Every intervention Outliyr has scored for oxidative stress, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for oxidative stress; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
61 of 113 evaluated interventions score 3.0+ out of 10 for oxidative stress · 13 comparisons
Kang 2011 reports Hydrogen-rich water improved quality-of-life and oxidative-stress direction during liver-tumor radiotherapy without reducing tumor response. Ohsawa 2007 points in the same direction, but route, dose, baseline status, and outcome tracking…
Rodrigues 2025 reports 4 RCTs; improved follicular-fluid total antioxidant capacity; inconsistent or unclear effects on MDA, catalase, SOD, fertilization rates, or pregnancy outcomes. Malcangi 2026 points in the same direction, but route,…
Kumar 2023 anchors the most relevant signal. Glycine fits antioxidant because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the endpoint. The score stays bounded because many…
It is the rate-limiting precursor to glutathione, the body's master intracellular antioxidant, a mechanism characterized in detail by Bavarsad Shahripour 2014. It also acts as a direct sulfhydryl scavenger. The clinical proof…
Human trials showed dose-dependent reductions in oxidized LDL after three weeks of olive-polyphenol intake. The caveat is that classic blood antioxidant-capacity assays overstate the story; the meaningful effect is targeted protection of…
High-Dose Melatonin scores highest for antioxidant use because the verified mechanism literature supports mitochondrial access, metabolite recycling, and both water-soluble and fat-soluble radical handling. The Reiter review describes melatonin as an antioxidant…
Melanotan I has credible photoprotection relevance because MC1R activation increases eumelanin, which reduces UV-induced oxidative stress and helps EPP patients tolerate sunlight. In the pivotal EPP publication, afamelanotide increased pain-free sun exposure…
Tzang 2024 reports 25 RCTs and 1024 participants; lower SBP, DBP, fasting blood glucose, and triglycerides; no significant adverse-effect excess. Tzang 2024 points in the same direction, but route, dose, baseline status,…
Karu 2010 supports mitochondrial signaling that can produce a hormetic redox response. The key word is hormetic: a small reactive-oxygen-species pulse can train endogenous antioxidant systems, while excessive dosing may flatten or…
It is a water-soluble reducing agent that neutralizes reactive oxygen species directly and regenerates oxidized vitamin E, and plasma and tissue antioxidant markers reliably rise with intake. The boundary is clinical: a…
GHK-Cu keeps the antioxidant score because copper handling, SOD-related biology, and gene-expression analyses point in the same direction. Pickart 2012 reviewed oxidative-stress and neuroinflammation pathways, but antioxidant status has not been proven…
Kihara 2002 anchors the strongest signal. The existing rationale points to this narrower claim: Heat stress can create hormetic oxidative signaling that trains endogenous defenses, but direct human antioxidant-marker evidence for infrared…
Kumar 2023 reported red-cell glutathione rose 225 percent and the oxidative markers TBARS and F2-isoprostane each fell 72 percent at 16 weeks, a much larger effect than oral glutathione achieves. The original…
Cheah 2017 gave healthy adults pure ergothioneine at 5 to 25 mg and confirmed it is avidly absorbed, retained with under 4% urinary loss, and concentrates in red blood cells and tissues…
Both fisetin and quercetin are flavonoid polyphenols; Guan 2024 found dietary senotherapeutic evidence is mostly animal-level and human evidence remains limited. The score stays bounded because Senolytics evidence for antioxidant can depend…
The mechanism is foundational rather than speculative: glutathione is the cell's master redox buffer and the cofactor for glutathione peroxidase. The catch is translation. Richie 2015 showed 6 months of 1,000 mg/day…
Melatonin deserves a moderate antioxidant score because melatonin and its metabolites act in both water and lipid compartments and enter mitochondria. The broad pharmacology review summarizes antioxidant, circadian, and immune roles across…
Pandit 2016 anchors the most relevant signal. Shilajit fits antioxidant when purified resin is matched to hormones, sperm parameters, strength fatigue, bone markers, or energy tracking. The score stays bounded because most…
Ramsay 2007 supports direction more than certainty. The existing rationale points to this narrower claim: Methylene blue can act as a low-dose redox cycler, but antioxidant claims are dose-dependent and easy to…
