Best Interventions for Heart Health, Ranked by Evidence

Every intervention Outliyr has scored for heart health, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for heart health; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.

74 of 136 evaluated interventions score 3.0+ out of 10 for heart health · 28 comparisons

Ranked for Heart Health

Category
  1. Taurine

    9.0–9.5 /10 for heart health 8.0–8.5/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Guan 2020 reports Confirmed meta-analysis on obesity, BP, and lipid outcomes; supports cardiometabolic breadth. Tzang 2024 points in the same direction, but route, dose, baseline status, and outcome tracking decide whether Taurine…

  2. Norwegian 4×4

    8.5–9.0 /10 for heart health 8.0–8.5/10 overall Strong recommend Cardiovascular

    The Norwegian 4x4 protocol combines four minutes of near-maximal effort with three minutes of active recovery, a pattern that consistently outperforms moderate continuous training in heart-failure and post-infarction cohorts. While the multicenter…

  3. Zone 2 Cardio

    8.5–9.0 /10 for heart health 8.0–8.5/10 overall Strong recommend Cardiovascular

    Lang 2024 is the cleanest verified anchor for this report. The existing rationale points to this narrower claim: Cardiorespiratory fitness is one of the strongest health predictors in the literature. this verified…

  4. Traditional Sauna (Finnish Dry-Heat)

    8.5–9.0 /10 for heart health 7.5–8.0/10 overall Strong recommend Sauna & Heat Therapy

    In the KIHD cohort, Laukkanen 2015 found 4 to 7 weekly sessions associated with a fatal cardiovascular disease hazard ratio of 0.50 and a sudden cardiac death hazard ratio of 0.37 versus…

  5. Infrared Sauna

    8.0–8.5 /10 for heart health 7.0–7.5/10 overall Strong recommend Sauna & Heat Therapy

    Hamaya 2025 is the cleanest verified anchor for this report. The existing rationale points to this narrower claim: Waon therapy clinical data support cardiovascular benefit when supervised: this verified source reported improved…

  6. HRV Biofeedback

    8.0–8.5 /10 for heart health 9.0–9.5/10 overall Top-tier Wearable & Tracker

    Slow-breathing meta-analyses support clinically meaningful systolic blood-pressure reduction in nonclinical populations per the broader 2024 Shao Mindfulness review of slow-breathing interventions; baroreflex sensitivity improves measurably with practice. The score stays bounded because…

  7. Magnesium

    8.0–8.5 /10 for heart health 8.5–9.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Argeros 2025 anchors the most relevant signal. Magnesium fits cardiovascular when low intake, stress load, mineral loss, or a form-specific target makes deficiency correction plausible. The score stays bounded because effects are…

  8. Semaglutide

    8.0–8.5 /10 for heart health 6.0–6.5/10 overall Worth trying Metabolic & Incretin Peptide

    Lincoff 2023 reported 20% lower 3-point MACE in adults with overweight or obesity and established CVD without diabetes. That makes Semaglutide more than a weight-loss drug for high-risk patients. The effect likely…

  9. Polyphenols (Dietary)

    7.5–8.0 /10 for heart health 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Sesso 2022, the COSMOS RCT in 21,442 older adults, found a cocoa-flavanol supplement (500 mg/day) cut cardiovascular death 27 percent (HR 0.73) over a median 3.6 years, though the primary composite missed…

  10. Spermidine

    7.5–8.0 /10 for heart health 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Kiechl 2018 is the cleanest verified anchor for this report. The existing rationale points to this narrower claim: this verified source supports cardiac autophagy and diastolic-function mechanisms in animals; this verified source…

  11. Tirzepatide

    7.5–8.0 /10 for heart health 6.0–6.5/10 overall Worth trying Metabolic & Incretin Peptide

    Tirzepatide shows promise for heart-failure with preserved ejection fraction in obese patients, where a trial demonstrated reduced composite clinical events and better health status versus placebo. The evidence tier remains moderate because…

  12. Spirulina

    7.5–8.0 /10 for heart health 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    The blood-pressure signal is real and replicated. Machowiec 2021 pooled 5 randomized trials in 230 subjects and found systolic pressure falling 4.59 mmHg and diastolic falling 7.02 mmHg, with the largest effect…

