Every intervention Outliyr has scored for memory, ranked by its BioHarmony score for this use case rather than its overall rating. The number beside each name is how well that one thing works for memory; the tier beside it is what it is worth once safety, cost and effort are counted across everything else.
47 of 83 evaluated interventions score 3.0+ out of 10 for memory · 8 comparisons
The strongest memory argument for Creatine Monohydrate is 7.0/10 because Avgerinos 2018 reports 6 RCTs; short-term memory and processing speed; vegetarian and elderly amplification. Dolan 2019 points in the same direction, but…
Read the Creatine Monohydrate report →Evidence puts Neurofeedback at 7.0/10 for memory, mainly through Treves et al. 2024. Memory benefits are mostly indirect through attention, working-memory, and arousal regulation rather than a dedicated memory protocol. Westwood 2025…
Read the Neurofeedback report →Lion's Mane memory earns 6.8/10 because Mori 2009 anchors the most relevant signal. Lion's Mane fits memory when the goal is gentle mushroom-based support for cognition, mood, nerve biology, or gut-immune signaling…
Read the Lion’s Mane report →Magnesium memory earns 6.6/10 because Slutsky 2010 anchors the most relevant signal. Magnesium fits memory when low intake, stress load, mineral loss, or a form-specific target makes deficiency correction plausible. The score…
Read the Magnesium report →The memory use case earns 6.5/10 for Phosphatidylserine, anchored by Shen et al. 2026. Memory is the primary clinical endpoint for PS. Positive bovine cortex trials contrast with more mixed soy and…
Read the Phosphatidylserine report →For memory, Methylene Blue lands at 6.5/10 because Rodriguez 2016 supports the strongest part of the claim. The existing rationale points to this narrower claim: The human memory signal is small but…
Read the Methylene Blue report →Memory scores 6.3/10 because Naeser 2011 found cognitive gains in chronic mild TBI cases after transcranial LED treatment. Memory claims are still emerging because trials are small and populations are specific. The…
Read the Red Light Therapy report →Zone 2 Cardio's 6.0/10 memory score starts with Kodama 2009, then gets narrowed by the evidence gap. The existing rationale points to this narrower claim: Aerobic exercise supports memory through hippocampal blood…
Read the Zone 2 Cardio report →On memory, Infrared Sauna deserves 6.0/10 because Hamaya 2025 makes the claim plausible but incomplete. The existing rationale points to this narrower claim: Memory score is driven by long-term dementia associations rather…
Read the Infrared Sauna report →For memory, Semax lands at 6.0/10 because context matters. Memory support is strongest in animal models: Dolotov et al. 2006 found hippocampal BDNF and TrkB changes with conditioned-learning effects, while Ellis et…
Read the Semax report →Memory support is plausible via cognitive-aging and post-stroke literature. Hadanny 2020 shows improvements clustered in attention, processing speed, and executive function rather than pure memory. Boussi-Gross 2014 reports memory improvement in chronic…
Read the Hyperbaric Oxygen Therapy report →Rapamycin memory earns 5.8/10 because Harrison 2009 anchors the most relevant signal. Rapamycin fits memory when mTORC1 modulation, autophagy, immune aging, or senescence biology is the actual target. The score stays bounded…
Read the Rapamycin report →On memory, Ca-AKG (Calcium Alpha-Ketoglutarate) deserves 5.8/10 because Shahmirzadi 2020 makes the claim plausible but incomplete. The existing rationale points to this narrower claim: Preclinical hippocampal LTP and synaptic tagging signal from…
Read the Ca-AKG (Calcium Alpha-Ketoglutarate) report →The memory score sits at 5.5/10 for HRV Biofeedback, reflecting the evidence in VA Whole Health. Some RCT evidence for working memory improvement with RF training, but Rosendo da Cunha e Silva…
Read the HRV Biofeedback report →For memory, Molecular Hydrogen scores 5.5/10 because Dhillon 2024 reports 25-article systematic review; mixed preliminary clinical evidence, heterogeneity, and need for stronger trials. Zhou 2024 points in the same direction, but route,…
Read the Molecular Hydrogen report →The memory case for Saffron lands at 5.5/10 because the evidence points to a plausible use case without proving a universal response. Zhang et al. 2025 is the best anchor here because…