The evidence points to a plausible use case without proving a universal response. Ehlers JP et al. 2024 is the best anchor here because it reports 176 participants randomized and missed primary…
Antioxidant support is plausible through iron sequestration and reduced hydroxyl-radical formation, but human outcome data are indirect. Pollio 2024 gives a small hyperferritinemia signal, and Berthon 2026 supports inflammatory-marker modulation. This does…
It is a defining feature of the molecule, not a marketing claim. CoQ10 is the main lipid-phase antioxidant in cell membranes and lipoproteins, where it regenerates vitamin E and limits LDL oxidation.…
The evidence points to a plausible use case without proving a universal response. Di Marco et al. 2019 is the best anchor here because it reports retinal neuroprotection review tying animal, mechanistic,…
Antioxidant biology is the cleanest single sulforaphane mechanism story. NRF2 target gene activation drives glutathione synthesis, glutathione S-transferases, NQO1, and HO-1, supporting endogenous antioxidant capacity rather than direct radical scavenging. Itoh 1997…
Filip 2007 supports the strongest part of the claim. The existing rationale points to this narrower claim: Indirect via TCA substrate support and redox cycling; no direct antioxidant-marker RCTs in humans. Animal…
Fucoidan reliably reduces oxidative-stress markers in preclinical models, and the human cytokine and inflammation data from Takahashi 2018 point in a consistent direction. The score stays mid-range because most direct antioxidant evidence…
Semaglutide can reduce oxidative burden by improving obesity, glucose, and inflammation, but it is not a primary redox therapy. Lincoff 2023 gives hard-outcome support for cardiometabolic risk reduction, which is more important…
Sagai 2011 reports Personally verified mechanism review; Nrf2 activation, NF-kB modulation, lipid oxidation products, dose-toxicity tension. The score stays conditional because Ozone Therapy still needs better outcome data for this exact use…
Curcumin activates the Nrf2 pathway, which upregulates your own antioxidant enzymes like glutathione and superoxide dismutase rather than acting as a direct scavenger. Human biomarker studies show reduced oxidative-stress markers alongside the…
Lang 2024 supports the strongest part of the claim. The existing rationale points to this narrower claim: Moderate aerobic exercise acts as a hormetic stressor that upregulates endogenous antioxidant defenses. The score…
Hagiyama 2024 reports 12 RCTs; 622 patients; low-certainty improvement in patient-reported outcomes and very-low-certainty strength signal after lower-limb surgeries. Wittholz 2024 points in the same direction, but route, dose, baseline status, and…
The pooled human data is mixed. Mohiti 2021 pooled 11 trials in 465 participants and found malondialdehyde reduction that did not reach significance, with IL-6 and TBARS trending down but non-significant. Individual…
Menon 2025 anchors the most relevant signal. Lion's Mane fits antioxidant when the goal is gentle mushroom-based support for cognition, mood, nerve biology, or gut-immune signaling over weeks. The score stays bounded…
Chlorella carries chlorophyll, beta-carotene, lutein, and vitamin C, and the cardiovascular meta-analysis by Fallah 2018 is consistent with reduced oxidative and inflammatory load, but few trials measure oxidative-stress endpoints directly with chlorella…
Mao 2012 showed that pine pollen at 500 to 1500 mg/kg restored antioxidant enzyme activity and lowered IL-6 and TNF-alpha in a D-galactose mouse aging model, and Zhou 2018 reported strong DPPH…
Antioxidant capacity is the headline chaga claim and the weakest in humans. The Ern 2023 review documents strong antioxidant and anti-inflammatory activity from chaga polysaccharides, triterpenoids, and phenolics, but the evidence is…
Melanotan II has a limited antioxidant-adjacent score through UV-pigmentation biology rather than systemic redox evidence. The tanning mechanism increases melanin, which can reduce UV injury in the skin, but MT-II lacks the…
Metformin can reduce mitochondrial electron pressure in some contexts, but antioxidant benefit is indirect and not a primary clinical outcome. Healthy users may experience mitochondrial training tradeoffs instead.
Mechanistic stress-resistance biology overlaps with redox pathways, but rapamycin is not an antioxidant intervention in human evidence.
Indirect exercise-like hormesis. The 2024 anti-inflammatory meta-analysis by Wang et al. supports endpoint-specific immune modulation, not a clean antioxidant intervention.