  13. Coenzyme Q10 (CoQ10 / Ubiquinol)

    7.5–8.0 /10 for heart health 7.0–7.5/10 overall Strong recommend Vitamin & Mineral & Nutrient

    The evidence reaches hard outcomes, not just biomarkers. In chronic heart failure, Mortensen 2014 (Q-SYMBIO, n=420) found 300 mg/day cut major adverse cardiac events from 26% to 15% (hazard ratio 0.50) and…

  14. Molecular Hydrogen

    7.0–7.5 /10 for heart health 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Jamialahmadi 2024 reports 7 trials; reported reductions in total cholesterol, triglycerides, and LDL, with no significant HDL change. Ye 2026 points in the same direction, but route, dose, baseline status, and outcome…

  15. Metformin

    7.0–7.5 /10 for heart health 6.5–7.0/10 overall Worth trying Metabolic & Glycemic Drug

    UKPDS reported lower myocardial infarction and all-cause mortality in overweight patients with newly diagnosed type 2 diabetes UK Prospective Diabetes Study Group 1998. A 10-year post-trial follow-up found that the Metformin subgroup…

  16. Rucking (Weighted Walking)

    7.0–7.5 /10 for heart health 7.0–7.5/10 overall Strong recommend Cardiovascular

    Rucking is built on walking, the movement with the strongest population mortality data. A 15-cohort meta-analysis of 47,471 adults found the highest step quartile had a hazard ratio of 0.47 for all-cause…

  17. Sprinting (Sprint Interval Training)

    7.0–7.5 /10 for heart health 6.0–6.5/10 overall Worth trying Cardiovascular

    Weston 2014 found interval training raised VO2peak about 3 mL/kg/min more than moderate continuous training in cardiometabolic-disease patients, roughly double the improvement. Under medical supervision, even high-intensity work is well tolerated in…

  18. Berberine

    6.5–7.0 /10 for heart health 6.5–7.0/10 overall Worth trying Botanical Extract (non-adaptogenic)

    LDL-C, triglycerides, and total cholesterol improve in dyslipidemic adults in Koppen 2017 and Blais 2023. The PCSK9, NPC1L1, and bile-acid mechanisms make cardiovascular use more credible than generic wellness use, but berberine…

  19. Blood-Flow Restriction Training

    6.5–7.0 /10 for heart health 8.0–8.5/10 overall Strong recommend Resistance & Strength

    Systemic reviews such as Miller 2021 describe vascular and cardiovascular effects, but the hemodynamic response requires population-specific caution. The score stays bounded because Blood-Flow Restriction Training evidence for cardiovascular can depend on…

  20. Astaxanthin

    6.5–7.0 /10 for heart health 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Laurindo 2025 reports 8 randomized controlled studies; 312 randomized participants by included-study table; triglycerides and HDL-C improved; LDL-C and total cholesterol were not significant; certainty low to very low. American points in…

  21. BPC-157

    6.5–7.0 /10 for heart health 7.5–8.0/10 overall Strong recommend Growth & Repair Peptide

    Vasireddi 2025 anchors the most relevant signal. BPC-157 fits cardiovascular when the target is tissue repair, vascular recruitment, or inflammation control, but the case still rests mostly on preclinical models. The score…

  22. TB-500 (Thymosin Beta-4 Fragment)

    6.5–7.0 /10 for heart health 7.5–8.0/10 overall Strong recommend Growth & Repair Peptide

    Cardiac repair evidence is mostly preclinical. Bock-Marquette 2004 showed improved cardiac function after coronary ligation in mice, while Zhou 2011 found TB4 did not reprogram epicardial cells into cardiomyocytes after myocardial infarction.…

  23. Rapamycin

    6.5–7.0 /10 for heart health 6.5–7.0/10 overall Worth trying Longevity & mTOR Drug

    Harrison 2009 anchors the most relevant signal. Rapamycin fits cardiovascular when mTORC1 modulation, autophagy, immune aging, or senescence biology is the actual target. The score stays bounded because human longevity endpoints remain…

