Best Interventions for More Energy, Ranked by Evidence

Every intervention Outliyr has scored for more energy, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for more energy; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.

84 of 144 evaluated interventions score 3.0+ out of 10 for more energy · 21 comparisons

Ranked for More Energy

Category
  1. Electrolytes

    7.5–8.0 /10 for more energy 8.5–9.0/10 overall Top-tier Vitamin & Mineral & Nutrient

    Borra 2025 anchors the strongest signal. The existing rationale points to this narrower claim: Dehydration-related fatigue can correct quickly with water and electrolytes. The effect is strongest when symptoms appear after sweat,…

  2. Creatine Monohydrate

    7.0–7.5 /10 for more energy 8.5–9.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Watanabe 2002 reports Cognitive performance under mental load and sleep deprivation. The score stays conditional because Creatine Monohydrate still needs better outcome data for this exact use case. The practical move is…

  3. Magnesium

    7.0–7.5 /10 for more energy 8.5–9.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    De Baaij 2015 anchors the most relevant signal. Magnesium fits energy when low intake, stress load, mineral loss, or a form-specific target makes deficiency correction plausible. The score stays bounded because effects…

  4. Red Light Therapy

    7.0–7.5 /10 for more energy 7.5–8.0/10 overall Strong recommend Light Therapy

    Red Light Therapy acts on mitochondrial photobiology, with Karu 2010 supporting ATP-related mechanisms at cytochrome c oxidase. The human outcome is more variable than the mechanism. Low-baseline users, overtrained athletes, and people…

  5. Modafinil

    7.0–7.5 /10 for more energy 5.5–6.0/10 overall Worth trying Eugeroic (wakefulness agent)

    The evidence points to a plausible use case without proving a universal response. Mann G et al. 2026 is the best anchor here because it reports five studies meta-analyzed, 997 participants and…

  6. TRT (Testosterone Replacement Therapy)

    7.0–7.5 /10 for more energy 5.5–6.0/10 overall Neutral Hormone Therapy

    Lincoff 2023 reports TRAVERSE cardiovascular outcomes trial in 5,246 hypogonadal men with cardiovascular risk; major cardiovascular events non-inferior, with monitoring-relevant safety signals. Cruickshank 2024 points in the same direction, but route, dose,…

  7. Ephedrine

    7.0–7.5 /10 for more energy 5.0–5.5/10 overall Neutral Sympathomimetic Stimulant

    Reliable acute stimulation via direct + indirect adrenergic activation; Tmax 1.8 hours, peak effect 1-2 hours. Tachyphylaxis develops within 2-4 weeks of continuous use. Caffeine + L-tyrosine + adequate sleep produce comparable…

  8. Methylene Blue

    6.5–7.0 /10 for more energy 6.0–6.5/10 overall Worth trying Mitochondrial & Redox Drug

    Rodriguez 2016 makes the claim plausible but incomplete. The existing rationale points to this narrower claim: Subjective energy is a consistent user report and fits the redox mechanism, but human evidence is…

  9. Zone 2 Cardio

    6.5–7.0 /10 for more energy 8.0–8.5/10 overall Strong recommend Cardiovascular

    Kodama 2009 supports direction more than certainty. The existing rationale points to this narrower claim: Daytime energy is a common downstream benefit as mitochondrial capacity, glucose handling, and sleep improve. Zone 2…

  10. Molecular Hydrogen

    6.5–7.0 /10 for more energy 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Dhillon 2024 reports 25-article systematic review; mixed preliminary clinical evidence, heterogeneity, and need for stronger trials. Zhou 2024 points in the same direction, but route, dose, baseline status, and outcome tracking decide…

  11. Shilajit

    6.5–7.0 /10 for more energy 7.0–7.5/10 overall Strong recommend Adaptogenic Herb

    Pandit 2016 anchors the most relevant signal. Shilajit fits energy when purified resin is matched to hormones, sperm parameters, strength fatigue, bone markers, or energy tracking. The score stays bounded because most…

  12. Bromantane (Ladasten)

    6.0–6.5 /10 for more energy 7.0–7.5/10 overall Strong recommend Synthetic Nootropic (non-racetam)

    Fatigue and asthenia are the best-supported clinical use case for Bromantane. The Voznesenskaia 2010 multicenter trial in 728 outpatients with asthenic syndrome reported a CGI-I responder rate of 90.8% at 50 to…