Read the Saffron report →Glycine memory earns 5.5/10 because Soh 2024 anchors the most relevant signal. Glycine fits memory because glycine participates in sleep signaling, glutathione, collagen, methylation, and nervous-system balance, depending on the endpoint. The…
Read the Glycine report →Vagus Nerve Stimulation has a 5.5/10 memory case because Tassorelli et al. 2018 supports a plausible benefit. Small human studies suggest possible memory effects, but the 2024 epilepsy cognition meta-analysis did not…
Read the Vagus Nerve Stimulation report →A 5.5/10 memory rating fits Tesamorelin, since Stanley et al. 2012 points to a real but bounded effect. Baker 2012 reported memory-related improvement after GHRH analog therapy in older adults and MCI.…
Read the Tesamorelin report →Population fit explains the 5.5/10 memory score for Modafinil because the evidence points to a plausible use case without proving a universal response. Mann G et al. 2026 is the best anchor…
Read the Modafinil report →Dihexa memory earns 5.5/10 because McCoy 2013 anchors the most relevant signal. Dihexa fits memory only as a research-chemical hypothesis around synaptogenesis and memory circuits, not as a proven human nootropic. The…
Read the Dihexa report →Sabroxy scores 5.2/10 for memory because the most relevant studies involve memory tasks, cognitive impairment, or working-memory endpoints. The strongest support comes from Dinda B. et al. 2015, but the practical rating…
Read the Sabroxy (Oroxylum indicum Extract) report →L-Theanine belongs in the 5.0/10 range for memory because the signal is conditional. Working-memory improvements appear mainly in caffeine-combination trials such as Owen 2008 and Haskell 2008. Standalone memory effects remain modest.…
Read the L-Theanine report →Evidence for Astaxanthin in memory lands at 5.0/10 because Liu 2024 reports 11 RCTs; 346 healthy participants; significant improvements reported across fatigue, cognition, and exercise-efficiency endpoints overall; endpoint details are limited. The…
Read the Astaxanthin report →Memory sits at a neutral 5.0/10 on early, mixed interventional data. The Yau 2024 pilot in 19 people with mild cognitive impairment found improved verbal learning in the treated group, and Zajac…
Read the Ergothioneine report →Piracetam scores 5.0/10 for memory because the most relevant studies involve memory tasks, cognitive impairment, or working-memory endpoints. The strongest support comes from Cohen P. et al. 2020, but the practical rating…
Read the Piracetam (Nootropil) report →Aniracetam scores 5.0/10 for memory because the most relevant studies involve memory tasks, cognitive impairment, or working-memory endpoints. The strongest support comes from Isaacson et al. 1991, but the practical rating stays…
Read the Aniracetam report →Oxiracetam scores 5.0/10 for memory because the most relevant studies involve memory tasks, cognitive impairment, or working-memory endpoints. The strongest support comes from Copani A. et al. 1992, but the practical rating…
Read the Oxiracetam report →Memory is a 5.0/10 use case because Semaglutide has no proven human memory benefit in this report, despite active interest in GLP-1 brain biology. Perkovic 2024 and other outcome trials support systemic…
Read the Semaglutide report →Resveratrol receives a 5.0/10 score for memory, based on the modest cognitive gains observed in a 24-month double-blind trial of postmenopausal women taking 75 mg twice daily Thaung Zaw 2020. Resveratrol's memory…
Read the Resveratrol report →Memory benefit remains unproven in humans without diabetes. The theoretical AMPK and insulin-sensitivity rationale is offset by B12-depletion risk and lack of direct memory RCT evidence.
Read the Metformin report →No dedicated tirzepatide memory trial was audit-verified; score reflects indirect metabolic-risk improvement rather than proven cognitive enhancement.
Read the Tirzepatide report →Dehydration can impair short-term cognitive performance; rehydration restores baseline rather than enhancing memory beyond normal.
Read the Electrolytes report →Aerobic fitness supports hippocampal health and memory over time. Norwegian 4x4 is a plausible route to that adaptation, but memory is not a primary measured endpoint in the foundational 4x4 trials.
Read the Norwegian 4×4 report →No direct memory evidence was verified. Any cognitive relevance is indirect through protein adequacy, frailty reduction, or metabolic health.