  24. Ergothioneine

    6.5–7.0 /10 for heart health 6.5–7.0/10 overall Worth trying Vitamin & Mineral & Nutrient

    The observational signal is unusually consistent. Smith 2020 followed 3,236 adults for a median 21.4 years and found each 1 SD higher plasma ergothioneine tracked with a coronary-disease hazard ratio of 0.85…

  25. Chlorella

    6.5–7.0 /10 for heart health 6.5–7.0/10 overall Worth trying Vitamin & Mineral & Nutrient

    Fallah 2018 pooled 19 RCTs (n=797) and found total cholesterol down 9.09 mg/dL, LDL down 8.32 mg/dL, and systolic blood pressure down 4.51 mmHg, all statistically significant. The effect sizes are modest,…

  26. Senolytics

    6.0–6.5 /10 for heart health 6.5–7.0/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Senescent endothelial-cell clearance supports vascular function in preclinical models; human cardiovascular outcome data for F+Q is absent. The score stays bounded because Senolytics evidence for cardiovascular can depend on age, disease context,…

  27. Resveratrol

    6.0–6.5 /10 for heart health 5.5–6.0/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Resveratrol's most credible signal is cardiovascular-risk support rather than broad prevention. Tomé-Carneiro 2012 reported inflammatory and fibrinolytic improvements with a grape nutraceutical in primary CVD prevention, but this corpus has product and…

  28. Electrolytes

    6.0–6.5 /10 for heart health 8.5–9.0/10 overall Top-tier Vitamin & Mineral & Nutrient

    Borra 2025 is the cleanest verified anchor for this report. The existing rationale points to this narrower claim: Potassium intake improves blood pressure and cardiovascular risk factors per this verified source; magnesium…

  29. Vitamin D3 + K2

    6.0–6.5 /10 for heart health 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Knapen 2015 anchors the most relevant signal. Vitamin D3 + K2 fits cardiovascular when deficiency, bone risk, immune seasonality, or fat-soluble nutrient gaps are present. The score stays bounded because benefits are…

  30. Vitamin C (Ascorbic Acid)

    6.0–6.5 /10 for heart health 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    The Juraschek 2012 meta-analysis of 29 randomized trials (median dose 500 mg/day, median 8 weeks) found a pooled systolic reduction of 3.84 mmHg, rising to 4.85 mmHg in hypertensive participants, with a…

  31. Omega-3

    6.0–6.5 /10 for heart health 6.5–7.0/10 overall Worth trying Vitamin & Mineral & Nutrient

    The evidence points to a plausible use case without proving a universal response. Abuknesha et al. 2025 is the best anchor here because it reports 34 randomized trials, 114,326 participants and atrial…

  32. Tesamorelin

    6.0–6.5 /10 for heart health 6.0–6.5/10 overall Worth trying Growth Hormone Secretagogue

    Tesamorelin improves some cardiometabolic risk surrogates through VAT reduction, triglyceride changes, inflammatory-marker shifts, and possibly carotid or adipose-quality pathways. Stanley 2011 supports inflammatory-marker improvement tied to VAT response. The score stays bounded…

  33. Exogenous Ketones

    6.0–6.5 /10 for heart health 5.5–6.0/10 overall Worth trying Exogenous Metabolite

    The most interesting therapeutic-adjacent signal. Nielsen 2019 gave acute 3-hydroxybutyrate to 16 chronic heart-failure patients and saw cardiac output rise about 2.0 L per minute with an 8-point bump in ejection fraction,…

  34. Retatrutide

    6.0–6.5 /10 for heart health 5.5–6.0/10 overall Neutral Metabolic & Incretin Peptide

    Rosenstock 2023 makes the claim plausible but incomplete. The existing rationale points to this narrower claim: Weight, blood pressure, triglyceride, glucose, and inflammation markers likely move favorably, but no completed cardiovascular outcomes…

  35. Glycine

    5.5–6.0 /10 for heart health 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Soh 2024 anchors the most relevant signal. Glycine fits cardiovascular because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the endpoint. The score stays bounded because many…

