Every intervention Outliyr has scored for male fertility, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for male fertility; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
31 of 99 evaluated interventions score 3.0+ out of 10 for male fertility · 8 comparisons
Biswas 2010 anchors the most relevant signal. Shilajit fits fertility male when purified resin is matched to hormones, sperm parameters, strength fatigue, bone markers, or energy tracking. The score stays bounded because…
Salman Yazdi 2014 found 830 nm irradiation improved human sperm motility in a controlled setting. That makes the male-fertility claim more concrete than most wellness-device claims. The caveat is translation: sperm experiments…
Semaglutide can improve the obesity and insulin-resistance context that often suppresses testosterone and sperm quality, while direct male-fertility trials remain limited. Moiz 2024 supports large weight-loss effects, which is the main pathway…
The evidence points to a plausible use case without proving a universal response. Lopresti et al. 2019 is the best anchor here because it reports randomized crossover study and direction supports hormonal…
Current audit data show no male-fertility randomized trial for Tirzepatide, so direct evidence is absent Franco 2025. Tirzepatide may improve fertility-male outcomes indirectly by reducing obesity and improving glycemic control, factors known…
Maleki-Hajiagha 2024 reports 4 clinical RCTs; 143 participants in main ART outcome meta-analysis; oocyte maturation and follicular-fluid total antioxidant capacity improved, while other ART/pregnancy outcomes were not significant. Dehpahni 2026 points in…
Tambi 2012 supports the strongest part of the claim. The existing rationale points to this narrower claim: the cited study and the cited study support male sexual or senior-function outcomes, and animal…
Kodama 2009 supports direction more than certainty. The existing rationale points to this narrower claim: Moderate exercise can support male fertility through metabolic health, vascular function, and body composition. Heat exposure from…
Tzang 2024 reports 25 RCTs and 1024 participants; lower SBP, DBP, fasting blood glucose, and triglycerides; no significant adverse-effect excess. Tzang 2024 points in the same direction, but route, dose, baseline status,…
Several RCTs and meta-analyses report that CoQ10 improves sperm concentration, motility, and morphology and lowers seminal oxidative stress, with a coherent antioxidant mechanism. The honest limit is that improvements in semen parameters…
High-Dose Melatonin has a borderline male-fertility score from antioxidant plausibility rather than a strong male fertility trial base. Oxidative stress matters for sperm quality, but the verified high-dose corpus is stronger for…
Male fertility support has direct kisspeptin-10 evidence, which is why it clears the high bar even though the data set is small. Intravenous kisspeptin-10 produced a dose-dependent LH rise and, on continuous…
Male fertility support is real but extrapolated, which is why it lands high yet under 5. Pulsatile GnRH and hCG plus hMG both induced virilization and spermatogenesis in men with hypogonadotropic hypogonadism…
No direct male-fertility evidence was verified for EAA supplementation. Do not extrapolate from general protein nutrition.
Male fertility and erectile-function data are small and heterogeneous; Maleki-saghooni 2018 supports erectile-function direction but not robust semen-parameter certainty.
No direct male fertility evidence. Vibration should not be treated as a fertility protocol.
No direct male-fertility indication exists. Any benefit is likely secondary to improved metabolic health in insulin-resistant men.
No direct male-fertility data for Ca-AKG. Do not extrapolate from unrelated AKG salts or mitochondrial fertility studies.
Ciftci 2009 (n=120) found 600 mg/day improved semen volume, motility, and viscosity over three months, but not concentration or morphology. A modest adjunct, not a proven fertility cure.
Testicular heat exposure can transiently reduce sperm parameters, which makes infrared sauna a poor fit for men actively trying to conceive. Use torso-only exposure, shorter sessions, or a pause window when conception…
The corrected male-infertility source Hosseini 2018 supports sperm motility and seminal DHA signals, but the effect is modest and dose-dependent.
Vitamin C is an antioxidant present in seminal fluid and has been studied for sperm quality on oxidative-stress grounds, but the human trial evidence is small, mixed, and usually combined with other…
Antioxidant support of sperm parameters is plausible through the broader thiol pathway, and NAC has some fertility data, but GlyNAC-specific human fertility evidence is absent.
Moderate exercise supports metabolic and hormonal health, while excessive intensity can impair recovery. Norwegian 4x4 is not a direct male-fertility protocol.
Khamidova 2005 rat reproduction study showed restoration of stress-violated spermatogenesis (PMID 16047676). Animal-only signal; not a human fertility intervention.
Antioxidant logic exists but no human male-fertility trial of ergothioneine supports a benefit.
Despite the phyto-androgen marketing, there is no human fertility or sperm-parameter study for pine pollen; the claim is mechanism and tradition only.
No human male-fertility trial has tested C15:0 supplementation for sperm count, motility, morphology, testosterone, or pregnancy outcomes. Wang 2024 (Wang 2024) is not a male-fertility study, but its developmental and maternal-metabolic findings…
Nothing matches those filters.
