Best Interventions for Inflammation, Ranked by Evidence

Every intervention Outliyr has scored for inflammation, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for inflammation; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.

90 of 129 evaluated interventions score 3.0+ out of 10 for inflammation · 16 comparisons

Ranked for Inflammation

Category
  1. Molecular Hydrogen

    8.0 /10 for inflammation 8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Molecular Hydrogen earns 8.0/10 for inflammation control because LeBaron 2020 reports 60 participants over 24 weeks; reported improved lipids, glucose, HbA1c, inflammatory markers, and redox markers. Sim 2020 points in the same…

    Read the Molecular Hydrogen report →
  2. Celebrex (Celecoxib)

    8.0 /10 for inflammation 5.8/10 overall Worth trying Other Pharmaceutical

    For anti inflammatory, Celebrex (Celecoxib) earns 8.0/10 because the evidence points to a plausible use case without proving a universal response. Farag N et al. 2025 is the best anchor here because…

    Read the Celebrex (Celecoxib) report →
  3. Red Light Therapy

    7.5 /10 for inflammation 8.0/10 overall Strong recommend Light Therapy

    Inflammation is one of the better Red Light Therapy targets, scoring 7.5/10 because Hamblin 2017 details NF-kB modulation, mitochondrial signaling, and local inflammatory effects. The practical strength is localized inflammation: joints, tendons,…

    Read the Red Light Therapy report →
  4. Astaxanthin

    7.5 /10 for inflammation 7.8/10 overall Strong recommend Vitamin & Mineral & Nutrient

    For inflammation control, Astaxanthin scores 7.5/10 because Malcangi 2026 reports 15 human RCTs; consistent reductions in several inflammatory and oxidative-stress markers plus increases in antioxidant capacity; better trials still needed. Ma 2022…

    Read the Astaxanthin report →
  5. Infrared Sauna

    7.5 /10 for inflammation 7.4/10 overall Strong recommend Sauna & Heat Therapy

    For anti-inflammatory, Infrared Sauna lands at 7.5/10 because Oosterveld 2009 supports the strongest part of the claim. The existing rationale points to this narrower claim: Heat exposure can influence inflammatory signaling through…

    Read the Infrared Sauna report →
  6. Semaglutide

    7.5 /10 for inflammation 6.0/10 overall Worth trying Metabolic & Incretin Peptide

    Anti-inflammatory scoring sits at 7.5/10 because Semaglutide reduces inflammatory load mainly through weight loss and metabolic repair, with Lincoff 2023 giving hard-outcome relevance in high-risk obesity. This is not a direct anti-inflammatory…

    Read the Semaglutide report →
  7. Taurine

    7.0 /10 for inflammation 8.1/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Evidence for Taurine in inflammation control lands at 7.0/10 because Ahmadian 2017 reports Heart-failure RCT; 500 mg three times daily for 2 weeks affected atherogenic and inflammatory markers. The score stays conditional…

    Read the Taurine report →
  8. Glycine

    7.0 /10 for inflammation 7.9/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Glycine anti inflammatory earns 7.0/10 because Kumar 2023 anchors the most relevant signal. Glycine fits anti inflammatory because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the…

    Read the Glycine report →
  9. BPC-157

    7.0 /10 for inflammation 7.5/10 overall Strong recommend Growth & Repair Peptide

    BPC-157 anti inflammatory earns 7.0/10 because Vasireddi 2025 anchors the most relevant signal. BPC-157 fits anti inflammatory when the target is tissue repair, vascular recruitment, or inflammation control, but the case still…

    Read the BPC-157 report →
  10. GHK-Cu

    7.0 /10 for inflammation 7.4/10 overall Strong recommend Cosmetic & Dermatologic Peptide

    Anti Inflammatory is a 7.0/10 fit for GHK-Cu, based on the evidence summarized in Pickart L, Margolina 2018. The v0 anti-inflammatory score is retained because copper-tripeptide biology intersects with IL-6, TGF-beta, tissue…

    Read the GHK-Cu report →
  11. Lactoferrin

    7.0 /10 for inflammation 7.3/10 overall Strong recommend Vitamin & Mineral & Nutrient

    The anti inflammatory use case earns 7.0/10 for Lactoferrin, anchored by Ariff et al. 2025. The anti-inflammatory subrating stays at 7.0 because lactoferrin consistently affects inflammatory signaling, but clinical translation varies. Berthon…