  13. Paraxanthine (Enfinity)

    6.0–6.5 /10 for more energy 6.5–7.0/10 overall Worth trying Stimulant & Methylxanthine

    The most plausible benefit is acute perceived energy or stimulant-like activation. The strongest support comes from Yoo C. et al. 2021, but the practical rating stays bounded by study size, replication, and…

  14. Tirzepatide

    6.0–6.5 /10 for more energy 6.0–6.5/10 overall Worth trying Metabolic & Incretin Peptide

    A Cochrane review of nine trials (7,111 participants) reports that Tirzepatide produces roughly a 10% body-weight reduction versus placebo, which is the primary driver of any perceived boost in energy Franco 2025.…

  15. Neurofeedback

    6.0–6.5 /10 for more energy 8.0–8.5/10 overall Strong recommend Neurostimulation & Neurofeedback

    Marzbani et al. 2016 supports the main pathway. Energy effects are secondary. Users may feel more mentally clear when attention, sleep, and arousal regulation improve, but neurofeedback is not a mitochondrial or…

  16. Norwegian 4×4

    6.0–6.5 /10 for more energy 8.0–8.5/10 overall Strong recommend Cardiovascular

    The original trial reported a clear VO2max gain after six weeks Helgerud 2007. Better aerobic capacity can make daily tasks feel easier, but trials usually measure fitness rather than subjective energy. The…

  17. Coenzyme Q10 (CoQ10 / Ubiquinol)

    6.0–6.5 /10 for more energy 7.0–7.5/10 overall Strong recommend Vitamin & Mineral & Nutrient

    CoQ10's role in ATP synthesis makes restored energy plausible where levels are low, such as statin users, older adults, or those with fatigue tied to cardiac or mitochondrial issues, and exercise capacity…

  18. Tongkat Ali

    6.0–6.5 /10 for more energy 6.5–7.0/10 overall Worth trying Adaptogenic Herb

    Tambi 2012 makes the claim plausible but incomplete. The existing rationale points to this narrower claim: Energy claims are mostly downstream of stress, mood, and testosterone-to-cortisol changes rather than direct fatigue trials.…

  19. Sprinting (Sprint Interval Training)

    6.0–6.5 /10 for more energy 6.0–6.5/10 overall Worth trying Cardiovascular

    Higher aerobic capacity from SIT, shown as a rapid VO2max gain in Gist 2014 and a near-doubling of endurance capacity in Burgomaster 2005, makes daily tasks feel easier over a few weeks.…

  20. Time-Restricted Eating

    5.5–6.0 /10 for more energy 6.5–7.0/10 overall Worth trying Fasting Protocol

    The evidence points to a plausible use case without proving a universal response. Sun Y et al. 2025 is the best anchor here because it reports 20 randomized trials, 1,242 participants and…

  21. Essential Amino Acids

    5.5–6.0 /10 for more energy 7.5–8.0/10 overall Strong recommend Amino Acid

    Hagiyama 2024 reports 12 RCTs; 622 patients; low-certainty improvement in patient-reported outcomes and very-low-certainty strength signal after lower-limb surgeries. Wittholz 2024 points in the same direction, but route, dose, baseline status, and…

  22. Glycine

    5.5–6.0 /10 for more energy 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Soh 2024 anchors the most relevant signal. Glycine fits energy because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the endpoint. The score stays bounded because many…

  23. Vagus Nerve Stimulation

    5.5–6.0 /10 for more energy 7.0–7.5/10 overall Strong recommend Neurostimulation & Neurofeedback

    Energy benefits are mostly indirect through better sleep and lower sympathetic load; no strong direct energy endpoint supports a higher rating. The score stays bounded because Vagus Nerve Stimulation evidence for energy…

  24. Whole-Body Vibration

    5.5–6.0 /10 for more energy 7.0–7.5/10 overall Strong recommend Vibration & Mechanical Stimulation

    Peng et al. 2024 reported a 7 % increase in concentric knee extensor torque after a single Whole-Body Vibration session, suggesting an acute boost in muscular power. Users frequently describe a short-term…

  25. Ketogenic Diet

    5.5–6.0 /10 for more energy 6.5–7.0/10 overall Worth trying Diet & Nutrition Protocol