Antioxidant support is mechanistically credible through Nrf2 and related pathways, but human endpoint evidence is not as strong as stress evidence. Withanolide signaling can shift endogenous antioxidant defenses, yet this remains a…
Strong chemistry and cell-level antioxidant signals are documented in Rice-Evans 1996 and Bors 1997. LDL oxidation by macrophages is inhibited in vitro (de Whalley 1990). Sarcoidosis users showed reductions in oxidative stress…
Indirect via metabolic improvement and visceral-fat reduction; no direct antioxidant mechanism or endpoint was audit-verified.
The mechanism is still hypothesis-stage. The fullerene cage may interact with reactive oxygen chemistry, and preclinical work such as the Prylutskyy skeletal-muscle cluster suggests an antioxidant signal, but no human trial has…
Intervals create hormetic oxidative stress that can upregulate endogenous antioxidant systems. Too much high-intensity work flips the signal toward excess stress rather than adaptation.
Indirect antioxidant role via mitophagy and cleanup of damaged cellular components.
Antioxidant status improvement is one of the better-supported secondary signals. Kozina 2007 specifically investigated antioxidant properties of pineal geroprotective peptides, but the strongest evidence remains animal and Russian-lab centered rather than independently…
Sprints create hormetic oxidative stress that can upregulate endogenous antioxidant defenses. Too much maximal work without recovery flips the signal toward excess stress rather than adaptation.
HBOT increases oxidative stress acutely and may upregulate antioxidant defenses. Leveque 2023 documents increased ROS and adaptive antioxidant response after hyperbaric exposure. Muth 2004 documents oxidative stress markers. The use case is…
Training-related reactive oxygen signaling may occur, but BFR-specific antioxidant adaptation data are not a main evidence pillar.
Oxidative-stress changes appear secondary to inflammation and immune regulation, not direct antioxidant action. No robust human antioxidant-marker program supports thymosin alpha-1 as a primary antioxidant.
Nrf2 and oxidative-stress signaling appear in preclinical models, but clinical antioxidant endpoints are modest and secondary. Berberine should not be scored like a direct antioxidant nutrient.
Omega-3 is oxidation-prone rather than directly antioxidant. Any antioxidant-like effect is indirect through inflammation resolution, and rancid oil can cut the other direction.
In-vitro antioxidant activity appears in reviews such as Rehman 2016, but human oxidative-stress biomarker trials are not strong enough to make this a main use case.
Blocking oxidative stress toxicity was one of J-147's founding assay readouts in neurons. Mechanistic and preclinical.
ROS scavenging and SOD or catalase upregulation appear in cell and rodent models. Shukla 2010 reviews apigenin's antioxidant and cancer-prevention mechanisms. Clinical antioxidant significance at standard supplemental doses remains unknown.
Mild uncoupling lowers mitochondrial reactive oxygen species, and a strong antioxidant effect accompanied the metabolic benefit in mice (Alexopoulos et al. 2020). Animal only.
ERR signaling can interact with oxidative-stress biology, and Bonanni et al. 2025 found ex vivo shifts in oxidative-stress-related myoblast markers. That is not enough to call SLU-PP-332 an antioxidant in humans.
Reduces oxidative stress markers in tissue injury models. The effect is better framed as cytoprotection inside injury models than as a broad antioxidant supplement.
NMN supports redox metabolism rather than acting as a direct antioxidant. Human oxidative-stress outcome evidence remains thin.
Trace minerals support antioxidant enzyme cofactors in theory, but no human oxidative-stress marker trial tested Quinton.
Nothing matches those filters.