    Read the Lactoferrin report →
  12. Thymosin Alpha-1

    7.0 /10 for inflammation 7.3/10 overall Strong recommend Immune Peptide

    Thymosin Alpha-1 anti inflammatory earns 7.0/10 because Wu 2025 anchors the most relevant signal. Thymosin Alpha-1 fits anti inflammatory when immune modulation is medically relevant and monitored rather than casually guessed. The…

    Read the Thymosin Alpha-1 report →
  13. Senolytics

    7.0 /10 for inflammation 6.6/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Evidence puts Senolytics at 7.0/10 for anti inflammatory, mainly through Farr et al. 2024. SASP suppression is central to the mechanism; Hickson 2019 supports marker movement for D+Q but is preliminary and…

    Read the Senolytics report →
  14. Ozone Therapy

    7.0 /10 for inflammation 5.1/10 overall Neutral Therapy & Modality

    Ozone Therapy earns 7.0/10 for inflammation control because Sagai 2011 reports Personally verified mechanism review; Nrf2 activation, NF-kB modulation, lipid oxidation products, dose-toxicity tension. The score stays conditional because Ozone Therapy still…

    Read the Ozone Therapy report →
  15. Vagus Nerve Stimulation

    6.8 /10 for inflammation 7.7/10 overall Strong recommend Neurostimulation & Neurofeedback

    Vagus Nerve Stimulation reaches 6.8/10 for anti inflammatory when the goal matches the population in Kim et al. 2022. The cholinergic anti-inflammatory pathway has direct human support from implanted VNS work, including…

    Read the Vagus Nerve Stimulation report →
  16. PEMF (Pulsed Electromagnetic Field Therapy)

    6.8 /10 for inflammation 7.5/10 overall Strong recommend PEMF

    For readers prioritizing anti inflammatory, PEMF (Pulsed Electromagnetic Field Therapy) scores 6.8/10 today. NF-kB modulation and cytokine shifts provide the anti-inflammatory rationale. Rohde 2015 found lower postoperative interleukin-1beta, pain, inflammation, and narcotic…

    Read the PEMF (Pulsed Electromagnetic Field Therapy) report →
  17. Rapamycin

    6.8 /10 for inflammation 6.8/10 overall Worth trying Pharmaceutical & Drug

    Rapamycin anti inflammatory earns 6.8/10 because Harrison 2009 anchors the most relevant signal. Rapamycin fits anti inflammatory when mTORC1 modulation, autophagy, immune aging, or senescence biology is the actual target. The score…

    Read the Rapamycin report →
  18. Ca-AKG (Calcium Alpha-Ketoglutarate)

    6.8 /10 for inflammation 6.5/10 overall Worth trying Vitamin & Mineral & Nutrient

    The anti-inflammatory case for Ca-AKG (Calcium Alpha-Ketoglutarate) is 6.8/10 because Demidenko 2021 gives the most relevant evidence anchor. The existing rationale points to this narrower claim: IL-10 dependence is supported by this…

    Read the Ca-AKG (Calcium Alpha-Ketoglutarate) report →
  19. Zone 2 Cardio

    6.5 /10 for inflammation 8.3/10 overall Strong recommend Cardiovascular

    Zone 2 Cardio's 6.5/10 anti-inflammatory score starts with Vabishchevich 2026, then gets narrowed by the evidence gap. The existing rationale points to this narrower claim: Moderate aerobic training lowers chronic inflammatory burden…

    Read the Zone 2 Cardio report →
  20. Traditional Sauna (Finnish Dry-Heat)

    6.5 /10 for inflammation 7.7/10 overall Strong recommend Sauna & Heat Therapy

    Anti-inflammatory effect scores 6.5/10. Laukkanen 2018 found sauna frequency inversely associated with C-reactive protein in 2,084 men, with mean CRP falling from 2.41 at 1 session per week to 1.65 at 4…

    Read the Traditional Sauna (Finnish Dry-Heat) report →
  21. Polyphenols (Dietary)

    6.5 /10 for inflammation 7.6/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Anti-inflammatory action scores 6.5/10. Multiple polyphenol classes lower circulating inflammatory markers including CRP in controlled trials, and the mechanism (modulation of NF-kB signaling and oxidative load) is well characterized. The Crowe-White 2022…

    Read the Polyphenols (Dietary) report →
  22. TB-500 (Thymosin Beta-4 Fragment)

    6.5 /10 for inflammation 7.5/10 overall Strong recommend Growth & Repair Peptide

    The strongest anti inflammatory case puts TB-500 (Thymosin Beta-4 Fragment) at 6.5/10. Anti-inflammatory support is stronger than many other secondary claims. Sosne 2007 reviews corneal anti-inflammatory mechanisms, and Wang 2024 shows pro-resolving…