    Leung GKW et al. 2025 is the best anchor here because it reports 33 randomized trials and 2821 individuals and ketogenic/low-carbohydrate diets reduced body weight, BMI, and body-fat percentage, with stronger subgroup…

  26. Senolytics

    5.5–6.0 /10 for more energy 6.5–7.0/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Reduced SASP inflammation may improve subjective energy in older or inflamed users, but human F+Q energy outcomes remain untested. The score stays bounded because Senolytics evidence for energy can depend on age,…

  27. NMN (Nicotinamide Mononucleotide)

    5.5–6.0 /10 for more energy 6.0–6.5/10 overall Worth trying Exogenous Metabolite

    Wang 2024 anchors the most relevant signal. NMN fits energy when raising NAD+ is likely to matter for older, metabolically stressed, or performance-tracking users. The score stays bounded because NAD+ rises more…

  28. Dynamine (Methylliberine)

    5.5–6.0 /10 for more energy 5.5–6.0/10 overall Worth trying Stimulant & Methylxanthine

    The most plausible benefit is acute perceived energy or stimulant-like activation. The strongest support comes from Cintineo H. et al. 2022, but the practical rating stays bounded by study size, replication, and…

  29. SLU-PP-332

    5.5–6.0 /10 for more energy 4.5–5.0/10 overall Neutral Research Compound

    The evidence for SLU-PP-332's impact on energy is limited to a single mouse study that reported a 12% increase in treadmill endurance and was documented by Billon et al. 2023. The proposed…

  30. Ca-AKG (Calcium Alpha-Ketoglutarate)

    5.0–5.5 /10 for more energy 6.5–7.0/10 overall Worth trying Vitamin & Mineral & Nutrient

    Shahmirzadi 2020 supports direction more than certainty. The existing rationale points to this narrower claim: Mechanistic energy-metabolism rationale exists, and Nick notes subjective performance benefit, but there are no controlled human energy…

  31. Phenylpiracetam (Phenotropil)

    5.0–5.5 /10 for more energy 5.5–6.0/10 overall Neutral Racetam

    The most plausible benefit is acute perceived energy or stimulant-like activation. The strongest support comes from Malykh A. et al. 2010, but the practical rating stays bounded by study size, replication, and…

  32. HRV Biofeedback

    5.0–5.5 /10 for more energy 9.0–9.5/10 overall Top-tier Wearable & Tracker

    Reduced fatigue as secondary outcome across multiple anxiety/depression studies. The score stays bounded because HRV Biofeedback evidence for energy can depend on breathing cadence, adherence, baseline HRV, and symptom tracking. In practice,…

  33. Vitamin C (Ascorbic Acid)

    5.0–5.5 /10 for more energy 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Fatigue is one of the earliest and most reversible symptoms of vitamin C deficiency. Genuinely low people, including smokers and those with poor diets, often report meaningful energy improvement on repletion, and…

  34. Spirulina

    5.0–5.5 /10 for more energy 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Kalafati 2010 used a double-blind crossover in 9 trained men at 6 g/day for 4 weeks and found time to fatigue rising from 2.05 to 2.70 minutes with a 10.9 percent rise…

  35. Rapamycin

    5.0–5.5 /10 for more energy 6.5–7.0/10 overall Worth trying Longevity & mTOR Drug

    Harrison 2009 anchors the most relevant signal. Rapamycin fits energy when mTORC1 modulation, autophagy, immune aging, or senescence biology is the actual target. The score stays bounded because human longevity endpoints remain…

  36. GlyNAC (Glycine + N-Acetylcysteine)

    5.0–5.5 /10 for more energy 6.5–7.0/10 overall Worth trying Amino Acid

    Improved mitochondrial fuel oxidation and lower oxidative stress are energy-relevant, and older participants reported better physical function, but there is no dedicated fatigue endpoint with a clean placebo comparison. Treat any energy…

  37. MOTS-c

    5.0–5.5 /10 for more energy 6.5–7.0/10 overall Worth trying Mitochondrial & Longevity Peptide

    MOTS-c earns an energy score from exercise-mimetic AMPK activation, Reynolds 2021 exercise biology, and Nick's subjective energy response. Human energy endpoints remain unvalidated. That makes MOTS-c more defensible when energy is a…

  38. Oxiracetam

    5.0–5.5 /10 for more energy 6.0–6.5/10 overall Worth trying Racetam

    The most plausible benefit is acute perceived energy or stimulant-like activation. The strongest support comes from Copani A. et al. 1992, but the practical rating stays bounded by study size, replication, and…