  36. Time-Restricted Eating

    5.5–6.0 /10 for heart health 6.5–7.0/10 overall Worth trying Fasting Protocol

    Liu D et al. 2022 is the best anchor here because it reports 139 participants adults with obesity and TRE plus calorie restriction did not add significant weight-loss or cardiometabolic advantage over…

  37. Quercetin

    5.5–6.0 /10 for heart health 6.5–7.0/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Quercetin lowers systolic BP by about 3.04 mmHg and diastolic BP by about 2.63 mmHg in the Serban 2016 meta-analysis of 7 RCTs (n=587), with effects strongest at doses 500 mg/day or…

  38. Essential Amino Acids

    5.5–6.0 /10 for heart health 7.5–8.0/10 overall Strong recommend Amino Acid

    Solerte 2008 reports Personally verified PMID; sarcopenia crossover study reporting lean-mass gains with amino acid supplementation. The score stays conditional because Essential Amino Acids still needs better outcome data for this exact…

  39. Whole-Body Vibration

    5.5–6.0 /10 for heart health 7.0–7.5/10 overall Strong recommend Vibration & Mechanical Stimulation

    A 2024 meta-analysis notes that Whole-Body Vibration produces acute heart-rate and blood-pressure spikes comparable to light-intensity exercise Wang 2024. While short-term hemodynamic responses suggest a mild aerobic stimulus, no randomized trials have…

  40. Fucoidan (Brown Seaweed Polysaccharide)

    5.5–6.0 /10 for heart health 6.0–6.5/10 overall Worth trying Vitamin & Mineral & Nutrient

    The single isolated-fucoidan human RCT, Hernandez-Corona 2014, gave 500 mg per day to 25 overweight adults for three months and found lower diastolic blood pressure and lower LDL-C. That is a genuine…

  41. SS-31 (Elamipretide)

    5.5–6.0 /10 for heart health 6.0–6.5/10 overall Worth trying Mitochondrial & Longevity Peptide

    The evidence points to a plausible use case without proving a universal response. Zhao C et al. 2026 is the best anchor here because it reports approval-focused review: Barth syndrome rationale, crossover…

  42. Quinton Marine Plasma (Seawater Minerals)

    5.5–6.0 /10 for heart health 5.5–6.0/10 overall Worth trying Vitamin & Mineral & Nutrient

    The nearest human signal is a deep-sea-water proxy, not the branded product. Ham 2020 ran a double-blind crossover RCT in 37 prediabetic adults using magnesium-rich deep-sea water (350 mg magnesium daily, 8…

  43. SLU-PP-332

    5.5–6.0 /10 for heart health 4.5–5.0/10 overall Neutral Research Compound

    The study showed that SLU-PP-332 enhanced ejection fraction, reduced fibrosis, and improved survival markers in a rodent model of pressure overload. Separate work by Billon 2023 demonstrated that SLU-PP-332 boosts aerobic exercise…

  44. Ca-AKG (Calcium Alpha-Ketoglutarate)

    5.0–5.5 /10 for heart health 6.5–7.0/10 overall Worth trying Vitamin & Mineral & Nutrient

    Filip 2007 gives the most relevant evidence anchor. The existing rationale points to this narrower claim: Mechanism is mostly neutral, while calcium load creates a dose-dependent caution. this verified source is calcium-supplement…

  45. Earthing

    5.0–5.5 /10 for heart health 6.5–7.0/10 overall Worth trying Grounding & Earthing

    Earthing's cardiovascular use case rests on a handful of small, unblinded or narrative studies that suggest modest effects on heart-rate variability and blood viscosity, but none meet the criteria for high-quality randomized…

  46. NR (Nicotinamide Riboside)

    5.0–5.5 /10 for heart health 6.0–6.5/10 overall Worth trying Exogenous Metabolite

    Conze 2019 is the cleanest verified anchor for this report. The existing rationale points to this narrower claim: this verified source found directional blood-pressure and arterial-stiffness signals in middle-aged and older adults…

  47. Orforglipron (Foundayo)

    5.0–5.5 /10 for heart health 5.5–6.0/10 overall Worth trying Weight-Management Drug (non-peptide)

    Cardiovascular evidence is reassuring but not yet a finished story. In its largest safety study the drug was noninferior to insulin glargine for major cardiovascular events, with a hazard ratio of 0.84,…