    Read the TB-500 (Thymosin Beta-4 Fragment) report →
  23. KPV (Lys-Pro-Val)

    6.5 /10 for inflammation 7.1/10 overall Strong recommend Immune Peptide

    For inflammation control, KPV (Lys-Pro-Val) scores 6.5/10 because Sung 2025 reports cell and 3D skin model study, not a clinical trial. Dalmasso 2008 points in the same direction, but route, dose, baseline…

    Read the KPV (Lys-Pro-Val) report →
  24. Curcumin

    6.3 /10 for inflammation 6.5/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Curcumin lowers C-reactive protein consistently across trials. A 2023 umbrella meta-analysis pooling over 5,800 participants (Naghsh and colleagues) reported a CRP effect size around 0.74, most pronounced under 10 weeks and at…

    Read the Curcumin report →
  25. Tirzepatide

    6.2 /10 for inflammation 6.1/10 overall Worth trying Metabolic & Incretin Peptide

    The anti-inflammatory potential of Tirzepatide scores 6.2/10, based on data from the obesity RCT showing modest reductions in CRP Jastreboff 2022. Tirzepatide's anti-inflammatory effect appears secondary to weight loss and metabolic improvement…

    Read the Tirzepatide report →
  26. High-Dose Melatonin

    6.1 /10 for inflammation 6.7/10 overall Worth trying Exogenous Metabolite

    High-Dose Melatonin has a moderate anti-inflammatory score because sepsis and COVID trials used higher doses and reported clinical or inflammatory improvements. A phase I sepsis dose-escalation study tested 20 to 100 mg…

    Read the High-Dose Melatonin report →
  27. Spirulina

    6.0 /10 for inflammation 7.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Anti-inflammatory lands at 6.0/10 because the inflammation evidence is real but smaller than the cardiometabolic case. Shahraki Jazinaki 2025 pooled 7 trials in 283 subjects and found C-reactive protein falling 0.55 mg/L,…

    Read the Spirulina report →
  28. Earthing

    6.0 /10 for inflammation 6.8/10 overall Worth trying Grounding & Earthing

    The anti-inflammatory rating for Earthing is 6.0 /10, based on a modest postoperative study that observed lower inflammatory markers in 84 patients (Sokal 2025). Earthing's anti-inflammatory claim rests on this single trial…

    Read the Earthing report →
  29. Omega-3

    6.0 /10 for inflammation 6.8/10 overall Worth trying Vitamin & Mineral & Nutrient

    The main limitation behind Omega-3's 6.0/10 anti inflammatory score is that the evidence points to a plausible use case without proving a universal response. Kaviani et al. 2022 is the best anchor…

    Read the Omega-3 report →
  30. Fucoidan (Brown Seaweed Polysaccharide)

    6.0 /10 for inflammation 6.4/10 overall Worth trying Vitamin & Mineral & Nutrient

    Fucoidan scores 6.0 out of 10 for anti-inflammatory use. In advanced cancer patients, Takahashi 2018 reported significant reductions in IL-1 beta, IL-6, and TNF-alpha within two weeks of fucoidan supplementation, and the…

    Read the Fucoidan (Brown Seaweed Polysaccharide) report →
  31. Hyperbaric Oxygen Therapy

    5.9 /10 for inflammation 6.2/10 overall Worth trying Hyperbaric

    The anti-inflammatory rating for Hyperbaric Oxygen Therapy is 5.9/10, reflecting results from a phase II randomised trial of 80 long-COVID patients Kjellberg 2025. Hyperbaric Oxygen Therapy is proposed to modulate inflammation in…

    Read the Hyperbaric Oxygen Therapy report →
  32. Metformin

    5.8 /10 for inflammation 6.9/10 overall Worth trying Other Pharmaceutical

    Metformin scores 5.8/10 for the anti-inflammatory use case, based on modest CRP reductions reported in diabetic trials such as the UK Prospective Diabetes Study Group 1998 UK Prospective Diabetes Study Group 1998.…

    Read the Metformin report →
  33. Time-Restricted Eating

    5.7 /10 for inflammation 6.9/10 overall Worth trying Fasting Protocol

    For anti inflammatory, Time-Restricted Eating earns 5.7/10 because the evidence points to a plausible use case without proving a universal response. World Anti-Doping Agency 2026 is the best anchor here because it…