  39. Semaglutide

    5.0–5.5 /10 for more energy 6.0–6.5/10 overall Worth trying Metabolic & Incretin Peptide

    Semaglutide can improve fatigue tied to obesity and glucose swings, but it can also cause fatigue through low intake, dehydration, nausea, or rapid weight loss. Wilding 2021 supports weight reduction, which is…

  40. Exogenous Ketones

    5.0–5.5 /10 for more energy 5.5–6.0/10 overall Worth trying Exogenous Metabolite

    Mixed and individual. Some users report a clean acute energy and focus lift from the rapid fuel shift, since the brain and muscle readily use BHB as a substrate; others feel GI-driven…

  41. Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga)

    5.0–5.5 /10 for more energy 5.0–5.5/10 overall Neutral Functional Mushroom

    Daytime energy and reduced tiredness are among the more believable felt effects of this class. The human support is the Tang 2005 reishi trial, where neurasthenia patients reported a 28.3 percent drop…

  42. Hyperbaric Oxygen Therapy

    4.5–5.0 /10 for more energy 5.5–6.0/10 overall Worth trying Hyperbaric

    Some users report energy improvements after full protocols, especially with fatigue syndromes, but Kjellberg 2025 weakens short-course long-COVID fatigue expectations.

  43. Blood-Flow Restriction Training

    4.5–5.0 /10 for more energy 8.0–8.5/10 overall Strong recommend Resistance & Strength

    Improved functional capacity can raise perceived energy over time, but BFR is not an acute energy intervention.

  44. Traditional Sauna (Finnish Dry-Heat)

    4.5–5.0 /10 for more energy 7.5–8.0/10 overall Strong recommend Sauna & Heat Therapy

    Many users report a refreshed, energized feeling after a session and the cooling rebound, but sauna is not a stimulant and there is no objective energy or fatigue trial for traditional sauna.…

  45. Astaxanthin

    4.5–5.0 /10 for more energy 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Some users report energy lift and exercise-efficiency reviews are directionally positive, but astaxanthin is not an acute stimulant.

  46. Full-Body EMS

    4.5–5.0 /10 for more energy 7.0–7.5/10 overall Strong recommend Resistance & Strength

    Better muscle function can translate to better daily energy, especially in deconditioned users. Evidence is indirect from strength and function outcomes rather than EMS-specific fatigue trials, so the score remains moderate.

  47. Rucking (Weighted Walking)

    4.5–5.0 /10 for more energy 7.0–7.5/10 overall Strong recommend Cardiovascular

    Regular aerobic conditioning typically improves daytime stamina and reduces fatigue over weeks, but rucking is also a genuine energy cost in the session and can drain you if load and volume are…

  48. Metformin

    4.5–5.0 /10 for more energy 6.5–7.0/10 overall Worth trying Metabolic & Glycemic Drug

    T2D users may feel more energy when glucose normalizes, while healthy users can experience fatigue or training-output tradeoffs. The direct energy score stays below neutral.

  49. Chlorella

    4.5–5.0 /10 for more energy 6.5–7.0/10 overall Worth trying Vitamin & Mineral & Nutrient

    Some users report steadier energy on chlorella, plausibly from correcting iron, B-vitamin, or general micronutrient gaps, but there is no controlled human evidence that it raises energy as a primary effect. It…

  50. Glutathione (GSH)

    4.5–5.0 /10 for more energy 6.0–6.5/10 overall Worth trying Amino Acid

    People with high oxidative-stress burden sometimes report better energy when glutathione status improves, and fatigue is the most common positive anecdote, but there is no dedicated fatigue RCT for glutathione supplementation with…

  51. NR (Nicotinamide Riboside)

    4.5–5.0 /10 for more energy 6.0–6.5/10 overall Worth trying Exogenous Metabolite

    NAD+ is essential for cellular energy metabolism, but most healthy adults report no obvious subjective energy effect despite biochemical elevation.

  52. SS-31 (Elamipretide)

    4.5–5.0 /10 for more energy 6.0–6.5/10 overall Worth trying Mitochondrial & Longevity Peptide

    Restoring ETC efficiency should improve cellular energy production, but Nick's N=1 was neutral and Karaa 2023 did not confirm broad PMM fatigue benefit.