Monthly out-of-pocket cost at the most accessible legitimate channel, at the dose the score was given for. 18 of 61 are not priced yet; those cells are left blank rather than guessed.
| Intervention | Monthly cost | At dose | How you get it |
|---|---|---|---|
| Molecular Hydrogen | Not priced yet | ||
| Astaxanthin | Not priced yet | ||
| Glycine | $2–$3 | 3 g oral glycine | Over the counter |
| NAC (N-Acetylcysteine) | $5–$15 | 600 to 1,200 mg/day | Over the counter |
| Polyphenols (Dietary) | Not priced yet | ||
| High-Dose Melatonin | Not priced yet | ||
| Melanotan I (Afamelanotide) | $38–$129 | Variable, microgram-to-milligram loading cycles, not clinically validated | Grey market |
| Taurine | $3–$10 | 1-3 g, 30-60 minutes before sleep | Over the counter |
| Red Light Therapy | $17–$43 | 10-20 min at 6-12 inches, full chest/face/back rotation | Over the counter |
| Vitamin C (Ascorbic Acid) | Not priced yet | ||
| GHK-Cu | $30–$100 | 0.5-3% topical serum or cream | Over the counter |
| Infrared Sauna | $36–$73 | 55-60 degrees C, 20-30 min | Over the counter |
| GlyNAC (Glycine + N-Acetylcysteine) | $10–$30 | Glycine and NAC at ~100 mg/kg/day each | Over the counter |
| Ergothioneine | Not priced yet | ||
| Senolytics | Not priced yet | ||
| Glutathione (GSH) | $20–$45 | 1,000 mg/day | Over the counter |
| Melatonin | $3–$8 | 0.5 to 3 mg | Over the counter |
| Shilajit | $25–$50 | 500 mg purified shilajit | Over the counter |
| Methylene Blue | $13–$40 | 0.5-5 mg oral | Over the counter |
| SS-31 (Elamipretide) | $200–$500 | 5-10 mg/day subcutaneous | Grey market |
| Lactoferrin | $25–$50 | 250-300 mg apolactoferrin | Over the counter |
| Coenzyme Q10 (CoQ10 / Ubiquinol) | $15–$40 | 100-200 mg/day | Over the counter |
| Saffron | Not priced yet | ||
| Sulforaphane | $25–$60 | Broccoli sprout extract delivering about 150 micromoles sulforaphane per day | Over the counter |
| Ca-AKG (Calcium Alpha-Ketoglutarate) | $15–$30 | 1 g/day generic Ca-AKG oral | Over the counter |
| Fucoidan (Brown Seaweed Polysaccharide) | Not priced yet | ||
| Semaglutide | $199–$349 | 0.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, 2.4 mg week 17 onward | Prescription |
| Ozone Therapy | $520–$2,600 | 20-30 mcg/mL ozone, roughly 1,000-1,500 mcg total per session | In clinic |
| Curcumin | $15–$40 | 500 mg curcuminoids | Over the counter |
| Zone 2 Cardio | Not priced yet | Over the counter | |
| Essential Amino Acids | Not priced yet | ||
| Spirulina | $10–$25 | 1 to 4.5 g/day | Over the counter |
| Lion’s Mane | $20–$40 | 3 g/day fruiting body extract | Over the counter |
| Chlorella | $10–$50 | 5-10 g/day | Over the counter |
| Pine Pollen | $20–$45 | 5 to 10 g powder per day | Over the counter |
| Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga) | $15–$40 | 1.5 to 1.8 g/day standardized extract | Over the counter |
| Melanotan II | $25–$55 | Variable | Research use only |
| Metformin | $4–$30 | 500 mg with dinner for 1 week, then 500 mg twice daily for 1 week, then increase by 500 mg/week toward 1000 mg twice daily as tolerated | Prescription |
| Rapamycin | $15–$50 | 3 mg | Prescription |
| Whole-Body Vibration | $50–$100 | 30 Hz, roughly 0.3g, 10-20 min standing | Over the counter |
| Ashwagandha | $15–$30 | 300 mg KSM-66 with breakfast and 300 mg with dinner | Over the counter |
| Quercetin | $20–$50 | 200 mg/day | Over the counter |
| Tirzepatide | $299–$449 | 2.5 to 5 to 7.5 to 10 to 12.5 to 15 mg | Prescription |
| C60 (Buckminsterfullerene) | Not priced yet | ||
| Norwegian 4×4 | Not priced yet | Over the counter | |
| Spermidine | $40–$90 | 1-3 mg/day oral WGE | Over the counter |
| Epitalon | $95–$1,100 | 5-10 mg/day subcutaneous | Grey market |
| Sprinting (Sprint Interval Training) | Not priced yet | ||
| Hyperbaric Oxygen Therapy | $3,000–$6,000 | 2.0 ATA for 90 minutes with air breaks | In clinic |
| Blood-Flow Restriction Training | Not priced yet | ||
| Thymosin Alpha-1 | $100–$400 | 1.6 mg subcutaneous | Prescription |
| Berberine | $15–$25 | 500 mg berberine HCl three times daily with meals | Over the counter |
| Omega-3 | $20–$40 | 1-2 g/day combined EPA+DHA | Over the counter |
| Tongkat Ali | $20–$40 | 200 mg/day Physta standardized extract | Over the counter |
| J-147 | Not priced yet | ||
| Apigenin | $15–$35 | 25-50 mg pure apigenin 30-60 min before bed | Over the counter |
| BAM15 | Not priced yet | ||
| SLU-PP-332 | $30–$80 | 3-5 mg/day oral | Research use only |
| BPC-157 | $40–$80 | 250 to 500 mcg SC 1 to 2x/day near injury site | Grey market |
| NMN (Nicotinamide Mononucleotide) | $40–$100 | 500 mg/day oral | Over the counter |
| Quinton Marine Plasma (Seawater Minerals) | Not priced yet |
Head-to-head reports and category rankings that name a winner on this use case.