    Read the Time-Restricted Eating report →
  34. HRV Biofeedback

    5.5 /10 for inflammation 9.0/10 overall Top-tier Wearable & Tracker

    A cautious anti inflammatory score of 5.5/10 fits HRV Biofeedback, with Vann-Adibe et al. 2025 preventing a stronger claim. Vagal anti-inflammatory pathway; reduced TNF-alpha in one small RCT. Mechanism plausible, direct human…

    Read the HRV Biofeedback report →
  35. Norwegian 4×4

    5.5 /10 for inflammation 8.5/10 overall Strong recommend Cardiovascular

    The Norwegian 4x4 protocol scores 5.5/10 for anti-inflammatory potential, with a meta-analysis reporting a modest 10 % reduction in resting C-reactive protein after 12 weeks of similar high-intensity interval training Poon 2024.…

    Read the Norwegian 4×4 report →
  36. Essential Amino Acids

    5.5 /10 for inflammation 8.0/10 overall Strong recommend Amino Acid

    The inflammation control case for Essential Amino Acids is 5.5/10 because Hagiyama 2024 reports 12 RCTs; 622 patients; low-certainty improvement in patient-reported outcomes and very-low-certainty strength signal after lower-limb surgeries. Wittholz 2024…

    Read the Essential Amino Acids report →
  37. Shilajit

    5.5 /10 for inflammation 7.4/10 overall Strong recommend Adaptogenic Herb

    Shilajit anti inflammatory earns 5.5/10 because Pandit 2016 anchors the most relevant signal. Shilajit fits anti inflammatory when purified resin is matched to hormones, sperm parameters, strength fatigue, bone markers, or energy…

    Read the Shilajit report →
  38. Whole-Body Vibration

    5.5 /10 for inflammation 7.3/10 overall Strong recommend Other Device

    The anti-inflammatory potential of Whole-Body Vibration scores 5.5/10, based on mixed findings in a meta-analysis Wang et al. 2024. Whole-Body Vibration produces an acute inflammatory response that resembles moderate exercise, which may…

    Read the Whole-Body Vibration report →
  39. Ashwagandha

    5.5 /10 for inflammation 6.8/10 overall Worth trying Adaptogenic Herb

    The main limitation behind Ashwagandha's 5.5/10 anti inflammatory score is that the evidence points to a plausible use case without proving a universal response. Fatima et al. 2024 is the best anchor…

    Read the Ashwagandha report →
  40. GlyNAC (Glycine + N-Acetylcysteine)

    5.5 /10 for inflammation 6.7/10 overall Worth trying Amino Acid

    Anti-inflammatory effects score 5.5/10. Kumar 2023 reported IL-6 down 78 percent and TNF-alpha down 54 percent at 16 weeks, with the anti-inflammatory cytokine IL-10 nearly doubling, a consistent and sizable shift across…

    Read the GlyNAC (Glycine + N-Acetylcysteine) report →
  41. Ergothioneine

    5.5 /10 for inflammation 6.6/10 overall Worth trying Vitamin & Mineral & Nutrient

    Anti-inflammatory support scores 5.5/10. The mechanism is sound: ergothioneine dampens reactive oxygen species and has reduced inflammatory markers in cell and animal models, and the cardiovascular protection seen in Smith 2020 is…

    Read the Ergothioneine report →
  42. Ketogenic Diet

    5.5 /10 for inflammation 6.6/10 overall Worth trying Practice & Lifestyle

    Mechanistically, Ketogenic Diet scores 5.5/10 for anti inflammatory because the evidence points to a plausible use case without proving a universal response. McKenzie AL et al. 2024 is the best anchor here…

    Read the Ketogenic Diet report →
  43. Urolithin A

    5.5 /10 for inflammation 6.5/10 overall Worth trying Exogenous Metabolite

    For readers prioritizing anti inflammatory, Urolithin A scores 5.5/10 today. Denk 2025 and the 2024 systematic review support anti-inflammatory and immune-metabolic signals, though disease-level inflammation outcomes are unproven. That makes Urolithin A…

    Read the Urolithin A report →
  44. Methylene Blue

    5.5 /10 for inflammation 6.1/10 overall Worth trying Pharmaceutical & Drug

    A 5.5/10 for anti-inflammatory fits Methylene Blue because Rothenberg 2025 supports direction more than certainty. The existing rationale points to this narrower claim: Anti-inflammatory claims are plausible through nitric-oxide pathway modulation, but…

    Read the Methylene Blue report →
  45. Vitamin C (Ascorbic Acid)