Read the Essential Amino Acids report →Yurko-Mauro 2010 supports DHA in age-related cognitive decline, but this does not establish Alzheimer's prevention or meaningful benefit for already-optimized adults.
Read the Omega-3 report →Schwarz 2022 did not hit the primary memory endpoint, so the memory score stays modest despite mechanistic interest.
Read the Spermidine report →Memory remains a 4 because Alzheimer's mouse and neuronal-injury models do not yet translate into human memory outcomes. Tucker 2024 is the newest signal, and it should be read as preclinical.
Read the GHK-Cu report →No direct memory evidence. Whole-body vibration should not be promoted as a cognitive enhancer for healthy adults.
Read the Whole-Body Vibration report →Memory tracks the same dementia data as the broader cognition picture, which is why it earns a moderate score with a real caveat rather than a high one. The pooled Alzheimer's cognitive…
Read the Cerebrolysin report →Hippocampal LTP support from Mikhaylova/Behnisch 2007 (PMID 17854844) is suggestive but no human memory-battery RCT exists.
Read the Bromantane (Ladasten) report →No direct memory RCT data were identified. Any memory claim would be extrapolated from mood and stress changes and should remain low-confidence.
Read the Tongkat Ali report →Memory support is mainly preclinical. BDNF and ethanol-memory models in Kolik 2019 fit the claim, but there is no robust human memory trial.
Read the Selank report →Memory claims should stay conservative because the strongest clinical test was null. The T Trials cognition substudy did not show memory benefit despite selecting older men with low testosterone and memory complaints.
Read the TRT (Testosterone Replacement Therapy) report →Rides on the same single long Theracurmin trial as cognition. Not replicated, not something to count on.
Read the Curcumin report →Dopaminergic protection may preserve memory circuits in animal models. No human memory endpoint is verified in the audit.
Read the BPC-157 report →Preclinical hippocampal protection is directionally relevant, but the audit found no human memory endpoint trial for SS-31 or elamipretide.
Read the SS-31 (Elamipretide) report →Nothing matches those filters.
Head-to-head reports and category rankings that name a winner on this use case.
Bromantane and semax tie at 7.1, and they are the only two in this category scored strong recommend. Selank is third at 6.9 if anxiety rather than focus…
Cerebrolysin scores 6.3 and P-21 scores 5.0, and the gap is entirely about human data. Cerebrolysin has thousands of trial participants, contested by two independent Cochrane reviews. P-21…
Neither, yet. Both have zero human trials, zero human pharmacokinetics and research-only access. PE-22-28 scores 4.9 and dihexa 4.4, and the gap is entirely safety: dihexa potentiates the…
Epitalon, if sleep is the question. It scores sleep quality 6.5 against pinealon's 1.7, because it acts on the pineal gland and melatonin output while pinealon is a…
Bromantane scores 7.1 and modafinil 5.9, and they answer different questions. Modafinil is the faster and better-documented wakefulness drug when sleep debt or diagnosed sleepiness is the problem.…
Semax scores 7.1 and cerebrolysin 6.3. Semax wins cognition, neuroplasticity and nerve regeneration, costs an ESTIMATED $12 to $60 a month, and goes up your nose. Cerebrolysin wins…
Semax scores 7.1 against dihexa's 4.4, and that gap is real. Semax wins every cognitive use case we scored and carries human stroke data. Dihexa has zero human…
NMN scores 6.3, NR 6.1, and direct NAD+ 5.0. The oral precursors win on evidence and price. NMN takes blood sugar and metabolic health. NR takes cardiovascular and…
Creatine Monohydrate, at 7.0 out of 10 for memory. The strongest memory argument for Creatine Monohydrate is 7.0/10 because Avgerinos 2018 reports 6 RCTs; short-term memory and processing speed; vegetarian and elderly amplification.
Of the top-scoring options, Glycine is the least expensive at about $2 a month, scoring 5.5 out of 10 for memory.
Dihexa scores 5.5 out of 10 for memory but only 4.4 overall, landing in the caution tier once safety, side effects, cost and effort are counted.
47 of the 83 interventions evaluated for memory score 3.0 out of 10 or better, which is the cut-off for appearing on this page.