  48. TRT (Testosterone Replacement Therapy)

    5.0–5.5 /10 for heart health 5.5–6.0/10 overall Neutral Hormone Therapy

    Lincoff 2023 reports TRAVERSE cardiovascular outcomes trial in 5,246 hypogonadal men with cardiovascular risk; major cardiovascular events non-inferior, with monitoring-relevant safety signals. Cruickshank 2024 points in the same direction, but route, dose,…

  49. Sulforaphane

    4.5–5.0 /10 for heart health 6.5–7.0/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Cardiovascular evidence is observational and indirect rather than RCT-anchored. Higher cruciferous vegetable intake is associated with lower stroke and cardiovascular mortality in cohort work (Joshipura 1999, Zhang 2011), and air pollution detox…

  50. Hyperbaric Oxygen Therapy

    4.5–5.0 /10 for heart health 5.5–6.0/10 overall Worth trying Hyperbaric

    HBOT has vascular and angiogenic mechanisms with small evidence in peripheral ischemia and erectile function. It is not a general cardiovascular prevention tool. Hadanny 2018 supports vascular endothelial effects in selected patients…

  51. Curcumin

    4.5–5.0 /10 for heart health 5.5–6.0/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Cardiovascular benefit is inferred from the inflammation and glycemic effects rather than from hard endpoint data. There are no large trials showing curcumin reduces heart attacks or strokes. The lipid data is…

  52. GHK-Cu

    4.5–5.0 /10 for heart health 7.0–7.5/10 overall Strong recommend Cosmetic & Dermatologic Peptide

    The cardiovascular score is unchanged because fibrinogen, antioxidant, and fibrosis pathways are relevant but indirect. Pickart 2014 discusses fibrinogen and tissue-repair genes, but no human cardiovascular endpoint trial supports risk reduction.

  53. Thymosin Beta-4 (Tβ4)

    4.5–5.0 /10 for heart health 7.0–7.5/10 overall Strong recommend Growth & Repair Peptide

    Cardiac repair has strong preclinical and mechanistic groundwork through the Bock-Marquette and Smart series showing Tβ4 activates integrin-linked kinase and mobilizes epicardial progenitors, per Bock-Marquette 2004, but the only RGN-352 Phase 2…

  54. GlyNAC (Glycine + N-Acetylcysteine)

    4.5–5.0 /10 for heart health 6.5–7.0/10 overall Worth trying Amino Acid

    Kumar 2023 reported lower systolic blood pressure and improved endothelial function in older adults, and the pilot noted reduced endothelial dysfunction, but these are small trials without cardiovascular event endpoints, so the…

  55. CagriSema (Cagrilintide + Semaglutide)

    4.5–5.0 /10 for heart health 5.0–5.5/10 overall Neutral Metabolic & Incretin Peptide

    Cardiovascular benefit is plausible but unproven for CagriSema specifically. Weight loss of this magnitude usually improves blood pressure and lipids, and the GLP-1 class has positive cardiovascular outcomes data from related drugs.…

  56. Ozone Therapy

    4.5–5.0 /10 for heart health 5.0–5.5/10 overall Neutral Ozone & Oxidative Therapy

    Preserved v0.x score. Cardiovascular prevention is a poor benefit-risk fit because systemic blood routes create the most important cardiovascular safety issue: gas embolism and paradoxical embolism risk. Marchetti and La Monaca 2000…

  57. L-Theanine

    4.0–4.5 /10 for heart health 7.5–8.0/10 overall Strong recommend Amino Acid

    Acute blood-pressure reduction under stress is plausible from stress-challenge work, but this is not a standalone cardiovascular intervention.

  58. Thymosin Alpha-1

    4.0–4.5 /10 for heart health 7.0–7.5/10 overall Strong recommend Immune Peptide

    Cardiovascular relevance is mostly secondary to sepsis and critical illness outcomes. Wu 2013 tracked severe sepsis outcomes, but no primary cardiovascular prevention or treatment indication is established.