    5.0 /10 for inflammation 7.7/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Vitamin C scores 5.0/10 as an anti-inflammatory. It lowers some oxidative-stress and inflammatory markers in trials, consistent with its reducing-agent chemistry, and the blood pressure and glycemic improvements in Juraschek 2012 and…

    Read the Vitamin C (Ascorbic Acid) report →
  46. Spermidine

    5.0 /10 for inflammation 7.6/10 overall Strong recommend Vitamin & Mineral & Nutrient

    For anti-inflammatory, Spermidine lands at 5.0/10 because Schwarz 2022 supports the strongest part of the claim. The existing rationale points to this narrower claim: this verified source measured biomarkers in older adults,…

    Read the Spermidine report →
  47. Lion’s Mane

    5.0 /10 for inflammation 7.2/10 overall Strong recommend Functional Mushroom

    Lion's Mane anti inflammatory earns 5.0/10 because Menon 2025 anchors the most relevant signal. Lion's Mane fits anti inflammatory when the goal is gentle mushroom-based support for cognition, mood, nerve biology, or…

    Read the Lion’s Mane report →
  48. Coenzyme Q10 (CoQ10 / Ubiquinol)

    5.0 /10 for inflammation 7.1/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Anti-inflammatory support sits at 5.0/10. Several trials report modest reductions in inflammatory markers like CRP and IL-6 with CoQ10, consistent with its membrane-antioxidant action, and this plausibly contributes to its cardiovascular effects.…

    Read the Coenzyme Q10 (CoQ10 / Ubiquinol) report →
  49. Quercetin

    5.0 /10 for inflammation 6.8/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Meta-analysis of human trials by Ou 2020 found no overall effect on CRP, IL-6, or TNF-alpha, with subgroup signals only. Disease-specific signals exist, including reductions in oxidative stress and inflammatory markers in…

    Read the Quercetin report →
  50. Sulforaphane

    5.0 /10 for inflammation 6.8/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Anti-inflammatory effect is biologically real but clinical translation is mixed. Selected cytokine and gastritis marker shifts are documented in small trials, and NRF2 activation suppresses NF-kB signaling preclinically. The negatives are notable:…

    Read the Sulforaphane report →
  51. Glutathione (GSH)

    5.0 /10 for inflammation 6.2/10 overall Worth trying Amino Acid

    Anti-inflammatory effects score 5.0/10 as a reasonable but indirect inference. Glutathione status modulates redox-sensitive inflammatory signaling, and the liposomal pilot reported a 35 percent drop in the oxidative marker 8-isoprostane. But no…

    Read the Glutathione (GSH) report →
  52. Tesamorelin

    5.0 /10 for inflammation 6.2/10 overall Worth trying Growth Hormone Secretagogue

    Tesamorelin has a 5.0/10 anti inflammatory case because Fourman et al. 2020 supports a plausible benefit. Stanley 2011 reported inflammatory-marker changes that tracked with visceral-fat reduction, and Fourman 2020 showed downregulation of…

    Read the Tesamorelin report →
  53. Sodium Butyrate

    5.0 /10 for inflammation 6.0/10 overall Worth trying Exogenous Metabolite

    Butyrate's anti-inflammatory action is well grounded in mechanism, since it inhibits HDACs and promotes regulatory T cells in the gut. In the active ulcerative colitis trial (n=36), oral sodium butyrate lowered ESR…

    Read the Sodium Butyrate report →
  54. Resveratrol

    5.0 /10 for inflammation 5.6/10 overall Neutral Botanical Extract (non-adaptogenic)

    Anti-inflammatory effects are plausible as a polyphenol-class pattern, but resveratrol-specific clinical superiority is not established. Tomé-Carneiro 2012 reported favorable inflammatory and fibrinolytic markers in CVD-risk patients, while Akbari 2020 found mixed lipid…

    Read the Resveratrol report →
  55. Retatrutide

    5.0 /10 for inflammation 5.6/10 overall Neutral Metabolic & Incretin Peptide

    The practical anti-inflammatory read on Retatrutide is 5.0/10 because Jastreboff 2023 anchors the strongest signal. The existing rationale points to this narrower claim: Inflammation may improve secondarily through fat loss, liver-fat reduction,…

    Read the Retatrutide report →
  56. Thymosin Beta-4 (Tβ4)

    4.6 /10 for inflammation 7.2/10 overall Strong recommend Growth & Repair Peptide

    Anti-inflammatory action is well-supported preclinically and biologically, but human direct-inflammation endpoints are thin. Tβ4 dampens NF-κB-driven cytokine output, and its cleavage product Ac-SDKP is independently anti-inflammatory and antifibrotic across heart, kidney, and…

    Read the Thymosin Beta-4 (Tβ4) report →
  57. Saffron

    4.5 /10 for inflammation 8.0/10 overall Strong recommend Botanical Extract (non-adaptogenic)

    Anti-inflammatory effects are mechanistically supported and appear in cardiometabolic and retinal models, but clinical inflammatory endpoints are weaker than mood and sleep outcomes.