  53. Semax

    4.0–4.5 /10 for more energy 7.0–7.5/10 overall Strong recommend Neuropeptide

    Acute mental energy is one of the more common community-reported benefits, but no formal fatigue, vitality, or mental-energy endpoint trial verifies the effect.

  54. Ergothioneine

    4.0–4.5 /10 for more energy 6.5–7.0/10 overall Worth trying Vitamin & Mineral & Nutrient

    Not a stimulant. Any fatigue benefit would be slow and antioxidant-mediated; no dedicated energy or fatigue trial supports a meaningful effect.

  55. Urolithin A

    4.0–4.5 /10 for more energy 6.5–7.0/10 overall Worth trying Exogenous Metabolite

    Mitochondrial biomarker changes can translate into energy for some low-baseline users, but subjective energy reports are mixed and not a proven acute effect.

  56. Tesamorelin

    4.0–4.5 /10 for more energy 6.0–6.5/10 overall Worth trying Growth Hormone Secretagogue

    Improved VAT, sleep quality, and metabolic markers may improve subjective energy in selected users. Tesamorelin has no stimulant mechanism, and energy outcomes were not primary endpoints in the pivotal evidence.

  57. Quinton Marine Plasma (Seawater Minerals)

    4.0–4.5 /10 for more energy 5.5–6.0/10 overall Worth trying Vitamin & Mineral & Nutrient

    Some users report a hydration or energy lift, but there is no controlled trial of Quinton for fatigue, and the mineral dose per ampoule is modest.

  58. Pine Pollen

    4.0–4.5 /10 for more energy 5.5–6.0/10 overall Neutral Adaptogenic Herb

    Pine pollen supplies amino acids, B vitamins, and minerals, which gives a nutritional basis for a general vitality effect, and TCM has used song hua fen as an energy tonic for centuries.…

  59. CJC-1295

    4.0–4.5 /10 for more energy 5.5–6.0/10 overall Neutral Growth Hormone Secretagogue

    Community reports improved energy and vitality; GH elevation can feel energizing, but this is not verified by controlled CJC-1295 outcome trials.

  60. Thymosin Beta-4 (Tβ4)

    3.5–4.0 /10 for more energy 7.0–7.5/10 overall Strong recommend Growth & Repair Peptide

    Energy gains are an indirect downstream of better tissue repair, recovery, and inflammation control, not a direct Tβ4 mechanism. No trial has measured energy or fatigue endpoints.

  61. NAC (N-Acetylcysteine)

    3.5–4.0 /10 for more energy 8.0–8.5/10 overall Strong recommend Amino Acid

    Some users report a subtle lift tied to better oxidative balance, but NAC is not a stimulant and has no direct energy or fatigue RCT base in healthy people.

  62. Spermidine

    3.5–4.0 /10 for more energy 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Indirect via mitochondrial quality control; no subjective-energy RCT.

  63. BPC-157

    3.5–4.0 /10 for more energy 7.5–8.0/10 overall Strong recommend Growth & Repair Peptide

    Indirect via reduced inflammation and improved tissue function. Energy claims are secondary and should be interpreted as feeling better after an injury heals, not direct mitochondrial stimulation.

  64. Lion’s Mane

    3.5–4.0 /10 for more energy 7.0–7.5/10 overall Strong recommend Functional Mushroom

    Energy effects are indirect through mood, sleep, gut-brain, and inflammation pathways. Lion's Mane is not a primary energy compound and should not be positioned like caffeine or creatine.

  65. Ashwagandha

    3.5–4.0 /10 for more energy 6.5–7.0/10 overall Worth trying Adaptogenic Herb

    Energy effects are restorative rather than stimulating. Users with poor sleep, elevated stress, or burnout-like physiology may feel more stable energy after stress improves. Low-stress users may feel sedated or blunted instead,…

  66. Fucoidan (Brown Seaweed Polysaccharide)

    3.5–4.0 /10 for more energy 6.0–6.5/10 overall Worth trying Vitamin & Mineral & Nutrient

    Fatigue improved in some cancer-support studies and not others; not an acute energy agent.