  59. Saffron

    4.0–4.5 /10 for heart health 7.0–7.5/10 overall Strong recommend Botanical Extract (non-adaptogenic)

    Zhang 2025 supports modest blood-pressure and lipid-marker improvements in metabolic syndrome-related populations, but there are no hard cardiovascular outcome trials.

  60. Ketogenic Diet

    4.0–4.5 /10 for heart health 6.5–7.0/10 overall Worth trying Diet & Nutrition Protocol

    Cardiovascular response is mixed: triglycerides and HDL often improve, while LDL-C and ApoB can rise meaningfully in responders. Buren 2021 found LDL-C increased in healthy young normal-weight women after ketogenic LCHF feeding,…

  61. NMN (Nicotinamide Mononucleotide)

    4.0–4.5 /10 for heart health 6.0–6.5/10 overall Worth trying Exogenous Metabolite

    Preclinical vascular data from de Picciotto 2016 support vascular-aging mechanisms, and Zhang 2026 found a small diastolic blood-pressure signal. No cardiovascular-event RCT exists.

  62. Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga)

    4.0–4.5 /10 for heart health 5.0–5.5/10 overall Neutral Functional Mushroom

    Reishi metabolic-syndrome RCT (Klupp 2016) found no blood pressure or lipid benefit; cordyceps cardiovascular data are preclinical. Mechanistic plausibility without human outcomes.

  63. Full-Body EMS

    3.5–4.0 /10 for heart health 7.0–7.5/10 overall Strong recommend Resistance & Strength

    Acute sessions increase cardiovascular work, and improved muscle mass may support vascular health. The evidence is not strong enough to position WB-EMS as a cardiovascular treatment or replacement for aerobic training.

  64. Ashwagandha

    3.5–4.0 /10 for heart health 6.5–7.0/10 overall Worth trying Adaptogenic Herb

    Cardiovascular benefit is indirect and modest. Stress, cortisol, sleep, inflammation, and blood-pressure endpoints can move in favorable directions in some trials, including Salve 2019. Ashwagandha is not a primary cardiovascular therapy, and…

  65. Tongkat Ali

    3.0–3.5 /10 for heart health 6.5–7.0/10 overall Worth trying Adaptogenic Herb

    Short-term standardized-extract trials generally do not show major liver, kidney, or lipid shifts, but there is no cardiovascular endpoint evidence. Estradiol can rise through aromatization in susceptible men.

  66. Survodutide (BI 456906)

    3.0–3.5 /10 for heart health 5.0–5.5/10 overall Neutral Metabolic & Incretin Peptide

    No proven cardiovascular benefit yet, and a heart-rate flag. A blood-pressure post-hoc was favorable, but a dedicated outcomes trial has not reported.

  67. Shilajit

    3.0–3.5 /10 for heart health 7.0–7.5/10 overall Strong recommend Adaptogenic Herb

    Limited direct cardiovascular evidence. Antioxidant and anti-inflammatory mechanisms may support vascular health, but no human cardiovascular RCT has tested shilajit as the primary intervention.

  68. MOTS-c

    3.0–3.5 /10 for heart health 6.5–7.0/10 overall Worth trying Mitochondrial & Longevity Peptide

    AMPK activation has cardioprotective downstream effects, but MOTS-c has no direct cardiovascular RCT. The cardiovascular score stays low because support is indirect, mostly from metabolic pathway reasoning and diabetic animal models rather…

  69. Urolithin A

    3.0–3.5 /10 for heart health 6.5–7.0/10 overall Worth trying Exogenous Metabolite

    Indirect mitochondrial and anti-inflammatory pathway only. Hodzic Kuerec 2024 found no clear cardiovascular outcome effect across the small human study base.

  70. Glutathione (GSH)

    3.0–3.5 /10 for heart health 6.0–6.5/10 overall Worth trying Amino Acid
  71. Pine Pollen

    3.0–3.5 /10 for heart health 5.5–6.0/10 overall Neutral Adaptogenic Herb

    No human cardiovascular outcome data; composition reviews note antioxidant effects only.