    Read the Saffron report →
  58. Berberine

    4.5 /10 for inflammation 6.8/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Vahedi-Mazdabadi 2023 supports inflammatory-biomarker reductions in randomized trials involving berberine or barberry. Translation to clinical inflammatory disease outcomes remains narrower than the mechanism suggests.

    Read the Berberine report →
  59. ARA-290 (Cibinetide)

    4.5 /10 for inflammation 6.5/10 overall Worth trying Growth & Repair Peptide

    Anti-inflammatory action is the core mechanism, well supported preclinically but thin on direct human inflammation endpoints. Activating the innate repair receptor dampens innate immune-cell activation and reprograms a tissue-damaging environment into a…

    Read the ARA-290 (Cibinetide) report →
  60. MOTS-c

    4.5 /10 for inflammation 6.5/10 overall Worth trying Mitochondrial & Longevity Peptide

    Zhai 2017 showed anti-inflammatory and anti-MRSA effects in mice, including reduced pro-inflammatory cytokine signaling. This supports a preclinical inflammation signal but not a human anti-inflammatory indication.

    Read the MOTS-c report →
  61. Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga)

    4.5 /10 for inflammation 5.8/10 overall Worth trying Functional Mushroom

    Consistent preclinical anti-inflammatory signal across reishi, cordyceps, and chaga polysaccharides and triterpenes, plus an O. sinensis dialysis meta-analysis showing lower CRP, but human outcome certainty is low.

    Read the Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga) report →
  62. Pine Pollen

    4.5 /10 for inflammation 5.7/10 overall Neutral Adaptogenic Herb

    Anti-inflammatory use lands at 4.5 out of 10. Choi 2007 showed Pinus densiflora pollen extract at 100 to 200 mg/kg inhibited formalin pain and carrageenan edema in mice comparably to indomethacin, and…

    Read the Pine Pollen report →
  63. TRT (Testosterone Replacement Therapy)

    4.5 /10 for inflammation 5.7/10 overall Neutral Pharmaceutical & Drug

    TRT may modestly improve inflammatory markers in hypogonadal men with metabolic syndrome, but it is not a primary anti-inflammatory therapy. Lifestyle, adiposity reduction, periodontal care, sleep, and omega-3 status usually matter more.

    Read the TRT (Testosterone Replacement Therapy) report →
  64. SLU-PP-332

    4.5 /10 for inflammation 4.7/10 overall Neutral Research Compound

    ERR activation modulated inflammatory gene expression in preclinical kidney models. Wang et al. 2023 supports a mouse anti-inflammatory signal, but there is no human CRP, cytokine, symptom, or inflammatory-disease endpoint.

    Read the SLU-PP-332 report →
  65. Full-Spectrum Hemp (CBD)

    4.2 /10 for inflammation 6.5/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Strong preclinical anti-inflammatory mechanism but limited direct human outcome data; rated cautiously below neutral pending controlled human inflammatory-marker trials.

    Read the Full-Spectrum Hemp (CBD) report →
  66. Blood-Flow Restriction Training

    4.0 /10 for inflammation 8.2/10 overall Strong recommend Resistance & Strength

    Some inflammatory-marker shifts appear in exercise studies, but BFR-specific anti-inflammatory evidence is limited and secondary.

    Read the Blood-Flow Restriction Training report →
  67. NAC (N-Acetylcysteine)

    4.0 /10 for inflammation 8.0/10 overall Strong recommend Amino Acid

    Glutathione repletion lowers oxidative and inflammatory load mechanistically, but dedicated anti-inflammatory clinical endpoints are inconsistent across trials.

    Read the NAC (N-Acetylcysteine) report →
  68. Sprinting (Sprint Interval Training)

    4.0 /10 for inflammation 6.9/10 overall Worth trying Cardiovascular

    Chronic training lowers systemic inflammation over months, but the all-out efforts of SIT are an acute oxidative and inflammatory stressor; net benefit depends on adequate recovery between sessions.