Melatonin, dosed low. It scores 7.5–8.0/10 against apigenin's 5.5–6.0/10 and wins the sleep rows outright. The morning hangover apigenin markets against comes from taking too much, not from…
CoQ10 scores 7.0–7.5/10 and methylene blue 6.0–6.5/10, yet methylene blue wins eleven of the seventeen shared use cases. The overall gap is risk, not effect. Methylene blue inhibits…
Epitalon, if sleep is the question. It scores sleep quality 6.5–7.0/10 against pinealon's 1.5–2.0/10, because it acts on the pineal gland and melatonin output while pinealon is a…
Lion's Mane scores 7.0–7.5/10 and the reishi, cordyceps and chaga blend category scores 5.0–5.5/10. If cognition is the goal, buy the one species: lion's mane takes cognition-focus 7.0/10…
Melanotan I is the safer tanning peptide and it scores higher, 6.0–6.5/10 against 4.5–5.0/10. Both darken skin through the same receptor. Melanotan II hits three more receptors, which…
Sulforaphane scores 6.5–7.0/10 and glutathione 6.0–6.5/10, and both have a delivery problem. Sulforaphane needs active myrosinase or you absorb half as much. Plain oral glutathione barely raises blood…
Different liver problems. NAC scores 8.0–8.5/10 and TUDCA 6.5–7.0/10, and NAC wins liver detox 8.0–8.5/10 against 6.5–7.0/10, but its liver evidence is toxin and oxidative damage. TUDCA owns…
MOTS-c scores 6.5–7.0/10 and SS-31 6.0–6.5/10, and neither one has a human trial behind the use you want. MOTS-c takes blood sugar and body composition. SS-31 takes the…
NAC scores 8.0–8.5/10 and glutathione 6.0–6.5/10, and that gap is real. NAC is the cheaper upstream precursor with a six-decade clinical record, so start there. Glutathione earns its…
Spirulina scores 7.5–8.0/10 and chlorella 6.5–7.0/10, so spirulina is the better default for most people. It leads on blood pressure, blood sugar, inflammation and breathing. Chlorella leads on…
Taurine scores 8.0–8.5/10 and glycine 7.5–8.0/10, close enough that the overall numbers pick nothing. Taurine wins cardiovascular and metabolic endpoints outright. Glycine wins antioxidant, skin and connective tissue.…
CoQ10 scores 7.0–7.5/10 and urolithin A scores 6.5–7.0/10, so CoQ10 wins on the numbers and costs two to six times less. It takes cardiovascular, energy, antioxidant and both…
Molecular Hydrogen, at 8.5–9.0 out of 10 for oxidative stress. Kang 2011 reports Hydrogen-rich water improved quality-of-life and oxidative-stress direction during liver-tumor radiotherapy without reducing tumor response.
Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 8.0–8.5 out of 10 for oxidative stress.
C60 (Buckminsterfullerene) scores 4.5–5.0 out of 10 for oxidative stress but only 4.0–4.5 overall, landing in the caution tier once safety, side effects, cost and effort are counted.
61 of the 113 interventions evaluated for oxidative stress score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