  72. Eloralintide (LY3841136)

    3.0–3.5 /10 for heart health 5.0–5.5/10 overall Neutral Metabolic & Incretin Peptide

    The cardiovascular picture for eloralintide points in two directions at once and no outcome trial exists to settle it. The sponsor reported blood-pressure improvement alongside the weight loss but published no numbers,…

  73. GHRP-6

    3.0–3.5 /10 for heart health 5.0–5.5/10 overall Neutral Growth Hormone Secretagogue

    Cardiovascular is the one place GHRP-6 has a distinct research story, but it is preclinical. A second receptor, CD36, mediates a cytoprotective heart effect, per Bodart 2002, and GHRP-6 reduced oxidant damage…

  74. C15 (Pentadecanoic Acid)

    3.0–3.5 /10 for heart health 3.0–3.5/10 overall Caution Vitamin & Mineral & Nutrient

    Steffen 2026 (Steffen 2026) found modest observational blood-pressure and hypertension associations in CARDIA and ARIC but no incident cardiovascular-disease association and no Mendelian-randomization support for causality. Sun 2025 supports biomarker-level interest in…

What each one costs

Monthly out-of-pocket cost at the most accessible legitimate channel, at the dose the score was given for. 23 of 74 are not priced yet; those cells are left blank rather than guessed.

InterventionMonthly costAt doseHow you get it
Taurine $3–$101-3 g, 30-60 minutes before sleepOver the counter
Norwegian 4×4 Not priced yetOver the counter
Zone 2 Cardio Not priced yetOver the counter
Traditional Sauna (Finnish Dry-Heat) $5015 to 20 minutes at 80 to 100 COver the counter
Infrared Sauna $36–$7355-60 degrees C, 20-30 minOver the counter
HRV Biofeedback $520 min/session at individual RF (4.5 to 6.5 bpm)Over the counter
Magnesium $10–$20200-400 mg glycinate elementalOver the counter
Semaglutide $199–$3490.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, 2.4 mg week 17 onwardPrescription
Polyphenols (Dietary) Not priced yet
Spermidine $40–$901-3 mg/day oral WGEOver the counter
Tirzepatide $299–$4492.5 to 5 to 7.5 to 10 to 12.5 to 15 mgPrescription
Spirulina $10–$251 to 4.5 g/dayOver the counter
Coenzyme Q10 (CoQ10 / Ubiquinol) $15–$40100-200 mg/dayOver the counter
Molecular Hydrogen Not priced yet
Metformin $4–$30500 mg with dinner for 1 week, then 500 mg twice daily for 1 week, then increase by 500 mg/week toward 1000 mg twice daily as toleratedPrescription
Rucking (Weighted Walking) Not priced yet
Sprinting (Sprint Interval Training) Not priced yet
Berberine $15–$25500 mg berberine HCl three times daily with mealsOver the counter
Blood-Flow Restriction Training Not priced yet
Astaxanthin Not priced yet
BPC-157 $40–$80250 to 500 mcg SC 1 to 2x/day near injury siteGrey market
TB-500 (Thymosin Beta-4 Fragment) Not priced yet
Rapamycin $15–$503 mgPrescription
Ergothioneine Not priced yet
Chlorella $10–$505-10 g/dayOver the counter
Senolytics Not priced yet
Resveratrol Not priced yet
Electrolytes Not priced yet
Vitamin D3 + K2 Not priced yet
Vitamin C (Ascorbic Acid) Not priced yet
Omega-3 $20–$401-2 g/day combined EPA+DHAOver the counter
Tesamorelin $250–$5002 mg subcutaneous daily in the eveningPrescription
Exogenous Ketones $38–$300Ester 10 to 25 g BHBOver the counter
Retatrutide $130–$9602 mg, then 4 mg, then 8 mg or 12 mg weekly depending on protocol and tolerabilityResearch use only
Glycine $2–$33 g oral glycineOver the counter
Time-Restricted Eating Not priced yet
Quercetin $20–$50200 mg/dayOver the counter
Essential Amino Acids Not priced yet
Whole-Body Vibration $50–$10030 Hz, roughly 0.3g, 10-20 min standingOver the counter
Fucoidan (Brown Seaweed Polysaccharide) Not priced yet
SS-31 (Elamipretide) $200–$5005-10 mg/day subcutaneousGrey market