    Read the Sprinting (Sprint Interval Training) report →
  69. Colostrum

    4.0 /10 for inflammation 6.8/10 overall Worth trying Vitamin & Mineral & Nutrient

    Lactoferrin, PRPs, and gut-barrier effects support an anti-inflammatory rationale, but human outcomes are indirect. Hajihashemi 2024 describes mixed gastrointestinal disease findings rather than broad anti-inflammatory clinical proof.

    Read the Colostrum report →
  70. Thymulin (Zinc-Thymulin)

    4.0 /10 for inflammation 6.6/10 overall Worth trying Immune Peptide

    Thymulin suppresses inflammatory signaling across several animal and cell models. It selectively reduced LPS-induced IL-1beta and blocked NF-kappaB nuclear movement in an alveolar model, per Haddad 2009, and it modulated NF-kappaB and…

    Read the Thymulin (Zinc-Thymulin) report →
  71. Chlorella

    4.0 /10 for inflammation 6.5/10 overall Worth trying Vitamin & Mineral & Nutrient

    Reductions in cardiovascular and liver markers are consistent with lower inflammatory load, but few chlorella trials measure inflammation directly as the primary endpoint, keeping this an inferred rather than demonstrated benefit.

    Read the Chlorella report →
  72. SS-31 (Elamipretide)

    4.0 /10 for inflammation 6.0/10 overall Worth trying Mitochondrial & Longevity Peptide

    Reduces mitochondrial ROS-driven inflammatory signaling in the mechanism literature, but human inflammatory biomarker evidence is limited and not a primary clinical endpoint strength.

    Read the SS-31 (Elamipretide) report →
  73. Exogenous Ketones

    4.0 /10 for inflammation 5.9/10 overall Worth trying Exogenous Metabolite

    BHB inhibits the NLRP3 inflammasome in preclinical models, a real and interesting mechanism, but human anti-inflammatory outcome data for exogenous ketones is sparse. Mechanism outpaces clinical proof.

    Read the Exogenous Ketones report →
  74. C15 (Pentadecanoic Acid)

    4.0 /10 for inflammation 4.9/10 overall Neutral Vitamin & Mineral & Nutrient

    Robinson 2024 (Robinson 2024) did not show a reliable full-cohort hs-CRP benefit over 12 weeks. Phang / Chooi TANGO did not establish systemic inflammatory-marker reduction as the main C15-specific outcome. Claims around…

    Read the C15 (Pentadecanoic Acid) report →
  75. Pentosan Polysulfate (Elmiron)

    4.0 /10 for inflammation 4.7/10 overall Neutral Other Pharmaceutical

    The anti-inflammatory effect is mechanistically well-described, especially for joints, where pentosan lowers inflammatory mediators and helps normalize joint fluid, per Ghosh 1999. That maps onto the clinical improvements seen in the small…

    Read the Pentosan Polysulfate (Elmiron) report →
  76. Tongkat Ali

    3.8 /10 for inflammation 7.0/10 overall Strong recommend Adaptogenic Herb

    Cortisol reduction is adjacent to inflammation control, but no direct CRP, IL-6, or clinical inflammatory-disease RCT supports a higher score.

    Read the Tongkat Ali report →
  77. VIP (Vasoactive Intestinal Peptide)

    3.8 /10 for inflammation 5.4/10 overall Neutral Neuropeptide

    Anti-inflammatory activity is VIP's best-characterized and most defensible claim, and it is the use most people are chasing. The cleanest human demonstration is a 4-week open-label inhaled-VIP study in 20 sarcoidosis patients…

    Read the VIP (Vasoactive Intestinal Peptide) report →
  78. Full-Body EMS

    3.5 /10 for inflammation 7.3/10 overall Strong recommend Resistance & Strength

    Muscle contraction releases myokines that can support lower inflammatory tone, but WB-EMS trials do not consistently improve inflammatory biomarkers. The score reflects indirect exercise physiology rather than direct anti-inflammatory evidence.

    Read the Full-Body EMS report →
  79. Rucking (Weighted Walking)

    3.5 /10 for inflammation 7.3/10 overall Strong recommend Cardiovascular

    Indirect. Regular moderate aerobic exercise lowers chronic inflammatory markers, but excessive loaded volume can raise them; the net depends on dose and recovery.