  67. Cold Plunge

    3.5–4.0 /10 for more energy 5.5–6.0/10 overall Neutral Cold Exposure

    Acute energy lift from sustained catecholamine elevation is one of the most reliable subjective effects in the cold-plunge corpus. Sramek 2000 documented the magnitude (NE +530 percent, DA +250 percent at 14…

  68. 5-Amino-1MQ

    3.5–4.0 /10 for more energy 4.5–5.0/10 overall Neutral Research Compound

    Energy is the most-reported subjective effect, and Nick feels it within 30 minutes, but no trial has measured it. The plausible route is restored NAD+ supporting cellular energy production.

  69. L-Theanine

    3.0–3.5 /10 for more energy 7.5–8.0/10 overall Strong recommend Amino Acid

    Indirect via caffeine optimization. L-theanine is not a primary energy intervention and may feel flattening in already-calm users.

  70. Polyphenols (Dietary)

    3.0–3.5 /10 for more energy 7.5–8.0/10 overall Strong recommend Vitamin & Mineral & Nutrient

    Any acute lift from coffee or tea is caffeine, not the polyphenols.

  71. GHK-Cu

    3.0–3.5 /10 for more energy 7.0–7.5/10 overall Strong recommend Cosmetic & Dermatologic Peptide

    Energy remains a 3 because mitochondrial and repair-gene claims are indirect. No human fatigue, ATP, or performance endpoint trial supports GHK-Cu for energy. Pickart 2018 is the review-level background.

  72. Thymosin Alpha-1

    3.0–3.5 /10 for more energy 7.0–7.5/10 overall Strong recommend Immune Peptide

    Some users report better energy during illness, but no objective fatigue or energy endpoint is established. Effects likely reflect recovery from immune suppression rather than stimulant-like energy.

  73. Saffron

    3.0–3.5 /10 for more energy 7.0–7.5/10 overall Strong recommend Botanical Extract (non-adaptogenic)

    Energy has no direct saffron RCT endpoint; any lift is indirect through better mood, lower perceived stress, and better sleep quality.

  74. Selank

    3.0–3.5 /10 for more energy 6.5–7.0/10 overall Worth trying Neuropeptide

    Russian clinical reports describe antiasthenic effects, and anxiety reduction often improves perceived energy. There is no fatigue-specific RCT.

  75. Berberine

    3.0–3.5 /10 for more energy 6.5–7.0/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Energy may improve when glucose volatility improves, but berberine is not an energizing supplement for healthy users. Complex I inhibition makes fatigue a plausible issue in some.

  76. Colostrum

    3.0–3.5 /10 for more energy 6.5–7.0/10 overall Worth trying Vitamin & Mineral & Nutrient

    Energy benefits are indirect through fewer illness days or less gut stress during training. Bovine colostrum is not an acute energy substrate, stimulant, or mitochondrial enhancer.

  77. Epitalon

    3.0–3.5 /10 for more energy 6.5–7.0/10 overall Worth trying Mitochondrial & Longevity Peptide

    Quality-of-life improvements in Russian elderly peptide literature included energy and vitality-like outcomes, but objective energy-metabolism endpoints are absent. Any energy effect is likely secondary to sleep or circadian rhythm rather than direct…

  78. Sodium Butyrate

    3.0–3.5 /10 for more energy 6.0–6.5/10 overall Worth trying Exogenous Metabolite

    Some people report steadier energy as gut inflammation settles, but no direct fatigue trials support this. Indirect at best.

  79. Curcumin

    3.0–3.5 /10 for more energy 5.5–6.0/10 overall Worth trying Botanical Extract (non-adaptogenic)

    Some people report steadier energy from lower inflammation, but no direct fatigue trials support this as a primary use.

  80. Retatrutide

    3.0–3.5 /10 for more energy 5.5–6.0/10 overall Neutral Metabolic & Incretin Peptide

    Glucagon is thermogenic and weight loss can improve daily energy in metabolic disease, but nausea and sustained caloric deficit can reduce energy. Retatrutide has no direct fatigue or vitality endpoint.