Monthly out-of-pocket cost at the most accessible legitimate channel, at the dose the score was given for. 8 of 31 are not priced yet; those cells are left blank rather than guessed.
| Intervention | Monthly cost | At dose | How you get it |
|---|---|---|---|
| Shilajit | $25–$50 | 500 mg purified shilajit | Over the counter |
| Red Light Therapy | $17–$43 | 10-20 min at 6-12 inches, full chest/face/back rotation | Over the counter |
| Semaglutide | $199–$349 | 0.25 mg weeks 1 to 4, 0.5 mg weeks 5 to 8, 1.0 mg weeks 9 to 12, 1.7 mg weeks 13 to 16, 2.4 mg week 17 onward | Prescription |
| Ashwagandha | $15–$30 | 300 mg KSM-66 with breakfast and 300 mg with dinner | Over the counter |
| Tirzepatide | $299–$449 | 2.5 to 5 to 7.5 to 10 to 12.5 to 15 mg | Prescription |
| Astaxanthin | Not priced yet | ||
| Tongkat Ali | $20–$40 | 200 mg/day Physta standardized extract | Over the counter |
| Zone 2 Cardio | Not priced yet | Over the counter | |
| Taurine | $3–$10 | 1-3 g, 30-60 minutes before sleep | Over the counter |
| Coenzyme Q10 (CoQ10 / Ubiquinol) | $15–$40 | 100-200 mg/day | Over the counter |
| High-Dose Melatonin | Not priced yet | ||
| Kisspeptin-10 | $25–$65 | 100 to 200 mcg per subcutaneous shot | Grey market |
| Gonadorelin (GnRH) | $50–$150 | Roughly 100 to 300 mcg | Prescription |
| Essential Amino Acids | Not priced yet | ||
| Glycine | $2–$3 | 3 g oral glycine | Over the counter |
| Saffron | Not priced yet | ||
| Whole-Body Vibration | $50–$100 | 30 Hz, roughly 0.3g, 10-20 min standing | Over the counter |
| Metformin | $4–$30 | 500 mg with dinner for 1 week, then 500 mg twice daily for 1 week, then increase by 500 mg/week toward 1000 mg twice daily as tolerated | Prescription |
| Ca-AKG (Calcium Alpha-Ketoglutarate) | $15–$30 | 1 g/day generic Ca-AKG oral | Over the counter |
| NAC (N-Acetylcysteine) | $5–$15 | 600 to 1,200 mg/day | Over the counter |
| Infrared Sauna | $36–$73 | 55-60 degrees C, 20-30 min | Over the counter |
| Omega-3 | $20–$40 | 1-2 g/day combined EPA+DHA | Over the counter |
| Spermidine | $40–$90 | 1-3 mg/day oral WGE | Over the counter |
| Vitamin C (Ascorbic Acid) | Not priced yet | ||
| GlyNAC (Glycine + N-Acetylcysteine) | $10–$30 | Glycine and NAC at ~100 mg/kg/day each | Over the counter |
| Norwegian 4×4 | Not priced yet | Over the counter | |
| Bromantane (Ladasten) | $12–$30 | 30 mg | Grey market |
| Ergothioneine | Not priced yet | ||
| Glutathione (GSH) | $20–$45 | 1,000 mg/day | Over the counter |
| Pine Pollen | $20–$45 | 5 to 10 g powder per day | Over the counter |
| C15 (Pentadecanoic Acid) | $40–$50 | 200 mg/day | Over the counter |
Head-to-head reports and category rankings that name a winner on this use case.
This page ranks by hormonal fit, not overall BioHarmony score. TRT leads at 9.0–9.5/10. Phosphatidylserine sits fifth at 5.5–6.0/10 despite the second highest overall score here, 7.0–7.5/10. That…
The scores tie at 6.0–6.5/10 and 6.0–6.5/10 and every shared subrating sits within half a point, so the numbers decide nothing. Access and evidence decide it. Gonadorelin is…
Kisspeptin-10 scores 6.0–6.5/10 and TRT 5.5–6.0/10, and TRT still wins 13 of the 15 use cases both reports score. The higher number reflects dependency and reversibility, not effect.…
Shilajit scores 7.0–7.5/10 and ashwagandha 6.5–7.0/10, but that gap is the least useful number here. These two do different jobs. Shilajit is the mineral and androgen play: male…
Ashwagandha scores 6.5–7.0/10 and tongkat ali 6.5–7.0/10, so the overall numbers do not decide it. Pick ashwagandha when stress, anxiety, or sleep is the complaint: its subratings there…
NAC scores 8.0–8.5/10 and glutathione 6.0–6.5/10, and that gap is real. NAC is the cheaper upstream precursor with a six-decade clinical record, so start there. Glutathione earns its…
Red light therapy scores 7.5–8.0/10 and infrared sauna 7.0–7.5/10, so buy the panel first. It costs less, targets skin, hair, joints and recovery directly, and carries higher evidence…
CoQ10 scores 7.0–7.5/10 and urolithin A scores 6.5–7.0/10, so CoQ10 wins on the numbers and costs two to six times less. It takes cardiovascular, energy, antioxidant and both…
Shilajit, at 7.5–8.0 out of 10 for male fertility. Biswas 2010 anchors the most relevant signal.
Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 4.5–5.0 out of 10 for male fertility.
C15 (Pentadecanoic Acid) scores 3.0–3.5 out of 10 for male fertility but only 3.0–3.5 overall, landing in the caution tier once safety, side effects, cost and effort are counted.
31 of the 99 interventions evaluated for male fertility score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