    Read the Rucking (Weighted Walking) report →
  80. Hyaluronic Acid

    3.5 /10 for inflammation 6.8/10 overall Worth trying Vitamin & Mineral & Nutrient

    Anti-inflammatory effects rate 3.5/10. Any benefit is indirect via joint and tissue support rather than systemic inflammatory-marker suppression. HA is not a reliable way to move CRP or IL-6, and trials do…

    Read the Hyaluronic Acid report →
  81. Apigenin

    3.5 /10 for inflammation 6.7/10 overall Worth trying Botanical Extract (non-adaptogenic)

    NF-kB suppression and IKK inhibition are well-characterized in cell and rodent inflammation models. Salehi 2019 summarizes broad preclinical anti-inflammatory data. No human RCT has measured inflammatory markers as a primary endpoint for…

    Read the Apigenin report →
  82. NMN (Nicotinamide Mononucleotide)

    3.5 /10 for inflammation 6.3/10 overall Worth trying Exogenous Metabolite

    NAD+ biology intersects with inflammatory pathways, but human NMN anti-inflammatory outcomes are not established. Keep this in the indirect-mechanism bucket.

    Read the NMN (Nicotinamide Mononucleotide) report →
  83. NR (Nicotinamide Riboside)

    3.5 /10 for inflammation 6.1/10 overall Worth trying Exogenous Metabolite

    Elhassan 2019, Norheim 2024, and Ahmadi 2025 support inflammatory-marker interest, but clinical outcome translation remains early.

    Read the NR (Nicotinamide Riboside) report →
  84. Quinton Marine Plasma (Seawater Minerals)

    3.5 /10 for inflammation 5.9/10 overall Worth trying Vitamin & Mineral & Nutrient

    Nasal irrigation reduces local inflammatory symptoms, but there is no systemic anti-inflammatory marker trial of the oral product.

    Read the Quinton Marine Plasma (Seawater Minerals) report →
  85. Collagen Peptides

    3.0 /10 for inflammation 7.6/10 overall Strong recommend Amino Acid

    UC-II has an immune-tolerance mechanism relevant to synovial inflammation, and Lugo 2013 supports joint-function benefit in healthy adults. Systemic inflammation endpoints remain weak.

    Read the Collagen Peptides report →
  86. Bromantane (Ladasten)

    3.0 /10 for inflammation 7.1/10 overall Strong recommend Other Pharmaceutical

    TNF-alpha and IL-6 reductions in mouse LPS-depression model (Tallerova 2011) and IL-6, IL-17, IL-4 reductions in C57BL/6 anxious-depression model (Tallerova 2011 EKF). No human inflammation RCT.

    Read the Bromantane (Ladasten) report →
  87. Semax

    3.0 /10 for inflammation 7.1/10 overall Strong recommend Neuropeptide

    Post-ischemic immune and inflammatory gene-expression effects appear in Medvedeva et al. 2014, but Semax is not a primary anti-inflammatory intervention for systemic conditions.

    Read the Semax report →
  88. Selank

    3.0 /10 for inflammation 6.9/10 overall Worth trying Neuropeptide

    Inflammation-gene modulation exists in mouse spleen models, including Kolomin 2014, but Selank is not a proven anti-inflammatory therapy.

    Read the Selank report →
  89. Epitalon

    3.0 /10 for inflammation 6.7/10 overall Worth trying Mitochondrial & Longevity Peptide

    Antioxidant and oxidative-stress findings imply possible downstream anti-inflammatory effects, but direct inflammatory-marker evidence is thin. No verified human Epitalon trial measured CRP, IL-6, TNF-alpha, pain inflammation, or disease-specific inflammatory outcomes.

    Read the Epitalon report →
  90. Orforglipron (Foundayo)

    3.0 /10 for inflammation 5.8/10 overall Worth trying Weight-Management Drug (non-peptide)

    hsCRP fell across trials, consistent with weight loss; not an anti-inflammatory drug in its own right.

    Read the Orforglipron (Foundayo) report →

Comparisons that judge inflammation

Head-to-head reports and category rankings that name a winner on this use case.

4 more comparisons touch on inflammation →

Questions about inflammation

What scores highest for inflammation?

Molecular Hydrogen, at 8.0 out of 10 for inflammation. Molecular Hydrogen earns 8.0/10 for inflammation control because LeBaron 2020 reports 60 participants over 24 weeks; reported improved lipids, glucose, HbA1c, inflammatory markers, and redox markers.

What is the cheapest thing that works for inflammation?

Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 7.0 out of 10 for inflammation.

How many interventions has Outliyr scored for inflammation?

90 of the 129 interventions evaluated for inflammation score 3.0 out of 10 or better, which is the cut-off for appearing on this page.