  81. NAD+ (Direct)

    3.0–3.5 /10 for more energy 5.0–5.5/10 overall Neutral Exogenous Metabolite

    Energy is the headline marketed claim and the most common same-session report after IV NAD+, but it rests on subjective drip-feel rather than controlled measurement. The one human study is pharmacokinetic, not…

  82. Tesofensine

    3.0–3.5 /10 for more energy 5.0–5.5/10 overall Neutral Weight-Management Drug (non-peptide)

    Energy and alertness are a side consequence of the stimulant-class mechanism, not a clean benefit. Raising central noradrenaline and dopamine produces a wakeful, appetite-suppressed state, and the modest rise in energy expenditure,…

  83. C15 (Pentadecanoic Acid)

    3.0–3.5 /10 for more energy 3.0–3.5/10 overall Caution Vitamin & Mineral & Nutrient

    Neither direct human RCT established a reliable subjective energy or objective fatigue benefit at 200 mg/day. Robinson 2024 (Robinson 2024) was designed around overweight and obesity biomarkers, while Chooi 2024 TANGO focused…

  84. C60 (Buckminsterfullerene)

    3.0–3.5 /10 for more energy 3.0–3.5/10 overall Caution Research Compound

    Anecdotal energy reports are common but uncontrolled. Longecity users describe stamina shifts, yet placebo contribution and responder bias are large. The proposed mitochondrial mechanism has no human ATP, respiration, or biogenesis endpoint…

What each one costs

Monthly out-of-pocket cost at the most accessible legitimate channel, at the dose the score was given for. 28 of 84 are not priced yet; those cells are left blank rather than guessed.

InterventionMonthly costAt doseHow you get it
Electrolytes Not priced yet
Creatine Monohydrate Not priced yet
Magnesium $10–$20200-400 mg glycinate elementalOver the counter
Red Light Therapy $17–$4310-20 min at 6-12 inches, full chest/face/back rotationOver the counter
Modafinil $18–$35200 mg oral tabletPrescription
TRT (Testosterone Replacement Therapy) $50–$300Clinician-selected formulation at the lowest dose likely to restore physiologic testosteronePrescription
Ephedrine Not priced yet
Methylene Blue $13–$400.5-5 mg oralOver the counter
Zone 2 Cardio Not priced yetOver the counter
Molecular Hydrogen Not priced yet
Shilajit $25–$50500 mg purified shilajitOver the counter
Bromantane (Ladasten) $12–$3030 mgGrey market
Paraxanthine (Enfinity) Not priced yet
Tirzepatide $299–$4492.5 to 5 to 7.5 to 10 to 12.5 to 15 mgPrescription
Neurofeedback Not priced yet
Norwegian 4×4 Not priced yetOver the counter
Coenzyme Q10 (CoQ10 / Ubiquinol) $15–$40100-200 mg/dayOver the counter
Tongkat Ali $20–$40200 mg/day Physta standardized extractOver the counter
Sprinting (Sprint Interval Training) Not priced yet
Time-Restricted Eating Not priced yet
Essential Amino Acids Not priced yet
Glycine $2–$33 g oral glycineOver the counter
Vagus Nerve Stimulation $4–$810-20 min auricular tVNS at comfortable perceptible intensityOver the counter
Whole-Body Vibration $50–$10030 Hz, roughly 0.3g, 10-20 min standingOver the counter
Ketogenic Diet $100Standard keto, 40-50 g total carbohydrate/dayOver the counter
Senolytics Not priced yet
NMN (Nicotinamide Mononucleotide) $40–$100500 mg/day oralOver the counter
Dynamine (Methylliberine) Not priced yet
SLU-PP-332 $30–$803-5 mg/day oralResearch use only
Ca-AKG (Calcium Alpha-Ketoglutarate) $15–$301 g/day generic Ca-AKG oralOver the counter
Phenylpiracetam (Phenotropil) $21–$42100-200 mgGrey market
HRV Biofeedback $520 min/session at individual RF (4.5 to 6.5 bpm)Over the counter
Vitamin C (Ascorbic Acid) Not priced yet
Spirulina $10–$251 to 4.5 g/dayOver the counter
Rapamycin $15–$503 mgPrescription
GlyNAC (Glycine + N-Acetylcysteine) $10–$30Glycine and NAC at ~100 mg/kg/day eachOver the counter
MOTS-c $100–$2005-10 mg SCResearch use only
Oxiracetam $15–$40800-2,400 mgGrey market
Semaglutide $199–$3490.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, 2.4 mg week 17 onwardPrescription