Quinton Marine Plasma (Seawater Minerals) Not priced yet
SLU-PP-332 $30–$803-5 mg/day oralResearch use only
Ca-AKG (Calcium Alpha-Ketoglutarate) $15–$301 g/day generic Ca-AKG oralOver the counter
Earthing Not priced yetOver the counter
NR (Nicotinamide Riboside) $40–$50250-300 mg/day oralOver the counter
Orforglipron (Foundayo) $149–$299Start low, step up to 36 mgPrescription
TRT (Testosterone Replacement Therapy) $50–$300Clinician-selected formulation at the lowest dose likely to restore physiologic testosteronePrescription
Sulforaphane $25–$60Broccoli sprout extract delivering about 150 micromoles sulforaphane per dayOver the counter
Hyperbaric Oxygen Therapy $3,000–$6,0002.0 ATA for 90 minutes with air breaksIn clinic
Curcumin $15–$40500 mg curcuminoidsOver the counter
GHK-Cu $30–$1000.5-3% topical serum or creamOver the counter
Thymosin Beta-4 (Tβ4) Not priced yet
GlyNAC (Glycine + N-Acetylcysteine) $10–$30Glycine and NAC at ~100 mg/kg/day eachOver the counter
CagriSema (Cagrilintide + Semaglutide) $80–$1600.25 mg, then 0.5 mg, then 1.0 mg, then 1.7 mg, then 2.4 mg of eachResearch use only
Ozone Therapy $520–$2,60020-30 mcg/mL ozone, roughly 1,000-1,500 mcg total per sessionIn clinic
L-Theanine $3–$8200 mg L-theanine + 100 mg caffeineOver the counter
Thymosin Alpha-1 $100–$4001.6 mg subcutaneousPrescription
Saffron Not priced yet
Ketogenic Diet $100Standard keto, 40-50 g total carbohydrate/dayOver the counter
NMN (Nicotinamide Mononucleotide) $40–$100500 mg/day oralOver the counter
Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga) $15–$401.5 to 1.8 g/day standardized extractOver the counter
Full-Body EMS Not priced yet
Ashwagandha $15–$30300 mg KSM-66 with breakfast and 300 mg with dinnerOver the counter
Tongkat Ali $20–$40200 mg/day Physta standardized extractOver the counter
Survodutide (BI 456906) $300–$5002.4, 4.8, or 6.0 mgResearch use only
Shilajit $25–$50500 mg purified shilajitOver the counter
MOTS-c $100–$2005-10 mg SCResearch use only
Urolithin A $50–$100500 mg/dayOver the counter
Glutathione (GSH) $20–$451,000 mg/dayOver the counter
Pine Pollen $20–$455 to 10 g powder per dayOver the counter
Eloralintide (LY3841136) $432–$5409 mg once weeklyResearch use only
GHRP-6 $20–$40100 mcgGrey market
C15 (Pentadecanoic Acid) $40–$50200 mg/dayOver the counter

Comparisons that judge heart health

Head-to-head reports and category rankings that name a winner on this use case.

Category ranking

Best GLP-1 Drugs Ranked by Evidence (2026)

This page ranks by the live body-composition subrating, not the overall BioHarmony score, since body composition is the goal this category is built around. Tirzepatide leads both measures.…

  • Tirzepatide
  • Retatrutide
  • Semaglutide
  • CagriSema
  • +5 more
Read the comparison →

16 more comparisons touch on heart health →

Questions about heart health

What scores highest for heart health?

Taurine, at 9.0–9.5 out of 10 for heart health. Guan 2020 reports Confirmed meta-analysis on obesity, BP, and lipid outcomes; supports cardiometabolic breadth.

What is the cheapest thing that works for heart health?

Of the top-scoring options, Taurine is the least expensive at about $3 a month, scoring 9.0–9.5 out of 10 for heart health.

What should I be careful with for heart health?

C15 (Pentadecanoic Acid) scores 3.0–3.5 out of 10 for heart health but only 3.0–3.5 overall, landing in the caution tier once safety, side effects, cost and effort are counted.

How many interventions has Outliyr scored for heart health?

74 of the 136 interventions evaluated for heart health score 3.0 out of 10 or better, which is the cut-off for appearing on this page.