.0/10, and it also carries the…
This page ranks by hormonal fit, not overall BioHarmony score. TRT leads at 9.0–9.5/10. Phosphatidylserine sits fifth at 5.5–6.0/10 despite the second highest overall score here, 7.0–7.5/10. That…
Neither, if fat loss is the goal. Both score 2.0–2.5/10 on body composition, which is the row a vendor sells them on. AOD-9604 scores 3.0–3.5/10 overall and its…
No. Berberine scores 6.5–7.0/10 and semaglutide 6.0–6.5/10, and that gap misleads almost everyone who reads it. Berberine scores higher because it is cheap, oral and easy to stop,…
BPC-157 for structural repair, KPV for inflammation you cannot afford to stimulate. BPC-157 scores gut health 9.0–9.5/10 against KPV's 7.0–7.5/10 and wins nearly every other row, because it…
Bromantane, for anything you plan to repeat. It scores 7.0–7.5/10 against phenylpiracetam's 5.5–6.0/10 and wins every shared use case that is not a floor tie: energy 6.2/10 to…
No. Omega-3 scores 6.5–7.0/10 and C15:0 3.0/10, and the evidence behind the two is not close. C15:0 has two small human trials. Omega-3 has outcome trials, prescription forms…
Tesamorelin, unless price is the only thing deciding. It is FDA-approved for visceral fat with Phase 3 trials behind it, while CJC-1295 is a gray-market research peptide whose…
These two get sold as the same thing, a scoop for gut and skin, and they share almost no mechanism. Colostrum is a gut and immune product: gut…
On weight loss they tie, and neither is a drug you can legitimately buy. Both score 7.5/10 for body composition, and both are investigational Lilly molecules with phase…
Tirzepatide, at 9.0–9.5 out of 10 for weight loss. Tirzepatide consistently lowers total mass, waist circumference, and body-fat percentage across diverse adult cohorts.
Of the top-scoring options, Spirulina is the least expensive at about $10 a month, scoring 6.0–6.5 out of 10 for weight loss.
C15 (Pentadecanoic Acid) scores 3.0–3.5 out of 10 for weight loss but only 3.0–3.5 overall, landing in the caution tier once safety, side effects, cost and effort are counted.
63 of the 119 interventions evaluated for weight loss score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