Exogenous Ketones $38–$300Ester 10 to 25 g BHBOver the counter
Adaptogenic Mushrooms (Reishi, Cordyceps, Chaga) $15–$401.5 to 1.8 g/day standardized extractOver the counter
Hyperbaric Oxygen Therapy $3,000–$6,0002.0 ATA for 90 minutes with air breaksIn clinic
Blood-Flow Restriction Training Not priced yet
Traditional Sauna (Finnish Dry-Heat) $5015 to 20 minutes at 80 to 100 COver the counter
Astaxanthin Not priced yet
Full-Body EMS Not priced yet
Rucking (Weighted Walking) Not priced yet
Metformin $4–$30500 mg with dinner for 1 week, then 500 mg twice daily for 1 week, then increase by 500 mg/week toward 1000 mg twice daily as toleratedPrescription
Chlorella $10–$505-10 g/dayOver the counter
Glutathione (GSH) $20–$451,000 mg/dayOver the counter
NR (Nicotinamide Riboside) $40–$50250-300 mg/day oralOver the counter
SS-31 (Elamipretide) $200–$5005-10 mg/day subcutaneousGrey market
Semax $12–$60300-600 mcg/day of 0.1% sprayGrey market
Ergothioneine Not priced yet
Urolithin A $50–$100500 mg/dayOver the counter
Tesamorelin $250–$5002 mg subcutaneous daily in the eveningPrescription
Quinton Marine Plasma (Seawater Minerals) Not priced yet
Pine Pollen $20–$455 to 10 g powder per dayOver the counter
CJC-1295 $80–$2001-2 mg subcutaneousGrey market
Thymosin Beta-4 (Tβ4) Not priced yet
NAC (N-Acetylcysteine) $5–$15600 to 1,200 mg/dayOver the counter
Spermidine $40–$901-3 mg/day oral WGEOver the counter
BPC-157 $40–$80250 to 500 mcg SC 1 to 2x/day near injury siteGrey market
Lion’s Mane $20–$403 g/day fruiting body extractOver the counter
Ashwagandha $15–$30300 mg KSM-66 with breakfast and 300 mg with dinnerOver the counter
Fucoidan (Brown Seaweed Polysaccharide) Not priced yet
Cold Plunge Not priced yetOver the counter
5-Amino-1MQ $95–$19050 to 100 mg oral, once dailyGrey market
L-Theanine $3–$8200 mg L-theanine + 100 mg caffeineOver the counter
Polyphenols (Dietary) Not priced yet
GHK-Cu $30–$1000.5-3% topical serum or creamOver the counter
Thymosin Alpha-1 $100–$4001.6 mg subcutaneousPrescription
Saffron Not priced yet
Selank $30–$600.15% intranasal spray, roughly 1-3 sprays per nostril per day depending on actuation sizeGrey market
Berberine $15–$25500 mg berberine HCl three times daily with mealsOver the counter
Colostrum $60–$8020 g/day powder, split AM/PM if toleratedOver the counter
Epitalon $95–$1,1005-10 mg/day subcutaneousGrey market
Sodium Butyrate Not priced yet
Curcumin $15–$40500 mg curcuminoidsOver the counter
Retatrutide $130–$9602 mg, then 4 mg, then 8 mg or 12 mg weekly depending on protocol and tolerabilityResearch use only
NAD+ (Direct) $300–$1,600250 to 750 mgIn clinic
Tesofensine Not priced yet
C15 (Pentadecanoic Acid) $40–$50200 mg/dayOver the counter
C60 (Buckminsterfullerene) Not priced yet

Comparisons that judge more energy

Head-to-head reports and category rankings that name a winner on this use case.

Category ranking

Best GLP-1 Drugs Ranked by Evidence (2026)

This page ranks by the live body-composition subrating, not the overall BioHarmony score, since body composition is the goal this category is built around. Tirzepatide leads both measures.…

  • Tirzepatide
  • Retatrutide
  • Semaglutide
  • CagriSema
  • +5 more
Read the comparison →

9 more comparisons touch on more energy →

Questions about more energy

What scores highest for more energy?

Electrolytes, at 7.5–8.0 out of 10 for more energy. Borra 2025 anchors the strongest signal.

What is the cheapest thing that works for more energy?

Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 5.5–6.0 out of 10 for more energy.

What should I be careful with for more energy?

C15 (Pentadecanoic Acid) scores 3.0–3.5 out of 10 for more energy but only 3.0–3.5 overall, landing in the caution tier once safety, side effects, cost and effort are counted.

How many interventions has Outliyr scored for more energy?

84 of the 144 interventions evaluated for more energy score 3.0 out of 10 or better, which is the cut-off for appearing on this page.